Tyrosine phospatase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tyrosine phospatase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H3Z4_LEIBR

TriTrypDb:

LbrM.04.0800 , LBRM2903_040015100

Length:

850

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3Z4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3Z4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0004721	phosphoprotein phosphatase activity	3	5
GO:0004725	protein tyrosine phosphatase activity	4	5
GO:0016787	hydrolase activity	2	5
GO:0016788	hydrolase activity, acting on ester bonds	3	5
GO:0016791	phosphatase activity	5	5
GO:0042578	phosphoric ester hydrolase activity	4	5
GO:0140096	catalytic activity, acting on a protein	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	365	369	PF00656	0.561
CLV_MEL_PAP_1	768	774	PF00089	0.691
CLV_NRD_NRD_1	14	16	PF00675	0.740
CLV_NRD_NRD_1	276	278	PF00675	0.552
CLV_NRD_NRD_1	299	301	PF00675	0.819
CLV_NRD_NRD_1	441	443	PF00675	0.423
CLV_NRD_NRD_1	523	525	PF00675	0.420
CLV_NRD_NRD_1	746	748	PF00675	0.744
CLV_PCSK_FUR_1	274	278	PF00082	0.552
CLV_PCSK_KEX2_1	14	16	PF00082	0.740
CLV_PCSK_KEX2_1	276	278	PF00082	0.552
CLV_PCSK_KEX2_1	299	301	PF00082	0.819
CLV_PCSK_KEX2_1	441	443	PF00082	0.423
CLV_PCSK_KEX2_1	583	585	PF00082	0.550
CLV_PCSK_KEX2_1	746	748	PF00082	0.744
CLV_PCSK_KEX2_1	845	847	PF00082	0.837
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.550
CLV_PCSK_PC1ET2_1	845	847	PF00082	0.741
CLV_PCSK_SKI1_1	513	517	PF00082	0.351
CLV_PCSK_SKI1_1	524	528	PF00082	0.268
CLV_PCSK_SKI1_1	592	596	PF00082	0.416
DEG_APCC_DBOX_1	441	449	PF00400	0.551
DEG_COP1_1	212	221	PF00400	0.530
DEG_SCF_FBW7_1	235	241	PF00400	0.668
DOC_CDC14_PxL_1	411	419	PF14671	0.249
DOC_CKS1_1	164	169	PF01111	0.536
DOC_CKS1_1	235	240	PF01111	0.683
DOC_CKS1_1	312	317	PF01111	0.721
DOC_CKS1_1	49	54	PF01111	0.551
DOC_CYCLIN_RxL_1	435	447	PF00134	0.551
DOC_CYCLIN_RxL_1	521	530	PF00134	0.551
DOC_CYCLIN_yCln2_LP_2	108	111	PF00134	0.553
DOC_CYCLIN_yCln2_LP_2	275	281	PF00134	0.711
DOC_CYCLIN_yCln2_LP_2	405	411	PF00134	0.550
DOC_CYCLIN_yCln2_LP_2	413	416	PF00134	0.537
DOC_CYCLIN_yCln2_LP_2	560	563	PF00134	0.551
DOC_MAPK_gen_1	144	154	PF00069	0.554
DOC_MAPK_gen_1	441	451	PF00069	0.551
DOC_MAPK_gen_1	478	485	PF00069	0.551
DOC_MAPK_gen_1	583	591	PF00069	0.548
