Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H411_LEIBR

TriTrypDb:

LbrM.04.0970 , LBRM2903_040017000

Length:

507

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0035869	ciliary transition zone	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H411

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H411

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	321	325	PF00656	0.598
CLV_C14_Caspase3-7	386	390	PF00656	0.502
CLV_C14_Caspase3-7	45	49	PF00656	0.618
CLV_NRD_NRD_1	113	115	PF00675	0.717
CLV_NRD_NRD_1	197	199	PF00675	0.611
CLV_NRD_NRD_1	259	261	PF00675	0.516
CLV_NRD_NRD_1	449	451	PF00675	0.628
CLV_PCSK_FUR_1	57	61	PF00082	0.703
CLV_PCSK_KEX2_1	113	115	PF00082	0.708
CLV_PCSK_KEX2_1	197	199	PF00082	0.613
CLV_PCSK_KEX2_1	258	260	PF00082	0.516
CLV_PCSK_KEX2_1	449	451	PF00082	0.628
CLV_PCSK_KEX2_1	59	61	PF00082	0.704
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.704
CLV_PCSK_PC7_1	254	260	PF00082	0.449
CLV_PCSK_SKI1_1	364	368	PF00082	0.631
CLV_PCSK_SKI1_1	59	63	PF00082	0.627
DEG_SCF_FBW7_1	174	180	PF00400	0.546
DEG_SCF_TRCP1_1	389	395	PF00400	0.590
DEG_SPOP_SBC_1	122	126	PF00917	0.580
DEG_SPOP_SBC_1	217	221	PF00917	0.686
DEG_SPOP_SBC_1	92	96	PF00917	0.666
DOC_CKS1_1	143	148	PF01111	0.597
DOC_CKS1_1	174	179	PF01111	0.550
DOC_CKS1_1	271	276	PF01111	0.466
DOC_MAPK_DCC_7	258	267	PF00069	0.585
DOC_MAPK_DCC_7	364	374	PF00069	0.577
DOC_MAPK_gen_1	258	267	PF00069	0.446
DOC_MAPK_MEF2A_6	258	267	PF00069	0.585
DOC_MAPK_MEF2A_6	360	369	PF00069	0.602
DOC_PP2B_PxIxI_1	262	268	PF00149	0.576
DOC_USP7_MATH_1	152	156	PF00917	0.575
DOC_USP7_MATH_1	229	233	PF00917	0.583
DOC_USP7_MATH_1	298	302	PF00917	0.568
DOC_USP7_MATH_1	43	47	PF00917	0.569
DOC_USP7_MATH_1	92	96	PF00917	0.667
DOC_WW_Pin1_4	123	128	PF00397	0.715
DOC_WW_Pin1_4	134	139	PF00397	0.592
DOC_WW_Pin1_4	142	147	PF00397	0.620
DOC_WW_Pin1_4	170	175	PF00397	0.626
DOC_WW_Pin1_4	231	236	PF00397	0.560
DOC_WW_Pin1_4	270	275	PF00397	0.566
DOC_WW_Pin1_4	392	397	PF00397	0.588
LIG_14-3-3_CanoR_1	10	14	PF00244	0.608
LIG_14-3-3_CanoR_1	187	196	PF00244	0.646
LIG_14-3-3_CanoR_1	198	204	PF00244	0.533
LIG_14-3-3_CanoR_1	207	217	PF00244	0.506
LIG_14-3-3_CanoR_1	28	34	PF00244	0.501
LIG_14-3-3_CanoR_1	353	362	PF00244	0.610
LIG_14-3-3_CanoR_1	459	467	PF00244	0.467
LIG_14-3-3_CanoR_1	97	101	PF00244	0.656
LIG_Actin_RPEL_3	319	338	PF02755	0.473
LIG_Actin_WH2_2	428	445	PF00022	0.601
LIG_APCC_ABBA_1	428	433	PF00400	0.610
LIG_FHA_1	143	149	PF00498	0.717
LIG_FHA_2	43	49	PF00498	0.559
LIG_FHA_2	468	474	PF00498	0.593
LIG_LIR_Apic_2	12	16	PF02991	0.608
LIG_LIR_Apic_2	269	274	PF02991	0.608
LIG_LIR_Apic_2	481	487	PF02991	0.617
LIG_LIR_Nem_3	249	253	PF02991	0.499
LIG_Pex14_1	13	17	PF04695	0.609
LIG_SH2_CRK	271	275	PF00017	0.606
LIG_SH2_GRB2like	36	39	PF00017	0.537
