Putative spermidine synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

spermidine synthase, putative

Species:

Leishmania braziliensis

UniProt:

A4H3X8_LEIBR

TriTrypDb:

LbrM.04.0630 , LBRM2903_040011400

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4H3X8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3X8

Function

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Biological processes
Term	Name	Level	Count
GO:0006576	biogenic amine metabolic process	5	11
GO:0006595	polyamine metabolic process	6	11
GO:0006596	polyamine biosynthetic process	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009308	amine metabolic process	4	11
GO:0009309	amine biosynthetic process	5	11
GO:0009987	cellular process	1	11
GO:0034641	cellular nitrogen compound metabolic process	3	11

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004766	spermidine synthase activity	4	8
GO:0016740	transferase activity	2	11
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	194	196	PF00675	0.207
CLV_NRD_NRD_1	265	267	PF00675	0.310
CLV_PCSK_KEX2_1	133	135	PF00082	0.366
CLV_PCSK_KEX2_1	194	196	PF00082	0.275
CLV_PCSK_KEX2_1	265	267	PF00082	0.310
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.366
CLV_PCSK_SKI1_1	103	107	PF00082	0.265
CLV_PCSK_SKI1_1	194	198	PF00082	0.236
CLV_PCSK_SKI1_1	286	290	PF00082	0.387
CLV_Separin_Metazoa	104	108	PF03568	0.478

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHF0	Leptomonas seymouri	84%	100%
A0A0S4J4V7	Bodo saltans	60%	100%
A0A1X0NLA3	Trypanosomatidae	69%	100%
A0A314LG79	Nicotiana attenuata	41%	77%
A0A3R7RGB1	Trypanosoma rangeli	67%	100%
A0A3S5H5B4	Leishmania donovani	89%	100%
A1A7G7	Escherichia coli O1:K1 / APEC	36%	100%
A1JJM8	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	35%	100%
A1WZR2	Halorhodospira halophila (strain DSM 244 / SL1)	35%	100%
A2BIX4	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	32%	100%

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