Acyltransferase-like protein, copy 1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyltransferase-like protein, copy 1

Species:

Leishmania braziliensis

UniProt:

A4H419_LEIBR

TriTrypDb:

LbrM.04.1050 , LBRM2903_040017800

Length:

337

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 27

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 28
NetGPI	no	yes: 0, no: 28

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	23
GO:0110165	cellular anatomical entity	1	23

Expansion

Sequence features

A4H419

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H419

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	4
GO:0006644	phospholipid metabolic process	4	4
GO:0006650	glycerophospholipid metabolic process	5	4
GO:0006654	phosphatidic acid biosynthetic process	6	4
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0008152	metabolic process	1	4
GO:0008610	lipid biosynthetic process	4	4
GO:0008654	phospholipid biosynthetic process	5	4
GO:0009058	biosynthetic process	2	4
GO:0009987	cellular process	1	4
GO:0019637	organophosphate metabolic process	3	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044255	cellular lipid metabolic process	3	4
GO:0045017	glycerolipid biosynthetic process	4	4
GO:0046473	phosphatidic acid metabolic process	6	4
GO:0046474	glycerophospholipid biosynthetic process	5	4
GO:0046486	glycerolipid metabolic process	4	4
GO:0071704	organic substance metabolic process	2	4
GO:0090407	organophosphate biosynthetic process	4	4
GO:1901576	organic substance biosynthetic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	29
GO:0016740	transferase activity	2	29
GO:0016746	acyltransferase activity	3	29
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	7	5
GO:0008374	O-acyltransferase activity	5	5
GO:0016411	acylglycerol O-acyltransferase activity	6	5
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	5
GO:0042171	lysophosphatidic acid acyltransferase activity	6	5
GO:0071617	lysophospholipid acyltransferase activity	5	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	157	163	PF00089	0.535
CLV_NRD_NRD_1	148	150	PF00675	0.546
CLV_NRD_NRD_1	23	25	PF00675	0.312
CLV_NRD_NRD_1	306	308	PF00675	0.607
CLV_PCSK_FUR_1	304	308	PF00082	0.688
CLV_PCSK_KEX2_1	23	25	PF00082	0.295
CLV_PCSK_KEX2_1	283	285	PF00082	0.541
CLV_PCSK_KEX2_1	304	306	PF00082	0.644
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.541
CLV_PCSK_SKI1_1	135	139	PF00082	0.509
CLV_PCSK_SKI1_1	319	323	PF00082	0.716
DOC_CKS1_1	130	135	PF01111	0.269
DOC_CYCLIN_yClb5_NLxxxL_5	35	44	PF00134	0.182
DOC_MAPK_DCC_7	68	76	PF00069	0.360
DOC_MAPK_gen_1	23	30	PF00069	0.517
DOC_MAPK_MEF2A_6	210	218	PF00069	0.304
DOC_MAPK_MEF2A_6	23	30	PF00069	0.521
DOC_MAPK_MEF2A_6	32	40	PF00069	0.476
DOC_MAPK_MEF2A_6	68	76	PF00069	0.348
DOC_PP1_RVXF_1	30	36	PF00149	0.430
DOC_PP1_RVXF_1	77	84	PF00149	0.316
DOC_PP1_RVXF_1	89	95	PF00149	0.321
DOC_PP1_RVXF_1	99	106	PF00149	0.369
DOC_PP2B_LxvP_1	324	327	PF13499	0.342
DOC_PP2B_LxvP_1	59	62	PF13499	0.411
DOC_WW_Pin1_4	129	134	PF00397	0.311
LIG_14-3-3_CanoR_1	101	106	PF00244	0.321
LIG_14-3-3_CanoR_1	307	317	PF00244	0.408
LIG_14-3-3_CanoR_1	79	84	PF00244	0.401
LIG_Actin_WH2_2	122	137	PF00022	0.374
LIG_APCC_ABBA_1	200	205	PF00400	0.310
LIG_FHA_1	138	144	PF00498	0.294
LIG_FHA_1	242	248	PF00498	0.361
LIG_FHA_1	48	54	PF00498	0.333
LIG_FHA_1	5	11	PF00498	0.262
LIG_FHA_1	61	67	PF00498	0.297
LIG_GBD_Chelix_1	277	285	PF00786	0.563
