TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/Tetratricopeptide repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4H3X5_LEIBR

TriTrypDb:

LbrM.04.0600 , LBRM2903_040011100

Length:

1560

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0030990	intraciliary transport particle	2	1
GO:0030991	intraciliary transport particle A	2	1
GO:0032991	protein-containing complex	1	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

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Expansion

Sequence features

A4H3X5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0010970	transport along microtubule	4	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0042802	identical protein binding	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1102	1106	PF00656	0.374
CLV_C14_Caspase3-7	908	912	PF00656	0.555
CLV_C14_Caspase3-7	97	101	PF00656	0.409
CLV_MEL_PAP_1	789	795	PF00089	0.489
CLV_NRD_NRD_1	1197	1199	PF00675	0.477
CLV_NRD_NRD_1	1243	1245	PF00675	0.519
CLV_NRD_NRD_1	1255	1257	PF00675	0.427
CLV_NRD_NRD_1	218	220	PF00675	0.258
CLV_NRD_NRD_1	266	268	PF00675	0.388
CLV_NRD_NRD_1	301	303	PF00675	0.451

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q1	Leptomonas seymouri	70%	99%
A0A1X0NLG9	Trypanosomatidae	43%	100%
A0A3R7KVH6	Trypanosoma rangeli	42%	100%
A0A3S7WNS5	Leishmania donovani	82%	100%
A4HS50	Leishmania infantum	82%	100%
C9ZY47	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AK37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
O97200	Leishmania major	82%	98%
Q0HA38	Mus musculus	27%	100%
Q6INC1	Xenopus laevis	24%	100%

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