RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania braziliensis

UniProt:

A4H3Y1_LEIBR

TriTrypDb:

LbrM.04.0660 , LBRM2903_040012600 , LBRM2903_040012700

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H3Y1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3Y1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	7
GO:0016740	transferase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	7
GO:0061630	ubiquitin protein ligase activity	5	7
GO:0061659	ubiquitin-like protein ligase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.589
CLV_NRD_NRD_1	170	172	PF00675	0.312
CLV_NRD_NRD_1	202	204	PF00675	0.281
CLV_NRD_NRD_1	5	7	PF00675	0.581
CLV_PCSK_FUR_1	101	105	PF00082	0.352
CLV_PCSK_KEX2_1	103	105	PF00082	0.378
CLV_PCSK_KEX2_1	170	172	PF00082	0.312
CLV_PCSK_KEX2_1	4	6	PF00082	0.684
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.378
CLV_PCSK_SKI1_1	220	224	PF00082	0.374
CLV_PCSK_SKI1_1	226	230	PF00082	0.416
CLV_PCSK_SKI1_1	324	328	PF00082	0.334
DEG_Nend_UBRbox_2	1	3	PF02207	0.505
DOC_CYCLIN_RxL_1	320	329	PF00134	0.216
DOC_CYCLIN_yCln2_LP_2	183	189	PF00134	0.532
DOC_MAPK_gen_1	4	11	PF00069	0.456
DOC_MAPK_MEF2A_6	220	227	PF00069	0.573
DOC_MAPK_MEF2A_6	232	240	PF00069	0.497
DOC_MAPK_MEF2A_6	241	249	PF00069	0.282
DOC_MAPK_MEF2A_6	4	11	PF00069	0.415
DOC_MAPK_NFAT4_5	220	228	PF00069	0.532
DOC_SPAK_OSR1_1	66	70	PF12202	0.363
DOC_USP7_MATH_1	286	290	PF00917	0.363
DOC_USP7_MATH_1	35	39	PF00917	0.458
DOC_WW_Pin1_4	113	118	PF00397	0.683
LIG_14-3-3_CanoR_1	226	235	PF00244	0.642
LIG_14-3-3_CanoR_1	277	287	PF00244	0.217
LIG_14-3-3_CanoR_1	78	88	PF00244	0.627
LIG_BRCT_BRCA1_1	279	283	PF00533	0.207
LIG_FHA_1	210	216	PF00498	0.635
LIG_FHA_1	22	28	PF00498	0.558
LIG_FHA_1	249	255	PF00498	0.297
LIG_FHA_1	293	299	PF00498	0.363
LIG_FHA_1	316	322	PF00498	0.302
LIG_FHA_2	136	142	PF00498	0.515
LIG_FHA_2	301	307	PF00498	0.526
LIG_GBD_Chelix_1	139	147	PF00786	0.207
LIG_LIR_Gen_1	248	257	PF02991	0.534
LIG_LIR_Gen_1	89	98	PF02991	0.613
LIG_LIR_Nem_3	166	172	PF02991	0.512
LIG_LIR_Nem_3	248	253	PF02991	0.216
LIG_LIR_Nem_3	82	87	PF02991	0.669
LIG_LIR_Nem_3	89	93	PF02991	0.574
LIG_Pex14_1	63	67	PF04695	0.429
LIG_SH2_CRK	169	173	PF00017	0.468
LIG_SH2_NCK_1	299	303	PF00017	0.394
LIG_SH2_NCK_1	90	94	PF00017	0.616
LIG_SH2_PTP2	252	255	PF00017	0.390
LIG_SH2_SRC	90	93	PF00017	0.548
LIG_SH2_STAP1	287	291	PF00017	0.391
LIG_SH2_STAP1	304	308	PF00017	0.525
LIG_SH2_STAT5	252	255	PF00017	0.390
LIG_SH2_STAT5	299	302	PF00017	0.517
LIG_SH3_3	273	279	PF00018	0.495
LIG_SH3_3	47	53	PF00018	0.268
LIG_Sin3_3	294	301	PF02671	0.216
LIG_SUMO_SIM_anti_2	197	203	PF11976	0.550
LIG_SUMO_SIM_anti_2	212	219	PF11976	0.603
LIG_SUMO_SIM_par_1	309	314	PF11976	0.270
LIG_TRFH_1	252	256	PF08558	0.541
LIG_UBA3_1	326	331	PF00899	0.495
MOD_CK1_1	192	198	PF00069	0.569
MOD_CK1_1	36	42	PF00069	0.404
MOD_CK2_1	255	261	PF00069	0.448
MOD_CK2_1	86	92	PF00069	0.635
MOD_GlcNHglycan	165	168	PF01048	0.296
MOD_GlcNHglycan	280	283	PF01048	0.512
MOD_GlcNHglycan	288	291	PF01048	0.291
MOD_GlcNHglycan	38	41	PF01048	0.644
MOD_GSK3_1	17	24	PF00069	0.533
MOD_GSK3_1	209	216	PF00069	0.615
MOD_GSK3_1	311	318	PF00069	0.363
MOD_GSK3_1	35	42	PF00069	0.426
MOD_GSK3_1	79	86	PF00069	0.669
MOD_N-GLC_1	17	22	PF02516	0.624
MOD_NEK2_1	209	214	PF00069	0.616
MOD_NEK2_1	245	250	PF00069	0.302
MOD_NEK2_1	33	38	PF00069	0.359
MOD_PIKK_1	105	111	PF00454	0.702
MOD_PKA_2	79	85	PF00069	0.564
MOD_PKB_1	224	232	PF00069	0.602
MOD_Plk_1	7	13	PF00069	0.472
MOD_Plk_4	135	141	PF00069	0.461
MOD_Plk_4	213	219	PF00069	0.600
MOD_Plk_4	245	251	PF00069	0.302
MOD_Plk_4	311	317	PF00069	0.476
MOD_ProDKin_1	113	119	PF00069	0.681
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.599
TRG_ENDOCYTIC_2	169	172	PF00928	0.468
TRG_ENDOCYTIC_2	252	255	PF00928	0.478
TRG_ENDOCYTIC_2	90	93	PF00928	0.721
TRG_ER_diArg_1	169	171	PF00400	0.512
TRG_ER_diArg_1	223	226	PF00400	0.591
TRG_ER_diArg_1	3	6	PF00400	0.490
TRG_ER_diArg_1	77	80	PF00400	0.642
TRG_Pf-PMV_PEXEL_1	324	329	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRM4	Leptomonas seymouri	53%	100%
A0A3S7WNQ6	Leishmania donovani	78%	100%
A4HS60	Leishmania infantum	77%	100%
E9AK47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q9NED8	Leishmania major	77%	99%