LeishMANIAdb
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Putative huntingtin interacting protein (HIP)

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative huntingtin interacting protein (HIP)
Gene product:
palmitoyl acyltransferase 1, putative
Species:
Leishmania braziliensis
UniProt:
A4H3X2_LEIBR
TriTrypDb:
LbrM.04.0570 , LBRM2903_040010700 * , LBRM2903_040010800 *
Length:
1035

Annotations

LeishMANIAdb annotations

Very putatively could be a palmitoyltransferase.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4H3X2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3X2

Function

Biological processes
Term Name Level Count
GO:0006497 protein lipidation 5 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0018345 protein palmitoylation 6 1
GO:0019538 protein metabolic process 3 1
GO:0036211 protein modification process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0043543 protein acylation 5 1
GO:0044238 primary metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0016409 palmitoyltransferase activity 5 9
GO:0016740 transferase activity 2 9
GO:0016746 acyltransferase activity 3 9
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 9
GO:0008374 O-acyltransferase activity 5 1
GO:0016416 O-palmitoyltransferase activity 6 1
GO:0047965 glycoprotein O-fatty-acyltransferase activity 4 1
GO:0140096 catalytic activity, acting on a protein 2 3
GO:0140103 catalytic activity, acting on a glycoprotein 3 1
GO:0016417 S-acyltransferase activity 5 2
GO:0019706 protein-cysteine S-palmitoyltransferase activity 4 2
GO:0019707 protein-cysteine S-acyltransferase activity 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 327 331 PF00656 0.699
CLV_C14_Caspase3-7 866 870 PF00656 0.748
CLV_C14_Caspase3-7 958 962 PF00656 0.623
CLV_NRD_NRD_1 464 466 PF00675 0.477
CLV_NRD_NRD_1 50 52 PF00675 0.440
CLV_NRD_NRD_1 556 558 PF00675 0.450
CLV_NRD_NRD_1 639 641 PF00675 0.455
CLV_PCSK_FUR_1 461 465 PF00082 0.459
CLV_PCSK_KEX2_1 461 463 PF00082 0.496
CLV_PCSK_KEX2_1 464 466 PF00082 0.482
CLV_PCSK_KEX2_1 50 52 PF00082 0.440
CLV_PCSK_KEX2_1 556 558 PF00082 0.417
CLV_PCSK_SKI1_1 198 202 PF00082 0.289
CLV_PCSK_SKI1_1 405 409 PF00082 0.291
CLV_PCSK_SKI1_1 477 481 PF00082 0.422
CLV_PCSK_SKI1_1 51 55 PF00082 0.414
CLV_PCSK_SKI1_1 535 539 PF00082 0.525
CLV_PCSK_SKI1_1 648 652 PF00082 0.407
CLV_PCSK_SKI1_1 656 660 PF00082 0.446
CLV_PCSK_SKI1_1 682 686 PF00082 0.265
CLV_PCSK_SKI1_1 746 750 PF00082 0.393
CLV_PCSK_SKI1_1 793 797 PF00082 0.273
CLV_PCSK_SKI1_1 831 835 PF00082 0.356
