TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania braziliensis

UniProt:

A4H3Y3_LEIBR

TriTrypDb:

LbrM.04.0680 , LBRM2903_040015900

Length:

562

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3Y3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3Y3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.593
CLV_NRD_NRD_1	293	295	PF00675	0.460
CLV_NRD_NRD_1	384	386	PF00675	0.232
CLV_NRD_NRD_1	449	451	PF00675	0.481
CLV_NRD_NRD_1	455	457	PF00675	0.495
CLV_NRD_NRD_1	82	84	PF00675	0.414
CLV_PCSK_KEX2_1	199	201	PF00082	0.320
CLV_PCSK_KEX2_1	213	215	PF00082	0.195
CLV_PCSK_KEX2_1	293	295	PF00082	0.458
CLV_PCSK_KEX2_1	384	386	PF00082	0.232
CLV_PCSK_KEX2_1	449	451	PF00082	0.579
CLV_PCSK_KEX2_1	82	84	PF00082	0.414
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.320
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.195
CLV_PCSK_SKI1_1	192	196	PF00082	0.183
CLV_PCSK_SKI1_1	214	218	PF00082	0.226
CLV_PCSK_SKI1_1	234	238	PF00082	0.317
CLV_PCSK_SKI1_1	33	37	PF00082	0.475
CLV_PCSK_SKI1_1	378	382	PF00082	0.229
DEG_APCC_DBOX_1	213	221	PF00400	0.229
DEG_SPOP_SBC_1	14	18	PF00917	0.505
DOC_CYCLIN_yCln2_LP_2	358	364	PF00134	0.233
DOC_MAPK_gen_1	159	167	PF00069	0.275
DOC_MAPK_gen_1	28	37	PF00069	0.474
DOC_MAPK_gen_1	456	466	PF00069	0.353
DOC_MAPK_MEF2A_6	105	114	PF00069	0.415
DOC_MAPK_MEF2A_6	116	125	PF00069	0.275
DOC_MAPK_MEF2A_6	161	169	PF00069	0.256
DOC_MAPK_MEF2A_6	457	466	PF00069	0.352
DOC_PP2B_LxvP_1	358	361	PF13499	0.226
DOC_PP4_FxxP_1	48	51	PF00568	0.429
DOC_USP7_MATH_1	10	14	PF00917	0.536
DOC_USP7_MATH_1	19	23	PF00917	0.588
DOC_USP7_MATH_1	258	262	PF00917	0.521
DOC_USP7_MATH_1	41	45	PF00917	0.461
DOC_USP7_MATH_1	55	59	PF00917	0.454
DOC_USP7_MATH_1	95	99	PF00917	0.498
DOC_WW_Pin1_4	332	337	PF00397	0.297
DOC_WW_Pin1_4	4	9	PF00397	0.603
DOC_WW_Pin1_4	458	463	PF00397	0.529
DOC_WW_Pin1_4	47	52	PF00397	0.430
DOC_WW_Pin1_4	64	69	PF00397	0.354
LIG_14-3-3_CanoR_1	192	197	PF00244	0.335
LIG_14-3-3_CanoR_1	20	24	PF00244	0.563
LIG_14-3-3_CanoR_1	42	51	PF00244	0.530
LIG_BIR_III_2	133	137	PF00653	0.476
LIG_CaM_IQ_9	424	440	PF13499	0.377
LIG_CtBP_PxDLS_1	120	124	PF00389	0.374
LIG_eIF4E_1	376	382	PF01652	0.248
LIG_eIF4E_1	535	541	PF01652	0.480
LIG_FHA_1	309	315	PF00498	0.587
LIG_FHA_1	327	333	PF00498	0.316
LIG_FHA_1	459	465	PF00498	0.392
LIG_FHA_1	512	518	PF00498	0.599
LIG_FHA_1	554	560	PF00498	0.584
LIG_FHA_2	193	199	PF00498	0.183
LIG_FHA_2	235	241	PF00498	0.426
LIG_FHA_2	507	513	PF00498	0.672
LIG_LIR_Apic_2	395	399	PF02991	0.295
LIG_LIR_Apic_2	46	51	PF02991	0.436
LIG_LIR_Gen_1	206	217	PF02991	0.268
LIG_LIR_Gen_1	553	562	PF02991	0.500
LIG_LIR_Nem_3	206	212	PF02991	0.286
LIG_LIR_Nem_3	397	403	PF02991	0.269
LIG_LIR_Nem_3	430	434	PF02991	0.295
LIG_LIR_Nem_3	486	492	PF02991	0.517
LIG_LIR_Nem_3	553	558	PF02991	0.656
LIG_LYPXL_yS_3	151	154	PF13949	0.266
LIG_NRBOX	410	416	PF00104	0.275
LIG_Pex14_2	466	470	PF04695	0.349
LIG_Rb_LxCxE_1	338	357	PF01857	0.243
LIG_REV1ctd_RIR_1	297	306	PF16727	0.399
LIG_SH2_CRK	209	213	PF00017	0.248
LIG_SH2_CRK	489	493	PF00017	0.586
LIG_SH2_NCK_1	543	547	PF00017	0.482
LIG_SH2_SRC	396	399	PF00017	0.292
LIG_SH2_SRC	543	546	PF00017	0.485
LIG_SH2_STAP1	190	194	PF00017	0.188
LIG_SH2_STAP1	370	374	PF00017	0.253
LIG_SH2_STAP1	376	380	PF00017	0.220
LIG_SH2_STAT3	177	180	PF00017	0.213
LIG_SH2_STAT3	403	406	PF00017	0.259
LIG_SH2_STAT5	215	218	PF00017	0.207
