CHCH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H401_LEIBR

TriTrypDb:

LbrM.04.0870 , LBRM2903_040012900

Length:

160

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H401

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H401

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0007005	mitochondrion organization	5	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.551
DOC_CKS1_1	35	40	PF01111	0.625
DOC_PP4_MxPP_1	155	158	PF00568	0.681
DOC_USP7_MATH_1	77	81	PF00917	0.571
DOC_USP7_MATH_1	8	12	PF00917	0.593
DOC_WW_Pin1_4	116	121	PF00397	0.484
DOC_WW_Pin1_4	34	39	PF00397	0.727
LIG_14-3-3_CanoR_1	16	25	PF00244	0.585
LIG_BIR_II_1	1	5	PF00653	0.587
LIG_FHA_1	117	123	PF00498	0.521
LIG_Pex14_1	141	145	PF04695	0.429
LIG_PTB_Apo_2	85	92	PF02174	0.585
LIG_PTB_Phospho_1	85	91	PF10480	0.616
LIG_SH2_SRC	89	92	PF00017	0.603
LIG_SH2_STAP1	125	129	PF00017	0.407
LIG_SH2_STAT3	145	148	PF00017	0.429
LIG_SH2_STAT5	145	148	PF00017	0.429
LIG_SH2_STAT5	56	59	PF00017	0.594
LIG_SH2_STAT5	89	92	PF00017	0.605
LIG_SH3_2	23	28	PF14604	0.556
LIG_SH3_3	151	157	PF00018	0.636
LIG_SH3_3	20	26	PF00018	0.637
LIG_SH3_3	43	49	PF00018	0.675
LIG_SH3_3	54	60	PF00018	0.560
LIG_SH3_3	95	101	PF00018	0.519
LIG_TRAF2_1	111	114	PF00917	0.631
MOD_CK1_1	11	17	PF00069	0.601
MOD_GlcNHglycan	10	13	PF01048	0.725
MOD_GlcNHglycan	134	137	PF01048	0.554
MOD_GlcNHglycan	18	21	PF01048	0.650
MOD_GlcNHglycan	66	69	PF01048	0.599
MOD_GSK3_1	144	151	PF00069	0.336
MOD_GSK3_1	7	14	PF00069	0.585
MOD_NEK2_1	1	6	PF00069	0.642
MOD_NEK2_1	33	38	PF00069	0.623
MOD_PIKK_1	144	150	PF00454	0.522
MOD_PIKK_1	96	102	PF00454	0.576
MOD_PKA_2	8	14	PF00069	0.669
MOD_Plk_4	77	83	PF00069	0.561
MOD_ProDKin_1	116	122	PF00069	0.478
MOD_ProDKin_1	34	40	PF00069	0.726

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NKW3	Trypanosomatidae	49%	100%
A0A3S5H5B8	Leishmania donovani	87%	100%
A0A3S5H5B9	Leishmania donovani	87%	100%
A4HS62	Leishmania infantum	86%	100%
A4HS63	Leishmania infantum	87%	100%
E9AK49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AK50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q9NED5	Leishmania major	84%	96%
Q9NED6	Leishmania major	90%	100%
V5BMV1	Trypanosoma cruzi	52%	100%