CLV_Separin_Metazoa 973 977 PF03568 0.651
DEG_APCC_DBOX_1 1021 1029 PF00400 0.664
DEG_APCC_DBOX_1 861 869 PF00400 0.556
DEG_APCC_DBOX_1 975 983 PF00400 0.569
DEG_Nend_Nbox_1 1 3 PF02207 0.604
DEG_SPOP_SBC_1 486 490 PF00917 0.500
DOC_CYCLIN_RxL_1 195 202 PF00134 0.434
DOC_CYCLIN_RxL_1 402 409 PF00134 0.539
DOC_CYCLIN_RxL_1 471 484 PF00134 0.624
DOC_CYCLIN_RxL_1 651 663 PF00134 0.676
DOC_CYCLIN_RxL_1 790 799 PF00134 0.532
DOC_CYCLIN_yCln2_LP_2 507 513 PF00134 0.584
DOC_CYCLIN_yCln2_LP_2 540 546 PF00134 0.279
DOC_MAPK_gen_1 157 164 PF00069 0.476
DOC_MAPK_gen_1 177 187 PF00069 0.554
DOC_MAPK_MEF2A_6 157 164 PF00069 0.612
DOC_MAPK_MEF2A_6 443 450 PF00069 0.676
DOC_MAPK_MEF2A_6 704 713 PF00069 0.342
DOC_PP2B_LxvP_1 507 510 PF13499 0.595
DOC_USP7_MATH_1 253 257 PF00917 0.624
DOC_USP7_MATH_1 300 304 PF00917 0.803
DOC_USP7_MATH_1 335 339 PF00917 0.770
DOC_USP7_MATH_1 566 570 PF00917 0.560
DOC_USP7_MATH_1 918 922 PF00917 0.676
DOC_USP7_UBL2_3 439 443 PF12436 0.674
DOC_WW_Pin1_4 180 185 PF00397 0.479
DOC_WW_Pin1_4 25 30 PF00397 0.718
DOC_WW_Pin1_4 285 290 PF00397 0.754
DOC_WW_Pin1_4 295 300 PF00397 0.729
DOC_WW_Pin1_4 301 306 PF00397 0.727
DOC_WW_Pin1_4 313 318 PF00397 0.800
DOC_WW_Pin1_4 387 392 PF00397 0.482
DOC_WW_Pin1_4 420 425 PF00397 0.496
LIG_14-3-3_CanoR_1 159 165 PF00244 0.627
LIG_14-3-3_CanoR_1 191 200 PF00244 0.404
LIG_14-3-3_CanoR_1 248 257 PF00244 0.599
LIG_14-3-3_CanoR_1 485 495 PF00244 0.525
LIG_14-3-3_CanoR_1 50 54 PF00244 0.622
LIG_14-3-3_CanoR_1 565 571 PF00244 0.599
LIG_14-3-3_CanoR_1 728 737 PF00244 0.333
LIG_14-3-3_CanoR_1 793 798 PF00244 0.473
LIG_14-3-3_CanoR_1 836 846 PF00244 0.561
LIG_14-3-3_CanoR_1 923 929 PF00244 0.758
LIG_APCC_ABBA_1 1 6 PF00400 0.646
LIG_APCC_ABBA_1 849 854 PF00400 0.522
LIG_APCC_ABBA_1 968 973 PF00400 0.704
LIG_BIR_III_4 211 215 PF00653 0.532
LIG_BRCT_BRCA1_1 320 324 PF00533 0.642
LIG_eIF4E_1 261 267 PF01652 0.577
LIG_eIF4E_1 441 447 PF01652 0.677
LIG_eIF4E_1 725 731 PF01652 0.204
LIG_FHA_1 146 152 PF00498 0.744
LIG_FHA_1 192 198 PF00498 0.448
LIG_FHA_1 347 353 PF00498 0.639
LIG_FHA_1 396 402 PF00498 0.595
LIG_FHA_1 420 426 PF00498 0.448
LIG_FHA_1 517 523 PF00498 0.402
LIG_FHA_1 615 621 PF00498 0.377
LIG_FHA_1 838 844 PF00498 0.688
LIG_FHA_1 93 99 PF00498 0.691
LIG_FHA_2 1004 1010 PF00498 0.703
LIG_FHA_2 127 133 PF00498 0.630
LIG_FHA_2 44 50 PF00498 0.600
LIG_FHA_2 632 638 PF00498 0.682
LIG_FHA_2 77 83 PF00498 0.662
LIG_FHA_2 794 800 PF00498 0.482
LIG_FHA_2 811 817 PF00498 0.581
LIG_FHA_2 864 870 PF00498 0.753
LIG_FHA_2 978 984 PF00498 0.686
LIG_GBD_Chelix_1 578 586 PF00786 0.322
