Axonemal_dynein_light_chain_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

axonemal dynein light chain, putative

Species:

Leishmania braziliensis

UniProt:

A4H403_LEIBR

TriTrypDb:

LbrM.04.0890 , LBRM2903_040013100

Length:

736

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H403

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H403

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.695
CLV_C14_Caspase3-7	115	119	PF00656	0.727
CLV_C14_Caspase3-7	248	252	PF00656	0.761
CLV_C14_Caspase3-7	29	33	PF00656	0.604
CLV_C14_Caspase3-7	294	298	PF00656	0.617
CLV_C14_Caspase3-7	303	307	PF00656	0.430
CLV_C14_Caspase3-7	370	374	PF00656	0.723
CLV_NRD_NRD_1	259	261	PF00675	0.743
CLV_NRD_NRD_1	397	399	PF00675	0.544
CLV_NRD_NRD_1	403	405	PF00675	0.588
CLV_NRD_NRD_1	409	411	PF00675	0.649
CLV_NRD_NRD_1	620	622	PF00675	0.411
CLV_NRD_NRD_1	7	9	PF00675	0.562
CLV_NRD_NRD_1	730	732	PF00675	0.703
CLV_PCSK_KEX2_1	203	205	PF00082	0.593
CLV_PCSK_KEX2_1	259	261	PF00082	0.743
CLV_PCSK_KEX2_1	397	399	PF00082	0.544
CLV_PCSK_KEX2_1	403	405	PF00082	0.588
CLV_PCSK_KEX2_1	409	411	PF00082	0.649
CLV_PCSK_KEX2_1	620	622	PF00082	0.411
CLV_PCSK_KEX2_1	7	9	PF00082	0.562
CLV_PCSK_KEX2_1	730	732	PF00082	0.703
CLV_PCSK_PC1ET2_1	203	205	PF00082	0.593
CLV_PCSK_PC7_1	255	261	PF00082	0.755
CLV_PCSK_SKI1_1	101	105	PF00082	0.521
CLV_PCSK_SKI1_1	163	167	PF00082	0.790
CLV_PCSK_SKI1_1	2	6	PF00082	0.806
CLV_PCSK_SKI1_1	260	264	PF00082	0.723
CLV_PCSK_SKI1_1	296	300	PF00082	0.705
CLV_PCSK_SKI1_1	31	35	PF00082	0.657
CLV_PCSK_SKI1_1	316	320	PF00082	0.627
CLV_PCSK_SKI1_1	379	383	PF00082	0.557
CLV_PCSK_SKI1_1	429	433	PF00082	0.656
CLV_PCSK_SKI1_1	482	486	PF00082	0.503
CLV_PCSK_SKI1_1	557	561	PF00082	0.559
CLV_PCSK_SKI1_1	606	610	PF00082	0.411
CLV_PCSK_SKI1_1	615	619	PF00082	0.411
CLV_PCSK_SKI1_1	620	624	PF00082	0.411
CLV_PCSK_SKI1_1	655	659	PF00082	0.411
CLV_PCSK_SKI1_1	683	687	PF00082	0.448
CLV_PCSK_SKI1_1	86	90	PF00082	0.744
CLV_Separin_Metazoa	283	287	PF03568	0.600
DEG_APCC_DBOX_1	315	323	PF00400	0.733
DEG_APCC_DBOX_1	368	376	PF00400	0.624
DEG_APCC_DBOX_1	457	465	PF00400	0.647
DEG_APCC_DBOX_1	672	680	PF00400	0.515
DEG_Nend_UBRbox_1	1	4	PF02207	0.706
DEG_SPOP_SBC_1	363	367	PF00917	0.763
DEG_SPOP_SBC_1	523	527	PF00917	0.574
DOC_CKS1_1	547	552	PF01111	0.789
DOC_CYCLIN_RxL_1	476	490	PF00134	0.668
DOC_CYCLIN_RxL_1	615	625	PF00134	0.513
