Complex I-B14.5a

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Complex I-B14.5a

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3W9_LEIBR

TriTrypDb:

LbrM.04.0540 , LBRM2903_040010400

Length:

325

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3W9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3W9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.523
CLV_NRD_NRD_1	14	16	PF00675	0.471
CLV_NRD_NRD_1	142	144	PF00675	0.567
CLV_NRD_NRD_1	197	199	PF00675	0.702
CLV_NRD_NRD_1	274	276	PF00675	0.753
CLV_NRD_NRD_1	70	72	PF00675	0.638
CLV_PCSK_KEX2_1	14	16	PF00082	0.449
CLV_PCSK_KEX2_1	142	144	PF00082	0.567
CLV_PCSK_KEX2_1	197	199	PF00082	0.702
CLV_PCSK_KEX2_1	27	29	PF00082	0.436
CLV_PCSK_KEX2_1	274	276	PF00082	0.546
CLV_PCSK_KEX2_1	54	56	PF00082	0.607
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.525
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.458
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.607
CLV_PCSK_PC7_1	193	199	PF00082	0.518
CLV_PCSK_SKI1_1	309	313	PF00082	0.528
CLV_PCSK_SKI1_1	91	95	PF00082	0.594
DEG_APCC_DBOX_1	78	86	PF00400	0.613
DEG_SPOP_SBC_1	231	235	PF00917	0.627
DOC_CYCLIN_RxL_1	28	39	PF00134	0.514
DOC_MAPK_gen_1	34	40	PF00069	0.444
DOC_PP2B_LxvP_1	95	98	PF13499	0.506
DOC_PP4_FxxP_1	208	211	PF00568	0.490
DOC_PP4_FxxP_1	58	61	PF00568	0.519
DOC_USP7_MATH_1	2	6	PF00917	0.496
DOC_USP7_MATH_1	213	217	PF00917	0.681
DOC_USP7_MATH_1	218	222	PF00917	0.675
DOC_USP7_MATH_1	224	228	PF00917	0.667
DOC_USP7_MATH_1	231	235	PF00917	0.637
DOC_USP7_MATH_1	317	321	PF00917	0.598
DOC_USP7_UBL2_3	199	203	PF12436	0.653
DOC_USP7_UBL2_3	309	313	PF12436	0.578
DOC_USP7_UBL2_3	318	322	PF12436	0.646
LIG_14-3-3_CanoR_1	113	119	PF00244	0.576
LIG_Actin_WH2_2	78	96	PF00022	0.592
LIG_BIR_II_1	1	5	PF00653	0.468
LIG_FHA_1	299	305	PF00498	0.568
LIG_FHA_1	88	94	PF00498	0.542
LIG_FHA_2	131	137	PF00498	0.504
LIG_FHA_2	149	155	PF00498	0.702
LIG_LIR_Apic_2	207	211	PF02991	0.493
LIG_LIR_Apic_2	88	92	PF02991	0.469
LIG_LIR_Gen_1	115	126	PF02991	0.485
LIG_LIR_Gen_1	53	63	PF02991	0.518
LIG_LIR_Nem_3	115	121	PF02991	0.498
LIG_LIR_Nem_3	53	59	PF02991	0.556
LIG_SH2_CRK	89	93	PF00017	0.591
LIG_SH2_NCK_1	118	122	PF00017	0.585
LIG_SH2_SRC	182	185	PF00017	0.491
LIG_SH2_STAT5	182	185	PF00017	0.726
LIG_SH2_STAT5	89	92	PF00017	0.569
LIG_SH3_2	49	54	PF14604	0.591
LIG_SH3_3	105	111	PF00018	0.549
LIG_SH3_3	46	52	PF00018	0.539
LIG_TRAF2_1	247	250	PF00917	0.630
LIG_TRAF2_1	48	51	PF00917	0.577
LIG_TYR_ITIM	116	121	PF00017	0.595
MOD_CK1_1	149	155	PF00069	0.517
MOD_CK1_1	171	177	PF00069	0.512
MOD_CK1_1	216	222	PF00069	0.674
MOD_CK1_1	226	232	PF00069	0.672
MOD_CK1_1	269	275	PF00069	0.658
MOD_CK1_1	296	302	PF00069	0.618
MOD_CK1_1	305	311	PF00069	0.573
MOD_CK1_1	4	10	PF00069	0.454
MOD_CK2_1	148	154	PF00069	0.579
MOD_CK2_1	160	166	PF00069	0.638
MOD_Cter_Amidation	195	198	PF01082	0.519
MOD_GlcNHglycan	150	154	PF01048	0.666
MOD_GlcNHglycan	194	197	PF01048	0.769
MOD_GlcNHglycan	218	221	PF01048	0.748
MOD_GlcNHglycan	257	260	PF01048	0.550
MOD_GlcNHglycan	295	298	PF01048	0.558
MOD_GlcNHglycan	305	308	PF01048	0.549
MOD_GlcNHglycan	44	47	PF01048	0.487
MOD_GSK3_1	214	221	PF00069	0.753
MOD_GSK3_1	222	229	PF00069	0.671
MOD_GSK3_1	255	262	PF00069	0.561
MOD_GSK3_1	265	272	PF00069	0.533
MOD_GSK3_1	276	283	PF00069	0.610
MOD_GSK3_1	298	305	PF00069	0.622
MOD_GSK3_1	317	324	PF00069	0.467
MOD_N-GLC_1	168	173	PF02516	0.598
MOD_N-GLC_1	276	281	PF02516	0.540
MOD_NEK2_1	1	6	PF00069	0.470
MOD_NEK2_1	295	300	PF00069	0.671
MOD_NEK2_1	36	41	PF00069	0.524
MOD_NEK2_2	22	27	PF00069	0.530
MOD_PKA_2	112	118	PF00069	0.491
MOD_PKA_2	192	198	PF00069	0.715
MOD_PKB_1	28	36	PF00069	0.345
MOD_Plk_1	36	42	PF00069	0.496
MOD_Plk_2-3	249	255	PF00069	0.526
MOD_Plk_4	276	282	PF00069	0.543
TRG_ENDOCYTIC_2	118	121	PF00928	0.593
TRG_ER_diArg_1	14	17	PF00400	0.471
TRG_ER_diArg_1	273	275	PF00400	0.698
TRG_NLS_Bipartite_1	10	31	PF00514	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II41	Leptomonas seymouri	60%	100%
A0A1X0NL53	Trypanosomatidae	38%	100%
A0A3S7WNR7	Leishmania donovani	80%	100%
A4HS44	Leishmania infantum	79%	100%
E9AK31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
O97206	Leishmania major	77%	98%
V5B9E1	Trypanosoma cruzi	38%	100%