DOC_MAPK_HePTP_8	510	522	PF00069	0.435
DOC_MAPK_MEF2A_6	513	522	PF00069	0.435
DOC_MAPK_MEF2A_6	584	593	PF00069	0.550
DOC_PP1_RVXF_1	523	530	PF00149	0.551
DOC_PP2B_LxvP_1	108	111	PF13499	0.665
DOC_PP2B_LxvP_1	326	329	PF13499	0.626
DOC_PP2B_LxvP_1	336	339	PF13499	0.573
DOC_PP2B_LxvP_1	405	408	PF13499	0.562
DOC_PP2B_LxvP_1	413	416	PF13499	0.537
DOC_PP2B_LxvP_1	559	562	PF13499	0.551
DOC_PP4_FxxP_1	215	218	PF00568	0.523
DOC_USP7_MATH_1	116	120	PF00917	0.635
DOC_USP7_MATH_1	129	133	PF00917	0.496
DOC_USP7_MATH_1	206	210	PF00917	0.542
DOC_USP7_MATH_1	289	293	PF00917	0.571
DOC_USP7_MATH_1	307	311	PF00917	0.698
DOC_USP7_MATH_1	318	322	PF00917	0.733
DOC_USP7_MATH_1	330	334	PF00917	0.632
DOC_USP7_MATH_1	596	600	PF00917	0.500
DOC_USP7_MATH_1	645	649	PF00917	0.642
DOC_USP7_MATH_1	69	73	PF00917	0.662
DOC_USP7_MATH_1	749	753	PF00917	0.595
DOC_USP7_MATH_1	762	766	PF00917	0.789
DOC_USP7_MATH_1	814	818	PF00917	0.709
DOC_USP7_MATH_1	844	848	PF00917	0.750
DOC_WW_Pin1_4	163	168	PF00397	0.650
DOC_WW_Pin1_4	170	175	PF00397	0.608
DOC_WW_Pin1_4	201	206	PF00397	0.730
DOC_WW_Pin1_4	234	239	PF00397	0.768
DOC_WW_Pin1_4	281	286	PF00397	0.540
DOC_WW_Pin1_4	311	316	PF00397	0.724
DOC_WW_Pin1_4	356	361	PF00397	0.596
DOC_WW_Pin1_4	44	49	PF00397	0.572
DOC_WW_Pin1_4	619	624	PF00397	0.532
DOC_WW_Pin1_4	635	640	PF00397	0.492
DOC_WW_Pin1_4	698	703	PF00397	0.610
DOC_WW_Pin1_4	754	759	PF00397	0.591
DOC_WW_Pin1_4	80	85	PF00397	0.688
DOC_WW_Pin1_4	833	838	PF00397	0.670
LIG_14-3-3_CanoR_1	177	182	PF00244	0.545
LIG_14-3-3_CanoR_1	276	282	PF00244	0.654
LIG_14-3-3_CanoR_1	361	365	PF00244	0.692
LIG_14-3-3_CanoR_1	379	384	PF00244	0.707
LIG_14-3-3_CanoR_1	446	452	PF00244	0.611
LIG_14-3-3_CanoR_1	618	622	PF00244	0.659
LIG_14-3-3_CanoR_1	771	777	PF00244	0.699
LIG_14-3-3_CterR_2	846	850	PF00244	0.733
LIG_BIR_II_1	1	5	PF00653	0.662
LIG_BIR_III_2	609	613	PF00653	0.533
LIG_BIR_III_4	368	372	PF00653	0.553
LIG_BRCT_BRCA1_1	211	215	PF00533	0.558
LIG_BRCT_BRCA1_1	344	348	PF00533	0.683
LIG_eIF4E_1	555	561	PF01652	0.551
LIG_EVH1_2	415	419	PF00568	0.551
LIG_FHA_1	455	461	PF00498	0.551
LIG_FHA_1	514	520	PF00498	0.580
LIG_FHA_1	540	546	PF00498	0.551
LIG_FHA_1	554	560	PF00498	0.445
LIG_FHA_1	586	592	PF00498	0.473
LIG_FHA_1	93	99	PF00498	0.622
LIG_FHA_2	363	369	PF00498	0.589
