PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tir chaperone protein (CesT) family/PDZ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H405_LEIBR

TriTrypDb:

LbrM.04.0910 , LBRM2903_040013300

Length:

780

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H405

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H405

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0008104	protein localization	4	10
GO:0009306	protein secretion	4	10
GO:0009987	cellular process	1	10
GO:0015031	protein transport	4	10
GO:0030254	protein secretion by the type III secretion system	4	10
GO:0032940	secretion by cell	3	10
GO:0033036	macromolecule localization	2	10
GO:0035592	establishment of protein localization to extracellular region	4	10
GO:0045184	establishment of protein localization	3	10
GO:0046903	secretion	4	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10
GO:0051641	cellular localization	2	10
GO:0055085	transmembrane transport	2	10
GO:0070727	cellular macromolecule localization	3	10
GO:0071692	protein localization to extracellular region	5	10
GO:0071702	organic substance transport	4	10
GO:0071705	nitrogen compound transport	4	10
GO:0071806	protein transmembrane transport	3	10
GO:0140352	export from cell	2	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.550
CLV_C14_Caspase3-7	359	363	PF00656	0.487
CLV_C14_Caspase3-7	407	411	PF00656	0.567
CLV_NRD_NRD_1	141	143	PF00675	0.559
CLV_NRD_NRD_1	185	187	PF00675	0.457
CLV_NRD_NRD_1	237	239	PF00675	0.451
CLV_NRD_NRD_1	322	324	PF00675	0.457
CLV_NRD_NRD_1	453	455	PF00675	0.330
CLV_NRD_NRD_1	744	746	PF00675	0.400
CLV_PCSK_FUR_1	278	282	PF00082	0.439
CLV_PCSK_KEX2_1	141	143	PF00082	0.564
CLV_PCSK_KEX2_1	184	186	PF00082	0.484
CLV_PCSK_KEX2_1	237	239	PF00082	0.485
CLV_PCSK_KEX2_1	27	29	PF00082	0.443
CLV_PCSK_KEX2_1	280	282	PF00082	0.513
CLV_PCSK_KEX2_1	322	324	PF00082	0.482
CLV_PCSK_KEX2_1	453	455	PF00082	0.330
CLV_PCSK_KEX2_1	744	746	PF00082	0.400
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.443
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.439
CLV_PCSK_PC7_1	276	282	PF00082	0.347
CLV_PCSK_SKI1_1	141	145	PF00082	0.494
CLV_PCSK_SKI1_1	261	265	PF00082	0.431
CLV_PCSK_SKI1_1	61	65	PF00082	0.554
DEG_APCC_DBOX_1	14	22	PF00400	0.498
DEG_APCC_DBOX_1	167	175	PF00400	0.376
DOC_CYCLIN_RxL_1	138	148	PF00134	0.610
DOC_CYCLIN_RxL_1	290	301	PF00134	0.530
DOC_MAPK_gen_1	27	33	PF00069	0.441
DOC_MAPK_gen_1	453	461	PF00069	0.530
DOC_MAPK_gen_1	760	770	PF00069	0.374
DOC_MAPK_MEF2A_6	763	772	PF00069	0.330
DOC_PP2B_LxvP_1	552	555	PF13499	0.530
DOC_PP2B_LxvP_1	672	675	PF13499	0.620
