Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3Y4_LEIBR

TriTrypDb:

LbrM.04.0700 , LBRM2903_040016400

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3Y4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3Y4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	32	34	PF00082	0.487
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.487
CLV_PCSK_SKI1_1	33	37	PF00082	0.482
DOC_MAPK_gen_1	32	38	PF00069	0.483
DOC_PP2B_LxvP_1	164	167	PF13499	0.528
DOC_PP2B_LxvP_1	184	187	PF13499	0.512
DOC_USP7_MATH_1	11	15	PF00917	0.682
DOC_USP7_MATH_1	187	191	PF00917	0.541
DOC_USP7_MATH_1	41	45	PF00917	0.568
DOC_USP7_MATH_1	92	96	PF00917	0.698
DOC_WW_Pin1_4	119	124	PF00397	0.596
DOC_WW_Pin1_4	61	66	PF00397	0.765
LIG_14-3-3_CanoR_1	19	24	PF00244	0.427
LIG_14-3-3_CanoR_1	227	235	PF00244	0.526
LIG_14-3-3_CanoR_1	99	107	PF00244	0.580
LIG_BIR_II_1	1	5	PF00653	0.779
LIG_DLG_GKlike_1	19	26	PF00625	0.392
LIG_FHA_1	120	126	PF00498	0.553
LIG_FHA_1	13	19	PF00498	0.715
LIG_LIR_Gen_1	147	156	PF02991	0.719
LIG_LIR_Gen_1	201	210	PF02991	0.476
LIG_LIR_Gen_1	22	30	PF02991	0.493
LIG_LIR_LC3C_4	201	205	PF02991	0.482
LIG_LIR_Nem_3	142	148	PF02991	0.672
LIG_LIR_Nem_3	201	205	PF02991	0.465
LIG_LIR_Nem_3	219	225	PF02991	0.548
LIG_LIR_Nem_3	22	26	PF02991	0.495
LIG_PDZ_Class_2	243	248	PF00595	0.469
LIG_SH2_CRK	148	152	PF00017	0.717
LIG_SH2_NCK_1	148	152	PF00017	0.717
LIG_SH2_PTP2	23	26	PF00017	0.479
LIG_SH2_STAP1	148	152	PF00017	0.615
LIG_SH2_STAT3	55	58	PF00017	0.395
LIG_SH2_STAT5	215	218	PF00017	0.670
LIG_SH2_STAT5	23	26	PF00017	0.479
LIG_SH2_STAT5	55	58	PF00017	0.608
LIG_SH2_STAT5	90	93	PF00017	0.588
LIG_SH3_3	156	162	PF00018	0.615
LIG_SH3_3	175	181	PF00018	0.695
LIG_SH3_3	31	37	PF00018	0.468
LIG_SUMO_SIM_par_1	162	168	PF11976	0.524
LIG_TRAF2_1	79	82	PF00917	0.567
LIG_TYR_ITIM	21	26	PF00017	0.505
MOD_CK1_1	100	106	PF00069	0.693
MOD_CK1_1	165	171	PF00069	0.675
MOD_CK1_1	190	196	PF00069	0.452
MOD_CK1_1	22	28	PF00069	0.560
MOD_CK2_1	25	31	PF00069	0.432
MOD_GlcNHglycan	112	115	PF01048	0.631
MOD_GlcNHglycan	167	170	PF01048	0.596
MOD_GlcNHglycan	94	97	PF01048	0.727
MOD_GSK3_1	1	8	PF00069	0.739
MOD_GSK3_1	187	194	PF00069	0.502
MOD_GSK3_1	204	211	PF00069	0.505
MOD_GSK3_1	88	95	PF00069	0.763
MOD_GSK3_1	97	104	PF00069	0.704
MOD_N-GLC_1	97	102	PF02516	0.596
MOD_NEK2_1	118	123	PF00069	0.546
MOD_NEK2_1	191	196	PF00069	0.473
MOD_PKA_2	226	232	PF00069	0.536
MOD_PKA_2	98	104	PF00069	0.559
MOD_Plk_1	191	197	PF00069	0.479
MOD_Plk_2-3	128	134	PF00069	0.555
MOD_Plk_2-3	226	232	PF00069	0.637
MOD_Plk_4	19	25	PF00069	0.544
MOD_Plk_4	192	198	PF00069	0.581
MOD_ProDKin_1	119	125	PF00069	0.598
MOD_ProDKin_1	61	67	PF00069	0.773
MOD_SUMO_for_1	116	119	PF00179	0.546
MOD_SUMO_rev_2	25	34	PF00179	0.497
TRG_DiLeu_BaEn_1	192	197	PF01217	0.583
TRG_DiLeu_BaEn_1	230	235	PF01217	0.619
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.705
TRG_ENDOCYTIC_2	148	151	PF00928	0.719
TRG_ENDOCYTIC_2	23	26	PF00928	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P497	Leptomonas seymouri	50%	100%
A0A3S7WNU9	Leishmania donovani	72%	100%
A4HS84	Leishmania infantum	73%	100%
E9AK72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
O97008	Leishmania major	74%	100%