Acyltransferase-like protein, copy 2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyltransferase-like protein, copy 2

Species:

Leishmania braziliensis

UniProt:

A4H420_LEIBR

TriTrypDb:

LbrM.04.1060 , LBRM2903_040017900

Length:

355

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 45

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 31
NetGPI	no	yes: 0, no: 31

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	27
GO:0110165	cellular anatomical entity	1	27

Expansion

Sequence features

A4H420

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H420

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	4
GO:0006644	phospholipid metabolic process	4	4
GO:0006650	glycerophospholipid metabolic process	5	4
GO:0006654	phosphatidic acid biosynthetic process	6	4
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0008152	metabolic process	1	4
GO:0008610	lipid biosynthetic process	4	4
GO:0008654	phospholipid biosynthetic process	5	4
GO:0009058	biosynthetic process	2	4
GO:0009987	cellular process	1	4
GO:0019637	organophosphate metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044255	cellular lipid metabolic process	3	4
GO:0045017	glycerolipid biosynthetic process	4	4
GO:0046473	phosphatidic acid metabolic process	6	4
GO:0046474	glycerophospholipid biosynthetic process	5	4
GO:0046486	glycerolipid metabolic process	4	4
GO:0071704	organic substance metabolic process	2	4
GO:0090407	organophosphate biosynthetic process	4	4
GO:1901576	organic substance biosynthetic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	32
GO:0016740	transferase activity	2	32
GO:0016746	acyltransferase activity	3	32
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	7	9
GO:0008374	O-acyltransferase activity	5	9
GO:0016411	acylglycerol O-acyltransferase activity	6	9
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	9
GO:0042171	lysophosphatidic acid acyltransferase activity	6	9
GO:0071617	lysophospholipid acyltransferase activity	5	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	175	181	PF00089	0.544
CLV_NRD_NRD_1	166	168	PF00675	0.554
CLV_NRD_NRD_1	324	326	PF00675	0.593
CLV_PCSK_FUR_1	322	326	PF00082	0.680
CLV_PCSK_KEX2_1	301	303	PF00082	0.548
CLV_PCSK_KEX2_1	322	324	PF00082	0.619
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.551
CLV_PCSK_SKI1_1	337	341	PF00082	0.713
CLV_PCSK_SKI1_1	46	50	PF00082	0.583
CLV_PCSK_SKI1_1	51	55	PF00082	0.420
DOC_CDC14_PxL_1	76	84	PF14671	0.427
DOC_CYCLIN_yCln2_LP_2	70	76	PF00134	0.444
DOC_MAPK_DCC_7	75	84	PF00069	0.619
DOC_MAPK_MEF2A_6	228	236	PF00069	0.305
DOC_MAPK_MEF2A_6	23	32	PF00069	0.530
DOC_MAPK_MEF2A_6	75	84	PF00069	0.602
DOC_PP1_RVXF_1	95	102	PF00149	0.399
DOC_PP2B_LxvP_1	342	345	PF13499	0.343
DOC_PP2B_LxvP_1	60	63	PF13499	0.430
DOC_PP2B_LxvP_1	77	80	PF13499	0.584
DOC_PP4_FxxP_1	140	143	PF00568	0.294
DOC_WW_Pin1_4	147	152	PF00397	0.321
LIG_14-3-3_CanoR_1	325	335	PF00244	0.399
LIG_AP2alpha_1	140	144	PF02296	0.266
LIG_AP2alpha_2	142	144	PF02296	0.297
LIG_APCC_ABBA_1	218	223	PF00400	0.286
LIG_BIR_III_4	113	117	PF00653	0.279
LIG_BRCT_BRCA1_1	92	96	PF00533	0.291
LIG_FHA_1	150	156	PF00498	0.280
LIG_FHA_1	260	266	PF00498	0.380
LIG_FHA_1	55	61	PF00498	0.339
LIG_GBD_Chelix_1	295	303	PF00786	0.561
LIG_LIR_Apic_2	138	143	PF02991	0.175
LIG_LIR_Gen_1	142	151	PF02991	0.290
LIG_LIR_Gen_1	240	249	PF02991	0.284
LIG_LIR_Gen_1	275	285	PF02991	0.342
LIG_LIR_Nem_3	138	144	PF02991	0.286
LIG_LIR_Nem_3	235	241	PF02991	0.288
LIG_LIR_Nem_3	250	255	PF02991	0.282
LIG_LIR_Nem_3	275	280	PF02991	0.349
LIG_LIR_Nem_3	49	55	PF02991	0.321
LIG_LIR_Nem_3	93	99	PF02991	0.213
LIG_MYND_1	17	21	PF01753	0.451
LIG_NRBOX	66	72	PF00104	0.342
LIG_PCNA_PIPBox_1	205	214	PF02747	0.189
LIG_PDZ_Class_2	350	355	PF00595	0.353
LIG_Pex14_2	140	144	PF04695	0.258
LIG_Pex14_2	172	176	PF04695	0.314
LIG_Pex14_2	182	186	PF04695	0.304
LIG_Pex14_2	96	100	PF04695	0.385
LIG_SH2_CRK	269	273	PF00017	0.423
LIG_SH2_PTP2	277	280	PF00017	0.374
LIG_SH2_PTP2	36	39	PF00017	0.256
LIG_SH2_STAT5	277	280	PF00017	0.302
LIG_SH2_STAT5	36	39	PF00017	0.339
LIG_SH2_STAT5	69	72	PF00017	0.413
LIG_SH2_STAT5	76	79	PF00017	0.552
LIG_SH3_3	14	20	PF00018	0.611
LIG_SUMO_SIM_par_1	253	260	PF11976	0.324
LIG_TRAF2_1	316	319	PF00917	0.316
LIG_TRFH_1	69	73	PF08558	0.237
LIG_TYR_ITIM	74	79	PF00017	0.607
LIG_WRC_WIRS_1	233	238	PF05994	0.285
MOD_CK1_1	190	196	PF00069	0.363
MOD_CK1_1	256	262	PF00069	0.410
MOD_CK1_1	291	297	PF00069	0.398
MOD_GlcNHglycan	189	192	PF01048	0.585
MOD_GSK3_1	157	164	PF00069	0.324
MOD_GSK3_1	331	338	PF00069	0.403
MOD_LATS_1	185	191	PF00433	0.189
MOD_N-GLC_1	135	140	PF02516	0.475
MOD_N-GLC_2	86	88	PF02516	0.181
MOD_NEK2_1	135	140	PF00069	0.264
MOD_NEK2_1	155	160	PF00069	0.248
MOD_NEK2_1	161	166	PF00069	0.312
MOD_NEK2_1	214	219	PF00069	0.324
MOD_NEK2_1	53	58	PF00069	0.353
MOD_NEK2_1	90	95	PF00069	0.271
MOD_NMyristoyl	1	7	PF02799	0.510
MOD_PIKK_1	46	52	PF00454	0.214
MOD_PKA_2	288	294	PF00069	0.281
MOD_Plk_1	135	141	PF00069	0.275
MOD_Plk_1	259	265	PF00069	0.349
MOD_Plk_4	136	142	PF00069	0.294
MOD_Plk_4	23	29	PF00069	0.442
MOD_Plk_4	240	246	PF00069	0.326
MOD_Plk_4	331	337	PF00069	0.300
MOD_ProDKin_1	147	153	PF00069	0.321
MOD_SUMO_rev_2	113	121	PF00179	0.272
MOD_SUMO_rev_2	329	334	PF00179	0.499
TRG_ENDOCYTIC_2	238	241	PF00928	0.322
TRG_ENDOCYTIC_2	252	255	PF00928	0.273
TRG_ENDOCYTIC_2	269	272	PF00928	0.380
TRG_ENDOCYTIC_2	277	280	PF00928	0.353
TRG_ENDOCYTIC_2	36	39	PF00928	0.382
TRG_ENDOCYTIC_2	76	79	PF00928	0.574
TRG_ER_diArg_1	322	325	PF00400	0.427
TRG_ER_diArg_1	39	42	PF00400	0.467
TRG_Pf-PMV_PEXEL_1	325	330	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.257

