Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H3Y5_LEIBR

TriTrypDb:

LbrM.04.0710 , LBRM2903_040016500

Length:

598

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3Y5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3Y5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	257	261	PF00656	0.684
CLV_C14_Caspase3-7	390	394	PF00656	0.545
CLV_C14_Caspase3-7	53	57	PF00656	0.700
CLV_NRD_NRD_1	113	115	PF00675	0.605
CLV_NRD_NRD_1	35	37	PF00675	0.680
CLV_NRD_NRD_1	66	68	PF00675	0.686
CLV_PCSK_KEX2_1	35	37	PF00082	0.680
CLV_PCSK_KEX2_1	66	68	PF00082	0.686
CLV_PCSK_SKI1_1	579	583	PF00082	0.557
DEG_Nend_UBRbox_2	1	3	PF02207	0.698
DEG_SPOP_SBC_1	396	400	PF00917	0.698
DEG_SPOP_SBC_1	434	438	PF00917	0.582
DEG_SPOP_SBC_1	80	84	PF00917	0.680
DOC_CKS1_1	315	320	PF01111	0.608
DOC_CYCLIN_yCln2_LP_2	565	571	PF00134	0.462
DOC_CYCLIN_yCln2_LP_2	573	576	PF00134	0.464
DOC_MAPK_gen_1	112	119	PF00069	0.513
DOC_MAPK_gen_1	378	387	PF00069	0.707
DOC_MAPK_MEF2A_6	112	121	PF00069	0.454
DOC_MAPK_MEF2A_6	35	42	PF00069	0.679
DOC_MAPK_MEF2A_6	378	387	PF00069	0.707
DOC_PP2B_LxvP_1	138	141	PF13499	0.542
DOC_PP2B_LxvP_1	573	576	PF13499	0.485
DOC_USP7_MATH_1	267	271	PF00917	0.664
DOC_USP7_MATH_1	361	365	PF00917	0.656
DOC_USP7_MATH_1	463	467	PF00917	0.651
DOC_USP7_MATH_1	486	490	PF00917	0.648
DOC_USP7_MATH_1	581	585	PF00917	0.526
DOC_USP7_MATH_1	80	84	PF00917	0.804
DOC_WW_Pin1_4	2	7	PF00397	0.603
DOC_WW_Pin1_4	223	228	PF00397	0.666
DOC_WW_Pin1_4	314	319	PF00397	0.609
DOC_WW_Pin1_4	325	330	PF00397	0.551
DOC_WW_Pin1_4	408	413	PF00397	0.557
DOC_WW_Pin1_4	437	442	PF00397	0.702
DOC_WW_Pin1_4	459	464	PF00397	0.678
DOC_WW_Pin1_4	8	13	PF00397	0.643
LIG_14-3-3_CanoR_1	188	193	PF00244	0.647
LIG_14-3-3_CanoR_1	291	300	PF00244	0.591
LIG_14-3-3_CanoR_1	345	352	PF00244	0.687
LIG_14-3-3_CanoR_1	547	551	PF00244	0.522
LIG_Clathr_ClatBox_1	448	452	PF01394	0.720
LIG_EVH1_1	24	28	PF00568	0.638
LIG_FHA_1	248	254	PF00498	0.559
LIG_FHA_1	299	305	PF00498	0.489
LIG_FHA_1	416	422	PF00498	0.701
LIG_FHA_1	434	440	PF00498	0.533
LIG_FHA_1	49	55	PF00498	0.698
LIG_FHA_1	560	566	PF00498	0.471
LIG_FHA_1	60	66	PF00498	0.576
LIG_FHA_2	331	337	PF00498	0.692
LIG_FHA_2	51	57	PF00498	0.698
LIG_GBD_Chelix_1	130	138	PF00786	0.512
LIG_IBAR_NPY_1	567	569	PF08397	0.422
