LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein
Species:
Leishmania braziliensis
UniProt:
A4H406_LEIBR
TriTrypDb:
LbrM.04.0920 , LBRM2903_040013400
Length:
663

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H406
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H406

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 389 393 PF00656 0.541
CLV_NRD_NRD_1 111 113 PF00675 0.618
CLV_NRD_NRD_1 324 326 PF00675 0.782
CLV_NRD_NRD_1 575 577 PF00675 0.792
CLV_NRD_NRD_1 610 612 PF00675 0.593
CLV_PCSK_FUR_1 573 577 PF00082 0.788
CLV_PCSK_KEX2_1 110 112 PF00082 0.756
CLV_PCSK_KEX2_1 324 326 PF00082 0.622
CLV_PCSK_KEX2_1 462 464 PF00082 0.638
CLV_PCSK_KEX2_1 575 577 PF00082 0.792
CLV_PCSK_KEX2_1 610 612 PF00082 0.593
CLV_PCSK_PC1ET2_1 462 464 PF00082 0.577
CLV_PCSK_SKI1_1 111 115 PF00082 0.580
CLV_PCSK_SKI1_1 205 209 PF00082 0.841
CLV_PCSK_SKI1_1 97 101 PF00082 0.654
DEG_APCC_DBOX_1 575 583 PF00400 0.585
DEG_APCC_DBOX_1 96 104 PF00400 0.692
DEG_SCF_FBW7_1 54 59 PF00400 0.614
DEG_SPOP_SBC_1 170 174 PF00917 0.592
DEG_SPOP_SBC_1 646 650 PF00917 0.561
DEG_SPOP_SBC_1 66 70 PF00917 0.624
DOC_CKS1_1 183 188 PF01111 0.666
DOC_CKS1_1 53 58 PF01111 0.614
DOC_CYCLIN_RxL_1 108 117 PF00134 0.571
DOC_MAPK_gen_1 479 489 PF00069 0.571
DOC_MAPK_RevD_3 596 611 PF00069 0.571
DOC_PP2B_LxvP_1 286 289 PF13499 0.575
DOC_PP4_FxxP_1 191 194 PF00568 0.606
DOC_SPAK_OSR1_1 463 467 PF12202 0.778
DOC_USP7_MATH_1 168 172 PF00917 0.772
DOC_USP7_MATH_1 187 191 PF00917 0.644
DOC_USP7_MATH_1 192 196 PF00917 0.801
DOC_USP7_MATH_1 342 346 PF00917 0.575
DOC_USP7_MATH_1 369 373 PF00917 0.749
DOC_USP7_MATH_1 384 388 PF00917 0.480
DOC_USP7_MATH_1 400 404 PF00917 0.614
DOC_USP7_MATH_1 407 411 PF00917 0.599
DOC_USP7_MATH_1 657 661 PF00917 0.779
DOC_USP7_MATH_1 99 103 PF00917 0.654
DOC_WW_Pin1_4 164 169 PF00397 0.855
DOC_WW_Pin1_4 182 187 PF00397 0.544
DOC_WW_Pin1_4 401 406 PF00397 0.638
DOC_WW_Pin1_4 449 454 PF00397 0.706
DOC_WW_Pin1_4 52 57 PF00397 0.635
DOC_WW_Pin1_4 637 642 PF00397 0.779
DOC_WW_Pin1_4 91 96 PF00397 0.642
LIG_14-3-3_CanoR_1 112 121 PF00244 0.663
LIG_14-3-3_CanoR_1 188 192 PF00244 0.620
LIG_14-3-3_CanoR_1 294 304 PF00244 0.594
LIG_14-3-3_CanoR_1 357 366 PF00244 0.575
LIG_14-3-3_CanoR_1 386 391 PF00244 0.741
LIG_14-3-3_CanoR_1 610 615 PF00244 0.832
LIG_14-3-3_CanoR_1 97 106 PF00244 0.632
LIG_FHA_1 170 176 PF00498 0.840
LIG_FHA_1 258 264 PF00498 0.598
LIG_FHA_1 280 286 PF00498 0.771
LIG_FHA_1 309 315 PF00498 0.550
LIG_FHA_1 317 323 PF00498 0.468
LIG_FHA_1 350 356 PF00498 0.628
LIG_FHA_1 366 372 PF00498 0.818
LIG_FHA_1 373 379 PF00498 0.661
LIG_FHA_1 620 626 PF00498 0.784
LIG_FHA_1 68 74 PF00498 0.612
LIG_FHA_2 122 128 PF00498 0.517
LIG_FHA_2 15 21 PF00498 0.802
LIG_LIR_Apic_2 190 194 PF02991 0.853
