rRNA biogenesis protein RRP36

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF947), putative

Species:

Leishmania braziliensis

UniProt:

A4H416_LEIBR

TriTrypDb:

LbrM.04.1020 , LBRM2903_040017600

Length:

223

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0030684	preribosome	3	1
GO:0030686	90S preribosome	4	1

Expansion

Sequence features

A4H416

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H416

Function

Biological processes
Term	Name	Level	Count
GO:0000469	cleavage involved in rRNA processing	7	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	12
GO:0090501	RNA phosphodiester bond hydrolysis	6	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.575
CLV_NRD_NRD_1	160	162	PF00675	0.328
CLV_NRD_NRD_1	169	171	PF00675	0.349
CLV_NRD_NRD_1	218	220	PF00675	0.321
CLV_NRD_NRD_1	43	45	PF00675	0.349
CLV_NRD_NRD_1	79	81	PF00675	0.279
CLV_NRD_NRD_1	91	93	PF00675	0.261
CLV_PCSK_KEX2_1	15	17	PF00082	0.613
CLV_PCSK_KEX2_1	160	162	PF00082	0.372
CLV_PCSK_KEX2_1	188	190	PF00082	0.355
CLV_PCSK_KEX2_1	193	195	PF00082	0.212
CLV_PCSK_KEX2_1	220	222	PF00082	0.363
CLV_PCSK_KEX2_1	43	45	PF00082	0.305
CLV_PCSK_KEX2_1	58	60	PF00082	0.381
CLV_PCSK_KEX2_1	79	81	PF00082	0.276
CLV_PCSK_KEX2_1	91	93	PF00082	0.272
CLV_PCSK_PC1ET2_1	188	190	PF00082	0.365
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.216
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.364
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.463
CLV_PCSK_PC7_1	189	195	PF00082	0.318
CLV_PCSK_PC7_1	87	93	PF00082	0.437
CLV_PCSK_SKI1_1	124	128	PF00082	0.378
CLV_PCSK_SKI1_1	166	170	PF00082	0.323
CLV_PCSK_SKI1_1	193	197	PF00082	0.321
CLV_PCSK_SKI1_1	58	62	PF00082	0.338
DEG_APCC_DBOX_1	91	99	PF00400	0.193
DEG_Nend_UBRbox_1	1	4	PF02207	0.511
DEG_SPOP_SBC_1	26	30	PF00917	0.265
DOC_CYCLIN_RxL_1	160	172	PF00134	0.405
DOC_PP2B_LxvP_1	128	131	PF13499	0.363
DOC_SPAK_OSR1_1	80	84	PF12202	0.414
DOC_USP7_MATH_1	26	30	PF00917	0.314
DOC_USP7_UBL2_3	177	181	PF12436	0.363
DOC_WW_Pin1_4	126	131	PF00397	0.352
LIG_14-3-3_CanoR_1	143	149	PF00244	0.378
LIG_14-3-3_CanoR_1	16	26	PF00244	0.323
LIG_14-3-3_CanoR_1	160	165	PF00244	0.202
LIG_14-3-3_CanoR_1	194	201	PF00244	0.367
LIG_FHA_1	18	24	PF00498	0.211
LIG_FHA_2	194	200	PF00498	0.195
LIG_LIR_Gen_1	199	206	PF02991	0.270
LIG_LIR_Nem_3	199	204	PF02991	0.270
LIG_LIR_Nem_3	62	68	PF02991	0.386
LIG_PCNA_APIM_2	213	219	PF02747	0.414
LIG_Pex14_2	49	53	PF04695	0.314
LIG_SH2_CRK	65	69	PF00017	0.284
LIG_SH2_STAP1	110	114	PF00017	0.414
LIG_SH2_STAT5	148	151	PF00017	0.356
LIG_SH2_STAT5	185	188	PF00017	0.363
LIG_SH2_STAT5	216	219	PF00017	0.269
LIG_SH3_1	181	187	PF00018	0.328
LIG_SH3_2	184	189	PF14604	0.328
LIG_SH3_3	181	187	PF00018	0.328
LIG_TRAF2_1	73	76	PF00917	0.328
LIG_WW_3	16	20	PF00397	0.193
MOD_CDK_SPxxK_3	126	133	PF00069	0.314
MOD_CK2_1	105	111	PF00069	0.295
MOD_GlcNHglycan	37	40	PF01048	0.462
MOD_GSK3_1	149	156	PF00069	0.360
MOD_GSK3_1	193	200	PF00069	0.193
MOD_GSK3_1	26	33	PF00069	0.386
MOD_NEK2_1	147	152	PF00069	0.303
MOD_PIKK_1	142	148	PF00454	0.288
MOD_PK_1	153	159	PF00069	0.338
MOD_PK_1	160	166	PF00069	0.270
MOD_PKA_1	160	166	PF00069	0.441
MOD_PKA_1	193	199	PF00069	0.193
MOD_PKA_2	142	148	PF00069	0.303
MOD_PKA_2	159	165	PF00069	0.410
MOD_PKA_2	193	199	PF00069	0.482
MOD_Plk_1	153	159	PF00069	0.338
MOD_Plk_4	19	25	PF00069	0.193
MOD_ProDKin_1	126	132	PF00069	0.352
MOD_SUMO_for_1	73	76	PF00179	0.241
MOD_SUMO_rev_2	122	129	PF00179	0.386
TRG_ENDOCYTIC_2	135	138	PF00928	0.414
TRG_ENDOCYTIC_2	65	68	PF00928	0.324
TRG_ER_diArg_1	15	17	PF00400	0.575
TRG_ER_diArg_1	218	221	PF00400	0.440
TRG_ER_diArg_1	43	45	PF00400	0.315
TRG_ER_diArg_1	79	81	PF00400	0.288
TRG_ER_diArg_1	90	92	PF00400	0.246
TRG_NLS_MonoCore_2	218	223	PF00514	0.405
TRG_NLS_MonoExtC_3	218	223	PF00514	0.414
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P373	Leptomonas seymouri	72%	100%
A0A0S4IME8	Bodo saltans	41%	96%
A0A1X0NLQ0	Trypanosomatidae	48%	100%
A0A3S5H5E2	Leishmania donovani	87%	100%
A0A422NNW0	Trypanosoma rangeli	46%	100%
A4HS99	Leishmania infantum	86%	100%
C9ZY93	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AK83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q9NF94	Leishmania major	86%	100%
V5BDM1	Trypanosoma cruzi	49%	100%