LIG_Integrin_isoDGR_2	165	167	PF01839	0.573
LIG_LIR_Apic_2	7	12	PF02991	0.587
LIG_LIR_Gen_1	511	521	PF02991	0.748
LIG_LIR_Nem_3	297	303	PF02991	0.577
LIG_LIR_Nem_3	511	516	PF02991	0.757
LIG_NRBOX	133	139	PF00104	0.520
LIG_PDZ_Class_2	593	598	PF00595	0.507
LIG_Pex14_2	125	129	PF04695	0.527
LIG_SH2_PTP2	98	101	PF00017	0.706
LIG_SH2_STAP1	300	304	PF00017	0.565
LIG_SH2_STAP1	513	517	PF00017	0.765
LIG_SH2_STAT3	303	306	PF00017	0.639
LIG_SH2_STAT5	300	303	PF00017	0.625
LIG_SH2_STAT5	513	516	PF00017	0.669
LIG_SH2_STAT5	98	101	PF00017	0.706
LIG_SH3_3	114	120	PF00018	0.665
LIG_SH3_3	22	28	PF00018	0.641
LIG_SH3_3	355	361	PF00018	0.672
LIG_SH3_3	43	49	PF00018	0.633
LIG_SH3_3	436	442	PF00018	0.636
LIG_SH3_3	522	528	PF00018	0.606
LIG_SUMO_SIM_anti_2	20	25	PF11976	0.520
LIG_SUMO_SIM_par_1	50	56	PF11976	0.700
LIG_TRAF2_1	276	279	PF00917	0.559
LIG_TRAF2_1	467	470	PF00917	0.758
LIG_TYR_ITIM	96	101	PF00017	0.559
MOD_CDK_SPxxK_3	314	321	PF00069	0.545
MOD_CDK_SPxxK_3	437	444	PF00069	0.678
MOD_CDK_SPxxK_3	461	468	PF00069	0.728
MOD_CK1_1	10	16	PF00069	0.607
MOD_CK1_1	151	157	PF00069	0.791
MOD_CK1_1	186	192	PF00069	0.628
MOD_CK1_1	234	240	PF00069	0.795
MOD_CK1_1	328	334	PF00069	0.546
MOD_CK1_1	368	374	PF00069	0.702
MOD_CK1_1	376	382	PF00069	0.814
MOD_CK1_1	416	422	PF00069	0.785
MOD_CK1_1	511	517	PF00069	0.662
MOD_CK1_1	82	88	PF00069	0.609
MOD_CK2_1	1	7	PF00069	0.554
MOD_CK2_1	173	179	PF00069	0.587
MOD_CK2_1	188	194	PF00069	0.822
MOD_CK2_1	437	443	PF00069	0.675
MOD_CK2_1	463	469	PF00069	0.781
MOD_Cter_Amidation	112	115	PF01082	0.569
MOD_GlcNHglycan	150	153	PF01048	0.644
MOD_GlcNHglycan	156	159	PF01048	0.599
MOD_GlcNHglycan	17	20	PF01048	0.669
MOD_GlcNHglycan	179	182	PF01048	0.590
MOD_GlcNHglycan	223	226	PF01048	0.658
MOD_GlcNHglycan	254	257	PF01048	0.770
MOD_GlcNHglycan	269	272	PF01048	0.642
MOD_GlcNHglycan	29	32	PF01048	0.559
MOD_GlcNHglycan	347	350	PF01048	0.687
MOD_GlcNHglycan	375	378	PF01048	0.639
MOD_GlcNHglycan	404	407	PF01048	0.669
MOD_GlcNHglycan	422	425	PF01048	0.528
MOD_GlcNHglycan	431	434	PF01048	0.699
MOD_GlcNHglycan	488	491	PF01048	0.694
MOD_GlcNHglycan	84	87	PF01048	0.567
MOD_GSK3_1	154	161	PF00069	0.661
MOD_GSK3_1	173	180	PF00069	0.649
MOD_GSK3_1	183	190	PF00069	0.609
MOD_GSK3_1	213	220	PF00069	0.668
