Nascent polypeptide associated complex subunit-like protein, copy 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nascent polypeptide associated complex subunit- like protein, copy 1

Species:

Leishmania braziliensis

UniProt:

A4H3Y9_LEIBR

TriTrypDb:

LbrM.04.0750 , LBRM2903_040013800

Length:

174

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	yes	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005854	nascent polypeptide-associated complex	2	13
GO:0032991	protein-containing complex	1	13
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H3Y9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3Y9

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0033036	macromolecule localization	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0051082	unfolded protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	150	152	PF00675	0.271
CLV_NRD_NRD_1	55	57	PF00675	0.376
CLV_PCSK_KEX2_1	33	35	PF00082	0.351
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.351
CLV_PCSK_SKI1_1	153	157	PF00082	0.401
CLV_PCSK_SKI1_1	34	38	PF00082	0.352
DOC_MAPK_gen_1	33	44	PF00069	0.562
DOC_MAPK_gen_1	56	63	PF00069	0.563
DOC_MAPK_MEF2A_6	41	50	PF00069	0.471
DOC_MAPK_RevD_3	140	153	PF00069	0.471
DOC_MAPK_RevD_3	42	57	PF00069	0.576
DOC_USP7_MATH_1	101	105	PF00917	0.763
DOC_USP7_MATH_1	107	111	PF00917	0.793
DOC_USP7_MATH_1	113	117	PF00917	0.604
DOC_USP7_MATH_1	147	151	PF00917	0.642
DOC_USP7_MATH_1	29	33	PF00917	0.716
DOC_USP7_UBL2_3	152	156	PF12436	0.471
DOC_USP7_UBL2_3	33	37	PF12436	0.553
DOC_USP7_UBL2_3	41	45	PF12436	0.554
LIG_APCC_ABBA_1	79	84	PF00400	0.562
LIG_BRCT_BRCA1_1	59	63	PF00533	0.593
LIG_FHA_1	112	118	PF00498	0.689
LIG_FHA_1	76	82	PF00498	0.556
LIG_FHA_1	88	94	PF00498	0.561
LIG_FHA_2	166	172	PF00498	0.642
LIG_LIR_Apic_2	69	74	PF02991	0.562
LIG_LIR_Gen_1	60	71	PF02991	0.642
LIG_LIR_Gen_1	76	87	PF02991	0.562
LIG_LIR_Nem_3	60	66	PF02991	0.642
LIG_LIR_Nem_3	76	82	PF02991	0.553
LIG_MYND_3	17	21	PF01753	0.557
LIG_RPA_C_Fungi	146	158	PF08784	0.527
LIG_SH2_CRK	71	75	PF00017	0.414
LIG_SH2_STAP1	35	39	PF00017	0.414
LIG_TRAF2_1	119	122	PF00917	0.883
LIG_TRAF2_1	2	5	PF00917	0.783
MOD_CK1_1	111	117	PF00069	0.759
MOD_CK2_1	115	121	PF00069	0.721
MOD_CK2_1	165	171	PF00069	0.527
MOD_GlcNHglycan	103	106	PF01048	0.575
MOD_GlcNHglycan	117	120	PF01048	0.777
MOD_GlcNHglycan	88	93	PF01048	0.658
MOD_GSK3_1	107	114	PF00069	0.776
MOD_N-GLC_1	147	152	PF02516	0.527
MOD_NEK2_1	87	92	PF00069	0.612
MOD_PIKK_1	142	148	PF00454	0.457
MOD_Plk_1	88	94	PF00069	0.636
MOD_Plk_2-3	16	22	PF00069	0.688
MOD_Plk_4	165	171	PF00069	0.527
MOD_Plk_4	75	81	PF00069	0.414
MOD_SUMO_for_1	44	47	PF00179	0.414
MOD_SUMO_rev_2	134	140	PF00179	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRE4	Leptomonas seymouri	84%	99%
A0A1X0NL03	Trypanosomatidae	62%	95%
A0A3S5H5C5	Leishmania donovani	89%	100%
A0A3S5H5C6	Leishmania donovani	88%	100%
A1CMF8	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	37%	85%
A1DLM0	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	37%	85%
A2R4V1	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	36%	86%
A3GHD3	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	32%	99%
A4HS73	Leishmania infantum	88%	100%
A4RC89	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	38%	87%
A5DGN9	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	32%	98%
A5DXK7	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	32%	96%
A6R641	Ajellomyces capsulatus (strain NAm1 / WU24)	40%	84%
A6SB28	Botryotinia fuckeliana (strain B05.10)	36%	82%
A6ZT99	Saccharomyces cerevisiae (strain YJM789)	37%	100%
A7EIZ1	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	34%	81%
A7TG43	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	38%	100%
C9ZY67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	93%
C9ZY68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	93%
E9AK60	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O97212	Leishmania major	90%	100%
P0C2C7	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	39%	86%
P0CP06	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	27%	91%
P0CP07	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	27%	91%
P38879	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
P87147	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q0UKB5	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	35%	82%
Q13765	Homo sapiens	45%	81%
Q1DHR3	Coccidioides immitis (strain RS)	36%	85%
Q2H4Z2	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	40%	87%
Q2U955	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	37%	86%
Q45FF9	Babesia divergens	33%	88%
Q4I2J8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	34%	83%
Q4P341	Ustilago maydis (strain 521 / FGSC 9021)	36%	92%
Q4WD81	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	37%	85%
Q54U07	Dictyostelium discoideum	30%	100%
Q5ANP2	Candida albicans (strain SC5314 / ATCC MYA-2876)	33%	98%
Q5AYK0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	37%	86%
Q5E9A1	Bos taurus	45%	81%
Q5R9I9	Pongo abelii	45%	81%
Q60817	Mus musculus	45%	81%
Q61UX1	Caenorhabditis briggsae	38%	88%
Q68F90	Xenopus tropicalis	45%	81%
Q6BSN9	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	32%	97%
Q6CDH0	Yarrowia lipolytica (strain CLIB 122 / E 150)	30%	88%
Q6CWG6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	37%	99%
Q6FJD5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	36%	100%
Q6ICZ8	Arabidopsis thaliana	38%	85%
Q6IP73	Xenopus laevis	45%	82%
Q6QN10	Chinchilla lanigera	44%	81%
Q756T5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	35%	100%
Q7SI17	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	40%	87%
Q86S66	Caenorhabditis elegans	38%	89%
Q8AWF2	Oreochromis niloticus	45%	81%
Q8JIU7	Danio rerio	45%	81%
Q8LGC6	Arabidopsis thaliana	43%	83%
Q94518	Drosophila melanogaster	52%	80%
Q94JX9	Arabidopsis thaliana	39%	80%
Q9BZK3	Homo sapiens	40%	82%
Q9H009	Homo sapiens	38%	81%
Q9LHG9	Arabidopsis thaliana	37%	86%
Q9M612	Pinus taeda	39%	85%
Q9SZY1	Arabidopsis thaliana	40%	82%
Q9U111	Leishmania major	89%	99%
V5BDN6	Trypanosoma cruzi	62%	96%