LIG_LIR_Apic_2	80	86	PF02991	0.238
LIG_LIR_Gen_1	124	134	PF02991	0.289
LIG_LIR_Gen_1	222	231	PF02991	0.263
LIG_LIR_Gen_1	257	267	PF02991	0.351
LIG_LIR_Nem_3	104	108	PF02991	0.287
LIG_LIR_Nem_3	120	126	PF02991	0.296
LIG_LIR_Nem_3	217	223	PF02991	0.280
LIG_LIR_Nem_3	232	237	PF02991	0.280
LIG_LIR_Nem_3	257	262	PF02991	0.349
LIG_PCNA_PIPBox_1	187	196	PF02747	0.196
LIG_PDZ_Class_2	332	337	PF00595	0.361
LIG_Pex14_2	154	158	PF04695	0.326
LIG_Pex14_2	164	168	PF04695	0.301
LIG_PTB_Apo_2	109	116	PF02174	0.272
LIG_PTB_Phospho_1	109	115	PF10480	0.183
LIG_SH2_CRK	126	130	PF00017	0.374
LIG_SH2_CRK	251	255	PF00017	0.425
LIG_SH2_PTP2	18	21	PF00017	0.249
LIG_SH2_PTP2	259	262	PF00017	0.381
LIG_SH2_STAP1	126	130	PF00017	0.367
LIG_SH2_STAT5	115	118	PF00017	0.225
LIG_SH2_STAT5	18	21	PF00017	0.305
LIG_SH2_STAT5	259	262	PF00017	0.331
LIG_SH3_3	127	133	PF00018	0.398
LIG_SUMO_SIM_par_1	235	242	PF11976	0.365
LIG_SUMO_SIM_par_1	6	12	PF11976	0.222
LIG_TRAF2_1	298	301	PF00917	0.315
LIG_TYR_ITIM	16	21	PF00017	0.379
LIG_WRC_WIRS_1	215	220	PF05994	0.284
MOD_CDK_SPxK_1	129	135	PF00069	0.335
MOD_CK1_1	172	178	PF00069	0.323
MOD_CK1_1	238	244	PF00069	0.410
MOD_CK1_1	273	279	PF00069	0.396
MOD_CK1_1	4	10	PF00069	0.488
MOD_CK1_1	47	53	PF00069	0.370
MOD_GlcNHglycan	171	174	PF01048	0.591
MOD_GlcNHglycan	46	49	PF01048	0.337
MOD_GSK3_1	139	146	PF00069	0.304
MOD_GSK3_1	313	320	PF00069	0.390
MOD_LATS_1	167	173	PF00433	0.196
MOD_N-GLC_1	117	122	PF02516	0.466
MOD_N-GLC_1	4	9	PF02516	0.182
MOD_NEK2_1	1	6	PF00069	0.457
MOD_NEK2_1	143	148	PF00069	0.300
MOD_NEK2_1	196	201	PF00069	0.317
MOD_PKA_2	270	276	PF00069	0.286
MOD_Plk_1	117	123	PF00069	0.266
MOD_Plk_1	241	247	PF00069	0.351
MOD_Plk_1	4	10	PF00069	0.182
MOD_Plk_4	118	124	PF00069	0.276
MOD_Plk_4	222	228	PF00069	0.336
MOD_Plk_4	313	319	PF00069	0.317
MOD_Plk_4	4	10	PF00069	0.472
MOD_Plk_4	79	85	PF00069	0.400
MOD_ProDKin_1	129	135	PF00069	0.311
MOD_SUMO_rev_2	311	316	PF00179	0.362
TRG_ENDOCYTIC_2	126	129	PF00928	0.385
TRG_ENDOCYTIC_2	18	21	PF00928	0.376
TRG_ENDOCYTIC_2	220	223	PF00928	0.310
TRG_ENDOCYTIC_2	234	237	PF00928	0.269
TRG_ENDOCYTIC_2	251	254	PF00928	0.363
TRG_ENDOCYTIC_2	259	262	PF00928	0.348
TRG_ER_diArg_1	23	25	PF00400	0.556
TRG_ER_diArg_1	304	307	PF00400	0.431
TRG_ER_diArg_1	88	91	PF00400	0.239
TRG_Pf-PMV_PEXEL_1	307	312	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P455	Leptomonas seymouri	55%	99%
A0A0N1HTP4	Leptomonas seymouri	58%	100%
A0A0N1I6V1	Leptomonas seymouri	35%	100%
A0A0S4IQ05	Bodo saltans	30%	99%
A0A0S4IR22	Bodo saltans	41%	100%
A0A0S4JRB2	Bodo saltans	33%	100%
A0A1X0P9F0	Trypanosomatidae	35%	100%
A0A3R7NKA0	Trypanosoma rangeli	36%	100%
A0A3S5H5E4	Leishmania donovani	66%	78%
A0A3S5H7L8	Leishmania donovani	34%	100%
A0A3S7WNW6	Leishmania donovani	56%	95%
A4H418	Leishmania braziliensis	87%	100%
A4H420	Leishmania braziliensis	75%	95%
A4HHM7	Leishmania braziliensis	35%	100%
A4HSA1	Leishmania infantum	65%	100%
A4HSA2	Leishmania infantum	56%	95%
A4I4U1	Leishmania infantum	32%	100%
A4I4U2	Leishmania infantum	34%	100%
C9ZLI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AE89	Leishmania major	32%	100%
E9AE90	Leishmania major	34%	100%
E9AK86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9ALJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B2X4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q9NF90	Leishmania major	57%	100%
Q9NF91	Leishmania major	68%	100%
V5C201	Trypanosoma cruzi	32%	100%