Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF974), putative

Species:

Leishmania braziliensis

UniProt:

A4H407_LEIBR

TriTrypDb:

LbrM.04.0930 , LBRM2903_040013500

Length:

642

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0030008	TRAPP complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0099023	vesicle tethering complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1990072	TRAPPIII protein complex	4	1

Expansion

Sequence features

A4H407

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H407

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	37	41	PF00656	0.490
CLV_C14_Caspase3-7	463	467	PF00656	0.521
CLV_C14_Caspase3-7	563	567	PF00656	0.500
CLV_C14_Caspase3-7	606	610	PF00656	0.664
CLV_NRD_NRD_1	140	142	PF00675	0.426
CLV_NRD_NRD_1	187	189	PF00675	0.429
CLV_NRD_NRD_1	91	93	PF00675	0.599
CLV_NRD_NRD_1	98	100	PF00675	0.711
CLV_PCSK_FUR_1	89	93	PF00082	0.582
CLV_PCSK_KEX2_1	140	142	PF00082	0.241
CLV_PCSK_KEX2_1	187	189	PF00082	0.429
CLV_PCSK_KEX2_1	91	93	PF00082	0.599
CLV_PCSK_KEX2_1	98	100	PF00082	0.702
CLV_PCSK_SKI1_1	148	152	PF00082	0.322
CLV_PCSK_SKI1_1	229	233	PF00082	0.321
DEG_Nend_UBRbox_3	1	3	PF02207	0.622
DEG_SCF_FBW7_1	450	456	PF00400	0.527
DEG_SPOP_SBC_1	597	601	PF00917	0.651
DOC_CKS1_1	450	455	PF01111	0.569
DOC_CYCLIN_yCln2_LP_2	45	51	PF00134	0.452
DOC_MAPK_DCC_7	350	359	PF00069	0.210
DOC_MAPK_HePTP_8	291	303	PF00069	0.425
DOC_MAPK_MEF2A_6	115	124	PF00069	0.650
DOC_MAPK_MEF2A_6	294	303	PF00069	0.353
DOC_MAPK_MEF2A_6	506	515	PF00069	0.401
DOC_PP1_RVXF_1	227	234	PF00149	0.298
DOC_PP2B_LxvP_1	136	139	PF13499	0.298
DOC_PP2B_LxvP_1	358	361	PF13499	0.425
DOC_PP2B_LxvP_1	45	48	PF13499	0.550
DOC_PP2B_LxvP_1	574	577	PF13499	0.502
DOC_USP7_MATH_1	16	20	PF00917	0.697
DOC_USP7_MATH_1	177	181	PF00917	0.438
DOC_USP7_MATH_1	22	26	PF00917	0.673
DOC_USP7_MATH_1	239	243	PF00917	0.350
DOC_USP7_MATH_1	348	352	PF00917	0.440
DOC_USP7_MATH_1	418	422	PF00917	0.316
DOC_USP7_MATH_1	448	452	PF00917	0.691
DOC_USP7_MATH_1	537	541	PF00917	0.427
DOC_USP7_MATH_1	567	571	PF00917	0.589
DOC_USP7_MATH_1	597	601	PF00917	0.652
DOC_WW_Pin1_4	104	109	PF00397	0.783
DOC_WW_Pin1_4	350	355	PF00397	0.273
DOC_WW_Pin1_4	393	398	PF00397	0.402
DOC_WW_Pin1_4	449	454	PF00397	0.536
DOC_WW_Pin1_4	487	492	PF00397	0.567
DOC_WW_Pin1_4	92	97	PF00397	0.661
LIG_14-3-3_CanoR_1	187	191	PF00244	0.389
LIG_14-3-3_CanoR_1	229	234	PF00244	0.203
LIG_14-3-3_CanoR_1	276	284	PF00244	0.407
LIG_14-3-3_CanoR_1	347	357	PF00244	0.235
LIG_14-3-3_CanoR_1	398	403	PF00244	0.439
LIG_14-3-3_CanoR_1	568	576	PF00244	0.500
LIG_14-3-3_CanoR_1	98	108	PF00244	0.782
LIG_Actin_WH2_2	239	254	PF00022	0.408
LIG_AP2alpha_2	85	87	PF02296	0.628
LIG_BRCT_BRCA1_1	122	126	PF00533	0.472
LIG_BRCT_BRCA1_1	233	237	PF00533	0.402
LIG_BRCT_BRCA1_1	276	280	PF00533	0.316
LIG_BRCT_BRCA1_1	365	369	PF00533	0.210