DOC_USP7_MATH_1	225	229	PF00917	0.447
DOC_USP7_MATH_1	437	441	PF00917	0.475
DOC_USP7_MATH_1	50	54	PF00917	0.515
DOC_USP7_MATH_1	589	593	PF00917	0.436
DOC_USP7_MATH_1	622	626	PF00917	0.672
DOC_USP7_MATH_1	656	660	PF00917	0.767
DOC_USP7_MATH_1	661	665	PF00917	0.726
DOC_USP7_MATH_1	680	684	PF00917	0.591
DOC_USP7_MATH_1	70	74	PF00917	0.293
DOC_USP7_MATH_1	715	719	PF00917	0.400
DOC_USP7_MATH_1	9	13	PF00917	0.605
DOC_WW_Pin1_4	113	118	PF00397	0.757
DOC_WW_Pin1_4	119	124	PF00397	0.603
DOC_WW_Pin1_4	125	130	PF00397	0.617
DOC_WW_Pin1_4	132	137	PF00397	0.517
DOC_WW_Pin1_4	417	422	PF00397	0.650
DOC_WW_Pin1_4	602	607	PF00397	0.694
DOC_WW_Pin1_4	624	629	PF00397	0.751
DOC_WW_Pin1_4	630	635	PF00397	0.733
DOC_WW_Pin1_4	643	648	PF00397	0.485
DOC_WW_Pin1_4	652	657	PF00397	0.729
DOC_WW_Pin1_4	667	672	PF00397	0.581
DOC_WW_Pin1_4	675	680	PF00397	0.622
DOC_WW_Pin1_4	93	98	PF00397	0.560
LIG_14-3-3_CanoR_1	168	172	PF00244	0.589
LIG_14-3-3_CanoR_1	226	234	PF00244	0.588
LIG_14-3-3_CanoR_1	39	43	PF00244	0.412
LIG_14-3-3_CanoR_1	416	421	PF00244	0.752
LIG_14-3-3_CanoR_1	577	587	PF00244	0.552
LIG_14-3-3_CanoR_1	636	645	PF00244	0.721
LIG_14-3-3_CanoR_1	650	656	PF00244	0.549
LIG_Actin_WH2_2	448	464	PF00022	0.275
LIG_APCC_ABBA_1	770	775	PF00400	0.203
LIG_BIR_II_1	1	5	PF00653	0.700
LIG_CtBP_PxDLS_1	456	462	PF00389	0.389
LIG_eIF4E_1	495	501	PF01652	0.490
LIG_eIF4E_1	705	711	PF01652	0.308
LIG_FHA_1	230	236	PF00498	0.344
LIG_FHA_1	407	413	PF00498	0.483
LIG_FHA_1	470	476	PF00498	0.449
LIG_FHA_1	480	486	PF00498	0.489
LIG_FHA_1	489	495	PF00498	0.459
LIG_FHA_1	579	585	PF00498	0.563
LIG_FHA_1	691	697	PF00498	0.404
LIG_FHA_1	769	775	PF00498	0.355
LIG_FHA_1	86	92	PF00498	0.436
LIG_FHA_2	405	411	PF00498	0.636
LIG_FHA_2	487	493	PF00498	0.444
LIG_FHA_2	701	707	PF00498	0.444
LIG_IRF3_LxIS_1	129	134	PF10401	0.498
LIG_LIR_Gen_1	214	224	PF02991	0.349
LIG_LIR_Gen_1	478	487	PF02991	0.447
LIG_LIR_Gen_1	544	553	PF02991	0.474
LIG_LIR_LC3C_4	707	712	PF02991	0.344
LIG_LIR_Nem_3	214	219	PF02991	0.354
LIG_LIR_Nem_3	373	379	PF02991	0.514
LIG_LIR_Nem_3	478	484	PF02991	0.447
LIG_LIR_Nem_3	742	746	PF02991	0.400
LIG_Rb_pABgroove_1	481	489	PF01858	0.502
LIG_SH2_CRK	333	337	PF00017	0.488
LIG_SH2_CRK	481	485	PF00017	0.447
LIG_SH2_CRK	487	491	PF00017	0.447
LIG_SH2_CRK	497	501	PF00017	0.447
LIG_SH2_CRK	676	680	PF00017	0.480
LIG_SH2_NCK_1	487	491	PF00017	0.530
LIG_SH2_NCK_1	676	680	PF00017	0.480
LIG_SH2_SRC	495	498	PF00017	0.490
LIG_SH2_SRC	705	708	PF00017	0.531
LIG_SH2_STAP1	481	485	PF00017	0.447
LIG_SH2_STAP1	497	501	PF00017	0.447
LIG_SH2_STAP1	519	523	PF00017	0.447
