Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H404_LEIBR

TriTrypDb:

LbrM.04.0900 , LBRM2903_040013200

Length:

1063

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H404

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H404

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1022	1026	PF00656	0.684
CLV_C14_Caspase3-7	424	428	PF00656	0.534
CLV_C14_Caspase3-7	781	785	PF00656	0.549
CLV_NRD_NRD_1	100	102	PF00675	0.599
CLV_NRD_NRD_1	1027	1029	PF00675	0.560
CLV_NRD_NRD_1	1046	1048	PF00675	0.689
CLV_NRD_NRD_1	1061	1063	PF00675	0.554
CLV_NRD_NRD_1	145	147	PF00675	0.679
CLV_NRD_NRD_1	187	189	PF00675	0.619
CLV_NRD_NRD_1	272	274	PF00675	0.698
CLV_NRD_NRD_1	293	295	PF00675	0.606
CLV_NRD_NRD_1	302	304	PF00675	0.581
CLV_NRD_NRD_1	573	575	PF00675	0.679
CLV_NRD_NRD_1	583	585	PF00675	0.587
CLV_NRD_NRD_1	591	593	PF00675	0.545
CLV_NRD_NRD_1	76	78	PF00675	0.690
CLV_NRD_NRD_1	908	910	PF00675	0.684
CLV_PCSK_FUR_1	580	584	PF00082	0.636
CLV_PCSK_KEX2_1	1027	1029	PF00082	0.560
CLV_PCSK_KEX2_1	1046	1048	PF00082	0.689
CLV_PCSK_KEX2_1	1061	1063	PF00082	0.554
CLV_PCSK_KEX2_1	145	147	PF00082	0.710
CLV_PCSK_KEX2_1	187	189	PF00082	0.619
CLV_PCSK_KEX2_1	272	274	PF00082	0.698
CLV_PCSK_KEX2_1	293	295	PF00082	0.606
CLV_PCSK_KEX2_1	302	304	PF00082	0.587
CLV_PCSK_KEX2_1	573	575	PF00082	0.672
CLV_PCSK_KEX2_1	582	584	PF00082	0.597
CLV_PCSK_KEX2_1	591	593	PF00082	0.549
CLV_PCSK_KEX2_1	75	77	PF00082	0.696
CLV_PCSK_KEX2_1	908	910	PF00082	0.684
CLV_PCSK_PC7_1	1057	1063	PF00082	0.677
CLV_PCSK_SKI1_1	486	490	PF00082	0.765
CLV_PCSK_SKI1_1	623	627	PF00082	0.629
CLV_PCSK_SKI1_1	65	69	PF00082	0.584
CLV_PCSK_SKI1_1	757	761	PF00082	0.656
CLV_PCSK_SKI1_1	830	834	PF00082	0.531
CLV_PCSK_SKI1_1	875	879	PF00082	0.517
DEG_APCC_DBOX_1	756	764	PF00400	0.644
DEG_APCC_DBOX_1	829	837	PF00400	0.503
DEG_APCC_DBOX_1	969	977	PF00400	0.655
DOC_CDC14_PxL_1	224	232	PF14671	0.561
DOC_CKS1_1	198	203	PF01111	0.622
DOC_CYCLIN_RxL_1	62	72	PF00134	0.582
DOC_CYCLIN_yCln2_LP_2	440	446	PF00134	0.630
DOC_CYCLIN_yCln2_LP_2	698	701	PF00134	0.578
DOC_MAPK_DCC_7	370	379	PF00069	0.694
DOC_MAPK_gen_1	187	193	PF00069	0.622
DOC_MAPK_gen_1	762	770	PF00069	0.669
DOC_MAPK_MEF2A_6	370	379	PF00069	0.694
DOC_MAPK_MEF2A_6	865	874	PF00069	0.441
DOC_PP2B_LxvP_1	193	196	PF13499	0.610
DOC_PP2B_LxvP_1	680	683	PF13499	0.524
DOC_PP2B_LxvP_1	698	701	PF13499	0.572
DOC_PP2B_LxvP_1	768	771	PF13499	0.656
DOC_PP4_FxxP_1	497	500	PF00568	0.760
DOC_PP4_FxxP_1	86	89	PF00568	0.594
DOC_USP7_MATH_1	1014	1018	PF00917	0.647
DOC_USP7_MATH_1	189	193	PF00917	0.630
DOC_USP7_MATH_1	29	33	PF00917	0.630