LIG_BRCT_BRCA1_1	539	543	PF00533	0.514
LIG_Clathr_ClatBox_1	423	427	PF01394	0.358
LIG_CSL_BTD_1	574	577	PF09270	0.502
LIG_deltaCOP1_diTrp_1	406	409	PF00928	0.228
LIG_EH1_1	368	376	PF00400	0.408
LIG_FHA_1	117	123	PF00498	0.672
LIG_FHA_1	210	216	PF00498	0.309
LIG_FHA_1	30	36	PF00498	0.599
LIG_FHA_1	362	368	PF00498	0.422
LIG_FHA_1	390	396	PF00498	0.437
LIG_FHA_1	40	46	PF00498	0.557
LIG_FHA_1	5	11	PF00498	0.616
LIG_FHA_2	260	266	PF00498	0.399
LIG_FHA_2	35	41	PF00498	0.498
LIG_FHA_2	458	464	PF00498	0.704
LIG_LIR_Apic_2	220	224	PF02991	0.431
LIG_LIR_Apic_2	306	311	PF02991	0.210
LIG_LIR_Apic_2	572	578	PF02991	0.457
LIG_LIR_Gen_1	197	207	PF02991	0.408
LIG_LIR_Gen_1	493	504	PF02991	0.343
LIG_LIR_Nem_3	149	154	PF02991	0.398
LIG_LIR_Nem_3	197	202	PF02991	0.408
LIG_LIR_Nem_3	281	287	PF02991	0.431
LIG_LIR_Nem_3	493	499	PF02991	0.405
LIG_LIR_Nem_3	60	65	PF02991	0.660
LIG_LIR_Nem_3	67	72	PF02991	0.575
LIG_LIR_Nem_3	77	83	PF02991	0.511
LIG_LIR_Nem_3	85	90	PF02991	0.506
LIG_PDZ_Class_2	637	642	PF00595	0.502
LIG_Pex14_1	233	237	PF04695	0.425
LIG_PTAP_UEV_1	481	486	PF05743	0.409
LIG_SH2_CRK	199	203	PF00017	0.408
LIG_SH2_CRK	524	528	PF00017	0.415
LIG_SH2_NCK_1	199	203	PF00017	0.408
LIG_SH2_PTP2	253	256	PF00017	0.408
LIG_SH2_STAP1	199	203	PF00017	0.408
LIG_SH2_STAP1	213	217	PF00017	0.342
LIG_SH2_STAP1	507	511	PF00017	0.492
LIG_SH2_STAT5	199	202	PF00017	0.425
LIG_SH2_STAT5	221	224	PF00017	0.224
LIG_SH2_STAT5	253	256	PF00017	0.425
LIG_SH2_STAT5	524	527	PF00017	0.496
LIG_SH2_STAT5	9	12	PF00017	0.519
LIG_SH3_3	106	112	PF00018	0.684
LIG_SH3_3	115	121	PF00018	0.694
LIG_SH3_3	171	177	PF00018	0.444
LIG_SH3_3	447	453	PF00018	0.599
LIG_SH3_3	479	485	PF00018	0.680
LIG_SH3_3	570	576	PF00018	0.436
LIG_SH3_3	579	585	PF00018	0.508
LIG_SUMO_SIM_anti_2	434	440	PF11976	0.342
LIG_SUMO_SIM_anti_2	544	549	PF11976	0.400
LIG_SUMO_SIM_anti_2	560	566	PF11976	0.476
MOD_CDC14_SPxK_1	95	98	PF00782	0.510
MOD_CDK_SPK_2	393	398	PF00069	0.408
MOD_CDK_SPxK_1	92	98	PF00069	0.499
MOD_CDK_SPxxK_3	108	115	PF00069	0.578
MOD_CDK_SPxxK_3	92	99	PF00069	0.503
MOD_CK1_1	102	108	PF00069	0.785
MOD_CK1_1	17	23	PF00069	0.804
MOD_CK1_1	197	203	PF00069	0.431
MOD_CK1_1	208	214	PF00069	0.432
MOD_CK1_1	25	31	PF00069	0.512
MOD_CK1_1	278	284	PF00069	0.363
MOD_CK1_1	340	346	PF00069	0.488
MOD_CK1_1	457	463	PF00069	0.810
MOD_CK1_1	490	496	PF00069	0.542
MOD_CK1_1	57	63	PF00069	0.642
MOD_CK2_1	239	245	PF00069	0.291
MOD_CK2_1	457	463	PF00069	0.705
MOD_CK2_1	61	67	PF00069	0.614
MOD_GlcNHglycan	16	19	PF01048	0.754
MOD_GlcNHglycan	177	180	PF01048	0.301
MOD_GlcNHglycan	223	227	PF01048	0.457
MOD_GlcNHglycan	277	280	PF01048	0.323
MOD_GlcNHglycan	28	31	PF01048	0.490
MOD_GlcNHglycan	339	342	PF01048	0.345
MOD_GlcNHglycan	344	347	PF01048	0.339
MOD_GlcNHglycan	420	423	PF01048	0.451
MOD_GlcNHglycan	445	448	PF01048	0.685