DOC_CYCLIN_yCln2_LP_2	121	127	PF00134	0.849
DOC_MAPK_gen_1	590	599	PF00069	0.606
DOC_MAPK_MEF2A_6	590	599	PF00069	0.707
DOC_MAPK_RevD_3	608	621	PF00069	0.411
DOC_PP1_RVXF_1	702	708	PF00149	0.294
DOC_PP4_FxxP_1	241	244	PF00568	0.672
DOC_USP7_MATH_1	11	15	PF00917	0.758
DOC_USP7_MATH_1	142	146	PF00917	0.545
DOC_USP7_MATH_1	258	262	PF00917	0.731
DOC_USP7_MATH_1	324	328	PF00917	0.566
DOC_USP7_MATH_1	330	334	PF00917	0.583
DOC_USP7_MATH_1	351	355	PF00917	0.576
DOC_USP7_MATH_1	507	511	PF00917	0.789
DOC_USP7_MATH_1	523	527	PF00917	0.745
DOC_USP7_MATH_1	567	571	PF00917	0.598
DOC_USP7_MATH_1	729	733	PF00917	0.449
DOC_WW_Pin1_4	120	125	PF00397	0.844
DOC_WW_Pin1_4	240	245	PF00397	0.681
DOC_WW_Pin1_4	320	325	PF00397	0.554
DOC_WW_Pin1_4	510	515	PF00397	0.723
DOC_WW_Pin1_4	546	551	PF00397	0.791
LIG_14-3-3_CanoR_1	101	109	PF00244	0.780
LIG_14-3-3_CanoR_1	160	169	PF00244	0.831
LIG_14-3-3_CanoR_1	229	239	PF00244	0.537
LIG_14-3-3_CanoR_1	259	265	PF00244	0.731
LIG_14-3-3_CanoR_1	369	373	PF00244	0.724
LIG_14-3-3_CanoR_1	450	457	PF00244	0.640
LIG_14-3-3_CanoR_1	488	497	PF00244	0.715
LIG_14-3-3_CanoR_1	501	507	PF00244	0.710
LIG_14-3-3_CanoR_1	606	611	PF00244	0.411
LIG_14-3-3_CanoR_1	640	649	PF00244	0.478
LIG_14-3-3_CanoR_1	714	722	PF00244	0.464
LIG_14-3-3_CanoR_1	730	735	PF00244	0.702
LIG_Actin_RPEL_3	599	618	PF02755	0.478
LIG_Actin_WH2_2	281	298	PF00022	0.453
LIG_Actin_WH2_2	336	351	PF00022	0.569
LIG_Actin_WH2_2	354	371	PF00022	0.706
LIG_Actin_WH2_2	415	431	PF00022	0.654
LIG_BIR_III_2	297	301	PF00653	0.517
LIG_CaM_IQ_9	93	108	PF13499	0.766
LIG_Clathr_ClatBox_1	445	449	PF01394	0.620
LIG_Clathr_ClatBox_1	461	465	PF01394	0.635
LIG_eIF4E_1	314	320	PF01652	0.717
LIG_EVH1_2	377	381	PF00568	0.675
LIG_FHA_1	231	237	PF00498	0.530
LIG_FHA_1	363	369	PF00498	0.760
LIG_FHA_1	43	49	PF00498	0.635
LIG_FHA_1	449	455	PF00498	0.639
LIG_FHA_1	541	547	PF00498	0.642
LIG_FHA_1	554	560	PF00498	0.761
LIG_FHA_1	580	586	PF00498	0.656
LIG_FHA_1	607	613	PF00498	0.411
LIG_FHA_1	717	723	PF00498	0.610
LIG_FHA_2	105	111	PF00498	0.795
LIG_FHA_2	243	249	PF00498	0.794
LIG_FHA_2	301	307	PF00498	0.509
LIG_FHA_2	465	471	PF00498	0.715
LIG_FHA_2	68	74	PF00498	0.681
LIG_LIR_Apic_2	238	244	PF02991	0.665
LIG_LIR_Gen_1	278	289	PF02991	0.696
LIG_LIR_Gen_1	578	588	PF02991	0.495
LIG_LIR_Nem_3	278	284	PF02991	0.605
LIG_LIR_Nem_3	578	583	PF02991	0.507