DOC_USP7_MATH_1	296	300	PF00917	0.666
DOC_USP7_MATH_1	417	421	PF00917	0.635
DOC_USP7_MATH_1	472	476	PF00917	0.778
DOC_USP7_MATH_1	572	576	PF00917	0.735
DOC_USP7_MATH_1	613	617	PF00917	0.890
DOC_USP7_MATH_1	632	636	PF00917	0.692
DOC_USP7_MATH_1	719	723	PF00917	0.719
DOC_USP7_MATH_1	780	784	PF00917	0.565
DOC_USP7_MATH_1	849	853	PF00917	0.532
DOC_USP7_MATH_1	920	924	PF00917	0.617
DOC_USP7_MATH_1	966	970	PF00917	0.537
DOC_WW_Pin1_4	197	202	PF00397	0.673
DOC_WW_Pin1_4	228	233	PF00397	0.699
DOC_WW_Pin1_4	238	243	PF00397	0.776
DOC_WW_Pin1_4	281	286	PF00397	0.637
DOC_WW_Pin1_4	294	299	PF00397	0.599
DOC_WW_Pin1_4	408	413	PF00397	0.680
DOC_WW_Pin1_4	44	49	PF00397	0.713
DOC_WW_Pin1_4	457	462	PF00397	0.552
DOC_WW_Pin1_4	534	539	PF00397	0.717
DOC_WW_Pin1_4	547	552	PF00397	0.751
DOC_WW_Pin1_4	597	602	PF00397	0.664
DOC_WW_Pin1_4	699	704	PF00397	0.638
DOC_WW_Pin1_4	707	712	PF00397	0.661
DOC_WW_Pin1_4	911	916	PF00397	0.707
LIG_14-3-3_CanoR_1	101	110	PF00244	0.600
LIG_14-3-3_CanoR_1	162	168	PF00244	0.581
LIG_14-3-3_CanoR_1	206	213	PF00244	0.679
LIG_14-3-3_CanoR_1	221	227	PF00244	0.604
LIG_14-3-3_CanoR_1	25	29	PF00244	0.575
LIG_14-3-3_CanoR_1	250	255	PF00244	0.684
LIG_14-3-3_CanoR_1	319	324	PF00244	0.635
LIG_14-3-3_CanoR_1	44	48	PF00244	0.542
LIG_14-3-3_CanoR_1	573	578	PF00244	0.568
LIG_14-3-3_CanoR_1	596	602	PF00244	0.792
LIG_14-3-3_CanoR_1	623	632	PF00244	0.759
LIG_14-3-3_CanoR_1	718	724	PF00244	0.787
LIG_14-3-3_CanoR_1	875	880	PF00244	0.593
LIG_14-3-3_CanoR_1	886	890	PF00244	0.691
LIG_14-3-3_CanoR_1	909	915	PF00244	0.789
LIG_14-3-3_CanoR_1	921	929	PF00244	0.704
LIG_Actin_WH2_2	1041	1059	PF00022	0.577
LIG_APCC_ABBA_1	819	824	PF00400	0.515
LIG_BIR_II_1	1	5	PF00653	0.579
LIG_BIR_III_2	282	286	PF00653	0.723
LIG_BRCT_BRCA1_1	296	300	PF00533	0.606
LIG_BRCT_BRCA1_1	621	625	PF00533	0.629
LIG_EVH1_2	1008	1012	PF00568	0.591
LIG_FHA_1	207	213	PF00498	0.721
LIG_FHA_1	247	253	PF00498	0.697
LIG_FHA_1	28	34	PF00498	0.573
LIG_FHA_1	413	419	PF00498	0.582
LIG_FHA_1	524	530	PF00498	0.610
LIG_FHA_1	550	556	PF00498	0.702
LIG_FHA_1	653	659	PF00498	0.589
LIG_FHA_1	693	699	PF00498	0.637
LIG_FHA_2	123	129	PF00498	0.630
LIG_FHA_2	387	393	PF00498	0.666
LIG_FHA_2	751	757	PF00498	0.522
LIG_GBD_Chelix_1	1048	1056	PF00786	0.576
LIG_GBD_Chelix_1	216	224	PF00786	0.696
LIG_GBD_Chelix_1	960	968	PF00786	0.496
LIG_Integrin_isoDGR_2	10	12	PF01839	0.594
LIG_LIR_Apic_2	225	229	PF02991	0.581
LIG_LIR_Apic_2	519	524	PF02991	0.702
LIG_LIR_Apic_2	85	89	PF02991	0.593
LIG_LIR_Gen_1	329	339	PF02991	0.542
LIG_LIR_Gen_1	656	667	PF02991	0.512
