Nucleolin_bd domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H414_LEIBR

TriTrypDb:

LbrM.04.1000 , LBRM2903_040017400

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H414

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H414

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.584
CLV_C14_Caspase3-7	99	103	PF00656	0.713
CLV_NRD_NRD_1	148	150	PF00675	0.598
CLV_NRD_NRD_1	188	190	PF00675	0.436
CLV_NRD_NRD_1	254	256	PF00675	0.643
CLV_NRD_NRD_1	287	289	PF00675	0.518
CLV_PCSK_KEX2_1	148	150	PF00082	0.538
CLV_PCSK_KEX2_1	232	234	PF00082	0.418
CLV_PCSK_KEX2_1	254	256	PF00082	0.658
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.516
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.433
CLV_Separin_Metazoa	13	17	PF03568	0.478
DOC_MAPK_gen_1	232	242	PF00069	0.519
DOC_MAPK_gen_1	257	267	PF00069	0.595
DOC_MAPK_gen_1	288	294	PF00069	0.517
DOC_MAPK_HePTP_8	7	19	PF00069	0.489
DOC_MAPK_MEF2A_6	10	19	PF00069	0.466
DOC_USP7_MATH_1	200	204	PF00917	0.536
DOC_USP7_MATH_1	271	275	PF00917	0.642
DOC_USP7_MATH_1	278	282	PF00917	0.645
DOC_USP7_MATH_1	283	287	PF00917	0.773
DOC_USP7_UBL2_3	228	232	PF12436	0.517
DOC_WW_Pin1_4	276	281	PF00397	0.735
LIG_14-3-3_CanoR_1	189	194	PF00244	0.434
LIG_14-3-3_CanoR_1	288	293	PF00244	0.672
LIG_APCC_ABBAyCdc20_2	289	295	PF00400	0.513
LIG_BH_BH3_1	46	62	PF00452	0.330
LIG_BIR_II_1	1	5	PF00653	0.515
LIG_BRCT_BRCA1_1	212	216	PF00533	0.309
LIG_BRCT_BRCA1_2	212	218	PF00533	0.328
LIG_FHA_1	10	16	PF00498	0.395
LIG_FHA_1	28	34	PF00498	0.410
LIG_FHA_2	150	156	PF00498	0.506
LIG_FHA_2	197	203	PF00498	0.571
LIG_FHA_2	42	48	PF00498	0.581
LIG_FHA_2	90	96	PF00498	0.546
LIG_NRBOX	10	16	PF00104	0.489
LIG_SH2_STAT3	234	237	PF00017	0.335
LIG_SH2_STAT5	207	210	PF00017	0.421
LIG_SH2_STAT5	49	52	PF00017	0.430
LIG_SH3_3	165	171	PF00018	0.542
LIG_SH3_3	192	198	PF00018	0.546
LIG_SUMO_SIM_anti_2	239	244	PF11976	0.519
LIG_TRAF2_1	152	155	PF00917	0.559
LIG_TRAF2_1	199	202	PF00917	0.577
LIG_TRAF2_1	203	206	PF00917	0.513
LIG_TRAF2_1	81	84	PF00917	0.633
LIG_UBA3_1	61	70	PF00899	0.339
MOD_CK1_1	169	175	PF00069	0.664
MOD_CK1_1	24	30	PF00069	0.361
MOD_CK1_1	52	58	PF00069	0.439
MOD_CK1_1	90	96	PF00069	0.736
MOD_CK2_1	149	155	PF00069	0.508
MOD_CK2_1	173	179	PF00069	0.566
MOD_CK2_1	196	202	PF00069	0.514
MOD_CK2_1	41	47	PF00069	0.570
MOD_CK2_1	79	85	PF00069	0.593
MOD_CK2_1	89	95	PF00069	0.620
MOD_GlcNHglycan	112	115	PF01048	0.536
MOD_GlcNHglycan	172	175	PF01048	0.678
MOD_GlcNHglycan	212	215	PF01048	0.321
MOD_GlcNHglycan	281	284	PF01048	0.576
MOD_GlcNHglycan	285	288	PF01048	0.627
MOD_GSK3_1	166	173	PF00069	0.612
MOD_GSK3_1	17	24	PF00069	0.380
MOD_GSK3_1	196	203	PF00069	0.553
MOD_GSK3_1	279	286	PF00069	0.703
MOD_N-GLC_1	24	29	PF02516	0.525
MOD_NEK2_1	17	22	PF00069	0.383
MOD_PKA_1	149	155	PF00069	0.658
MOD_PKA_1	189	195	PF00069	0.431
MOD_PKA_1	288	294	PF00069	0.574
MOD_PKA_2	287	293	PF00069	0.582
MOD_PKB_1	194	202	PF00069	0.434
MOD_Plk_1	200	206	PF00069	0.530
MOD_Plk_1	24	30	PF00069	0.518
MOD_Plk_1	263	269	PF00069	0.555
MOD_Plk_2-3	120	126	PF00069	0.581
MOD_Plk_2-3	95	101	PF00069	0.615
MOD_Plk_4	288	294	PF00069	0.638
MOD_Plk_4	52	58	PF00069	0.419
MOD_ProDKin_1	276	282	PF00069	0.735
MOD_SUMO_rev_2	2	12	PF00179	0.458
TRG_DiLeu_BaEn_1	13	18	PF01217	0.318
TRG_ER_diArg_1	193	196	PF00400	0.401
TRG_ER_diArg_1	254	257	PF00400	0.644
TRG_NLS_MonoCore_2	147	152	PF00514	0.507
TRG_NLS_MonoExtC_3	148	153	PF00514	0.571
TRG_NLS_MonoExtN_4	147	153	PF00514	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2T4	Leptomonas seymouri	59%	96%
A0A3R7MS09	Trypanosoma rangeli	39%	69%
A0A3S5H5E1	Leishmania donovani	67%	100%
A4HS97	Leishmania infantum	67%	100%
E9AK81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	100%
Q9NF96	Leishmania major	69%	67%
V5DEF7	Trypanosoma cruzi	36%	100%