Acyltransferase-like protein, copy 1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyltransferase-like protein, copy 1

Species:

Leishmania braziliensis

UniProt:

A4H418_LEIBR

TriTrypDb:

LbrM.04.1040 , LBRM2903_040017800

Length:

233

Annotations

LeishMANIAdb annotations

This conserved lipid acyltransferase has many re-entrant segments but only one true TM helix. Most closely related to bacterial acyltransferases.. Heavily expanded in kinetoplastids for unknown reasons. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

A4H418

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H418

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	2
GO:0006644	phospholipid metabolic process	4	2
GO:0006650	glycerophospholipid metabolic process	5	2
GO:0006654	phosphatidic acid biosynthetic process	6	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0008610	lipid biosynthetic process	4	2
GO:0008654	phospholipid biosynthetic process	5	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0019637	organophosphate metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0045017	glycerolipid biosynthetic process	4	2
GO:0046473	phosphatidic acid metabolic process	6	2
GO:0046474	glycerophospholipid biosynthetic process	5	2
GO:0046486	glycerolipid metabolic process	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0090407	organophosphate biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	23
GO:0016740	transferase activity	2	23
GO:0016746	acyltransferase activity	3	23
GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity	7	2
GO:0008374	O-acyltransferase activity	5	2
GO:0016411	acylglycerol O-acyltransferase activity	6	2
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	2
GO:0042171	lysophosphatidic acid acyltransferase activity	6	2
GO:0071617	lysophospholipid acyltransferase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	169	175	PF00089	0.202
CLV_MEL_PAP_1	68	74	PF00089	0.378
CLV_NRD_NRD_1	59	61	PF00675	0.369
CLV_PCSK_SKI1_1	46	50	PF00082	0.348
DEG_Nend_UBRbox_1	1	4	PF02207	0.242
DOC_CKS1_1	41	46	PF01111	0.335
DOC_MAPK_MEF2A_6	121	129	PF00069	0.331
DOC_PP1_RVXF_1	10	17	PF00149	0.428
DOC_PP1_RVXF_1	184	191	PF00149	0.249
DOC_SPAK_OSR1_1	175	179	PF12202	0.237
DOC_USP7_MATH_1	219	223	PF00917	0.510
DOC_WW_Pin1_4	40	45	PF00397	0.346
LIG_14-3-3_CanoR_1	12	17	PF00244	0.383
LIG_14-3-3_CanoR_1	220	224	PF00244	0.643
LIG_Actin_WH2_2	33	48	PF00022	0.454
LIG_APCC_ABBA_1	111	116	PF00400	0.315
LIG_deltaCOP1_diTrp_1	153	159	PF00928	0.319
LIG_FHA_1	49	55	PF00498	0.364
LIG_LIR_Gen_1	133	142	PF02991	0.269
LIG_LIR_Gen_1	35	45	PF02991	0.297
LIG_LIR_Nem_3	128	134	PF02991	0.308
LIG_LIR_Nem_3	143	148	PF02991	0.342
LIG_LIR_Nem_3	15	19	PF02991	0.335
LIG_LIR_Nem_3	31	37	PF02991	0.344
LIG_PCNA_PIPBox_1	98	107	PF02747	0.184
LIG_Pex14_2	65	69	PF04695	0.353
LIG_Pex14_2	75	79	PF04695	0.335
LIG_PTB_Apo_2	20	27	PF02174	0.331
LIG_PTB_Phospho_1	20	26	PF10480	0.184
LIG_SH2_CRK	37	41	PF00017	0.396
LIG_SH2_STAP1	37	41	PF00017	0.450
LIG_SH2_STAT5	26	29	PF00017	0.472
LIG_SH3_3	221	227	PF00018	0.673
LIG_SH3_3	38	44	PF00018	0.184
LIG_WRC_WIRS_1	126	131	PF05994	0.313
MOD_CDK_SPxK_1	40	46	PF00069	0.382
MOD_CK1_1	83	89	PF00069	0.319
MOD_CMANNOS	156	159	PF00535	0.443
MOD_GlcNHglycan	82	85	PF01048	0.477
MOD_GSK3_1	50	57	PF00069	0.343
MOD_LATS_1	78	84	PF00433	0.184
MOD_N-GLC_1	28	33	PF02516	0.291
MOD_NEK2_1	107	112	PF00069	0.359
MOD_NEK2_1	54	59	PF00069	0.341
MOD_PKA_2	181	187	PF00069	0.299
MOD_PKA_2	219	225	PF00069	0.644
MOD_Plk_1	152	158	PF00069	0.404
MOD_Plk_1	28	34	PF00069	0.291
MOD_Plk_4	133	139	PF00069	0.371
MOD_Plk_4	219	225	PF00069	0.669
MOD_Plk_4	29	35	PF00069	0.313
MOD_ProDKin_1	40	46	PF00069	0.346
MOD_SUMO_rev_2	210	219	PF00179	0.331
TRG_ENDOCYTIC_2	131	134	PF00928	0.369
TRG_ENDOCYTIC_2	145	148	PF00928	0.334
TRG_ENDOCYTIC_2	200	203	PF00928	0.428
TRG_ENDOCYTIC_2	37	40	PF00928	0.427
TRG_ER_diArg_1	1	4	PF00400	0.313
TRG_ER_diLys_1	229	233	PF00400	0.433
TRG_NES_CRM1_1	168	181	PF08389	0.297
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.237

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P455	Leptomonas seymouri	55%	68%
A0A0N1HTP4	Leptomonas seymouri	64%	76%
A0A0N1I6V1	Leptomonas seymouri	41%	76%
A0A0N1IKX5	Leptomonas seymouri	40%	76%
A0A0S4IQ05	Bodo saltans	37%	69%
A0A0S4IR22	Bodo saltans	49%	76%
A0A0S4JRB2	Bodo saltans	35%	73%
A0A1X0P9F0	Trypanosomatidae	36%	77%
A0A3R7NKA0	Trypanosoma rangeli	39%	78%
A0A3S5H7L8	Leishmania donovani	38%	72%
A4H419	Leishmania braziliensis	87%	69%
A4HHM7	Leishmania braziliensis	40%	76%
A4HSA1	Leishmania infantum	72%	76%
A4I4U1	Leishmania infantum	36%	72%
A4I4U2	Leishmania infantum	39%	76%
C9ZLI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	76%
E9AE89	Leishmania major	35%	73%
E9AE90	Leishmania major	38%	76%
E9AK86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	76%
E9ALJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	75%
V5C201	Trypanosoma cruzi	35%	77%