MOD_GSK3_1	231	238	PF00069	0.631
MOD_GSK3_1	243	250	PF00069	0.690
MOD_GSK3_1	283	290	PF00069	0.691
MOD_GSK3_1	294	301	PF00069	0.546
MOD_GSK3_1	361	368	PF00069	0.558
MOD_GSK3_1	396	403	PF00069	0.683
MOD_GSK3_1	413	420	PF00069	0.530
MOD_GSK3_1	429	436	PF00069	0.546
MOD_GSK3_1	459	466	PF00069	0.720
MOD_GSK3_1	477	484	PF00069	0.827
MOD_GSK3_1	486	493	PF00069	0.682
MOD_GSK3_1	511	518	PF00069	0.564
MOD_GSK3_1	56	63	PF00069	0.701
MOD_GSK3_1	78	85	PF00069	0.623
MOD_N-GLC_1	373	378	PF02516	0.564
MOD_N-GLC_1	459	464	PF02516	0.727
MOD_N-GLC_1	78	83	PF02516	0.604
MOD_NEK2_1	1	6	PF00069	0.573
MOD_NEK2_1	125	130	PF00069	0.524
MOD_NEK2_1	148	153	PF00069	0.684
MOD_NEK2_1	184	189	PF00069	0.632
MOD_NEK2_1	235	240	PF00069	0.724
MOD_NEK2_1	417	422	PF00069	0.546
MOD_PIKK_1	283	289	PF00454	0.693
MOD_PIKK_1	330	336	PF00454	0.696
MOD_PIKK_1	490	496	PF00454	0.565
MOD_PKA_2	187	193	PF00069	0.644
MOD_PKA_2	217	223	PF00069	0.570
MOD_PKA_2	499	505	PF00069	0.697
MOD_PKA_2	511	517	PF00069	0.532
MOD_PKA_2	546	552	PF00069	0.524
MOD_PKB_1	289	297	PF00069	0.519
MOD_Plk_1	125	131	PF00069	0.520
MOD_Plk_1	231	237	PF00069	0.699
MOD_Plk_1	508	514	PF00069	0.566
MOD_Plk_2-3	50	56	PF00069	0.545
MOD_Plk_4	125	131	PF00069	0.520
MOD_Plk_4	142	148	PF00069	0.577
MOD_Plk_4	299	305	PF00069	0.507
MOD_Plk_4	381	387	PF00069	0.704
MOD_ProDKin_1	10	16	PF00069	0.647
MOD_ProDKin_1	2	8	PF00069	0.603
MOD_ProDKin_1	223	229	PF00069	0.665
MOD_ProDKin_1	314	320	PF00069	0.608
MOD_ProDKin_1	325	331	PF00069	0.549
MOD_ProDKin_1	408	414	PF00069	0.556
MOD_ProDKin_1	437	443	PF00069	0.701
MOD_ProDKin_1	459	465	PF00069	0.678
MOD_SUMO_rev_2	389	396	PF00179	0.550
TRG_DiLeu_BaEn_2	590	596	PF01217	0.457
TRG_DiLeu_BaEn_4	339	345	PF01217	0.688
TRG_DiLeu_BaLyEn_6	569	574	PF01217	0.497
TRG_ENDOCYTIC_2	513	516	PF00928	0.768
TRG_ENDOCYTIC_2	98	101	PF00928	0.550
TRG_ER_diArg_1	288	291	PF00400	0.539
TRG_ER_diArg_1	34	36	PF00400	0.686
TRG_ER_diArg_1	65	67	PF00400	0.697
TRG_Pf-PMV_PEXEL_1	167	172	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	572	577	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V5	Leptomonas seymouri	38%	100%
A0A3S7WNU3	Leishmania donovani	75%	100%
E9AK73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
O97009	Leishmania major	75%	98%