COPI associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

COPI associated protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H417_LEIBR

TriTrypDb:

LbrM.04.1030 , LBRM2903_040017700

Length:

281

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4H417

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H417

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.443
CLV_NRD_NRD_1	80	82	PF00675	0.260
CLV_PCSK_KEX2_1	150	152	PF00082	0.443
CLV_PCSK_KEX2_1	80	82	PF00082	0.260
CLV_PCSK_SKI1_1	24	28	PF00082	0.248
CLV_PCSK_SKI1_1	85	89	PF00082	0.379
CLV_PCSK_SKI1_1	99	103	PF00082	0.395
DEG_Nend_Nbox_1	1	3	PF02207	0.585
DEG_SCF_FBW7_1	246	251	PF00400	0.631
DOC_CYCLIN_yCln2_LP_2	192	198	PF00134	0.594
DOC_MAPK_gen_1	97	106	PF00069	0.546
DOC_MAPK_MEF2A_6	24	33	PF00069	0.549
DOC_MAPK_MEF2A_6	47	56	PF00069	0.238
DOC_PP2B_LxvP_1	192	195	PF13499	0.593
DOC_USP7_MATH_1	13	17	PF00917	0.538
DOC_USP7_MATH_1	171	175	PF00917	0.660
DOC_USP7_MATH_1	178	182	PF00917	0.681
DOC_USP7_MATH_1	221	225	PF00917	0.645
DOC_USP7_MATH_2	227	233	PF00917	0.649
DOC_WW_Pin1_4	206	211	PF00397	0.683
DOC_WW_Pin1_4	244	249	PF00397	0.632
DOC_WW_Pin1_4	48	53	PF00397	0.349
LIG_14-3-3_CanoR_1	74	79	PF00244	0.460
LIG_Actin_WH2_2	66	82	PF00022	0.261
LIG_FHA_1	189	195	PF00498	0.598
LIG_FHA_1	245	251	PF00498	0.630
LIG_FHA_2	254	260	PF00498	0.638
LIG_GBD_Chelix_1	123	131	PF00786	0.383
LIG_IBAR_NPY_1	226	228	PF08397	0.641
LIG_LIR_Gen_1	44	52	PF02991	0.415
LIG_LIR_Nem_3	154	159	PF02991	0.556
LIG_LIR_Nem_3	37	41	PF02991	0.286
LIG_LIR_Nem_3	44	48	PF02991	0.437
LIG_PCNA_yPIPBox_3	47	60	PF02747	0.238
LIG_Pex14_1	22	26	PF04695	0.592
LIG_Pex14_1	86	90	PF04695	0.546
LIG_Pex14_2	102	106	PF04695	0.513
LIG_SH2_CRK	60	64	PF00017	0.411
LIG_SH2_STAT5	103	106	PF00017	0.411
LIG_SH2_STAT5	60	63	PF00017	0.404
LIG_SH2_STAT5	89	92	PF00017	0.569
LIG_SH3_3	135	141	PF00018	0.290
LIG_SH3_3	172	178	PF00018	0.608
LIG_SH3_3	243	249	PF00018	0.678
LIG_SUMO_SIM_anti_2	30	35	PF11976	0.513
LIG_SUMO_SIM_par_1	32	37	PF11976	0.296
LIG_TRAF2_1	227	230	PF00917	0.647
LIG_UBA3_1	42	47	PF00899	0.261
LIG_WRC_WIRS_1	35	40	PF05994	0.299
LIG_WRC_WIRS_1	42	47	PF05994	0.258
MOD_CDC14_SPxK_1	209	212	PF00782	0.626
MOD_CDK_SPxK_1	206	212	PF00069	0.623
MOD_CK1_1	164	170	PF00069	0.686
MOD_CK1_1	180	186	PF00069	0.688
MOD_CK1_1	260	266	PF00069	0.613
MOD_CK1_1	6	12	PF00069	0.673
MOD_CK2_1	253	259	PF00069	0.642
MOD_GlcNHglycan	166	169	PF01048	0.557
MOD_GlcNHglycan	180	183	PF01048	0.433
MOD_GlcNHglycan	223	226	PF01048	0.443
MOD_GlcNHglycan	229	234	PF01048	0.519
MOD_GlcNHglycan	5	8	PF01048	0.441
MOD_GlcNHglycan	69	72	PF01048	0.411
MOD_GSK3_1	216	223	PF00069	0.750
MOD_GSK3_1	244	251	PF00069	0.646
MOD_GSK3_1	253	260	PF00069	0.660
MOD_N-GLC_1	112	117	PF02516	0.261
MOD_N-GLC_1	13	18	PF02516	0.337
MOD_N-GLC_2	184	186	PF02516	0.407
MOD_NEK2_1	1	6	PF00069	0.751
MOD_NEK2_1	241	246	PF00069	0.657
MOD_NEK2_1	27	32	PF00069	0.416
MOD_NEK2_1	62	67	PF00069	0.381
MOD_PIKK_1	6	12	PF00454	0.596
MOD_PK_1	74	80	PF00069	0.438
MOD_PKA_2	253	259	PF00069	0.642
MOD_Plk_1	13	19	PF00069	0.530
MOD_Plk_1	260	266	PF00069	0.592
MOD_Plk_4	34	40	PF00069	0.354
MOD_Plk_4	41	47	PF00069	0.354
MOD_ProDKin_1	206	212	PF00069	0.685
MOD_ProDKin_1	244	250	PF00069	0.633
MOD_ProDKin_1	48	54	PF00069	0.349
MOD_SUMO_for_1	264	267	PF00179	0.580
TRG_DiLeu_BaEn_4	229	235	PF01217	0.651
TRG_ENDOCYTIC_2	103	106	PF00928	0.411
TRG_ENDOCYTIC_2	60	63	PF00928	0.387
TRG_ENDOCYTIC_2	84	87	PF00928	0.505
TRG_ENDOCYTIC_2	89	92	PF00928	0.557
TRG_ER_diArg_1	150	152	PF00400	0.547
TRG_ER_diArg_1	79	81	PF00400	0.471
TRG_ER_diArg_1	96	99	PF00400	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R6	Leptomonas seymouri	38%	84%
A0A3S5H5E3	Leishmania donovani	50%	100%
A4HSA0	Leishmania infantum	49%	100%
E9AK84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	96%
Q9NF92	Leishmania major	47%	95%