LIG_SH2_STAT5	403	406	PF00017	0.336
LIG_SH3_2	289	294	PF14604	0.457
LIG_SH3_3	2	8	PF00018	0.513
LIG_SH3_3	241	247	PF00018	0.527
LIG_SH3_3	286	292	PF00018	0.417
LIG_SH3_3	302	308	PF00018	0.362
LIG_SH3_3	330	336	PF00018	0.328
LIG_SH3_3	505	511	PF00018	0.558
LIG_SH3_3	530	536	PF00018	0.484
LIG_SUMO_SIM_anti_2	338	343	PF11976	0.236
LIG_WW_3	290	294	PF00397	0.534
MOD_CDK_SPxxK_3	64	71	PF00069	0.399
MOD_CK1_1	13	19	PF00069	0.484
MOD_CK1_1	188	194	PF00069	0.224
MOD_CK1_1	260	266	PF00069	0.480
MOD_CK1_1	268	274	PF00069	0.459
MOD_CK1_1	275	281	PF00069	0.353
MOD_CK1_1	326	332	PF00069	0.394
MOD_CK1_1	44	50	PF00069	0.522
MOD_CK1_1	53	59	PF00069	0.419
MOD_CK1_1	551	557	PF00069	0.647
MOD_CK1_1	6	12	PF00069	0.507
MOD_CK2_1	192	198	PF00069	0.183
MOD_CK2_1	260	266	PF00069	0.741
MOD_CK2_1	275	281	PF00069	0.307
MOD_CK2_1	332	338	PF00069	0.289
MOD_CK2_1	351	357	PF00069	0.288
MOD_CK2_1	506	512	PF00069	0.510
MOD_DYRK1A_RPxSP_1	64	68	PF00069	0.409
MOD_GlcNHglycan	12	15	PF01048	0.532
MOD_GlcNHglycan	17	20	PF01048	0.530
MOD_GlcNHglycan	43	46	PF01048	0.455
MOD_GlcNHglycan	529	532	PF01048	0.732
MOD_GlcNHglycan	550	553	PF01048	0.698
MOD_GlcNHglycan	71	74	PF01048	0.376
MOD_GlcNHglycan	97	100	PF01048	0.634
MOD_GSK3_1	15	22	PF00069	0.572
MOD_GSK3_1	188	195	PF00069	0.298
MOD_GSK3_1	257	264	PF00069	0.501
MOD_GSK3_1	268	275	PF00069	0.427
MOD_GSK3_1	418	425	PF00069	0.294
MOD_GSK3_1	43	50	PF00069	0.484
MOD_GSK3_1	500	507	PF00069	0.639
MOD_GSK3_1	523	530	PF00069	0.689
MOD_GSK3_1	6	13	PF00069	0.605
MOD_GSK3_1	71	78	PF00069	0.488
MOD_N-GLC_1	258	263	PF02516	0.576
MOD_N-GLC_1	89	94	PF02516	0.667
MOD_NEK2_1	112	117	PF00069	0.398
MOD_NEK2_1	153	158	PF00069	0.394
MOD_NEK2_1	165	170	PF00069	0.464
MOD_NEK2_1	265	270	PF00069	0.491
MOD_NEK2_1	75	80	PF00069	0.487
MOD_NMyristoyl	1	7	PF02799	0.523
MOD_PIKK_1	308	314	PF00454	0.635
MOD_PIKK_1	351	357	PF00454	0.283
MOD_PKA_1	293	299	PF00069	0.446
MOD_PKA_2	19	25	PF00069	0.624
MOD_PKA_2	293	299	PF00069	0.619
MOD_PKA_2	326	332	PF00069	0.364
MOD_PKA_2	41	47	PF00069	0.566
MOD_PKA_2	523	529	PF00069	0.513
MOD_Plk_1	258	264	PF00069	0.476
MOD_Plk_1	265	271	PF00069	0.449
MOD_Plk_1	511	517	PF00069	0.634
MOD_Plk_4	165	171	PF00069	0.454
MOD_Plk_4	265	271	PF00069	0.464
MOD_Plk_4	272	278	PF00069	0.402
MOD_Plk_4	389	395	PF00069	0.422
MOD_Plk_4	554	560	PF00069	0.531
MOD_ProDKin_1	332	338	PF00069	0.289
MOD_ProDKin_1	4	10	PF00069	0.599
MOD_ProDKin_1	458	464	PF00069	0.521
MOD_ProDKin_1	47	53	PF00069	0.422
MOD_ProDKin_1	64	70	PF00069	0.347
MOD_SUMO_rev_2	228	236	PF00179	0.339
TRG_DiLeu_BaEn_1	107	112	PF01217	0.413
TRG_DiLeu_BaEn_1	142	147	PF01217	0.434
TRG_DiLeu_BaEn_4	107	113	PF01217	0.411
TRG_DiLeu_BaLyEn_6	149	154	PF01217	0.290
TRG_DiLeu_LyEn_5	142	147	PF01217	0.272
TRG_ENDOCYTIC_2	151	154	PF00928	0.259
TRG_ENDOCYTIC_2	209	212	PF00928	0.244
TRG_ENDOCYTIC_2	370	373	PF00928	0.241
TRG_ENDOCYTIC_2	434	437	PF00928	0.331
TRG_ENDOCYTIC_2	489	492	PF00928	0.586
TRG_ER_diArg_1	292	294	PF00400	0.462
TRG_ER_diArg_1	383	385	PF00400	0.231
TRG_ER_diArg_1	448	450	PF00400	0.468
TRG_NLS_MonoExtN_4	455	460	PF00514	0.510
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.277

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IQD5	Bodo saltans	31%	77%
A0A422N931	Trypanosoma rangeli	56%	91%
C9ZY79	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	93%
V5BDM9	Trypanosoma cruzi	55%	94%