LIG_FHA_2	656	662	PF00498	0.561
LIG_LIR_Apic_2	212	218	PF02991	0.523
LIG_LIR_Apic_2	554	558	PF02991	0.551
LIG_LIR_Gen_1	537	545	PF02991	0.551
LIG_LIR_LC3C_4	150	154	PF02991	0.554
LIG_LIR_Nem_3	159	165	PF02991	0.539
LIG_LIR_Nem_3	537	541	PF02991	0.628
LIG_LYPXL_yS_3	431	434	PF13949	0.551
LIG_MYND_1	558	562	PF01753	0.551
LIG_NRBOX	522	528	PF00104	0.551
LIG_PCNA_PIPBox_1	134	143	PF02747	0.554
LIG_PCNA_PIPBox_1	388	397	PF02747	0.527
LIG_Pex14_2	344	348	PF04695	0.545
LIG_PTB_Apo_2	433	440	PF02174	0.551
LIG_PTB_Phospho_1	433	439	PF10480	0.551
LIG_RPA_C_Fungi	295	307	PF08784	0.550
LIG_SH2_CRK	555	559	PF00017	0.412
LIG_SH2_GRB2like	141	144	PF00017	0.558
LIG_SH2_GRB2like	686	689	PF00017	0.516
LIG_SH2_NCK_1	575	579	PF00017	0.545
LIG_SH2_PTP2	126	129	PF00017	0.527
LIG_SH2_PTP2	686	689	PF00017	0.679
LIG_SH2_SRC	686	689	PF00017	0.679
LIG_SH2_STAT3	383	386	PF00017	0.540
LIG_SH2_STAT5	124	127	PF00017	0.654
LIG_SH2_STAT5	141	144	PF00017	0.558
LIG_SH2_STAT5	258	261	PF00017	0.692
LIG_SH2_STAT5	439	442	PF00017	0.412
LIG_SH2_STAT5	506	509	PF00017	0.412
LIG_SH2_STAT5	514	517	PF00017	0.349
LIG_SH2_STAT5	555	558	PF00017	0.442
LIG_SH2_STAT5	686	689	PF00017	0.679
LIG_SH3_1	104	110	PF00018	0.541
LIG_SH3_3	104	110	PF00018	0.656
LIG_SH3_3	161	167	PF00018	0.666
LIG_SH3_3	202	208	PF00018	0.545
LIG_SH3_3	250	256	PF00018	0.726
LIG_SH3_3	309	315	PF00018	0.729
LIG_SH3_3	326	332	PF00018	0.718
LIG_SH3_3	450	456	PF00018	0.513
LIG_SH3_3	46	52	PF00018	0.543
LIG_SH3_3	560	566	PF00018	0.412
LIG_SH3_3	633	639	PF00018	0.698
LIG_SH3_3	826	832	PF00018	0.687
LIG_SUMO_SIM_anti_2	447	454	PF11976	0.412
LIG_SUMO_SIM_anti_2	516	522	PF11976	0.412
LIG_SUMO_SIM_par_1	333	340	PF11976	0.540
LIG_UBA3_1	518	525	PF00899	0.396
LIG_WW_1	455	458	PF00397	0.412
MOD_CDK_SPK_2	356	361	PF00069	0.566
MOD_CDK_SPxxK_3	170	177	PF00069	0.534
MOD_CK1_1	10	16	PF00069	0.673
MOD_CK1_1	169	175	PF00069	0.714
MOD_CK1_1	204	210	PF00069	0.816
MOD_CK1_1	284	290	PF00069	0.538
MOD_CK1_1	302	308	PF00069	0.613
MOD_CK1_1	488	494	PF00069	0.412
MOD_CK1_1	718	724	PF00069	0.702
MOD_CK1_1	751	757	PF00069	0.600
MOD_CK1_1	801	807	PF00069	0.752
MOD_CK1_1	818	824	PF00069	0.527
MOD_CK1_1	836	842	PF00069	0.691
MOD_CK1_1	97	103	PF00069	0.619
MOD_CK2_1	709	715	PF00069	0.612
MOD_Cter_Amidation	297	300	PF01082	0.705