LIG_MYND_1	217	221	PF01753	0.560
LIG_NRBOX	618	624	PF00104	0.513
LIG_RPA_C_Fungi	393	405	PF08784	0.449
LIG_SH2_PTP2	281	284	PF00017	0.691
LIG_SH2_SRC	139	142	PF00017	0.821
LIG_SH2_STAT5	239	242	PF00017	0.675
LIG_SH2_STAT5	281	284	PF00017	0.691
LIG_SH2_STAT5	314	317	PF00017	0.702
LIG_SH2_STAT5	460	463	PF00017	0.653
LIG_SH2_STAT5	678	681	PF00017	0.397
LIG_SH3_1	560	566	PF00018	0.711
LIG_SH3_3	121	127	PF00018	0.747
LIG_SH3_3	132	138	PF00018	0.786
LIG_SH3_3	215	221	PF00018	0.564
LIG_SH3_3	306	312	PF00018	0.615
LIG_SH3_3	372	378	PF00018	0.686
LIG_SH3_3	451	457	PF00018	0.640
LIG_SH3_3	50	56	PF00018	0.778
LIG_SH3_3	560	566	PF00018	0.711
LIG_SH3_3	607	613	PF00018	0.411
LIG_SUMO_SIM_anti_2	280	287	PF11976	0.698
LIG_SUMO_SIM_anti_2	54	61	PF11976	0.507
LIG_SUMO_SIM_par_1	287	294	PF11976	0.696
LIG_SUMO_SIM_par_1	443	449	PF11976	0.608
LIG_SUMO_SIM_par_1	543	549	PF11976	0.583
LIG_SUMO_SIM_par_1	608	614	PF11976	0.411
LIG_SUMO_SIM_par_1	64	70	PF11976	0.514
LIG_TRAF2_1	643	646	PF00917	0.375
LIG_TRAF2_1	710	713	PF00917	0.367
LIG_TYR_ITIM	279	284	PF00017	0.604
LIG_WW_1	136	139	PF00397	0.570
LIG_WW_3	376	380	PF00397	0.581
MOD_CDK_SPxK_1	546	552	PF00069	0.791
MOD_CDK_SPxxK_3	510	517	PF00069	0.614
MOD_CK1_1	113	119	PF00069	0.750
MOD_CK1_1	161	167	PF00069	0.828
MOD_CK1_1	197	203	PF00069	0.606
MOD_CK1_1	242	248	PF00069	0.695
MOD_CK1_1	333	339	PF00069	0.556
MOD_CK1_1	510	516	PF00069	0.705
MOD_CK1_1	524	530	PF00069	0.690
MOD_CK1_1	641	647	PF00069	0.261
MOD_CK2_1	184	190	PF00069	0.603
MOD_CK2_1	320	326	PF00069	0.523
MOD_CK2_1	464	470	PF00069	0.614
MOD_CK2_1	707	713	PF00069	0.261
MOD_GlcNHglycan	196	199	PF01048	0.806
MOD_GlcNHglycan	268	271	PF01048	0.657
MOD_GlcNHglycan	275	278	PF01048	0.626
MOD_GlcNHglycan	336	339	PF01048	0.562
MOD_GlcNHglycan	340	343	PF01048	0.585
MOD_GlcNHglycan	504	507	PF01048	0.835
MOD_GlcNHglycan	509	512	PF01048	0.761
MOD_GlcNHglycan	533	536	PF01048	0.802
MOD_GlcNHglycan	569	572	PF01048	0.716
MOD_GlcNHglycan	575	578	PF01048	0.662
MOD_GSK3_1	194	201	PF00069	0.603
MOD_GSK3_1	287	294	PF00069	0.599
MOD_GSK3_1	320	327	PF00069	0.542
MOD_GSK3_1	330	337	PF00069	0.562
MOD_GSK3_1	347	354	PF00069	0.712
MOD_GSK3_1	363	370	PF00069	0.643
MOD_GSK3_1	521	528	PF00069	0.782
MOD_GSK3_1	569	576	PF00069	0.695
MOD_N-GLC_1	351	356	PF02516	0.539
MOD_N-GLC_1	521	526	PF02516	0.711
MOD_NEK2_1	227	232	PF00069	0.656
