Ribosomal_L30 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3Z6_LEIBR

TriTrypDb:

LbrM.04.0820 , LBRM2903_040015300

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3Z6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3Z6

PDB structure(s): 7aih_S , 7am2_S , 7ane_S

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.759
CLV_NRD_NRD_1	172	174	PF00675	0.635
CLV_NRD_NRD_1	217	219	PF00675	0.611
CLV_NRD_NRD_1	282	284	PF00675	0.636
CLV_NRD_NRD_1	65	67	PF00675	0.610
CLV_NRD_NRD_1	95	97	PF00675	0.551
CLV_PCSK_FUR_1	280	284	PF00082	0.640
CLV_PCSK_KEX2_1	125	127	PF00082	0.759
CLV_PCSK_KEX2_1	172	174	PF00082	0.635
CLV_PCSK_KEX2_1	219	221	PF00082	0.597
CLV_PCSK_KEX2_1	282	284	PF00082	0.636
CLV_PCSK_KEX2_1	297	299	PF00082	0.413
CLV_PCSK_KEX2_1	303	305	PF00082	0.577
CLV_PCSK_KEX2_1	65	67	PF00082	0.599
CLV_PCSK_KEX2_1	95	97	PF00082	0.551
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.597
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.658
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.577
CLV_PCSK_SKI1_1	297	301	PF00082	0.658
CLV_PCSK_SKI1_1	304	308	PF00082	0.564
DEG_APCC_DBOX_1	217	225	PF00400	0.347
DEG_APCC_DBOX_1	282	290	PF00400	0.634
DEG_Nend_UBRbox_1	1	4	PF02207	0.491
DEG_ODPH_VHL_1	166	179	PF01847	0.370
DEG_SCF_FBW7_1	101	108	PF00400	0.540
DEG_SPOP_SBC_1	160	164	PF00917	0.754
DOC_CYCLIN_RxL_1	195	203	PF00134	0.597
DOC_CYCLIN_RxL_1	291	302	PF00134	0.558
DOC_MAPK_gen_1	172	179	PF00069	0.599
DOC_MAPK_gen_1	195	204	PF00069	0.601
DOC_MAPK_gen_1	218	230	PF00069	0.604
DOC_MAPK_gen_1	273	281	PF00069	0.646
DOC_MAPK_MEF2A_6	13	22	PF00069	0.487
DOC_MAPK_MEF2A_6	195	204	PF00069	0.601
DOC_PP1_RVXF_1	199	205	PF00149	0.457
DOC_WW_Pin1_4	11	16	PF00397	0.574
DOC_WW_Pin1_4	128	133	PF00397	0.569
DOC_WW_Pin1_4	45	50	PF00397	0.528
DOC_WW_Pin1_4	97	102	PF00397	0.791
LIG_14-3-3_CanoR_1	81	85	PF00244	0.597
LIG_14-3-3_CanoR_1	95	101	PF00244	0.661
LIG_Actin_WH2_2	272	289	PF00022	0.641
LIG_APCC_ABBAyCdc20_2	287	293	PF00400	0.633
LIG_BRCT_BRCA1_1	24	28	PF00533	0.459
LIG_CORNRBOX	26	34	PF00104	0.467
LIG_CtBP_PxDLS_1	17	21	PF00389	0.466
LIG_FHA_1	129	135	PF00498	0.616
LIG_FHA_1	161	167	PF00498	0.722
LIG_FHA_1	206	212	PF00498	0.507
LIG_FHA_2	62	68	PF00498	0.541
LIG_LIR_Gen_1	25	34	PF02991	0.523
LIG_LIR_Gen_1	3	12	PF02991	0.496
LIG_LIR_Nem_3	249	253	PF02991	0.624
LIG_LIR_Nem_3	25	31	PF02991	0.459
LIG_LIR_Nem_3	3	9	PF02991	0.494
LIG_Pex14_1	72	76	PF04695	0.508
LIG_Pex14_2	187	191	PF04695	0.611
LIG_SH2_CRK	171	175	PF00017	0.629
LIG_SH2_CRK	76	80	PF00017	0.502
LIG_SH2_STAT5	76	79	PF00017	0.498
LIG_SH3_3	180	186	PF00018	0.310
LIG_SH3_3	209	215	PF00018	0.477
LIG_SH3_3	264	270	PF00018	0.695
LIG_SH3_3	95	101	PF00018	0.540
LIG_SUMO_SIM_par_1	16	21	PF11976	0.504
LIG_TRFH_1	82	86	PF08558	0.503
MOD_CK1_1	113	119	PF00069	0.447
MOD_CK1_1	16	22	PF00069	0.452
MOD_CK1_1	7	13	PF00069	0.508
MOD_CK1_1	97	103	PF00069	0.535
MOD_CK2_1	61	67	PF00069	0.542
MOD_DYRK1A_RPxSP_1	13	17	PF00069	0.482
MOD_GlcNHglycan	151	154	PF01048	0.656
MOD_GlcNHglycan	310	313	PF01048	0.485
MOD_GSK3_1	105	112	PF00069	0.542
MOD_GSK3_1	130	137	PF00069	0.532
MOD_GSK3_1	156	163	PF00069	0.762
MOD_GSK3_1	16	23	PF00069	0.485
MOD_GSK3_1	7	14	PF00069	0.543
MOD_GSK3_1	97	104	PF00069	0.532
MOD_NEK2_1	135	140	PF00069	0.673
MOD_NEK2_1	18	23	PF00069	0.391
MOD_NEK2_1	205	210	PF00069	0.513
MOD_NEK2_1	4	9	PF00069	0.527
MOD_NEK2_1	80	85	PF00069	0.521
MOD_NEK2_1	94	99	PF00069	0.503
MOD_PK_1	263	269	PF00069	0.701
MOD_PKA_2	80	86	PF00069	0.525
MOD_PKA_2	94	100	PF00069	0.496
MOD_Plk_2-3	246	252	PF00069	0.632
MOD_Plk_4	105	111	PF00069	0.704
MOD_Plk_4	114	120	PF00069	0.619
MOD_Plk_4	130	136	PF00069	0.682
MOD_Plk_4	206	212	PF00069	0.621
MOD_ProDKin_1	11	17	PF00069	0.572
MOD_ProDKin_1	128	134	PF00069	0.573
MOD_ProDKin_1	45	51	PF00069	0.533
MOD_ProDKin_1	97	103	PF00069	0.792
MOD_SUMO_rev_2	231	241	PF00179	0.612
TRG_DiLeu_BaEn_1	237	242	PF01217	0.620
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.652
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.633
TRG_ENDOCYTIC_2	171	174	PF00928	0.636
TRG_ENDOCYTIC_2	76	79	PF00928	0.498
TRG_ER_diArg_1	124	126	PF00400	0.515
TRG_ER_diArg_1	171	173	PF00400	0.647
TRG_ER_diArg_1	217	220	PF00400	0.608
TRG_ER_diArg_1	222	225	PF00400	0.528
TRG_ER_diArg_1	279	282	PF00400	0.640
TRG_ER_diArg_1	283	286	PF00400	0.569
TRG_ER_diArg_1	94	96	PF00400	0.545
TRG_NLS_MonoExtN_4	215	222	PF00514	0.614
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.595
TRG_Pf-PMV_PEXEL_1	251	256	PF00026	0.646
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WNU5	Leishmania donovani	76%	100%
A4HS83	Leishmania infantum	76%	100%
E9AK69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	82%
Q9U0Z7	Leishmania major	65%	78%