LIG_IBAR_NPY_1 850 852 PF08397 0.654
LIG_LIR_Gen_1 260 267 PF02991 0.518
LIG_LIR_Gen_1 52 61 PF02991 0.610
LIG_LIR_Gen_1 550 558 PF02991 0.442
LIG_LIR_Gen_1 62 71 PF02991 0.623
LIG_LIR_Gen_1 621 630 PF02991 0.287
LIG_LIR_Gen_1 816 826 PF02991 0.635
LIG_LIR_Nem_3 260 264 PF02991 0.524
LIG_LIR_Nem_3 437 441 PF02991 0.695
LIG_LIR_Nem_3 52 57 PF02991 0.600
LIG_LIR_Nem_3 550 554 PF02991 0.275
LIG_LIR_Nem_3 588 593 PF02991 0.530
LIG_LIR_Nem_3 60 66 PF02991 0.552
LIG_LIR_Nem_3 621 626 PF02991 0.428
LIG_LIR_Nem_3 726 730 PF02991 0.319
LIG_LIR_Nem_3 816 822 PF02991 0.593
LIG_LYPXL_SIV_4 223 231 PF13949 0.607
LIG_LYPXL_yS_3 224 227 PF13949 0.612
LIG_MLH1_MIPbox_1 320 324 PF16413 0.642
LIG_NRBOX 581 587 PF00104 0.322
LIG_PCNA_yPIPBox_3 157 165 PF02747 0.608
LIG_Pex14_1 572 576 PF04695 0.390
LIG_Pex14_2 434 438 PF04695 0.629
LIG_Rb_pABgroove_1 816 824 PF01858 0.618
LIG_REV1ctd_RIR_1 831 840 PF16727 0.532
LIG_SH2_CRK 261 265 PF00017 0.601
LIG_SH2_CRK 644 648 PF00017 0.639
LIG_SH2_CRK 768 772 PF00017 0.342
LIG_SH2_CRK 844 848 PF00017 0.684
LIG_SH2_NCK_1 220 224 PF00017 0.603
LIG_SH2_PTP2 623 626 PF00017 0.483
LIG_SH2_SRC 789 792 PF00017 0.404
LIG_SH2_STAP1 220 224 PF00017 0.600
LIG_SH2_STAP1 241 245 PF00017 0.621
LIG_SH2_STAP1 261 265 PF00017 0.601
LIG_SH2_STAP1 548 552 PF00017 0.220
LIG_SH2_STAP1 587 591 PF00017 0.377
LIG_SH2_STAP1 596 600 PF00017 0.470
LIG_SH2_STAP1 723 727 PF00017 0.367
LIG_SH2_STAP1 768 772 PF00017 0.400
LIG_SH2_STAT3 19 22 PF00017 0.709
LIG_SH2_STAT3 676 679 PF00017 0.525
LIG_SH2_STAT3 852 855 PF00017 0.655
LIG_SH2_STAT5 1024 1027 PF00017 0.632
LIG_SH2_STAT5 20 23 PF00017 0.638
LIG_SH2_STAT5 265 268 PF00017 0.600
LIG_SH2_STAT5 419 422 PF00017 0.404
LIG_SH2_STAT5 528 531 PF00017 0.471
LIG_SH2_STAT5 551 554 PF00017 0.527
LIG_SH2_STAT5 587 590 PF00017 0.265
LIG_SH2_STAT5 591 594 PF00017 0.404
LIG_SH2_STAT5 623 626 PF00017 0.409
LIG_SH2_STAT5 676 679 PF00017 0.486
LIG_SH2_STAT5 810 813 PF00017 0.632
LIG_SH2_STAT5 852 855 PF00017 0.621
LIG_SH3_3 148 154 PF00018 0.612
LIG_SH3_3 219 225 PF00018 0.606
LIG_SH3_3 665 671 PF00018 0.465
LIG_SH3_3 768 774 PF00018 0.416
LIG_SUMO_SIM_anti_2 349 357 PF11976 0.625
LIG_SUMO_SIM_anti_2 40 46 PF11976 0.647
LIG_SUMO_SIM_anti_2 400 405 PF11976 0.491
LIG_TRAF2_1 1006 1009 PF00917 0.708
LIG_TRAF2_1 131 134 PF00917 0.633
LIG_TRFH_1 19 23 PF08558 0.706
LIG_TYR_ITIM 222 227 PF00017 0.615
LIG_TYR_ITSM 586 593 PF00017 0.355
LIG_UBA3_1 585 594 PF00899 0.358
LIG_WRC_WIRS_1 161 166 PF05994 0.588
LIG_WRC_WIRS_1 396 401 PF05994 0.404
LIG_WRC_WIRS_1 66 71 PF05994 0.619
