Putative heat shock protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H3Z0_LEIBR

TriTrypDb:

LbrM.04.0760 , LBRM2903_040013900

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0020016	ciliary pocket	2	1

Expansion

Sequence features

A4H3Z0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3Z0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.411
CLV_NRD_NRD_1	158	160	PF00675	0.333
CLV_NRD_NRD_1	30	32	PF00675	0.331
CLV_NRD_NRD_1	409	411	PF00675	0.508
CLV_PCSK_KEX2_1	158	160	PF00082	0.310
CLV_PCSK_KEX2_1	30	32	PF00082	0.330
CLV_PCSK_KEX2_1	409	411	PF00082	0.511
CLV_PCSK_KEX2_1	448	450	PF00082	0.709
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.709
CLV_PCSK_SKI1_1	170	174	PF00082	0.444
CLV_PCSK_SKI1_1	31	35	PF00082	0.307
CLV_PCSK_SKI1_1	586	590	PF00082	0.444
DEG_APCC_DBOX_1	169	177	PF00400	0.444
DEG_APCC_DBOX_1	72	80	PF00400	0.657
DEG_SCF_FBW7_2	381	388	PF00400	0.411
DEG_SPOP_SBC_1	395	399	PF00917	0.490
DEG_SPOP_SBC_1	504	508	PF00917	0.621
DEG_SPOP_SBC_1	531	535	PF00917	0.632
DOC_CDC14_PxL_1	459	467	PF14671	0.444
DOC_CKS1_1	324	329	PF01111	0.211
DOC_CKS1_1	375	380	PF01111	0.513
DOC_MAPK_gen_1	158	166	PF00069	0.532
DOC_MAPK_gen_1	288	298	PF00069	0.561
DOC_MAPK_gen_1	415	423	PF00069	0.591
DOC_MAPK_MEF2A_6	158	165	PF00069	0.548
DOC_MAPK_MEF2A_6	170	177	PF00069	0.356
DOC_MAPK_MEF2A_6	188	195	PF00069	0.361
DOC_PP2B_LxvP_1	164	167	PF13499	0.444
DOC_PP4_FxxP_1	248	251	PF00568	0.561
DOC_PP4_FxxP_1	280	283	PF00568	0.411
DOC_USP7_MATH_1	232	236	PF00917	0.511
DOC_USP7_MATH_1	395	399	PF00917	0.579
DOC_USP7_MATH_1	425	429	PF00917	0.471
DOC_USP7_MATH_1	453	457	PF00917	0.465
DOC_USP7_MATH_1	496	500	PF00917	0.784
DOC_USP7_MATH_1	531	535	PF00917	0.718
DOC_USP7_MATH_1	563	567	PF00917	0.793
DOC_USP7_MATH_2	125	131	PF00917	0.391
DOC_WW_Pin1_4	187	192	PF00397	0.234
DOC_WW_Pin1_4	220	225	PF00397	0.591
DOC_WW_Pin1_4	323	328	PF00397	0.234
DOC_WW_Pin1_4	347	352	PF00397	0.280
DOC_WW_Pin1_4	374	379	PF00397	0.575
DOC_WW_Pin1_4	381	386	PF00397	0.587
LIG_14-3-3_CanoR_1	282	290	PF00244	0.411
LIG_14-3-3_CanoR_1	505	512	PF00244	0.718
LIG_14-3-3_CanoR_1	542	550	PF00244	0.783
LIG_14-3-3_CanoR_1	558	565	PF00244	0.793
LIG_AP2alpha_2	246	248	PF02296	0.591
LIG_BRCT_BRCA1_1	222	226	PF00533	0.576
LIG_deltaCOP1_diTrp_1	126	131	PF00928	0.362
LIG_FHA_1	106	112	PF00498	0.450
LIG_FHA_1	149	155	PF00498	0.383
LIG_FHA_1	188	194	PF00498	0.391
LIG_FHA_1	20	26	PF00498	0.576
LIG_FHA_1	331	337	PF00498	0.317
LIG_FHA_1	583	589	PF00498	0.743
LIG_FHA_2	19	25	PF00498	0.498
LIG_FHA_2	204	210	PF00498	0.444
LIG_FHA_2	326	332	PF00498	0.368