MOD_NEK2_1	291	296	PF00069	0.717
MOD_NEK2_1	334	339	PF00069	0.554
MOD_NEK2_1	382	387	PF00069	0.413
MOD_NEK2_1	464	469	PF00069	0.501
MOD_NEK2_1	486	491	PF00069	0.707
MOD_NEK2_1	569	574	PF00069	0.581
MOD_NEK2_1	67	72	PF00069	0.645
MOD_NEK2_1	707	712	PF00069	0.261
MOD_NEK2_2	11	16	PF00069	0.774
MOD_NEK2_2	555	560	PF00069	0.805
MOD_NEK2_2	575	580	PF00069	0.439
MOD_PIKK_1	641	647	PF00454	0.411
MOD_PKA_1	730	736	PF00069	0.733
MOD_PKA_2	230	236	PF00069	0.489
MOD_PKA_2	258	264	PF00069	0.731
MOD_PKA_2	368	374	PF00069	0.731
MOD_PKA_2	449	455	PF00069	0.639
MOD_PKA_2	487	493	PF00069	0.713
MOD_PKA_2	500	506	PF00069	0.798
MOD_PKA_2	713	719	PF00069	0.460
MOD_PKA_2	729	735	PF00069	0.696
MOD_PKB_1	99	107	PF00069	0.774
MOD_Plk_1	291	297	PF00069	0.472
MOD_Plk_1	300	306	PF00069	0.447
MOD_Plk_1	464	470	PF00069	0.614
MOD_Plk_1	590	596	PF00069	0.713
MOD_Plk_1	655	661	PF00069	0.261
MOD_Plk_1	707	713	PF00069	0.278
MOD_Plk_2-3	287	293	PF00069	0.438
MOD_Plk_4	541	547	PF00069	0.666
MOD_Plk_4	575	581	PF00069	0.514
MOD_Plk_4	595	601	PF00069	0.608
MOD_Plk_4	655	661	PF00069	0.261
MOD_ProDKin_1	120	126	PF00069	0.842
MOD_ProDKin_1	240	246	PF00069	0.683
MOD_ProDKin_1	320	326	PF00069	0.557
MOD_ProDKin_1	510	516	PF00069	0.723
MOD_ProDKin_1	546	552	PF00069	0.791
MOD_SUMO_for_1	462	465	PF00179	0.730
MOD_SUMO_for_1	518	521	PF00179	0.574
MOD_SUMO_rev_2	292	300	PF00179	0.487
MOD_SUMO_rev_2	413	422	PF00179	0.456
MOD_SUMO_rev_2	691	695	PF00179	0.411
TRG_DiLeu_BaEn_1	280	285	PF01217	0.693
TRG_DiLeu_BaEn_1	614	619	PF01217	0.411
TRG_DiLeu_BaEn_4	423	429	PF01217	0.674
TRG_DiLeu_BaLyEn_6	147	152	PF01217	0.775
TRG_DiLeu_BaLyEn_6	618	623	PF01217	0.513
TRG_ENDOCYTIC_2	281	284	PF00928	0.590
TRG_ENDOCYTIC_2	383	386	PF00928	0.565
TRG_ER_diArg_1	228	231	PF00400	0.508
TRG_ER_diArg_1	408	410	PF00400	0.657
TRG_ER_diArg_1	475	478	PF00400	0.493
TRG_ER_diArg_1	619	621	PF00400	0.411
TRG_ER_diArg_1	672	675	PF00400	0.513
TRG_ER_diArg_1	98	101	PF00400	0.663
TRG_NES_CRM1_1	435	449	PF08389	0.457
TRG_Pf-PMV_PEXEL_1	420	424	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	592	596	PF00026	0.711
TRG_Pf-PMV_PEXEL_1	620	624	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTA8	Leptomonas seymouri	45%	98%
A0A3S7WNS6	Leishmania donovani	68%	100%
A4HS65	Leishmania infantum	68%	100%
E9AK52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	99%
Q9NED3	Leishmania major	68%	97%