LIG_SH2_STAT3	332	335	PF00017	0.496
LIG_SH2_STAT5	481	484	PF00017	0.447
LIG_SH2_STAT5	495	498	PF00017	0.447
LIG_SH2_STAT5	619	622	PF00017	0.702
LIG_SH2_STAT5	676	679	PF00017	0.556
LIG_SH3_3	30	36	PF00018	0.440
LIG_SH3_3	600	606	PF00018	0.660
LIG_SH3_3	608	614	PF00018	0.583
LIG_SH3_3	631	637	PF00018	0.542
LIG_SUMO_SIM_anti_2	482	489	PF11976	0.549
LIG_SUMO_SIM_anti_2	706	713	PF11976	0.282
LIG_SUMO_SIM_par_1	128	135	PF11976	0.648
LIG_SUMO_SIM_par_1	142	148	PF11976	0.637
LIG_SUMO_SIM_par_1	468	478	PF11976	0.447
LIG_SUMO_SIM_par_1	87	92	PF11976	0.412
LIG_TRAF2_1	195	198	PF00917	0.561
LIG_TRAF2_1	243	246	PF00917	0.495
LIG_TYR_ITAM	478	500	PF00017	0.447
LIG_TYR_ITIM	485	490	PF00017	0.389
LIG_UBA3_1	253	261	PF00899	0.524
MOD_CDC14_SPxK_1	633	636	PF00782	0.480
MOD_CDK_SPK_2	643	648	PF00069	0.479
MOD_CDK_SPxK_1	630	636	PF00069	0.488
MOD_CDK_SPxK_1	93	99	PF00069	0.559
MOD_CDK_SPxxK_3	643	650	PF00069	0.638
MOD_CK1_1	132	138	PF00069	0.627
MOD_CK1_1	38	44	PF00069	0.434
MOD_CK1_1	386	392	PF00069	0.676
MOD_CK1_1	400	406	PF00069	0.631
MOD_CK1_1	415	421	PF00069	0.695
MOD_CK1_1	561	567	PF00069	0.456
MOD_CK1_1	624	630	PF00069	0.631
MOD_CK1_1	659	665	PF00069	0.593
MOD_CK2_1	191	197	PF00069	0.512
MOD_CK2_1	486	492	PF00069	0.444
MOD_CK2_1	700	706	PF00069	0.451
MOD_Cter_Amidation	25	28	PF01082	0.466
MOD_GlcNHglycan	193	196	PF01048	0.628
MOD_GlcNHglycan	388	391	PF01048	0.628
MOD_GlcNHglycan	399	402	PF01048	0.611
MOD_GlcNHglycan	425	428	PF01048	0.668
MOD_GlcNHglycan	548	551	PF01048	0.322
MOD_GlcNHglycan	638	641	PF01048	0.498
MOD_GlcNHglycan	663	666	PF01048	0.642
MOD_GlcNHglycan	682	685	PF01048	0.650
MOD_GSK3_1	125	132	PF00069	0.744
MOD_GSK3_1	225	232	PF00069	0.488
MOD_GSK3_1	400	407	PF00069	0.677
MOD_GSK3_1	412	419	PF00069	0.571
MOD_GSK3_1	469	476	PF00069	0.451
MOD_GSK3_1	496	503	PF00069	0.590
MOD_GSK3_1	554	561	PF00069	0.469
MOD_GSK3_1	598	605	PF00069	0.687
MOD_GSK3_1	618	625	PF00069	0.714
MOD_GSK3_1	626	633	PF00069	0.742
MOD_GSK3_1	652	659	PF00069	0.680
MOD_N-GLC_1	680	685	PF02516	0.655
MOD_NEK2_1	131	136	PF00069	0.534
MOD_NEK2_1	167	172	PF00069	0.537
MOD_NEK2_1	286	291	PF00069	0.504
MOD_NEK2_1	412	417	PF00069	0.682
MOD_NEK2_1	423	428	PF00069	0.584
MOD_NEK2_1	486	491	PF00069	0.470
MOD_NEK2_1	496	501	PF00069	0.463
MOD_NEK2_1	523	528	PF00069	0.539
MOD_NEK2_1	548	553	PF00069	0.474
MOD_NEK2_1	620	625	PF00069	0.615
MOD_NEK2_1	690	695	PF00069	0.413
MOD_NEK2_1	768	773	PF00069	0.308
MOD_NEK2_1	77	82	PF00069	0.543
MOD_NEK2_2	437	442	PF00069	0.434
MOD_OFUCOSY	48	55	PF10250	0.457
MOD_PIKK_1	229	235	PF00454	0.398
MOD_PIKK_1	554	560	PF00454	0.530
MOD_PIKK_1	622	628	PF00454	0.485
MOD_PIKK_1	656	662	PF00454	0.667
MOD_PIKK_1	9	15	PF00454	0.587
MOD_PKA_2	167	173	PF00069	0.636
MOD_PKA_2	191	197	PF00069	0.524
MOD_PKA_2	225	231	PF00069	0.468
MOD_PKA_2	38	44	PF00069	0.403
MOD_PKA_2	415	421	PF00069	0.629
MOD_PKA_2	635	641	PF00069	0.688
MOD_PKB_1	414	422	PF00069	0.631
MOD_Plk_1	479	485	PF00069	0.476
MOD_Plk_1	523	529	PF00069	0.530
MOD_Plk_4	437	443	PF00069	0.469
MOD_Plk_4	479	485	PF00069	0.447
MOD_Plk_4	496	502	PF00069	0.447
MOD_Plk_4	523	529	PF00069	0.506
MOD_Plk_4	548	554	PF00069	0.467
MOD_Plk_4	692	698	PF00069	0.451
MOD_Plk_4	715	721	PF00069	0.404
MOD_ProDKin_1	113	119	PF00069	0.754
MOD_ProDKin_1	125	131	PF00069	0.617
MOD_ProDKin_1	132	138	PF00069	0.506
MOD_ProDKin_1	417	423	PF00069	0.654
MOD_ProDKin_1	602	608	PF00069	0.700
MOD_ProDKin_1	624	630	PF00069	0.754
MOD_ProDKin_1	643	649	PF00069	0.485
MOD_ProDKin_1	652	658	PF00069	0.726
MOD_ProDKin_1	667	673	PF00069	0.581
MOD_ProDKin_1	675	681	PF00069	0.623
MOD_ProDKin_1	93	99	PF00069	0.569
MOD_SUMO_for_1	254	257	PF00179	0.524
MOD_SUMO_for_1	279	282	PF00179	0.348
MOD_SUMO_rev_2	257	263	PF00179	0.454
TRG_DiLeu_BaEn_1	347	352	PF01217	0.537
TRG_DiLeu_BaEn_1	480	485	PF01217	0.530
TRG_DiLeu_BaEn_1	706	711	PF01217	0.279
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.672
TRG_DiLeu_BaLyEn_6	139	144	PF01217	0.637
TRG_ENDOCYTIC_2	333	336	PF00928	0.446
TRG_ENDOCYTIC_2	481	484	PF00928	0.447
TRG_ENDOCYTIC_2	487	490	PF00928	0.447
TRG_ENDOCYTIC_2	497	500	PF00928	0.447
TRG_ENDOCYTIC_2	519	522	PF00928	0.447
TRG_ER_diArg_1	141	143	PF00400	0.554
TRG_ER_diArg_1	183	186	PF00400	0.491
TRG_ER_diArg_1	297	300	PF00400	0.448
TRG_ER_diArg_1	322	324	PF00400	0.509
TRG_ER_diArg_1	413	416	PF00400	0.633
TRG_ER_diArg_1	452	454	PF00400	0.530
TRG_ER_diArg_1	647	650	PF00400	0.481
TRG_ER_diArg_1	743	745	PF00400	0.414
TRG_NES_CRM1_1	450	463	PF08389	0.331
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	186	191	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	316	321	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	322	327	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	453	457	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	563	568	PF00026	0.302
TRG_Pf-PMV_PEXEL_1	745	749	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I193	Leptomonas seymouri	57%	99%
A0A0S4ILT7	Bodo saltans	37%	100%
A0A1X0NMQ4	Trypanosomatidae	35%	100%
A0A3R7NDD0	Trypanosoma rangeli	35%	100%
A0A3S5H5C1	Leishmania donovani	78%	98%
A4HS67	Leishmania infantum	78%	98%
E9AK54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	98%
Q9U110	Leishmania major	77%	100%