WASH_WAHD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H408_LEIBR

TriTrypDb:

LbrM.04.0940 , LBRM2903_040013600

Length:

833

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H408

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H408

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.658
CLV_C14_Caspase3-7	34	38	PF00656	0.607
CLV_C14_Caspase3-7	767	771	PF00656	0.686
CLV_C14_Caspase3-7	786	790	PF00656	0.837
CLV_NRD_NRD_1	105	107	PF00675	0.411
CLV_NRD_NRD_1	127	129	PF00675	0.389
CLV_NRD_NRD_1	195	197	PF00675	0.722
CLV_NRD_NRD_1	258	260	PF00675	0.572
CLV_NRD_NRD_1	411	413	PF00675	0.610
CLV_NRD_NRD_1	472	474	PF00675	0.670
CLV_NRD_NRD_1	512	514	PF00675	0.847
CLV_NRD_NRD_1	516	518	PF00675	0.780
CLV_NRD_NRD_1	534	536	PF00675	0.765
CLV_NRD_NRD_1	538	540	PF00675	0.814
CLV_NRD_NRD_1	756	758	PF00675	0.734
CLV_PCSK_FUR_1	125	129	PF00082	0.512
CLV_PCSK_FUR_1	193	197	PF00082	0.719
CLV_PCSK_FUR_1	532	536	PF00082	0.707
CLV_PCSK_KEX2_1	105	107	PF00082	0.411
CLV_PCSK_KEX2_1	127	129	PF00082	0.358
CLV_PCSK_KEX2_1	195	197	PF00082	0.722
CLV_PCSK_KEX2_1	258	260	PF00082	0.572
CLV_PCSK_KEX2_1	411	413	PF00082	0.610
CLV_PCSK_KEX2_1	472	474	PF00082	0.670
CLV_PCSK_KEX2_1	512	514	PF00082	0.845
CLV_PCSK_KEX2_1	516	518	PF00082	0.778
CLV_PCSK_KEX2_1	534	536	PF00082	0.766
CLV_PCSK_KEX2_1	538	540	PF00082	0.813
CLV_PCSK_KEX2_1	755	757	PF00082	0.731
CLV_PCSK_PC7_1	123	129	PF00082	0.294
CLV_PCSK_PC7_1	512	518	PF00082	0.847
CLV_PCSK_PC7_1	534	540	PF00082	0.828
CLV_PCSK_SKI1_1	128	132	PF00082	0.265
CLV_PCSK_SKI1_1	154	158	PF00082	0.810
CLV_PCSK_SKI1_1	318	322	PF00082	0.571
CLV_PCSK_SKI1_1	453	457	PF00082	0.753
CLV_PCSK_SKI1_1	756	760	PF00082	0.737
CLV_Separin_Metazoa	357	361	PF03568	0.556
DEG_APCC_DBOX_1	452	460	PF00400	0.772
DEG_SCF_TRCP1_1	215	221	PF00400	0.587
DEG_SPOP_SBC_1	23	27	PF00917	0.568
DEG_SPOP_SBC_1	329	333	PF00917	0.786
DEG_SPOP_SBC_1	682	686	PF00917	0.606
DEG_SPOP_SBC_1	822	826	PF00917	0.601
DOC_CDC14_PxL_1	53	61	PF14671	0.729
DOC_CDC14_PxL_1	594	602	PF14671	0.598
DOC_CKS1_1	430	435	PF01111	0.769
DOC_CYCLIN_yClb3_PxF_3	652	658	PF00134	0.566
DOC_MAPK_DCC_7	136	145	PF00069	0.368
DOC_MAPK_gen_1	136	145	PF00069	0.471
DOC_PP2B_LxvP_1	242	245	PF13499	0.581
DOC_PP2B_LxvP_1	59	62	PF13499	0.623
DOC_PP2B_LxvP_1	600	603	PF13499	0.843
DOC_PP2B_LxvP_1	648	651	PF13499	0.603
DOC_PP2B_LxvP_1	693	696	PF13499	0.551
DOC_PP2B_LxvP_1	815	818	PF13499	0.709
DOC_PP4_FxxP_1	191	194	PF00568	0.816
DOC_PP4_FxxP_1	266	269	PF00568	0.576
DOC_PP4_FxxP_1	430	433	PF00568	0.612
DOC_PP4_MxPP_1	679	682	PF00568	0.587
DOC_USP7_MATH_1	144	148	PF00917	0.700
DOC_USP7_MATH_1	155	159	PF00917	0.657
DOC_USP7_MATH_1	194	198	PF00917	0.713
DOC_USP7_MATH_1	23	27	PF00917	0.698
DOC_USP7_MATH_1	324	328	PF00917	0.705
DOC_USP7_MATH_1	329	333	PF00917	0.735
DOC_USP7_MATH_1	364	368	PF00917	0.797
DOC_USP7_MATH_1	380	384	PF00917	0.524
DOC_USP7_MATH_1	392	396	PF00917	0.700
DOC_USP7_MATH_1	448	452	PF00917	0.620
DOC_USP7_MATH_1	589	593	PF00917	0.633
DOC_USP7_MATH_1	62	66	PF00917	0.651
DOC_USP7_MATH_1	637	641	PF00917	0.810
DOC_USP7_MATH_1	665	669	PF00917	0.781
DOC_USP7_MATH_1	74	78	PF00917	0.286
DOC_USP7_MATH_1	743	747	PF00917	0.784
DOC_USP7_MATH_1	822	826	PF00917	0.849
DOC_USP7_MATH_1	99	103	PF00917	0.512
DOC_WW_Pin1_4	195	200	PF00397	0.800
DOC_WW_Pin1_4	405	410	PF00397	0.693
DOC_WW_Pin1_4	429	434	PF00397	0.583
DOC_WW_Pin1_4	504	509	PF00397	0.733
DOC_WW_Pin1_4	715	720	PF00397	0.780
DOC_WW_Pin1_4	784	789	PF00397	0.696
DOC_WW_Pin1_4	793	798	PF00397	0.719
LIG_14-3-3_CanoR_1	113	121	PF00244	0.451
LIG_14-3-3_CanoR_1	125	133	PF00244	0.419
LIG_14-3-3_CanoR_1	193	199	PF00244	0.661
LIG_14-3-3_CanoR_1	247	257	PF00244	0.817
LIG_14-3-3_CanoR_1	32	37	PF00244	0.645
LIG_14-3-3_CanoR_1	347	353	PF00244	0.616
LIG_14-3-3_CanoR_1	360	369	PF00244	0.684
LIG_14-3-3_CanoR_1	411	418	PF00244	0.598
LIG_14-3-3_CanoR_1	512	519	PF00244	0.595
LIG_14-3-3_CanoR_1	538	543	PF00244	0.595
LIG_14-3-3_CanoR_1	611	616	PF00244	0.741
LIG_14-3-3_CanoR_1	806	816	PF00244	0.630
LIG_14-3-3_CanoR_1	98	107	PF00244	0.304
LIG_APCC_ABBAyCdc20_2	756	762	PF00400	0.593
LIG_BIR_II_1	1	5	PF00653	0.536
LIG_BIR_III_4	161	165	PF00653	0.549
LIG_BRCT_BRCA1_1	187	191	PF00533	0.817
LIG_CtBP_PxDLS_1	698	702	PF00389	0.587
LIG_EVH1_1	594	598	PF00568	0.670
LIG_EVH1_1	648	652	PF00568	0.602
LIG_EVH1_1	693	697	PF00568	0.556
LIG_EVH1_1	815	819	PF00568	0.709
LIG_EVH1_2	654	658	PF00568	0.575
LIG_FHA_1	127	133	PF00498	0.512
LIG_FHA_1	287	293	PF00498	0.727
LIG_FHA_1	310	316	PF00498	0.577
LIG_FHA_1	413	419	PF00498	0.731
LIG_FHA_1	429	435	PF00498	0.610
LIG_FHA_1	48	54	PF00498	0.619
LIG_FHA_1	747	753	PF00498	0.817
LIG_FHA_1	86	92	PF00498	0.265
LIG_FHA_1	9	15	PF00498	0.614
LIG_FHA_2	129	135	PF00498	0.403
LIG_FHA_2	241	247	PF00498	0.583
LIG_FHA_2	487	493	PF00498	0.765
LIG_FHA_2	539	545	PF00498	0.824
LIG_FHA_2	553	559	PF00498	0.738
LIG_FHA_2	765	771	PF00498	0.684
LIG_Integrin_RGD_1	259	261	PF01839	0.572
LIG_LIR_Apic_2	188	194	PF02991	0.716
LIG_LIR_Apic_2	228	232	PF02991	0.831
LIG_LIR_Apic_2	264	269	PF02991	0.573
LIG_LIR_Apic_2	427	433	PF02991	0.587
LIG_MYND_1	691	695	PF01753	0.552
LIG_PROFILIN_1	616	622	PF00235	0.708
LIG_PROFILIN_1	649	655	PF00235	0.680
LIG_PROFILIN_1	688	694	PF00235	0.620
LIG_PROFILIN_1	725	731	PF00235	0.790
LIG_PROFILIN_1	732	738	PF00235	0.683
LIG_RPA_C_Fungi	35	47	PF08784	0.713
LIG_SH2_CRK	229	233	PF00017	0.827
LIG_SH2_CRK	439	443	PF00017	0.695
LIG_SH2_NCK_1	48	52	PF00017	0.622
LIG_SH2_STAP1	48	52	PF00017	0.723
LIG_SH3_1	196	202	PF00018	0.806
LIG_SH3_1	234	240	PF00018	0.575
LIG_SH3_1	647	653	PF00018	0.713
LIG_SH3_1	723	729	PF00018	0.727
LIG_SH3_3	134	140	PF00018	0.411
LIG_SH3_3	196	202	PF00018	0.737
LIG_SH3_3	234	240	PF00018	0.606
LIG_SH3_3	266	272	PF00018	0.703
LIG_SH3_3	363	369	PF00018	0.772
LIG_SH3_3	592	598	PF00018	0.769
LIG_SH3_3	600	606	PF00018	0.686
LIG_SH3_3	613	619	PF00018	0.675
LIG_SH3_3	631	637	PF00018	0.652
LIG_SH3_3	646	652	PF00018	0.707
LIG_SH3_3	667	673	PF00018	0.718
LIG_SH3_3	685	691	PF00018	0.555
LIG_SH3_3	692	698	PF00018	0.725
LIG_SH3_3	713	719	PF00018	0.817
LIG_SH3_3	722	728	PF00018	0.678
LIG_SH3_3	729	735	PF00018	0.600
LIG_SH3_3	813	819	PF00018	0.702
LIG_SUMO_SIM_par_1	288	297	PF11976	0.689
LIG_SUMO_SIM_par_1	422	427	PF11976	0.544
LIG_TRAF2_1	555	558	PF00917	0.657
LIG_WW_2	619	622	PF00397	0.705
LIG_WW_2	691	694	PF00397	0.552
MOD_CDC14_SPxK_1	408	411	PF00782	0.762
MOD_CDK_SPK_2	504	509	PF00069	0.587
MOD_CDK_SPK_2	793	798	PF00069	0.592
MOD_CDK_SPxK_1	405	411	PF00069	0.561
MOD_CDK_SPxxK_3	405	412	PF00069	0.639
MOD_CK1_1	17	23	PF00069	0.710
MOD_CK1_1	181	187	PF00069	0.644
MOD_CK1_1	206	212	PF00069	0.734
MOD_CK1_1	264	270	PF00069	0.714
MOD_CK1_1	28	34	PF00069	0.659
