Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H3X9_LEIBR

TriTrypDb:

LbrM.04.0640 , LBRM2903_040011600

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H3X9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3X9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.530
CLV_NRD_NRD_1	162	164	PF00675	0.483
CLV_NRD_NRD_1	170	172	PF00675	0.498
CLV_NRD_NRD_1	19	21	PF00675	0.413
CLV_NRD_NRD_1	66	68	PF00675	0.716
CLV_PCSK_KEX2_1	118	120	PF00082	0.530
CLV_PCSK_KEX2_1	162	164	PF00082	0.483
CLV_PCSK_KEX2_1	170	172	PF00082	0.498
CLV_PCSK_KEX2_1	19	21	PF00082	0.463
CLV_PCSK_KEX2_1	5	7	PF00082	0.516
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.516
DEG_APCC_DBOX_1	19	27	PF00400	0.559
DOC_MAPK_gen_1	170	179	PF00069	0.708
DOC_MAPK_gen_1	19	25	PF00069	0.655
DOC_MAPK_gen_1	5	15	PF00069	0.727
DOC_PP4_FxxP_1	27	30	PF00568	0.547
DOC_USP7_MATH_1	107	111	PF00917	0.548
DOC_USP7_MATH_1	260	264	PF00917	0.465
DOC_USP7_UBL2_3	144	148	PF12436	0.555
DOC_WW_Pin1_4	26	31	PF00397	0.576
DOC_WW_Pin1_4	81	86	PF00397	0.428
LIG_14-3-3_CanoR_1	111	120	PF00244	0.596
LIG_14-3-3_CanoR_1	20	26	PF00244	0.555
LIG_14-3-3_CanoR_1	235	241	PF00244	0.714
LIG_14-3-3_CanoR_1	261	265	PF00244	0.411
LIG_14-3-3_CanoR_1	76	82	PF00244	0.409
LIG_BIR_II_1	1	5	PF00653	0.687
LIG_BRCT_BRCA1_1	21	25	PF00533	0.711
LIG_BRCT_BRCA1_1	41	45	PF00533	0.222
LIG_deltaCOP1_diTrp_1	59	65	PF00928	0.426
LIG_EH1_1	99	107	PF00400	0.261
LIG_FHA_1	184	190	PF00498	0.546
LIG_FHA_1	8	14	PF00498	0.778
LIG_FHA_2	131	137	PF00498	0.704
LIG_GBD_Chelix_1	229	237	PF00786	0.392
LIG_LIR_Apic_2	24	30	PF02991	0.546
LIG_LIR_Gen_1	42	53	PF02991	0.416
LIG_LIR_Gen_1	89	97	PF02991	0.513
LIG_LIR_Nem_3	42	48	PF02991	0.416
LIG_LIR_Nem_3	59	65	PF02991	0.506
LIG_LIR_Nem_3	89	93	PF02991	0.513
LIG_MLH1_MIPbox_1	41	45	PF16413	0.513
LIG_PTAP_UEV_1	8	13	PF05743	0.626
LIG_SH2_GRB2like	236	239	PF00017	0.658
LIG_SH2_GRB2like	246	249	PF00017	0.402
LIG_SH2_NCK_1	202	206	PF00017	0.261
LIG_SH2_PTP2	246	249	PF00017	0.411
LIG_SH2_SRC	236	239	PF00017	0.538
LIG_SH2_STAT5	236	239	PF00017	0.669
LIG_SH2_STAT5	243	246	PF00017	0.597
LIG_SH2_STAT5	44	47	PF00017	0.513
LIG_SH3_1	6	12	PF00018	0.774
LIG_SH3_3	129	135	PF00018	0.713
LIG_SH3_3	15	21	PF00018	0.686
LIG_SH3_3	6	12	PF00018	0.722
LIG_SH3_3	79	85	PF00018	0.556
LIG_Sin3_3	253	260	PF02671	0.474
LIG_SUMO_SIM_anti_2	186	193	PF11976	0.433
LIG_SUMO_SIM_anti_2	254	259	PF11976	0.513
LIG_SUMO_SIM_par_1	186	193	PF11976	0.420
LIG_SUMO_SIM_par_1	45	50	PF11976	0.303
LIG_TYR_ITIM	41	46	PF00017	0.261
LIG_WRC_WIRS_1	87	92	PF05994	0.261
MOD_CK1_1	203	209	PF00069	0.407
MOD_CK1_1	75	81	PF00069	0.728
MOD_CK2_1	130	136	PF00069	0.686
MOD_Cter_Amidation	65	68	PF01082	0.752
MOD_GlcNHglycan	51	54	PF01048	0.506
MOD_GlcNHglycan	77	80	PF01048	0.731
MOD_GSK3_1	130	137	PF00069	0.683
MOD_GSK3_1	190	197	PF00069	0.411
MOD_GSK3_1	47	54	PF00069	0.517
MOD_GSK3_1	68	75	PF00069	0.700
MOD_NEK2_1	33	38	PF00069	0.402
MOD_NEK2_1	39	44	PF00069	0.357
MOD_NEK2_1	61	66	PF00069	0.677
MOD_NEK2_2	236	241	PF00069	0.566
MOD_PIKK_1	203	209	PF00454	0.407
MOD_PKA_1	162	168	PF00069	0.465
MOD_PKA_1	19	25	PF00069	0.604
MOD_PKA_2	162	168	PF00069	0.465
MOD_PKA_2	19	25	PF00069	0.578
MOD_PKA_2	260	266	PF00069	0.411
MOD_PKA_2	66	72	PF00069	0.644
MOD_PKA_2	7	13	PF00069	0.660
MOD_PKA_2	75	81	PF00069	0.648
MOD_PKB_1	70	78	PF00069	0.746
MOD_Plk_4	101	107	PF00069	0.513
MOD_Plk_4	21	27	PF00069	0.564
MOD_Plk_4	251	257	PF00069	0.369
MOD_Plk_4	260	266	PF00069	0.343
MOD_Plk_4	33	39	PF00069	0.345
MOD_ProDKin_1	26	32	PF00069	0.445
MOD_ProDKin_1	81	87	PF00069	0.523
MOD_SUMO_for_1	4	7	PF00179	0.508
TRG_ENDOCYTIC_2	246	249	PF00928	0.355
TRG_ENDOCYTIC_2	43	46	PF00928	0.353
TRG_ER_diArg_1	118	120	PF00400	0.669
TRG_ER_diArg_1	169	171	PF00400	0.574
TRG_ER_diArg_1	18	20	PF00400	0.556
TRG_ER_diArg_1	70	73	PF00400	0.748
TRG_Pf-PMV_PEXEL_1	111	116	PF00026	0.550

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB33	Leptomonas seymouri	50%	100%
A0A3S7WNS4	Leishmania donovani	74%	100%
A4HS54	Leishmania infantum	75%	100%
E9AK41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q95Z83	Leishmania major	74%	100%