MOD_GlcNHglycan	100	103	PF01048	0.669
MOD_GlcNHglycan	118	121	PF01048	0.729
MOD_GlcNHglycan	168	171	PF01048	0.540
MOD_GlcNHglycan	197	200	PF01048	0.635
MOD_GlcNHglycan	208	211	PF01048	0.534
MOD_GlcNHglycan	244	247	PF01048	0.597
MOD_GlcNHglycan	291	294	PF01048	0.724
MOD_GlcNHglycan	301	304	PF01048	0.740
MOD_GlcNHglycan	309	312	PF01048	0.682
MOD_GlcNHglycan	320	323	PF01048	0.817
MOD_GlcNHglycan	395	398	PF01048	0.697
MOD_GlcNHglycan	405	408	PF01048	0.590
MOD_GlcNHglycan	598	601	PF01048	0.719
MOD_GlcNHglycan	623	626	PF01048	0.665
MOD_GlcNHglycan	628	631	PF01048	0.619
MOD_GlcNHglycan	643	646	PF01048	0.533
MOD_GlcNHglycan	65	68	PF01048	0.606
MOD_GlcNHglycan	658	661	PF01048	0.524
MOD_GlcNHglycan	698	701	PF01048	0.660
MOD_GlcNHglycan	725	728	PF01048	0.622
MOD_GlcNHglycan	736	739	PF01048	0.565
MOD_GlcNHglycan	762	765	PF01048	0.779
MOD_GlcNHglycan	772	775	PF01048	0.661
MOD_GlcNHglycan	778	781	PF01048	0.567
MOD_GlcNHglycan	784	787	PF01048	0.604
MOD_GlcNHglycan	790	793	PF01048	0.533
MOD_GlcNHglycan	800	803	PF01048	0.640
MOD_GlcNHglycan	806	809	PF01048	0.616
MOD_GlcNHglycan	810	813	PF01048	0.551
MOD_GlcNHglycan	817	820	PF01048	0.525
MOD_GlcNHglycan	829	832	PF01048	0.617
MOD_GlcNHglycan	838	841	PF01048	0.689
MOD_GSK3_1	143	150	PF00069	0.749
MOD_GSK3_1	165	172	PF00069	0.702
MOD_GSK3_1	173	180	PF00069	0.574
MOD_GSK3_1	197	204	PF00069	0.732
MOD_GSK3_1	230	237	PF00069	0.804
MOD_GSK3_1	238	245	PF00069	0.647
MOD_GSK3_1	277	284	PF00069	0.552
MOD_GSK3_1	285	292	PF00069	0.514
MOD_GSK3_1	307	314	PF00069	0.782
MOD_GSK3_1	352	359	PF00069	0.681
MOD_GSK3_1	375	382	PF00069	0.631
MOD_GSK3_1	389	396	PF00069	0.630
MOD_GSK3_1	399	406	PF00069	0.641
MOD_GSK3_1	44	51	PF00069	0.660
MOD_GSK3_1	592	599	PF00069	0.626
MOD_GSK3_1	617	624	PF00069	0.675
MOD_GSK3_1	635	642	PF00069	0.523
MOD_GSK3_1	651	658	PF00069	0.574
MOD_GSK3_1	714	721	PF00069	0.700
MOD_GSK3_1	723	730	PF00069	0.645
MOD_GSK3_1	747	754	PF00069	0.571
MOD_GSK3_1	756	763	PF00069	0.622
MOD_GSK3_1	76	83	PF00069	0.735
MOD_GSK3_1	800	807	PF00069	0.673
MOD_GSK3_1	814	821	PF00069	0.512
MOD_GSK3_1	832	839	PF00069	0.700
MOD_GSK3_1	85	92	PF00069	0.718
MOD_GSK3_1	94	101	PF00069	0.590
MOD_N-GLC_1	261	266	PF02516	0.519
MOD_N-GLC_1	754	759	PF02516	0.616
MOD_NEK2_1	211	216	PF00069	0.783
MOD_NEK2_1	362	367	PF00069	0.602
MOD_NEK2_1	43	48	PF00069	0.637
MOD_NEK2_1	640	645	PF00069	0.556
MOD_NEK2_1	655	660	PF00069	0.523
MOD_NEK2_1	709	714	PF00069	0.568
MOD_NEK2_1	775	780	PF00069	0.633
MOD_NEK2_1	827	832	PF00069	0.556
MOD_NEK2_2	570	575	PF00069	0.502
MOD_NEK2_2	651	656	PF00069	0.629
MOD_OFUCOSY	290	295	PF10250	0.548
MOD_PIKK_1	153	159	PF00454	0.549
MOD_PIKK_1	209	215	PF00454	0.765
MOD_PIKK_1	353	359	PF00454	0.608
MOD_PIKK_1	71	77	PF00454	0.679
MOD_PK_1	277	283	PF00069	0.547
MOD_PKA_1	299	305	PF00069	0.712
MOD_PKA_2	143	149	PF00069	0.607
MOD_PKA_2	241	247	PF00069	0.536
MOD_PKA_2	299	305	PF00069	0.771
MOD_PKA_2	360	366	PF00069	0.703
MOD_PKA_2	539	545	PF00069	0.412
MOD_PKA_2	617	623	PF00069	0.639
MOD_PKA_2	655	661	PF00069	0.563
MOD_PKA_2	770	776	PF00069	0.700
MOD_PKA_2	798	804	PF00069	0.720
MOD_PKB_1	442	450	PF00069	0.412
MOD_PKB_1	590	598	PF00069	0.565
MOD_Plk_1	261	267	PF00069	0.519
MOD_Plk_2-3	454	460	PF00069	0.412
MOD_Plk_4	343	349	PF00069	0.615
MOD_Plk_4	409	415	PF00069	0.543
MOD_Plk_4	447	453	PF00069	0.412
MOD_Plk_4	570	576	PF00069	0.616
MOD_Plk_4	7	13	PF00069	0.687
MOD_ProDKin_1	163	169	PF00069	0.648
MOD_ProDKin_1	170	176	PF00069	0.609
MOD_ProDKin_1	201	207	PF00069	0.730
MOD_ProDKin_1	234	240	PF00069	0.763
MOD_ProDKin_1	281	287	PF00069	0.540
MOD_ProDKin_1	311	317	PF00069	0.723
MOD_ProDKin_1	356	362	PF00069	0.599
MOD_ProDKin_1	44	50	PF00069	0.572
MOD_ProDKin_1	619	625	PF00069	0.534
MOD_ProDKin_1	635	641	PF00069	0.494
MOD_ProDKin_1	698	704	PF00069	0.610
MOD_ProDKin_1	754	760	PF00069	0.593
MOD_ProDKin_1	80	86	PF00069	0.687
MOD_ProDKin_1	833	839	PF00069	0.671
MOD_SUMO_for_1	479	482	PF00179	0.412
MOD_SUMO_rev_2	454	463	PF00179	0.412
TRG_DiLeu_BaEn_1	492	497	PF01217	0.412
TRG_DiLeu_BaLyEn_6	555	560	PF01217	0.412
TRG_ENDOCYTIC_2	124	127	PF00928	0.654
TRG_ENDOCYTIC_2	431	434	PF00928	0.412
TRG_ENDOCYTIC_2	686	689	PF00928	0.679
TRG_ER_diArg_1	273	276	PF00400	0.565
TRG_ER_diArg_1	440	442	PF00400	0.496
TRG_ER_diArg_1	443	446	PF00400	0.481
TRG_ER_diArg_1	589	592	PF00400	0.528
TRG_ER_diArg_1	746	748	PF00400	0.744
TRG_Pf-PMV_PEXEL_1	524	528	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5D1	Leishmania donovani	68%	97%
A4HS81	Leishmania infantum	66%	100%
E9AK67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	98%
Q9U0Z9	Leishmania major	65%	98%