MOD_CDK_SPxK_1 25 31 PF00069 0.606
MOD_CK1_1 144 150 PF00069 0.778
MOD_CK1_1 338 344 PF00069 0.689
MOD_CK1_1 430 436 PF00069 0.624
MOD_CK1_1 733 739 PF00069 0.289
MOD_CK1_1 837 843 PF00069 0.684
MOD_CK1_1 883 889 PF00069 0.637
MOD_CK1_1 902 908 PF00069 0.680
MOD_CK1_1 977 983 PF00069 0.695
MOD_CK2_1 1003 1009 PF00069 0.706
MOD_CK2_1 120 126 PF00069 0.632
MOD_CK2_1 127 133 PF00069 0.615
MOD_CK2_1 487 493 PF00069 0.518
MOD_CK2_1 49 55 PF00069 0.563
MOD_CK2_1 631 637 PF00069 0.683
MOD_CK2_1 76 82 PF00069 0.722
MOD_CK2_1 800 806 PF00069 0.664
MOD_CK2_1 936 942 PF00069 0.761
MOD_CK2_1 977 983 PF00069 0.714
MOD_GlcNHglycan 1030 1033 PF01048 0.413
MOD_GlcNHglycan 109 112 PF01048 0.591
MOD_GlcNHglycan 122 125 PF01048 0.633
MOD_GlcNHglycan 142 146 PF01048 0.506
MOD_GlcNHglycan 336 340 PF01048 0.639
MOD_GlcNHglycan 341 344 PF01048 0.497
MOD_GlcNHglycan 365 368 PF01048 0.563
MOD_GlcNHglycan 370 373 PF01048 0.545
MOD_GlcNHglycan 453 456 PF01048 0.500
MOD_GlcNHglycan 507 510 PF01048 0.332
MOD_GlcNHglycan 628 631 PF01048 0.470
MOD_GlcNHglycan 71 74 PF01048 0.445
MOD_GlcNHglycan 732 735 PF01048 0.485
MOD_GlcNHglycan 85 88 PF01048 0.405
MOD_GlcNHglycan 886 889 PF01048 0.559
MOD_GlcNHglycan 892 895 PF01048 0.555
MOD_GlcNHglycan 901 904 PF01048 0.562
MOD_GlcNHglycan 920 923 PF01048 0.387
MOD_GlcNHglycan 963 966 PF01048 0.501
MOD_GlcNHglycan 976 979 PF01048 0.408
MOD_GSK3_1 1024 1031 PF00069 0.651
MOD_GSK3_1 107 114 PF00069 0.668
MOD_GSK3_1 141 148 PF00069 0.786
MOD_GSK3_1 249 256 PF00069 0.601
MOD_GSK3_1 334 341 PF00069 0.813
MOD_GSK3_1 342 349 PF00069 0.736
MOD_GSK3_1 350 357 PF00069 0.772
MOD_GSK3_1 430 437 PF00069 0.672
MOD_GSK3_1 481 488 PF00069 0.600
MOD_GSK3_1 561 568 PF00069 0.612
MOD_GSK3_1 610 617 PF00069 0.296
MOD_GSK3_1 65 72 PF00069 0.622
MOD_GSK3_1 689 696 PF00069 0.412
MOD_GSK3_1 729 736 PF00069 0.275
MOD_GSK3_1 800 807 PF00069 0.678
MOD_GSK3_1 880 887 PF00069 0.715
MOD_GSK3_1 895 902 PF00069 0.679
MOD_LATS_1 469 475 PF00433 0.539
MOD_N-GLC_1 350 355 PF02516 0.530
MOD_N-GLC_1 486 491 PF02516 0.433
MOD_N-GLC_1 76 81 PF02516 0.455
MOD_N-GLC_1 793 798 PF02516 0.332
MOD_N-GLC_2 870 872 PF02516 0.421
MOD_NEK2_1 160 165 PF00069 0.627
MOD_NEK2_1 249 254 PF00069 0.542
MOD_NEK2_1 257 262 PF00069 0.573
MOD_NEK2_1 427 432 PF00069 0.601
MOD_NEK2_1 43 48 PF00069 0.676
MOD_NEK2_1 434 439 PF00069 0.736
MOD_NEK2_1 516 521 PF00069 0.376
MOD_NEK2_1 547 552 PF00069 0.295
MOD_NEK2_1 585 590 PF00069 0.414
MOD_NEK2_1 626 631 PF00069 0.400
MOD_NEK2_1 69 74 PF00069 0.640
MOD_NEK2_1 713 718 PF00069 0.464