MOD_CK1_1	294	300	PF00069	0.746
MOD_CK1_1	319	325	PF00069	0.659
MOD_CK1_1	331	337	PF00069	0.719
MOD_CK1_1	35	41	PF00069	0.518
MOD_CK1_1	488	494	PF00069	0.827
MOD_CK1_1	549	555	PF00069	0.832
MOD_CK1_1	65	71	PF00069	0.704
MOD_CK1_1	746	752	PF00069	0.831
MOD_CK1_1	764	770	PF00069	0.732
MOD_CK1_1	771	777	PF00069	0.733
MOD_CK1_1	787	793	PF00069	0.839
MOD_CK1_1	823	829	PF00069	0.817
MOD_CK2_1	128	134	PF00069	0.411
MOD_CK2_1	204	210	PF00069	0.638
MOD_CK2_1	240	246	PF00069	0.581
MOD_CK2_1	419	425	PF00069	0.543
MOD_CK2_1	486	492	PF00069	0.736
MOD_CK2_1	544	550	PF00069	0.761
MOD_CK2_1	552	558	PF00069	0.721
MOD_CK2_1	824	830	PF00069	0.593
MOD_Cter_Amidation	125	128	PF01082	0.512
MOD_GlcNHglycan	16	19	PF01048	0.754
MOD_GlcNHglycan	176	179	PF01048	0.709
MOD_GlcNHglycan	180	183	PF01048	0.668
MOD_GlcNHglycan	214	218	PF01048	0.726
MOD_GlcNHglycan	333	336	PF01048	0.765
MOD_GlcNHglycan	362	365	PF01048	0.704
MOD_GlcNHglycan	37	40	PF01048	0.539
MOD_GlcNHglycan	390	393	PF01048	0.636
MOD_GlcNHglycan	419	422	PF01048	0.680
MOD_GlcNHglycan	560	563	PF01048	0.683
MOD_GlcNHglycan	568	571	PF01048	0.776
MOD_GlcNHglycan	639	642	PF01048	0.815
MOD_GlcNHglycan	64	67	PF01048	0.672
MOD_GlcNHglycan	658	661	PF01048	0.809
MOD_GlcNHglycan	663	666	PF01048	0.863
MOD_GlcNHglycan	745	748	PF01048	0.794
MOD_GlcNHglycan	76	79	PF01048	0.333
MOD_GlcNHglycan	770	773	PF01048	0.829
MOD_GlcNHglycan	809	812	PF01048	0.705
MOD_GSK3_1	128	135	PF00069	0.429
MOD_GSK3_1	174	181	PF00069	0.670
MOD_GSK3_1	204	211	PF00069	0.735
MOD_GSK3_1	24	31	PF00069	0.793
MOD_GSK3_1	319	326	PF00069	0.703
MOD_GSK3_1	360	367	PF00069	0.682
MOD_GSK3_1	388	395	PF00069	0.605
MOD_GSK3_1	401	408	PF00069	0.620
MOD_GSK3_1	521	528	PF00069	0.586
MOD_GSK3_1	576	583	PF00069	0.805
MOD_GSK3_1	607	614	PF00069	0.685
MOD_GSK3_1	61	68	PF00069	0.714
MOD_GSK3_1	661	668	PF00069	0.759
MOD_GSK3_1	74	81	PF00069	0.298
MOD_GSK3_1	743	750	PF00069	0.738
MOD_GSK3_1	762	769	PF00069	0.633
MOD_GSK3_1	771	778	PF00069	0.742
MOD_GSK3_1	787	794	PF00069	0.837
MOD_GSK3_1	820	827	PF00069	0.754
MOD_N-GLC_1	381	386	PF02516	0.636
MOD_N-GLC_1	552	557	PF02516	0.588
MOD_NEK2_1	132	137	PF00069	0.411
MOD_NEK2_1	281	286	PF00069	0.678
MOD_NEK2_1	428	433	PF00069	0.717