LIG_LIR_Apic_2 419 425 PF02991 0.556
LIG_LIR_Apic_2 51 56 PF02991 0.608
LIG_LIR_Gen_1 558 567 PF02991 0.650
LIG_LIR_Nem_3 260 264 PF02991 0.608
LIG_LIR_Nem_3 330 336 PF02991 0.558
LIG_LIR_Nem_3 558 563 PF02991 0.764
LIG_MYND_1 164 168 PF01753 0.608
LIG_Pex14_1 627 631 PF04695 0.535
LIG_SH2_CRK 333 337 PF00017 0.727
LIG_SH2_CRK 53 57 PF00017 0.613
LIG_SH2_CRK 560 564 PF00017 0.568
LIG_SH2_NCK_1 422 426 PF00017 0.660
LIG_SH2_NCK_1 654 658 PF00017 0.545
LIG_SH2_SRC 634 637 PF00017 0.552
LIG_SH2_STAT3 567 570 PF00017 0.597
LIG_SH2_STAT5 652 655 PF00017 0.804
LIG_SH3_1 240 246 PF00018 0.590
LIG_SH3_3 240 246 PF00018 0.674
LIG_SH3_3 371 377 PF00018 0.542
LIG_SH3_3 429 435 PF00018 0.633
LIG_SH3_3 466 472 PF00018 0.582
LIG_SH3_3 484 490 PF00018 0.720
LIG_SH3_3 635 641 PF00018 0.769
LIG_SH3_3 87 93 PF00018 0.752
LIG_SH3_5 550 554 PF00018 0.569
LIG_TRAF2_1 124 127 PF00917 0.515
LIG_TRAF2_2 194 199 PF00917 0.589
LIG_TRAF2_2 472 477 PF00917 0.576
LIG_WW_3 185 189 PF00397 0.594
MOD_CDC14_SPxK_1 94 97 PF00782 0.573
MOD_CDK_SPK_2 449 454 PF00069 0.558
MOD_CDK_SPxK_1 182 188 PF00069 0.595
MOD_CDK_SPxK_1 91 97 PF00069 0.577
MOD_CK1_1 101 107 PF00069 0.719
MOD_CK1_1 171 177 PF00069 0.812
MOD_CK1_1 224 230 PF00069 0.805
MOD_CK1_1 244 250 PF00069 0.562
MOD_CK1_1 3 9 PF00069 0.812
MOD_CK1_1 305 311 PF00069 0.560
MOD_CK1_1 327 333 PF00069 0.562
MOD_CK1_1 351 357 PF00069 0.826
MOD_CK1_1 372 378 PF00069 0.728
MOD_CK1_1 401 407 PF00069 0.720
MOD_CK1_1 410 416 PF00069 0.646
MOD_CK1_1 497 503 PF00069 0.729
MOD_CK1_1 506 512 PF00069 0.759
MOD_CK1_1 525 531 PF00069 0.679
MOD_CK1_1 559 565 PF00069 0.813
MOD_CK1_1 581 587 PF00069 0.803
MOD_CK1_1 59 65 PF00069 0.712
MOD_CK1_1 637 643 PF00069 0.820
MOD_CK1_1 655 661 PF00069 0.487
MOD_CK2_1 121 127 PF00069 0.624
MOD_CK2_1 14 20 PF00069 0.568
MOD_CK2_1 307 313 PF00069 0.553
MOD_CK2_1 610 616 PF00069 0.672
MOD_Cter_Amidation 460 463 PF01082 0.573
MOD_Cter_Amidation 608 611 PF01082 0.582
MOD_GlcNHglycan 227 230 PF01048 0.769
MOD_GlcNHglycan 247 250 PF01048 0.588
MOD_GlcNHglycan 319 322 PF01048 0.611
MOD_GlcNHglycan 337 340 PF01048 0.674
MOD_GlcNHglycan 371 374 PF01048 0.658
MOD_GlcNHglycan 38 41 PF01048 0.611
MOD_GlcNHglycan 409 412 PF01048 0.656
MOD_GlcNHglycan 437 440 PF01048 0.800
MOD_GlcNHglycan 457 461 PF01048 0.485
MOD_GlcNHglycan 5 8 PF01048 0.579
MOD_GlcNHglycan 506 509 PF01048 0.794
MOD_GlcNHglycan 587 590 PF01048 0.622
MOD_GlcNHglycan 607 610 PF01048 0.813
MOD_GlcNHglycan 84 87 PF01048 0.708
MOD_GSK3_1 164 171 PF00069 0.698
MOD_GSK3_1 177 184 PF00069 0.574
MOD_GSK3_1 221 228 PF00069 0.783
MOD_GSK3_1 241 248 PF00069 0.593
MOD_GSK3_1 295 302 PF00069 0.647
MOD_GSK3_1 365 372 PF00069 0.821
MOD_GSK3_1 386 393 PF00069 0.596
MOD_GSK3_1 401 408 PF00069 0.700
MOD_GSK3_1 444 451 PF00069 0.586
MOD_GSK3_1 478 485 PF00069 0.579
MOD_GSK3_1 48 55 PF00069 0.720
MOD_GSK3_1 493 500 PF00069 0.666
MOD_GSK3_1 519 526 PF00069 0.722
MOD_GSK3_1 527 534 PF00069 0.593
MOD_GSK3_1 549 556 PF00069 0.679
MOD_GSK3_1 559 566 PF00069 0.771
MOD_GSK3_1 581 588 PF00069 0.786
MOD_GSK3_1 596 603 PF00069 0.680
MOD_GSK3_1 605 612 PF00069 0.788
MOD_GSK3_1 630 637 PF00069 0.656
MOD_GSK3_1 642 649 PF00069 0.602
MOD_GSK3_1 65 72 PF00069 0.674
MOD_GSK3_1 652 659 PF00069 0.604
MOD_N-GLC_1 225 230 PF02516 0.592
MOD_N-GLC_1 519 524 PF02516 0.634
MOD_N-GLC_1 535 540 PF02516 0.638
MOD_N-GLC_2 651 653 PF02516 0.806
MOD_NEK2_1 113 118 PF00069 0.574
MOD_NEK2_1 169 174 PF00069 0.595
MOD_NEK2_1 198 203 PF00069 0.582
MOD_NEK2_1 221 226 PF00069 0.602
MOD_NEK2_1 317 322 PF00069 0.781
MOD_NEK2_1 358 363 PF00069 0.737
MOD_NEK2_1 437 442 PF00069 0.540
MOD_NEK2_1 448 453 PF00069 0.585
MOD_NEK2_1 493 498 PF00069 0.812
MOD_NEK2_1 537 542 PF00069 0.560
MOD_NEK2_1 563 568 PF00069 0.818
MOD_NEK2_1 630 635 PF00069 0.728
MOD_NMyristoyl 1 7 PF02799 0.592
MOD_PIKK_1 192 198 PF00454 0.595
MOD_PIKK_1 230 236 PF00454 0.598
MOD_PIKK_1 305 311 PF00454 0.663
MOD_PIKK_1 386 392 PF00454 0.778
MOD_PIKK_1 470 476 PF00454 0.574
MOD_PIKK_1 48 54 PF00454 0.754
MOD_PIKK_1 501 507 PF00454 0.569
MOD_PKA_1 324 330 PF00069 0.588
MOD_PKA_1 610 616 PF00069 0.581
MOD_PKA_2 187 193 PF00069 0.606
MOD_PKA_2 274 280 PF00069 0.835
MOD_PKA_2 299 305 PF00069 0.677
MOD_PKA_2 324 330 PF00069 0.588
MOD_PKA_2 500 506 PF00069 0.817
MOD_PKA_2 556 562 PF00069 0.566
MOD_PKA_2 609 615 PF00069 0.829
MOD_Plk_1 121 127 PF00069 0.520
MOD_Plk_1 325 331 PF00069 0.606
MOD_Plk_1 519 525 PF00069 0.618
MOD_Plk_4 351 357 PF00069 0.736
MOD_Plk_4 437 443 PF00069 0.649
MOD_Plk_4 519 525 PF00069 0.691
MOD_ProDKin_1 164 170 PF00069 0.854
MOD_ProDKin_1 182 188 PF00069 0.546
MOD_ProDKin_1 401 407 PF00069 0.633
MOD_ProDKin_1 449 455 PF00069 0.707
MOD_ProDKin_1 52 58 PF00069 0.636
MOD_ProDKin_1 637 643 PF00069 0.779
MOD_ProDKin_1 91 97 PF00069 0.644
TRG_DiLeu_BaEn_1 20 25 PF01217 0.574
TRG_DiLeu_BaLyEn_6 281 286 PF01217 0.586
TRG_DiLeu_BaLyEn_6 488 493 PF01217 0.699
TRG_ENDOCYTIC_2 333 336 PF00928 0.727
TRG_ENDOCYTIC_2 560 563 PF00928 0.567
TRG_ER_diArg_1 109 112 PF00400 0.666
TRG_ER_diArg_1 272 275 PF00400 0.823
TRG_ER_diArg_1 428 431 PF00400 0.569
TRG_ER_diArg_1 574 576 PF00400 0.790
TRG_Pf-PMV_PEXEL_1 312 316 PF00026 0.554
TRG_Pf-PMV_PEXEL_1 415 419 PF00026 0.572

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H5C2 Leishmania donovani 47% 93%
A4HS68 Leishmania infantum 47% 93%
E9AK55 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 99%
O97216 Leishmania major 48% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS