Putative serine peptidase, Clan S-, family S54

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine peptidase, Clan S-, family S54, putative

Species:

Leishmania braziliensis

UniProt:

A4H3Z5_LEIBR

TriTrypDb:

LbrM.04.0810 , LBRM2903_040015200

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4H3Z5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3Z5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004252	serine-type endopeptidase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0008236	serine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0017171	serine hydrolase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	246	250	PF00082	0.241
DEG_SCF_FBW7_1	23	30	PF00400	0.598
DEG_SPOP_SBC_1	2	6	PF00917	0.569
DOC_ANK_TNKS_1	67	74	PF00023	0.553
DOC_CYCLIN_RxL_1	271	282	PF00134	0.474
DOC_PP1_RVXF_1	218	225	PF00149	0.280
DOC_PP4_FxxP_1	77	80	PF00568	0.574
DOC_USP7_MATH_1	2	6	PF00917	0.715
DOC_USP7_MATH_1	27	31	PF00917	0.763
DOC_WW_Pin1_4	23	28	PF00397	0.756
LIG_14-3-3_CanoR_1	164	168	PF00244	0.315
LIG_AP2alpha_2	64	66	PF02296	0.593
LIG_BIR_II_1	1	5	PF00653	0.565
LIG_Clathr_ClatBox_1	211	215	PF01394	0.280
LIG_deltaCOP1_diTrp_1	121	130	PF00928	0.282
LIG_deltaCOP1_diTrp_1	145	152	PF00928	0.241
LIG_deltaCOP1_diTrp_1	243	248	PF00928	0.280
LIG_EH_1	204	208	PF12763	0.280
LIG_EVH1_1	75	79	PF00568	0.600
LIG_EVH1_2	228	232	PF00568	0.241
LIG_FHA_1	234	240	PF00498	0.303
LIG_FHA_1	271	277	PF00498	0.467
LIG_FHA_1	81	87	PF00498	0.449
LIG_FHA_2	248	254	PF00498	0.452
LIG_LIR_Gen_1	121	130	PF02991	0.308
LIG_LIR_Gen_1	166	174	PF02991	0.315
LIG_LIR_Gen_1	236	244	PF02991	0.280
LIG_LIR_Nem_3	106	111	PF02991	0.381
LIG_LIR_Nem_3	121	126	PF02991	0.263
LIG_LIR_Nem_3	166	171	PF02991	0.315
LIG_LIR_Nem_3	236	241	PF02991	0.280
LIG_LIR_Nem_3	243	248	PF02991	0.280
LIG_LYPXL_S_1	126	130	PF13949	0.441
LIG_Pex14_1	123	127	PF04695	0.342
LIG_Pex14_2	130	134	PF04695	0.308
LIG_Pex14_2	77	81	PF04695	0.567
LIG_PTB_Apo_2	129	136	PF02174	0.266
LIG_PTB_Phospho_1	129	135	PF10480	0.266
LIG_SH2_STAT5	266	269	PF00017	0.295
LIG_SH2_STAT5	74	77	PF00017	0.603
LIG_SH2_STAT5	98	101	PF00017	0.296
LIG_SH3_3	225	231	PF00018	0.256
LIG_SH3_3	73	79	PF00018	0.598
LIG_SUMO_SIM_par_1	210	215	PF11976	0.374
LIG_UBA3_1	275	280	PF00899	0.384
MOD_CDK_SPK_2	23	28	PF00069	0.756
MOD_CK1_1	6	12	PF00069	0.645
MOD_CK2_1	247	253	PF00069	0.452
MOD_CMANNOS	147	150	PF00535	0.452
MOD_GlcNHglycan	176	179	PF01048	0.197
MOD_GlcNHglycan	69	72	PF01048	0.482
MOD_GlcNHglycan	8	11	PF01048	0.506
MOD_GSK3_1	170	177	PF00069	0.302
MOD_GSK3_1	2	9	PF00069	0.701
MOD_GSK3_1	23	30	PF00069	0.777
MOD_N-GLC_1	121	126	PF02516	0.609
MOD_NEK2_1	1	6	PF00069	0.623
MOD_NEK2_1	152	157	PF00069	0.241
MOD_NEK2_1	160	165	PF00069	0.241
MOD_NEK2_1	170	175	PF00069	0.280
MOD_NEK2_1	233	238	PF00069	0.280
MOD_NEK2_1	66	71	PF00069	0.561
MOD_PKA_2	163	169	PF00069	0.266
MOD_PKA_2	18	24	PF00069	0.749
MOD_PKA_2	67	73	PF00069	0.557
MOD_Plk_1	121	127	PF00069	0.407
MOD_Plk_4	152	158	PF00069	0.252
MOD_Plk_4	163	169	PF00069	0.241
MOD_ProDKin_1	23	29	PF00069	0.757
TRG_ENDOCYTIC_2	127	130	PF00928	0.243
TRG_ENDOCYTIC_2	189	192	PF00928	0.452
TRG_ENDOCYTIC_2	74	77	PF00928	0.603
TRG_ENDOCYTIC_2	98	101	PF00928	0.282
TRG_ER_diArg_1	197	200	PF00400	0.441
TRG_Pf-PMV_PEXEL_1	274	279	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA30	Leptomonas seymouri	83%	75%
A0A0S4IM64	Bodo saltans	70%	89%
A0A1X0NLI4	Trypanosomatidae	75%	86%
A0A3R7RFZ5	Trypanosoma rangeli	75%	88%
A0A3S7WNU2	Leishmania donovani	92%	72%
A4HS82	Leishmania infantum	92%	72%
C9ZY76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	87%
E9AK68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	79%
Q9U0Z8	Leishmania major	92%	100%
V5DEG5	Trypanosoma cruzi	83%	100%