NTP_transf_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleotidyltransferase domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H3X0_LEIBR

TriTrypDb:

LbrM.04.0550 , LBRM2903_040010500

Length:

3055

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	6
GO:0031499	TRAMP complex	3	6
GO:0032991	protein-containing complex	1	6
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	6
GO:0140513	nuclear protein-containing complex	2	6

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Expansion

Sequence features

A4H3X0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006396	RNA processing	6	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016070	RNA metabolic process	5	6
GO:0031123	RNA 3'-end processing	7	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0043170	macromolecule metabolic process	3	6

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004652	obsolete polynucleotide adenylyltransferase activity	6	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016779	nucleotidyltransferase activity	4	6
GO:0050265	RNA uridylyltransferase activity	4	6
GO:0070566	adenylyltransferase activity	5	6
GO:0070569	uridylyltransferase activity	5	6
GO:0140098	catalytic activity, acting on RNA	3	6
GO:0140640	catalytic activity, acting on a nucleic acid	2	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1150	1154	PF00656	0.537
CLV_C14_Caspase3-7	1224	1228	PF00656	0.597
CLV_C14_Caspase3-7	129	133	PF00656	0.425
CLV_C14_Caspase3-7	1573	1577	PF00656	0.539
CLV_C14_Caspase3-7	1964	1968	PF00656	0.613
CLV_C14_Caspase3-7	226	230	PF00656	0.686
CLV_C14_Caspase3-7	337	341	PF00656	0.476
CLV_C14_Caspase3-7	58	62	PF00656	0.480
CLV_NRD_NRD_1	1040	1042	PF00675	0.583
CLV_NRD_NRD_1	1093	1095	PF00675	0.336

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WNR5	Leishmania donovani	56%	100%
A4HS45	Leishmania infantum	56%	100%
E9AK32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
O97205	Leishmania major	56%	96%

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