LIG_SH2_STAP1	409	413	PF00017	0.444
LIG_SH2_STAT3	253	256	PF00017	0.451
LIG_SH2_STAT5	65	68	PF00017	0.615
LIG_SH3_3	138	144	PF00018	0.702
LIG_SH3_3	171	177	PF00018	0.611
LIG_SH3_3	182	188	PF00018	0.654
LIG_SH3_3	219	225	PF00018	0.625
LIG_SH3_3	390	396	PF00018	0.592
LIG_SH3_3	424	430	PF00018	0.570
LIG_SH3_3	66	72	PF00018	0.615
LIG_SH3_3	98	104	PF00018	0.701
LIG_SUMO_SIM_anti_2	422	428	PF11976	0.451
LIG_TRAF2_1	155	158	PF00917	0.571
LIG_TRAF2_1	346	349	PF00917	0.610
LIG_TRAF2_1	470	473	PF00917	0.595
LIG_TRFH_1	244	248	PF08558	0.661
MOD_CK1_1	173	179	PF00069	0.610
MOD_CK1_1	202	208	PF00069	0.638
MOD_CK1_1	29	35	PF00069	0.583
MOD_CK1_1	96	102	PF00069	0.607
MOD_CK2_1	152	158	PF00069	0.574
MOD_CK2_1	343	349	PF00069	0.638
MOD_CK2_1	467	473	PF00069	0.610
MOD_CK2_1	48	54	PF00069	0.573
MOD_Cter_Amidation	111	114	PF01082	0.676
MOD_Cter_Amidation	57	60	PF01082	0.562
MOD_DYRK1A_RPxSP_1	142	146	PF00069	0.576
MOD_GlcNHglycan	130	134	PF01048	0.812
MOD_GlcNHglycan	150	153	PF01048	0.665
MOD_GlcNHglycan	154	157	PF01048	0.693
MOD_GlcNHglycan	160	164	PF01048	0.646
MOD_GlcNHglycan	189	192	PF01048	0.541
MOD_GlcNHglycan	28	31	PF01048	0.618
MOD_GlcNHglycan	304	307	PF01048	0.607
MOD_GlcNHglycan	389	392	PF01048	0.587
MOD_GlcNHglycan	400	403	PF01048	0.446
MOD_GlcNHglycan	45	48	PF01048	0.597
MOD_GlcNHglycan	80	83	PF01048	0.601
MOD_GlcNHglycan	98	101	PF01048	0.700
MOD_GSK3_1	148	155	PF00069	0.617
MOD_GSK3_1	159	166	PF00069	0.625
MOD_GSK3_1	173	180	PF00069	0.619
MOD_GSK3_1	198	205	PF00069	0.556
MOD_GSK3_1	216	223	PF00069	0.641
MOD_GSK3_1	242	249	PF00069	0.656
MOD_GSK3_1	298	305	PF00069	0.582
MOD_GSK3_1	324	331	PF00069	0.624
MOD_GSK3_1	383	390	PF00069	0.556
MOD_GSK3_1	88	95	PF00069	0.694
MOD_N-GLC_1	217	222	PF02516	0.554
MOD_NEK2_1	148	153	PF00069	0.603
MOD_NEK2_2	242	247	PF00069	0.644
MOD_PIKK_1	116	122	PF00454	0.599
MOD_PKA_2	246	252	PF00069	0.615
MOD_PKA_2	458	464	PF00069	0.461
MOD_PKA_2	9	15	PF00069	0.609
MOD_PKA_2	96	102	PF00069	0.656
MOD_Plk_1	129	135	PF00069	0.579
MOD_Plk_1	217	223	PF00069	0.556
MOD_Plk_2-3	324	330	PF00069	0.626
MOD_Plk_4	383	389	PF00069	0.518
MOD_ProDKin_1	123	129	PF00069	0.715
MOD_ProDKin_1	134	140	PF00069	0.593
MOD_ProDKin_1	142	148	PF00069	0.620
MOD_ProDKin_1	170	176	PF00069	0.627
MOD_ProDKin_1	231	237	PF00069	0.560
MOD_ProDKin_1	270	276	PF00069	0.567
MOD_ProDKin_1	392	398	PF00069	0.580
TRG_ENDOCYTIC_2	335	338	PF00928	0.625
TRG_ER_diArg_1	113	115	PF00400	0.678
TRG_ER_diArg_1	196	198	PF00400	0.640
TRG_ER_diArg_1	257	260	PF00400	0.526
TRG_ER_diArg_1	449	451	PF00400	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5D8	Leishmania donovani	66%	97%
A4HS94	Leishmania infantum	65%	100%
E9AK78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q9U1D2	Leishmania major	68%	98%