LIG_IRF3_LxIS_1	111	118	PF10401	0.485
LIG_LIR_Apic_2	245	251	PF02991	0.591
LIG_LIR_Apic_2	279	283	PF02991	0.411
LIG_LIR_Gen_1	295	306	PF02991	0.427
LIG_LIR_Gen_1	344	354	PF02991	0.344
LIG_LIR_Gen_1	456	466	PF02991	0.351
LIG_LIR_Gen_1	9	18	PF02991	0.500
LIG_LIR_Nem_3	130	134	PF02991	0.293
LIG_LIR_Nem_3	26	32	PF02991	0.436
LIG_LIR_Nem_3	295	301	PF02991	0.439
LIG_LIR_Nem_3	305	309	PF02991	0.491
LIG_LIR_Nem_3	344	349	PF02991	0.344
LIG_LIR_Nem_3	456	461	PF02991	0.351
LIG_LIR_Nem_3	9	14	PF02991	0.520
LIG_MYND_1	247	251	PF01753	0.591
LIG_NRBOX	86	92	PF00104	0.655
LIG_Pex14_1	198	202	PF04695	0.444
LIG_Pex14_2	280	284	PF04695	0.411
LIG_SH2_CRK	29	33	PF00017	0.500
LIG_SH2_CRK	304	308	PF00017	0.485
LIG_SH2_CRK	68	72	PF00017	0.616
LIG_SH2_NCK_1	255	259	PF00017	0.411
LIG_SH2_NCK_1	68	72	PF00017	0.631
LIG_SH2_PTP2	162	165	PF00017	0.485
LIG_SH2_STAP1	304	308	PF00017	0.485
LIG_SH2_STAT5	162	165	PF00017	0.485
LIG_SH2_STAT5	202	205	PF00017	0.401
LIG_SH2_STAT5	218	221	PF00017	0.531
LIG_SH2_STAT5	304	307	PF00017	0.403
LIG_SH2_STAT5	355	358	PF00017	0.401
LIG_SH2_STAT5	368	371	PF00017	0.531
LIG_SH3_3	131	137	PF00018	0.308
LIG_SH3_3	241	247	PF00018	0.597
LIG_SH3_3	335	341	PF00018	0.280
LIG_SH3_3	375	381	PF00018	0.555
LIG_SUMO_SIM_anti_2	149	154	PF11976	0.444
LIG_SUMO_SIM_anti_2	208	214	PF11976	0.233
LIG_SUMO_SIM_par_1	143	149	PF11976	0.460
LIG_SUMO_SIM_par_1	150	156	PF11976	0.401
LIG_SUMO_SIM_par_1	162	168	PF11976	0.209
LIG_SUMO_SIM_par_1	360	366	PF11976	0.369
LIG_TRAF2_1	124	127	PF00917	0.211
LIG_TRAF2_1	227	230	PF00917	0.411
LIG_TRAF2_1	440	443	PF00917	0.266
LIG_WRC_WIRS_1	303	308	PF05994	0.429
LIG_WRC_WIRS_1	342	347	PF05994	0.369
MOD_CDK_SPxxK_3	323	330	PF00069	0.233
MOD_CK1_1	264	270	PF00069	0.466
MOD_CK1_1	397	403	PF00069	0.680
MOD_CK1_1	514	520	PF00069	0.755
MOD_CK1_1	543	549	PF00069	0.793
MOD_CK2_1	18	24	PF00069	0.356
MOD_CK2_1	224	230	PF00069	0.296
MOD_CK2_1	267	273	PF00069	0.359
MOD_CK2_1	325	331	PF00069	0.314
MOD_CK2_1	360	366	PF00069	0.436
MOD_CK2_1	376	382	PF00069	0.306
MOD_CK2_1	410	416	PF00069	0.673
MOD_CK2_1	532	538	PF00069	0.538
MOD_CMANNOS	128	131	PF00535	0.444
MOD_CMANNOS	198	201	PF00535	0.444
MOD_GlcNHglycan	234	237	PF01048	0.440
MOD_GlcNHglycan	269	272	PF01048	0.462
MOD_GlcNHglycan	333	336	PF01048	0.484
MOD_GlcNHglycan	390	393	PF01048	0.272
MOD_GlcNHglycan	412	415	PF01048	0.635
MOD_GlcNHglycan	427	430	PF01048	0.455
MOD_GlcNHglycan	450	453	PF01048	0.557
MOD_GlcNHglycan	454	458	PF01048	0.482
MOD_GlcNHglycan	507	510	PF01048	0.751
MOD_GlcNHglycan	514	517	PF01048	0.806
MOD_GlcNHglycan	534	537	PF01048	0.736
MOD_GlcNHglycan	538	541	PF01048	0.772