MOD_GlcNHglycan	482	485	PF01048	0.482
MOD_GlcNHglycan	600	603	PF01048	0.625
MOD_GSK3_1	10	17	PF00069	0.651
MOD_GSK3_1	116	123	PF00069	0.572
MOD_GSK3_1	205	212	PF00069	0.413
MOD_GSK3_1	22	29	PF00069	0.608
MOD_GSK3_1	229	236	PF00069	0.340
MOD_GSK3_1	270	277	PF00069	0.394
MOD_GSK3_1	337	344	PF00069	0.488
MOD_GSK3_1	389	396	PF00069	0.408
MOD_GSK3_1	449	456	PF00069	0.676
MOD_GSK3_1	490	497	PF00069	0.481
MOD_GSK3_1	50	57	PF00069	0.460
MOD_GSK3_1	537	544	PF00069	0.427
MOD_GSK3_1	609	616	PF00069	0.704
MOD_GSK3_1	99	106	PF00069	0.711
MOD_N-GLC_1	197	202	PF02516	0.201
MOD_N-GLC_1	294	299	PF02516	0.337
MOD_N-GLC_1	4	9	PF02516	0.635
MOD_N-GLC_1	499	504	PF02516	0.553
MOD_N-GLC_1	555	560	PF02516	0.307
MOD_NEK2_1	100	105	PF00069	0.734
MOD_NEK2_1	124	129	PF00069	0.669
MOD_NEK2_1	186	191	PF00069	0.265
MOD_NEK2_1	231	236	PF00069	0.307
MOD_NEK2_1	275	280	PF00069	0.431
MOD_NEK2_1	337	342	PF00069	0.225
MOD_NEK2_1	437	442	PF00069	0.484
MOD_NEK2_1	499	504	PF00069	0.466
MOD_NEK2_1	51	56	PF00069	0.521
MOD_NEK2_1	541	546	PF00069	0.392
MOD_NEK2_1	569	574	PF00069	0.569
MOD_NEK2_1	613	618	PF00069	0.684
MOD_NEK2_2	161	166	PF00069	0.242
MOD_NEK2_2	177	182	PF00069	0.159
MOD_NEK2_2	233	238	PF00069	0.425
MOD_PIKK_1	259	265	PF00454	0.331
MOD_PIKK_1	54	60	PF00454	0.609
MOD_PKA_2	186	192	PF00069	0.425
MOD_PKA_2	270	276	PF00069	0.417
MOD_PKA_2	567	573	PF00069	0.458
MOD_PKB_1	227	235	PF00069	0.312
MOD_Plk_1	161	167	PF00069	0.408
MOD_Plk_1	197	203	PF00069	0.206
MOD_Plk_1	208	214	PF00069	0.434
MOD_Plk_1	239	245	PF00069	0.307
MOD_Plk_1	294	300	PF00069	0.337
MOD_Plk_4	197	203	PF00069	0.481
MOD_Plk_4	239	245	PF00069	0.256
MOD_Plk_4	363	369	PF00069	0.320
MOD_Plk_4	379	385	PF00069	0.477
MOD_Plk_4	39	45	PF00069	0.397
MOD_Plk_4	51	57	PF00069	0.469
MOD_Plk_4	543	549	PF00069	0.405
MOD_Plk_4	569	575	PF00069	0.451
MOD_ProDKin_1	104	110	PF00069	0.785
MOD_ProDKin_1	350	356	PF00069	0.273
MOD_ProDKin_1	393	399	PF00069	0.402
MOD_ProDKin_1	449	455	PF00069	0.536
MOD_ProDKin_1	487	493	PF00069	0.554
MOD_ProDKin_1	92	98	PF00069	0.668
MOD_SUMO_for_1	237	240	PF00179	0.425
TRG_DiLeu_BaEn_1	434	439	PF01217	0.546
TRG_DiLeu_BaLyEn_6	390	395	PF01217	0.210
TRG_DiLeu_BaLyEn_6	482	487	PF01217	0.610
TRG_ENDOCYTIC_2	199	202	PF00928	0.408
TRG_ER_diArg_1	139	141	PF00400	0.241
TRG_ER_diArg_1	186	188	PF00400	0.368
TRG_ER_diArg_1	89	92	PF00400	0.575
TRG_ER_diArg_1	98	100	PF00400	0.698

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHB8	Leptomonas seymouri	47%	99%
A0A1X0NLJ7	Trypanosomatidae	31%	100%
A0A3R7LPQ4	Trypanosoma rangeli	30%	100%
A0A3S5H5C3	Leishmania donovani	72%	100%
A4HS69	Leishmania infantum	72%	100%
C9ZY64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AK56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
O97215	Leishmania major	70%	100%
V5BIB6	Trypanosoma cruzi	29%	100%