LIG_LIR_Gen_1	855	866	PF02991	0.494
LIG_LIR_Nem_3	249	254	PF02991	0.694
LIG_LIR_Nem_3	329	335	PF02991	0.543
LIG_LIR_Nem_3	339	345	PF02991	0.630
LIG_LIR_Nem_3	693	699	PF02991	0.582
LIG_LIR_Nem_3	855	861	PF02991	0.517
LIG_MYND_1	228	232	PF01753	0.725
LIG_MYND_1	711	715	PF01753	0.554
LIG_MYND_3	682	686	PF01753	0.698
LIG_NRBOX	1047	1053	PF00104	0.643
LIG_NRBOX	215	221	PF00104	0.694
LIG_NRBOX	340	346	PF00104	0.594
LIG_PCNA_yPIPBox_3	724	734	PF02747	0.578
LIG_SH2_CRK	459	463	PF00017	0.725
LIG_SH2_STAT3	822	825	PF00017	0.598
LIG_SH2_STAT5	223	226	PF00017	0.755
LIG_SH2_STAT5	459	462	PF00017	0.824
LIG_SH2_STAT5	822	825	PF00017	0.598
LIG_SH3_1	511	517	PF00018	0.658
LIG_SH3_1	697	703	PF00018	0.592
LIG_SH3_2	285	290	PF14604	0.681
LIG_SH3_3	1004	1010	PF00018	0.735
LIG_SH3_3	192	198	PF00018	0.815
LIG_SH3_3	226	232	PF00018	0.679
LIG_SH3_3	236	242	PF00018	0.731
LIG_SH3_3	282	288	PF00018	0.691
LIG_SH3_3	372	378	PF00018	0.696
LIG_SH3_3	511	517	PF00018	0.773
LIG_SH3_3	526	532	PF00018	0.718
LIG_SH3_3	535	541	PF00018	0.785
LIG_SH3_3	55	61	PF00018	0.713
LIG_SH3_3	607	613	PF00018	0.707
LIG_SH3_3	697	703	PF00018	0.592
LIG_SH3_3	740	746	PF00018	0.675
LIG_SH3_3	768	774	PF00018	0.662
LIG_SH3_3	947	953	PF00018	0.665
LIG_SUMO_SIM_anti_2	34	40	PF11976	0.701
LIG_SUMO_SIM_anti_2	677	683	PF11976	0.678
LIG_SUMO_SIM_par_1	556	562	PF11976	0.588
LIG_TRAF2_1	32	35	PF00917	0.672
LIG_TRAF2_1	399	402	PF00917	0.659
LIG_TRAF2_1	488	491	PF00917	0.710
LIG_TRAF2_1	779	782	PF00917	0.568
LIG_TRAF2_1	837	840	PF00917	0.665
LIG_TRFH_1	86	90	PF08558	0.586
LIG_UBA3_1	832	841	PF00899	0.511
LIG_WW_3	196	200	PF00397	0.609
LIG_WW_3	287	291	PF00397	0.707
LIG_WW_3	770	774	PF00397	0.666
MOD_CDK_SPK_2	197	202	PF00069	0.621
MOD_CDK_SPxK_1	457	463	PF00069	0.557
MOD_CDK_SPxxK_3	711	718	PF00069	0.701
MOD_CK1_1	1017	1023	PF00069	0.805
MOD_CK1_1	120	126	PF00069	0.730
MOD_CK1_1	161	167	PF00069	0.700
MOD_CK1_1	307	313	PF00069	0.655
MOD_CK1_1	322	328	PF00069	0.671
MOD_CK1_1	40	46	PF00069	0.605
MOD_CK1_1	476	482	PF00069	0.651
MOD_CK1_1	576	582	PF00069	0.774
MOD_CK1_1	597	603	PF00069	0.676
MOD_CK1_1	690	696	PF00069	0.725
MOD_CK1_1	702	708	PF00069	0.602
MOD_CK1_1	741	747	PF00069	0.569
MOD_CK1_1	933	939	PF00069	0.596
MOD_CK2_1	179	185	PF00069	0.600
MOD_CK2_1	29	35	PF00069	0.610
MOD_CK2_1	386	392	PF00069	0.672
MOD_CK2_1	43	49	PF00069	0.678
MOD_CK2_1	750	756	PF00069	0.531
MOD_CK2_1	776	782	PF00069	0.569
MOD_CK2_1	79	85	PF00069	0.715
MOD_CK2_1	910	916	PF00069	0.611
MOD_Cter_Amidation	185	188	PF01082	0.610
MOD_Cter_Amidation	99	102	PF01082	0.602
MOD_DYRK1A_RPxSP_1	294	298	PF00069	0.603