MOD_GlcNHglycan	6	9	PF01048	0.472
MOD_GSK3_1	111	118	PF00069	0.467
MOD_GSK3_1	19	26	PF00069	0.485
MOD_GSK3_1	216	223	PF00069	0.408
MOD_GSK3_1	257	264	PF00069	0.394
MOD_GSK3_1	369	376	PF00069	0.390
MOD_GSK3_1	384	391	PF00069	0.326
MOD_GSK3_1	488	495	PF00069	0.571
MOD_GSK3_1	496	503	PF00069	0.568
MOD_GSK3_1	532	539	PF00069	0.763
MOD_GSK3_1	548	555	PF00069	0.735
MOD_GSK3_1	582	589	PF00069	0.704
MOD_N-GLC_2	237	239	PF02516	0.233
MOD_NEK2_1	111	116	PF00069	0.406
MOD_NEK2_1	146	151	PF00069	0.432
MOD_NEK2_1	153	158	PF00069	0.367
MOD_NEK2_1	369	374	PF00069	0.407
MOD_NEK2_1	394	399	PF00069	0.364
MOD_NEK2_1	511	516	PF00069	0.576
MOD_NEK2_1	577	582	PF00069	0.766
MOD_NEK2_1	67	72	PF00069	0.539
MOD_NEK2_1	86	91	PF00069	0.669
MOD_PIKK_1	23	29	PF00454	0.461
MOD_PIKK_1	325	331	PF00454	0.412
MOD_PIKK_1	563	569	PF00454	0.796
MOD_PIKK_1	577	583	PF00454	0.569
MOD_PK_1	257	263	PF00069	0.233
MOD_PKA_1	448	454	PF00069	0.526
MOD_PKA_2	267	273	PF00069	0.233
MOD_PKA_2	448	454	PF00069	0.565
MOD_PKA_2	504	510	PF00069	0.653
MOD_PKA_2	536	542	PF00069	0.783
MOD_PKA_2	563	569	PF00069	0.796
MOD_PKA_2	582	588	PF00069	0.538
MOD_Plk_1	496	502	PF00069	0.542
MOD_Plk_1	586	592	PF00069	0.651
MOD_Plk_4	148	154	PF00069	0.387
MOD_Plk_4	213	219	PF00069	0.420
MOD_Plk_4	302	308	PF00069	0.453
MOD_Plk_4	341	347	PF00069	0.368
MOD_Plk_4	370	376	PF00069	0.440
MOD_Plk_4	469	475	PF00069	0.291
MOD_Plk_4	86	92	PF00069	0.630
MOD_ProDKin_1	187	193	PF00069	0.266
MOD_ProDKin_1	220	226	PF00069	0.485
MOD_ProDKin_1	323	329	PF00069	0.266
MOD_ProDKin_1	347	353	PF00069	0.280
MOD_ProDKin_1	374	380	PF00069	0.463
MOD_ProDKin_1	381	387	PF00069	0.480
MOD_SUMO_for_1	440	443	PF00179	0.440
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.444
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.233
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.245
TRG_ENDOCYTIC_2	11	14	PF00928	0.334
TRG_ENDOCYTIC_2	162	165	PF00928	0.444
TRG_ENDOCYTIC_2	29	32	PF00928	0.334
TRG_ENDOCYTIC_2	304	307	PF00928	0.410
TRG_ENDOCYTIC_2	68	71	PF00928	0.457
TRG_ER_diArg_1	157	159	PF00400	0.485
TRG_ER_diArg_1	29	31	PF00400	0.437
TRG_ER_diArg_1	62	65	PF00400	0.397
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.437
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R3	Leptomonas seymouri	49%	100%
A0A3R7M9P3	Trypanosoma rangeli	26%	100%
A0A3S7WNV0	Leishmania donovani	72%	100%
A4HS75	Leishmania infantum	73%	100%
C9ZY69	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AK61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
O97211	Leishmania major	72%	96%
V5BMT5	Trypanosoma cruzi	28%	100%