MOD_NEK2_1	791	796	PF00069	0.723
MOD_NEK2_1	807	812	PF00069	0.763
MOD_NEK2_1	821	826	PF00069	0.568
MOD_NEK2_1	85	90	PF00069	0.372
MOD_PIKK_1	218	224	PF00454	0.592
MOD_PIKK_1	525	531	PF00454	0.599
MOD_PIKK_1	581	587	PF00454	0.854
MOD_PIKK_1	65	71	PF00454	0.457
MOD_PIKK_1	672	678	PF00454	0.592
MOD_PIKK_1	699	705	PF00454	0.665
MOD_PIKK_1	737	743	PF00454	0.761
MOD_PIKK_1	99	105	PF00454	0.512
MOD_PK_1	259	265	PF00069	0.570
MOD_PK_1	32	38	PF00069	0.712
MOD_PKA_1	411	417	PF00069	0.558
MOD_PKA_1	512	518	PF00069	0.847
MOD_PKA_1	538	544	PF00069	0.597
MOD_PKA_2	126	132	PF00069	0.442
MOD_PKA_2	194	200	PF00069	0.711
MOD_PKA_2	246	252	PF00069	0.577
MOD_PKA_2	31	37	PF00069	0.662
MOD_PKA_2	410	416	PF00069	0.598
MOD_PKA_2	511	517	PF00069	0.835
MOD_PKA_2	538	544	PF00069	0.597
MOD_PKA_2	566	572	PF00069	0.770
MOD_PKA_2	610	616	PF00069	0.739
MOD_Plk_1	316	322	PF00069	0.571
MOD_Plk_2-3	210	216	PF00069	0.650
MOD_Plk_2-3	544	550	PF00069	0.665
MOD_Plk_4	128	134	PF00069	0.411
MOD_Plk_4	286	292	PF00069	0.703
MOD_Plk_4	419	425	PF00069	0.644
MOD_Plk_4	747	753	PF00069	0.817
MOD_ProDKin_1	195	201	PF00069	0.795
MOD_ProDKin_1	405	411	PF00069	0.693
MOD_ProDKin_1	429	435	PF00069	0.580
MOD_ProDKin_1	504	510	PF00069	0.734
MOD_ProDKin_1	715	721	PF00069	0.781
MOD_ProDKin_1	784	790	PF00069	0.693
MOD_ProDKin_1	793	799	PF00069	0.721
MOD_SUMO_rev_2	475	483	PF00179	0.578
TRG_DiLeu_BaLyEn_6	595	600	PF01217	0.595
TRG_ENDOCYTIC_2	375	378	PF00928	0.695
TRG_ENDOCYTIC_2	439	442	PF00928	0.695
TRG_ER_diArg_1	105	107	PF00400	0.419
TRG_ER_diArg_1	124	127	PF00400	0.199
TRG_ER_diArg_1	192	195	PF00400	0.717
TRG_ER_diArg_1	257	259	PF00400	0.578
TRG_ER_diArg_1	471	473	PF00400	0.670
TRG_ER_diArg_1	532	535	PF00400	0.752
TRG_ER_diArg_1	571	574	PF00400	0.778
TRG_ER_diArg_1	755	757	PF00400	0.829
TRG_ER_diArg_1	803	806	PF00400	0.839
TRG_Pf-PMV_PEXEL_1	453	458	PF00026	0.775
TRG_Pf-PMV_PEXEL_1	461	466	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	757	762	PF00026	0.844

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAV3	Leptomonas seymouri	42%	96%
A0A3S7WNR6	Leishmania donovani	69%	100%
A4HS70	Leishmania infantum	69%	100%
E9AK57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
O97214	Leishmania major	67%	98%