MOD_DYRK1A_RPxSP_1	44	48	PF00069	0.588
MOD_GlcNHglycan	1019	1022	PF01048	0.740
MOD_GlcNHglycan	137	140	PF01048	0.742
MOD_GlcNHglycan	16	19	PF01048	0.608
MOD_GlcNHglycan	167	171	PF01048	0.711
MOD_GlcNHglycan	181	184	PF01048	0.761
MOD_GlcNHglycan	304	307	PF01048	0.803
MOD_GlcNHglycan	351	355	PF01048	0.588
MOD_GlcNHglycan	39	42	PF01048	0.700
MOD_GlcNHglycan	392	396	PF01048	0.503
MOD_GlcNHglycan	408	411	PF01048	0.587
MOD_GlcNHglycan	482	485	PF01048	0.626
MOD_GlcNHglycan	534	537	PF01048	0.628
MOD_GlcNHglycan	563	566	PF01048	0.577
MOD_GlcNHglycan	570	573	PF01048	0.643
MOD_GlcNHglycan	597	600	PF01048	0.768
MOD_GlcNHglycan	615	618	PF01048	0.676
MOD_GlcNHglycan	690	693	PF01048	0.683
MOD_GlcNHglycan	740	743	PF01048	0.559
MOD_GlcNHglycan	778	781	PF01048	0.622
MOD_GlcNHglycan	79	82	PF01048	0.719
MOD_GlcNHglycan	887	890	PF01048	0.576
MOD_GlcNHglycan	945	948	PF01048	0.629
MOD_GlcNHglycan	956	959	PF01048	0.740
MOD_GlcNHglycan	964	967	PF01048	0.511
MOD_GlcNHglycan	98	101	PF01048	0.607
MOD_GSK3_1	113	120	PF00069	0.718
MOD_GSK3_1	131	138	PF00069	0.775
MOD_GSK3_1	234	241	PF00069	0.691
MOD_GSK3_1	246	253	PF00069	0.699
MOD_GSK3_1	277	284	PF00069	0.635
MOD_GSK3_1	302	309	PF00069	0.683
MOD_GSK3_1	322	329	PF00069	0.711
MOD_GSK3_1	350	357	PF00069	0.507
MOD_GSK3_1	39	46	PF00069	0.713
MOD_GSK3_1	408	415	PF00069	0.713
MOD_GSK3_1	417	424	PF00069	0.634
MOD_GSK3_1	472	479	PF00069	0.673
MOD_GSK3_1	568	575	PF00069	0.700
MOD_GSK3_1	613	620	PF00069	0.871
MOD_GSK3_1	623	630	PF00069	0.685
MOD_GSK3_1	688	695	PF00069	0.768
MOD_GSK3_1	701	708	PF00069	0.629
MOD_GSK3_1	776	783	PF00069	0.609
MOD_GSK3_1	900	907	PF00069	0.636
MOD_GSK3_1	962	969	PF00069	0.683
MOD_N-GLC_1	477	482	PF02516	0.595
MOD_N-GLC_2	246	248	PF02516	0.549
MOD_NEK2_1	304	309	PF00069	0.759
MOD_NEK2_1	421	426	PF00069	0.551
MOD_NEK2_1	477	482	PF00069	0.595
MOD_NEK2_1	587	592	PF00069	0.791
MOD_NEK2_1	755	760	PF00069	0.480
MOD_NEK2_2	189	194	PF00069	0.624
MOD_NEK2_2	719	724	PF00069	0.722
MOD_OFUCOSY	320	326	PF10250	0.674
MOD_PIKK_1	111	117	PF00454	0.598
MOD_PIKK_1	477	483	PF00454	0.592
MOD_PIKK_1	615	621	PF00454	0.651
MOD_PIKK_1	624	630	PF00454	0.699
MOD_PIKK_1	702	708	PF00454	0.651
MOD_PIKK_1	750	756	PF00454	0.531
MOD_PIKK_1	933	939	PF00454	0.681
MOD_PK_1	250	256	PF00069	0.623
MOD_PK_1	319	325	PF00069	0.556
MOD_PK_1	573	579	PF00069	0.546
MOD_PK_1	766	772	PF00069	0.529
MOD_PK_1	79	85	PF00069	0.594
MOD_PKA_1	302	308	PF00069	0.606
MOD_PKA_1	573	579	PF00069	0.703
MOD_PKA_2	161	167	PF00069	0.586
MOD_PKA_2	24	30	PF00069	0.574
MOD_PKA_2	302	308	PF00069	0.720