MOD_NEK2_1 730 735 PF00069 0.317
MOD_NEK2_1 834 839 PF00069 0.631
MOD_NEK2_1 974 979 PF00069 0.663
MOD_NEK2_2 618 623 PF00069 0.253
MOD_NEK2_2 92 97 PF00069 0.538
MOD_NEK2_2 924 929 PF00069 0.620
MOD_PIKK_1 1003 1009 PF00454 0.714
MOD_PIKK_1 101 107 PF00454 0.783
MOD_PIKK_1 191 197 PF00454 0.518
MOD_PIKK_1 427 433 PF00454 0.579
MOD_PIKK_1 766 772 PF00454 0.400
MOD_PIKK_1 783 789 PF00454 0.358
MOD_PIKK_1 837 843 PF00454 0.691
MOD_PIKK_1 936 942 PF00454 0.761
MOD_PK_1 37 43 PF00069 0.688
MOD_PK_1 594 600 PF00069 0.329
MOD_PKA_1 556 562 PF00069 0.542
MOD_PKA_2 450 456 PF00069 0.758
MOD_PKA_2 49 55 PF00069 0.630
MOD_PKA_2 556 562 PF00069 0.620
MOD_PKA_2 835 841 PF00069 0.549
MOD_Plk_1 350 356 PF00069 0.625
MOD_Plk_1 793 799 PF00069 0.545
MOD_Plk_1 804 810 PF00069 0.678
MOD_Plk_2-3 49 55 PF00069 0.630
MOD_Plk_4 213 219 PF00069 0.436
MOD_Plk_4 288 294 PF00069 0.622
MOD_Plk_4 318 324 PF00069 0.700
MOD_Plk_4 350 356 PF00069 0.638
MOD_Plk_4 547 553 PF00069 0.291
MOD_Plk_4 585 591 PF00069 0.354
MOD_Plk_4 618 624 PF00069 0.279
MOD_Plk_4 65 71 PF00069 0.557
MOD_Plk_4 654 660 PF00069 0.570
MOD_Plk_4 793 799 PF00069 0.532
MOD_Plk_4 805 811 PF00069 0.593
MOD_Plk_4 817 823 PF00069 0.505
MOD_ProDKin_1 180 186 PF00069 0.479
MOD_ProDKin_1 25 31 PF00069 0.721
MOD_ProDKin_1 285 291 PF00069 0.754
MOD_ProDKin_1 295 301 PF00069 0.728
MOD_ProDKin_1 313 319 PF00069 0.738
MOD_ProDKin_1 387 393 PF00069 0.482
MOD_ProDKin_1 420 426 PF00069 0.496
MOD_SUMO_for_1 750 753 PF00179 0.193
TRG_DiLeu_BaEn_1 726 731 PF01217 0.339
TRG_DiLeu_BaLyEn_6 13 18 PF01217 0.681
TRG_DiLeu_BaLyEn_6 156 161 PF01217 0.521
TRG_DiLeu_BaLyEn_6 245 250 PF01217 0.608
TRG_ENDOCYTIC_2 224 227 PF00928 0.587
TRG_ENDOCYTIC_2 261 264 PF00928 0.602
TRG_ENDOCYTIC_2 551 554 PF00928 0.536
TRG_ENDOCYTIC_2 590 593 PF00928 0.431
TRG_ENDOCYTIC_2 623 626 PF00928 0.409
TRG_ENDOCYTIC_2 644 647 PF00928 0.641
TRG_ENDOCYTIC_2 687 690 PF00928 0.601
TRG_ENDOCYTIC_2 727 730 PF00928 0.317
TRG_ENDOCYTIC_2 768 771 PF00928 0.342
TRG_ENDOCYTIC_2 819 822 PF00928 0.575
TRG_ER_diArg_1 461 464 PF00400 0.702
TRG_NES_CRM1_1 787 799 PF08389 0.469
TRG_Pf-PMV_PEXEL_1 198 202 PF00026 0.269

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1P9Z8 Leptomonas seymouri 50% 97%
A0A1X0NKY1 Trypanosomatidae 32% 100%
A0A3S5H5B0 Leishmania donovani 68% 97%
A4HS47 Leishmania infantum 68% 97%
C9ZY45 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
E9AK34 Leishmania mexicana (strain MHOM/GT/2001/U1103) 68% 98%
O97203 Leishmania major 67% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS