Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H422_LEIBR

TriTrypDb:

LbrM.04.1080 , LBRM2903_040018200

Length:

140

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H422

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H422

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	55	57	PF00082	0.464
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.539
DEG_APCC_DBOX_1	110	118	PF00400	0.356
DEG_Nend_Nbox_1	1	3	PF02207	0.544
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.508
DOC_USP7_MATH_1	122	126	PF00917	0.535
DOC_USP7_MATH_1	84	88	PF00917	0.431
DOC_WW_Pin1_4	134	139	PF00397	0.396
DOC_WW_Pin1_4	16	21	PF00397	0.588
LIG_14-3-3_CanoR_1	10	20	PF00244	0.436
LIG_14-3-3_CanoR_1	113	117	PF00244	0.433
LIG_BRCT_BRCA1_1	124	128	PF00533	0.519
LIG_FHA_1	16	22	PF00498	0.436
LIG_FHA_1	65	71	PF00498	0.459
LIG_FHA_2	48	54	PF00498	0.476
LIG_FHA_2	60	66	PF00498	0.418
LIG_LIR_Gen_1	115	124	PF02991	0.497
LIG_LIR_Gen_1	76	86	PF02991	0.319
LIG_LIR_Nem_3	115	121	PF02991	0.495
LIG_LIR_Nem_3	76	82	PF02991	0.318
LIG_SH2_CRK	118	122	PF00017	0.397
LIG_SH2_STAT5	123	126	PF00017	0.518
LIG_SH3_3	17	23	PF00018	0.561
LIG_SUMO_SIM_anti_2	112	119	PF11976	0.405
LIG_TYR_ITIM	116	121	PF00017	0.510
MOD_CDC14_SPxK_1	137	140	PF00782	0.418
MOD_CDK_SPxK_1	134	140	PF00069	0.404
MOD_CK1_1	15	21	PF00069	0.631
MOD_CK1_1	47	53	PF00069	0.602
MOD_CK1_1	85	91	PF00069	0.439
MOD_CK2_1	59	65	PF00069	0.496
MOD_GlcNHglycan	105	108	PF01048	0.489
MOD_GlcNHglycan	14	17	PF01048	0.566
MOD_GlcNHglycan	84	87	PF01048	0.433
MOD_GlcNHglycan	88	91	PF01048	0.442
MOD_GSK3_1	112	119	PF00069	0.468
MOD_GSK3_1	132	139	PF00069	0.566
MOD_GSK3_1	8	15	PF00069	0.553
MOD_GSK3_1	82	89	PF00069	0.482
MOD_N-GLC_1	28	33	PF02516	0.381
MOD_NEK2_1	103	108	PF00069	0.481
MOD_NEK2_1	116	121	PF00069	0.474
MOD_NEK2_1	132	137	PF00069	0.581
MOD_NEK2_1	3	8	PF00069	0.494
MOD_NEK2_1	66	71	PF00069	0.443
MOD_NEK2_1	73	78	PF00069	0.382
MOD_PKA_2	11	17	PF00069	0.575
MOD_PKA_2	112	118	PF00069	0.478
MOD_PKA_2	39	45	PF00069	0.402
MOD_PKA_2	59	65	PF00069	0.476
MOD_PKB_1	10	18	PF00069	0.438
MOD_Plk_1	28	34	PF00069	0.405
MOD_Plk_1	44	50	PF00069	0.427
MOD_Plk_4	112	118	PF00069	0.493
MOD_ProDKin_1	134	140	PF00069	0.406
MOD_ProDKin_1	16	22	PF00069	0.585
MOD_SUMO_rev_2	47	57	PF00179	0.586
TRG_DiLeu_BaLyEn_6	34	39	PF01217	0.516
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.413
TRG_ENDOCYTIC_2	118	121	PF00928	0.395
TRG_ER_diArg_1	57	60	PF00400	0.543
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAB6	Leptomonas seymouri	58%	99%
A0A1X0NLC3	Trypanosomatidae	42%	100%
A0A3S7WNY1	Leishmania donovani	74%	100%
A4HSA4	Leishmania infantum	74%	100%
C9ZY96	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AK88	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q9NF88	Leishmania major	73%	94%
V5AYA9	Trypanosoma cruzi	34%	100%