Putative tyrosine phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tyrosine phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4H3X6_LEIBR

TriTrypDb:

LbrM.04.0610 , LBRM2903_040011200

Length:

287

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3X6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3X6

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016311	dephosphorylation	5	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004721	phosphoprotein phosphatase activity	3	9
GO:0004725	protein tyrosine phosphatase activity	4	6
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016791	phosphatase activity	5	9
GO:0042578	phosphoric ester hydrolase activity	4	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	138	140	PF00082	0.295
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.295
CLV_PCSK_SKI1_1	203	207	PF00082	0.462
CLV_PCSK_SKI1_1	44	48	PF00082	0.315
DEG_COP1_1	7	15	PF00400	0.376
DEG_MDM2_SWIB_1	166	173	PF02201	0.438
DEG_SCF_FBW7_1	171	178	PF00400	0.485
DOC_CKS1_1	172	177	PF01111	0.324
DOC_CKS1_1	2	7	PF01111	0.447
DOC_CYCLIN_yCln2_LP_2	162	168	PF00134	0.426
DOC_MAPK_DCC_7	8	17	PF00069	0.372
DOC_MAPK_gen_1	42	49	PF00069	0.495
DOC_MAPK_MEF2A_6	8	17	PF00069	0.372
DOC_PP2B_LxvP_1	162	165	PF13499	0.435
DOC_PP2B_PxIxI_1	267	273	PF00149	0.476
DOC_USP7_MATH_1	250	254	PF00917	0.653
DOC_USP7_UBL2_3	203	207	PF12436	0.604
DOC_WW_Pin1_4	1	6	PF00397	0.460
DOC_WW_Pin1_4	160	165	PF00397	0.378
DOC_WW_Pin1_4	171	176	PF00397	0.370
DOC_WW_Pin1_4	194	199	PF00397	0.412
DOC_WW_Pin1_4	230	235	PF00397	0.599
LIG_14-3-3_CanoR_1	139	147	PF00244	0.495
LIG_14-3-3_CanoR_1	176	180	PF00244	0.438
LIG_Actin_WH2_2	31	46	PF00022	0.430
LIG_APCC_ABBA_1	131	136	PF00400	0.473
LIG_FHA_1	113	119	PF00498	0.362
LIG_FHA_1	215	221	PF00498	0.514
LIG_FHA_1	97	103	PF00498	0.522
LIG_LIR_Apic_2	45	51	PF02991	0.448
LIG_LIR_Gen_1	14	25	PF02991	0.506
LIG_LIR_Gen_1	149	160	PF02991	0.464
LIG_LIR_Gen_1	169	177	PF02991	0.414
LIG_LIR_Gen_1	79	89	PF02991	0.472
LIG_LIR_Nem_3	132	137	PF02991	0.451
LIG_LIR_Nem_3	14	20	PF02991	0.480
LIG_LIR_Nem_3	149	155	PF02991	0.433
LIG_LIR_Nem_3	169	173	PF02991	0.412
LIG_LIR_Nem_3	79	84	PF02991	0.477
LIG_Pex14_2	166	170	PF04695	0.426
LIG_SH2_CRK	156	160	PF00017	0.484
LIG_SH2_CRK	196	200	PF00017	0.498
LIG_SH2_PTP2	152	155	PF00017	0.448
LIG_SH2_SRC	54	57	PF00017	0.482
LIG_SH2_STAT5	152	155	PF00017	0.465
LIG_SH2_STAT5	204	207	PF00017	0.467
LIG_SH2_STAT5	48	51	PF00017	0.473
LIG_SH3_1	244	250	PF00018	0.534
LIG_SH3_2	198	203	PF14604	0.399
LIG_SH3_3	195	201	PF00018	0.379
LIG_SH3_3	235	241	PF00018	0.601
LIG_SH3_3	244	250	PF00018	0.652
LIG_SH3_3	7	13	PF00018	0.472
LIG_SUMO_SIM_par_1	129	136	PF11976	0.516
LIG_TYR_ITIM	194	199	PF00017	0.500
MOD_CDK_SPK_2	171	176	PF00069	0.466
MOD_CDK_SPxxK_3	1	8	PF00069	0.451
MOD_CK1_1	129	135	PF00069	0.448
MOD_CK1_1	227	233	PF00069	0.679
MOD_CK1_1	36	42	PF00069	0.393
MOD_CK2_1	129	135	PF00069	0.495
MOD_CK2_1	179	185	PF00069	0.433
MOD_GlcNHglycan	209	212	PF01048	0.598
MOD_GlcNHglycan	226	229	PF01048	0.645
MOD_GlcNHglycan	252	255	PF01048	0.686
MOD_GlcNHglycan	257	260	PF01048	0.644
MOD_GlcNHglycan	26	29	PF01048	0.264
MOD_GlcNHglycan	38	41	PF01048	0.264
MOD_GlcNHglycan	93	96	PF01048	0.242
MOD_GSK3_1	11	18	PF00069	0.589
MOD_GSK3_1	171	178	PF00069	0.393
MOD_GSK3_1	224	231	PF00069	0.731
MOD_GSK3_1	24	31	PF00069	0.477
MOD_GSK3_1	262	269	PF00069	0.674
MOD_N-GLC_1	15	20	PF02516	0.368
MOD_N-GLC_1	207	212	PF02516	0.650
MOD_N-GLC_1	33	38	PF02516	0.279
MOD_NEK2_1	166	171	PF00069	0.415
MOD_NEK2_1	229	234	PF00069	0.662
MOD_PIKK_1	245	251	PF00454	0.674
MOD_PK_1	42	48	PF00069	0.516
MOD_PKA_2	175	181	PF00069	0.470
MOD_Plk_1	15	21	PF00069	0.487
MOD_Plk_1	33	39	PF00069	0.479
MOD_Plk_4	114	120	PF00069	0.590
MOD_Plk_4	129	135	PF00069	0.368
MOD_Plk_4	166	172	PF00069	0.438
MOD_Plk_4	175	181	PF00069	0.390
MOD_Plk_4	262	268	PF00069	0.601
MOD_ProDKin_1	1	7	PF00069	0.455
MOD_ProDKin_1	160	166	PF00069	0.379
MOD_ProDKin_1	171	177	PF00069	0.362
MOD_ProDKin_1	194	200	PF00069	0.414
MOD_ProDKin_1	230	236	PF00069	0.599
MOD_SUMO_rev_2	132	140	PF00179	0.495
TRG_DiLeu_BaLyEn_6	100	105	PF01217	0.495
TRG_ENDOCYTIC_2	137	140	PF00928	0.483
TRG_ENDOCYTIC_2	152	155	PF00928	0.483
TRG_ENDOCYTIC_2	156	159	PF00928	0.522
TRG_ENDOCYTIC_2	196	199	PF00928	0.493
TRG_ER_diArg_1	41	44	PF00400	0.516
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JUF6	Bodo saltans	64%	93%
A0A3S5H5B2	Leishmania donovani	77%	93%
A0A422N9L9	Trypanosoma rangeli	76%	90%
A4HS51	Leishmania infantum	77%	93%
C9ZY49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	89%
E9AK38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	98%
Q95Z86	Leishmania major	79%	100%