Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H421_LEIBR

TriTrypDb:

LbrM.04.1070 , LBRM2903_040018000 , LBRM2903_040018100

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H421

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H421

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	317	321	PF00656	0.534
CLV_C14_Caspase3-7	388	392	PF00656	0.527
CLV_C14_Caspase3-7	447	451	PF00656	0.543
CLV_NRD_NRD_1	173	175	PF00675	0.522
CLV_NRD_NRD_1	216	218	PF00675	0.563
CLV_PCSK_KEX2_1	173	175	PF00082	0.522
CLV_PCSK_KEX2_1	216	218	PF00082	0.563
CLV_PCSK_SKI1_1	303	307	PF00082	0.646
DEG_SCF_FBW7_1	108	115	PF00400	0.519
DEG_SPOP_SBC_1	218	222	PF00917	0.561
DEG_SPOP_SBC_1	304	308	PF00917	0.624
DOC_CKS1_1	109	114	PF01111	0.521
DOC_CYCLIN_yCln2_LP_2	35	41	PF00134	0.317
DOC_MAPK_gen_1	49	58	PF00069	0.502
DOC_MAPK_HePTP_8	46	58	PF00069	0.512
DOC_MAPK_MEF2A_6	49	58	PF00069	0.566
DOC_MAPK_NFAT4_5	51	59	PF00069	0.503
DOC_PP1_RVXF_1	276	283	PF00149	0.476
DOC_PP2B_LxvP_1	152	155	PF13499	0.477
DOC_PP2B_LxvP_1	234	237	PF13499	0.562
DOC_PP4_MxPP_1	464	467	PF00568	0.530
DOC_USP7_MATH_1	112	116	PF00917	0.521
DOC_USP7_MATH_1	120	124	PF00917	0.530
DOC_USP7_MATH_1	182	186	PF00917	0.678
DOC_USP7_MATH_1	218	222	PF00917	0.568
DOC_USP7_MATH_1	339	343	PF00917	0.640
DOC_USP7_MATH_1	448	452	PF00917	0.556
DOC_USP7_MATH_1	8	12	PF00917	0.733
DOC_WW_Pin1_4	108	113	PF00397	0.639
DOC_WW_Pin1_4	160	165	PF00397	0.465
DOC_WW_Pin1_4	209	214	PF00397	0.628
DOC_WW_Pin1_4	235	240	PF00397	0.573
DOC_WW_Pin1_4	244	249	PF00397	0.622
DOC_WW_Pin1_4	319	324	PF00397	0.783
DOC_WW_Pin1_4	4	9	PF00397	0.687
DOC_WW_Pin1_4	56	61	PF00397	0.535
LIG_14-3-3_CanoR_1	303	311	PF00244	0.623
LIG_14-3-3_CanoR_1	334	339	PF00244	0.547
LIG_14-3-3_CanoR_1	386	390	PF00244	0.614
LIG_Actin_WH2_2	41	59	PF00022	0.440
LIG_APCC_ABBA_1	431	436	PF00400	0.629
LIG_BIR_II_1	1	5	PF00653	0.737
LIG_BIR_III_2	320	324	PF00653	0.554
LIG_BIR_III_4	69	73	PF00653	0.434
LIG_BRCT_BRCA1_1	147	151	PF00533	0.546
LIG_FHA_1	229	235	PF00498	0.554
LIG_FHA_1	306	312	PF00498	0.627
LIG_FHA_1	451	457	PF00498	0.538
LIG_FHA_2	142	148	PF00498	0.471
LIG_FHA_2	17	23	PF00498	0.540
LIG_FHA_2	320	326	PF00498	0.586
LIG_FHA_2	422	428	PF00498	0.652
LIG_FHA_2	97	103	PF00498	0.537
LIG_LIR_Gen_1	148	159	PF02991	0.591
LIG_LIR_Gen_1	166	175	PF02991	0.495
LIG_LIR_Nem_3	102	108	PF02991	0.698
LIG_LIR_Nem_3	148	154	PF02991	0.624
LIG_LIR_Nem_3	166	171	PF02991	0.526
LIG_LYPXL_yS_3	105	108	PF13949	0.541
LIG_MYND_1	10	14	PF01753	0.501
LIG_NRBOX	29	35	PF00104	0.485
LIG_PCNA_yPIPBox_3	21	34	PF02747	0.491
LIG_PTAP_UEV_1	178	183	PF05743	0.466
LIG_SH2_NCK_1	75	79	PF00017	0.461
LIG_SH2_STAT5	23	26	PF00017	0.600
LIG_SH3_2	179	184	PF14604	0.486
LIG_SH3_3	103	109	PF00018	0.565
LIG_SH3_3	176	182	PF00018	0.432
LIG_SH3_3	207	213	PF00018	0.595
LIG_SH3_3	245	251	PF00018	0.693
LIG_SH3_3	404	410	PF00018	0.706
LIG_SH3_3	459	465	PF00018	0.721
LIG_SH3_CIN85_PxpxPR_1	237	242	PF14604	0.554
LIG_TRAF2_1	327	330	PF00917	0.736
LIG_TRAF2_1	381	384	PF00917	0.550
MOD_CDK_SPK_2	237	242	PF00069	0.554
MOD_CDK_SPxxK_3	209	216	PF00069	0.545
MOD_CDK_SPxxK_3	235	242	PF00069	0.555
MOD_CK1_1	145	151	PF00069	0.565
MOD_CK1_1	2	8	PF00069	0.695
MOD_CK1_1	240	246	PF00069	0.681
MOD_CK1_1	401	407	PF00069	0.616
MOD_CK1_1	443	449	PF00069	0.709
MOD_CK1_1	451	457	PF00069	0.624
MOD_CK1_1	458	464	PF00069	0.572
MOD_CK2_1	141	147	PF00069	0.478
MOD_CK2_1	319	325	PF00069	0.579
MOD_CK2_1	396	402	PF00069	0.544
MOD_CK2_1	96	102	PF00069	0.523
MOD_GlcNHglycan	117	121	PF01048	0.389
MOD_GlcNHglycan	127	130	PF01048	0.534
MOD_GlcNHglycan	144	147	PF01048	0.541
MOD_GlcNHglycan	165	168	PF01048	0.480
MOD_GlcNHglycan	179	182	PF01048	0.485
MOD_GlcNHglycan	185	188	PF01048	0.546
MOD_GlcNHglycan	221	224	PF01048	0.586
MOD_GlcNHglycan	255	258	PF01048	0.590
MOD_GlcNHglycan	283	286	PF01048	0.498
MOD_GlcNHglycan	3	7	PF01048	0.694
MOD_GlcNHglycan	342	345	PF01048	0.708
MOD_GlcNHglycan	402	406	PF01048	0.642
MOD_GlcNHglycan	411	414	PF01048	0.547
MOD_GlcNHglycan	446	449	PF01048	0.620
MOD_GlcNHglycan	457	460	PF01048	0.705
MOD_GSK3_1	108	115	PF00069	0.577
MOD_GSK3_1	116	123	PF00069	0.580
MOD_GSK3_1	141	148	PF00069	0.473
MOD_GSK3_1	163	170	PF00069	0.493
MOD_GSK3_1	2	9	PF00069	0.694
MOD_GSK3_1	224	231	PF00069	0.639
MOD_GSK3_1	240	247	PF00069	0.642
MOD_GSK3_1	303	310	PF00069	0.669
MOD_GSK3_1	319	326	PF00069	0.691
MOD_GSK3_1	354	361	PF00069	0.550
MOD_GSK3_1	394	401	PF00069	0.593
MOD_GSK3_1	417	424	PF00069	0.678
MOD_GSK3_1	439	446	PF00069	0.684
MOD_GSK3_1	448	455	PF00069	0.612
MOD_N-GLC_1	448	453	PF02516	0.539
MOD_N-GLC_2	94	96	PF02516	0.551
MOD_NEK2_1	1	6	PF00069	0.551
MOD_NEK2_1	314	319	PF00069	0.520
MOD_NEK2_1	33	38	PF00069	0.484
MOD_PIKK_1	33	39	PF00454	0.479
MOD_PKA_2	183	189	PF00069	0.631
MOD_PKA_2	333	339	PF00069	0.552
MOD_PKA_2	385	391	PF00069	0.580
MOD_Plk_1	228	234	PF00069	0.551
MOD_Plk_2-3	16	22	PF00069	0.387
MOD_Plk_2-3	358	364	PF00069	0.722
MOD_Plk_4	147	153	PF00069	0.604
MOD_Plk_4	167	173	PF00069	0.505
MOD_ProDKin_1	108	114	PF00069	0.634
MOD_ProDKin_1	160	166	PF00069	0.464
MOD_ProDKin_1	209	215	PF00069	0.629
MOD_ProDKin_1	235	241	PF00069	0.569
MOD_ProDKin_1	244	250	PF00069	0.620
MOD_ProDKin_1	319	325	PF00069	0.786
MOD_ProDKin_1	4	10	PF00069	0.686
MOD_ProDKin_1	56	62	PF00069	0.529
MOD_SUMO_rev_2	293	299	PF00179	0.744
MOD_SUMO_rev_2	370	376	PF00179	0.551
TRG_DiLeu_BaEn_2	146	152	PF01217	0.399
TRG_ENDOCYTIC_2	105	108	PF00928	0.658
TRG_ENDOCYTIC_2	15	18	PF00928	0.513
TRG_ENDOCYTIC_2	434	437	PF00928	0.630
TRG_ENDOCYTIC_2	75	78	PF00928	0.456
TRG_ER_diArg_1	172	174	PF00400	0.514
TRG_ER_diArg_1	241	244	PF00400	0.561
TRG_ER_diArg_1	287	290	PF00400	0.660
TRG_ER_diArg_1	50	53	PF00400	0.511
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WNX2	Leishmania donovani	63%	97%
A4HSA3	Leishmania infantum	63%	97%
E9AK87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	99%
Q9NF89	Leishmania major	63%	99%