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P455	Leptomonas seymouri	60%	100%
A0A0N1HTP4	Leptomonas seymouri	54%	100%
A0A0N1I6V1	Leptomonas seymouri	35%	100%
A0A0S4IQ05	Bodo saltans	29%	100%
A0A0S4IR22	Bodo saltans	39%	100%
A0A0S4JRB2	Bodo saltans	32%	100%
A0A1X0NUQ7	Trypanosomatidae	27%	100%
A0A3Q8IFY7	Leishmania donovani	30%	100%
A0A3R7NKA0	Trypanosoma rangeli	34%	100%
A0A3S5H5E4	Leishmania donovani	54%	82%
A0A3S5H7L8	Leishmania donovani	33%	100%
A0A3S5IQW0	Trypanosoma rangeli	27%	100%
A0A3S7WNW6	Leishmania donovani	70%	100%
A4H419	Leishmania braziliensis	75%	100%
A4HHM7	Leishmania braziliensis	34%	100%
A4HKI5	Leishmania braziliensis	30%	100%
A4HSA1	Leishmania infantum	53%	100%
A4HSA2	Leishmania infantum	70%	100%
A4I4U2	Leishmania infantum	33%	100%
A4I816	Leishmania infantum	30%	100%
C9ZLI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AE90	Leishmania major	32%	100%
E9AK86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
E9ALJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B2X4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
Q4Q582	Leishmania major	31%	100%
Q9NF90	Leishmania major	71%	100%
Q9NF91	Leishmania major	55%	100%
V5ALB6	Trypanosoma cruzi	25%	100%
V5C201	Trypanosoma cruzi	32%	100%