MOD_PKA_2	43	49	PF00069	0.545
MOD_PKA_2	572	578	PF00069	0.655
MOD_PKA_2	587	593	PF00069	0.805
MOD_PKA_2	595	601	PF00069	0.709
MOD_PKA_2	774	780	PF00069	0.687
MOD_PKA_2	885	891	PF00069	0.639
MOD_PKA_2	910	916	PF00069	0.822
MOD_PKA_2	920	926	PF00069	0.711
MOD_PKA_2	933	939	PF00069	0.558
MOD_PKB_1	75	83	PF00069	0.701
MOD_PKB_1	764	772	PF00069	0.682
MOD_Plk_1	147	153	PF00069	0.705
MOD_Plk_1	189	195	PF00069	0.641
MOD_Plk_1	277	283	PF00069	0.602
MOD_Plk_1	391	397	PF00069	0.505
MOD_Plk_1	426	432	PF00069	0.532
MOD_Plk_1	473	479	PF00069	0.822
MOD_Plk_1	48	54	PF00069	0.598
MOD_Plk_1	755	761	PF00069	0.479
MOD_Plk_1	828	834	PF00069	0.507
MOD_Plk_1	84	90	PF00069	0.706
MOD_Plk_1	854	860	PF00069	0.523
MOD_Plk_2-3	277	283	PF00069	0.602
MOD_Plk_4	573	579	PF00069	0.546
MOD_Plk_4	661	667	PF00069	0.630
MOD_Plk_4	674	680	PF00069	0.526
MOD_Plk_4	956	962	PF00069	0.514
MOD_ProDKin_1	197	203	PF00069	0.673
MOD_ProDKin_1	228	234	PF00069	0.698
MOD_ProDKin_1	238	244	PF00069	0.773
MOD_ProDKin_1	281	287	PF00069	0.638
MOD_ProDKin_1	294	300	PF00069	0.601
MOD_ProDKin_1	408	414	PF00069	0.676
MOD_ProDKin_1	44	50	PF00069	0.713
MOD_ProDKin_1	457	463	PF00069	0.557
MOD_ProDKin_1	534	540	PF00069	0.716
MOD_ProDKin_1	547	553	PF00069	0.744
MOD_ProDKin_1	597	603	PF00069	0.666
MOD_ProDKin_1	699	705	PF00069	0.638
MOD_ProDKin_1	707	713	PF00069	0.656
MOD_ProDKin_1	911	917	PF00069	0.707
TRG_DiLeu_BaEn_1	1044	1049	PF01217	0.543
TRG_DiLeu_BaEn_2	391	397	PF01217	0.662
TRG_DiLeu_BaLyEn_6	529	534	PF01217	0.627
TRG_DiLeu_BaLyEn_6	553	558	PF01217	0.677
TRG_DiLeu_BaLyEn_6	763	768	PF01217	0.589
TRG_ENDOCYTIC_2	459	462	PF00928	0.708
TRG_ENDOCYTIC_2	648	651	PF00928	0.612
TRG_ENDOCYTIC_2	798	801	PF00928	0.497
TRG_ER_diArg_1	1045	1047	PF00400	0.596
TRG_ER_diArg_1	1061	1063	PF00400	0.549
TRG_ER_diArg_1	153	156	PF00400	0.733
TRG_ER_diArg_1	187	189	PF00400	0.619
TRG_ER_diArg_1	272	274	PF00400	0.652
TRG_ER_diArg_1	292	294	PF00400	0.599
TRG_ER_diArg_1	302	304	PF00400	0.579
TRG_ER_diArg_1	580	583	PF00400	0.644
TRG_ER_diArg_1	75	77	PF00400	0.683
TRG_ER_diArg_1	762	765	PF00400	0.583
TRG_ER_diArg_1	772	775	PF00400	0.641
TRG_ER_diArg_1	908	910	PF00400	0.633
TRG_NES_CRM1_1	1044	1058	PF08389	0.500
TRG_NES_CRM1_1	656	671	PF08389	0.616
TRG_Pf-PMV_PEXEL_1	1046	1050	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.584

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZU1	Leptomonas seymouri	32%	100%
A0A3S7WNS9	Leishmania donovani	64%	97%
A4HS66	Leishmania infantum	65%	100%
E9AK53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	99%
Q9NED2	Leishmania major	63%	100%