Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H3Z8_LEIBR

TriTrypDb:

LbrM.04.0840 , LBRM2903_040015800

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3Z8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3Z8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	65	67	PF00675	0.531
CLV_PCSK_SKI1_1	12	16	PF00082	0.433
CLV_PCSK_SKI1_1	143	147	PF00082	0.543
CLV_PCSK_SKI1_1	217	221	PF00082	0.656
CLV_PCSK_SKI1_1	52	56	PF00082	0.541
DEG_APCC_DBOX_1	65	73	PF00400	0.515
DEG_Kelch_Keap1_1	232	237	PF01344	0.780
DEG_Nend_Nbox_1	1	3	PF02207	0.464
DEG_SPOP_SBC_1	47	51	PF00917	0.468
DOC_CKS1_1	54	59	PF01111	0.531
DOC_MAPK_gen_1	66	72	PF00069	0.538
DOC_USP7_MATH_1	104	108	PF00917	0.521
DOC_USP7_MATH_1	127	131	PF00917	0.560
DOC_USP7_MATH_1	14	18	PF00917	0.433
DOC_USP7_MATH_1	250	254	PF00917	0.543
DOC_USP7_MATH_1	27	31	PF00917	0.414
DOC_USP7_MATH_1	47	51	PF00917	0.468
DOC_USP7_MATH_1	87	91	PF00917	0.760
DOC_WW_Pin1_4	248	253	PF00397	0.531
DOC_WW_Pin1_4	53	58	PF00397	0.526
DOC_WW_Pin1_4	79	84	PF00397	0.756
LIG_14-3-3_CanoR_1	217	224	PF00244	0.677
LIG_BRCT_BRCA1_1	2	6	PF00533	0.451
LIG_FHA_1	210	216	PF00498	0.640
LIG_FHA_1	218	224	PF00498	0.706
LIG_FHA_2	216	222	PF00498	0.658
LIG_LIR_Apic_2	132	137	PF02991	0.547
LIG_LIR_Nem_3	201	207	PF02991	0.701
LIG_MYND_1	160	164	PF01753	0.544
LIG_MYND_1	53	57	PF01753	0.525
LIG_SH2_CRK	103	107	PF00017	0.776
LIG_SH2_CRK	204	208	PF00017	0.735
LIG_SH2_CRK	81	85	PF00017	0.542
LIG_SH2_NCK_1	103	107	PF00017	0.776
LIG_SH2_NCK_1	24	28	PF00017	0.452
LIG_SH2_STAP1	147	151	PF00017	0.530
LIG_SH2_STAP1	24	28	PF00017	0.452
LIG_SH2_STAT3	188	191	PF00017	0.684
LIG_SH2_STAT5	188	191	PF00017	0.684
LIG_SH3_3	123	129	PF00018	0.551
LIG_SH3_3	173	179	PF00018	0.694
LIG_SH3_3	244	250	PF00018	0.645
LIG_SH3_3	30	36	PF00018	0.452
LIG_SH3_CIN85_PxpxPR_1	57	62	PF14604	0.527
LIG_SUMO_SIM_par_1	206	214	PF11976	0.659
LIG_TRAF2_1	179	182	PF00917	0.548
LIG_TYR_ITSM	200	207	PF00017	0.697
MOD_CK1_1	107	113	PF00069	0.558
MOD_CK1_1	248	254	PF00069	0.744
MOD_CK2_1	215	221	PF00069	0.650
MOD_GlcNHglycan	111	114	PF01048	0.787
MOD_GlcNHglycan	131	134	PF01048	0.546
MOD_GlcNHglycan	29	32	PF01048	0.453
MOD_GlcNHglycan	37	40	PF01048	0.366
MOD_GSK3_1	104	111	PF00069	0.555
MOD_GSK3_1	139	146	PF00069	0.603
MOD_GSK3_1	170	177	PF00069	0.699
MOD_GSK3_1	182	189	PF00069	0.609
MOD_GSK3_1	190	197	PF00069	0.604
MOD_GSK3_1	206	213	PF00069	0.663
MOD_GSK3_1	70	77	PF00069	0.510
MOD_N-GLC_1	191	196	PF02516	0.668
MOD_NEK2_1	139	144	PF00069	0.544
MOD_NEK2_1	15	20	PF00069	0.448
MOD_NEK2_1	170	175	PF00069	0.604
MOD_NEK2_1	70	75	PF00069	0.510
MOD_NEK2_2	87	92	PF00069	0.545
MOD_PIKK_1	170	176	PF00454	0.687
MOD_PKA_2	107	113	PF00069	0.558
MOD_PKA_2	127	133	PF00069	0.544
MOD_Plk_1	117	123	PF00069	0.564
MOD_Plk_1	15	21	PF00069	0.439
MOD_Plk_1	245	251	PF00069	0.762
MOD_Plk_4	182	188	PF00069	0.500
MOD_ProDKin_1	248	254	PF00069	0.537
MOD_ProDKin_1	53	59	PF00069	0.528
MOD_ProDKin_1	79	85	PF00069	0.758
MOD_SUMO_rev_2	177	186	PF00179	0.611
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.440
TRG_DiLeu_BaLyEn_6	50	55	PF01217	0.510
TRG_ENDOCYTIC_2	204	207	PF00928	0.745
TRG_ENDOCYTIC_2	81	84	PF00928	0.540
TRG_ER_diArg_1	75	78	PF00400	0.528
TRG_NLS_MonoExtC_3	65	71	PF00514	0.519
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WNW2	Leishmania donovani	62%	100%
A4HS89	Leishmania infantum	61%	100%
O97006	Leishmania major	62%	100%