TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4H3W2_LEIBR

TriTrypDb:

LbrM.04.0460 , LBRM2903_040009200

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3W2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3W2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	6	8	PF00675	0.652
CLV_PCSK_KEX2_1	8	10	PF00082	0.646
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.699
CLV_PCSK_SKI1_1	137	141	PF00082	0.477
CLV_PCSK_SKI1_1	201	205	PF00082	0.353
CLV_PCSK_SKI1_1	244	248	PF00082	0.396
CLV_PCSK_SKI1_1	249	253	PF00082	0.346
CLV_PCSK_SKI1_1	271	275	PF00082	0.387
CLV_PCSK_SKI1_1	39	43	PF00082	0.391
DEG_ODPH_VHL_1	53	65	PF01847	0.439
DOC_CDC14_PxL_1	51	59	PF14671	0.452
DOC_CYCLIN_RxL_1	244	256	PF00134	0.370
DOC_PP1_RVXF_1	175	181	PF00149	0.422
DOC_SPAK_OSR1_1	97	101	PF12202	0.510
DOC_USP7_UBL2_3	15	19	PF12436	0.609
LIG_14-3-3_CanoR_1	39	44	PF00244	0.520
LIG_14-3-3_CanoR_1	7	16	PF00244	0.546
LIG_APCC_ABBA_1	53	58	PF00400	0.509
LIG_BIR_II_1	1	5	PF00653	0.725
LIG_BIR_III_1	1	5	PF00653	0.512
LIG_BIR_III_3	1	5	PF00653	0.800
LIG_eIF4E_1	146	152	PF01652	0.412
LIG_FHA_1	223	229	PF00498	0.475
LIG_FHA_1	309	315	PF00498	0.476
LIG_FHA_1	334	340	PF00498	0.501
LIG_FHA_1	8	14	PF00498	0.662
LIG_FHA_2	168	174	PF00498	0.454
LIG_FHA_2	265	271	PF00498	0.465
LIG_GBD_Chelix_1	147	155	PF00786	0.293
LIG_NRBOX	146	152	PF00104	0.496
LIG_NRBOX	250	256	PF00104	0.416
LIG_PCNA_yPIPBox_3	244	255	PF02747	0.508
LIG_PCNA_yPIPBox_3	83	96	PF02747	0.407
LIG_PDZ_Class_1	355	360	PF00595	0.358
LIG_Pex14_1	29	33	PF04695	0.372
LIG_SH2_CRK	144	148	PF00017	0.419
LIG_SH2_SRC	56	59	PF00017	0.455
LIG_SH2_STAP1	144	148	PF00017	0.487
LIG_SH2_STAP1	217	221	PF00017	0.451
LIG_SH2_STAT5	117	120	PF00017	0.485
LIG_SH2_STAT5	146	149	PF00017	0.447
LIG_SH2_STAT5	33	36	PF00017	0.384
LIG_SH2_STAT5	56	59	PF00017	0.500
LIG_SH3_3	49	55	PF00018	0.521
LIG_SUMO_SIM_anti_2	250	256	PF11976	0.523
LIG_SUMO_SIM_anti_2	298	306	PF11976	0.695
LIG_SUMO_SIM_par_1	250	256	PF11976	0.450
LIG_TRAF2_1	234	237	PF00917	0.549
LIG_TRAF2_1	295	298	PF00917	0.472
LIG_TRFH_1	51	55	PF08558	0.534
LIG_UBA3_1	151	159	PF00899	0.348
LIG_WRC_WIRS_1	40	45	PF05994	0.516
MOD_CK2_1	102	108	PF00069	0.476
MOD_CK2_1	151	157	PF00069	0.489
MOD_CK2_1	167	173	PF00069	0.539
MOD_CK2_1	264	270	PF00069	0.492
MOD_CK2_1	273	279	PF00069	0.415
MOD_CK2_1	303	309	PF00069	0.672
MOD_CK2_1	341	347	PF00069	0.478
MOD_CK2_1	56	62	PF00069	0.432
MOD_GlcNHglycan	105	108	PF01048	0.550
MOD_GlcNHglycan	137	140	PF01048	0.545
MOD_GlcNHglycan	196	199	PF01048	0.471
MOD_GlcNHglycan	305	308	PF01048	0.642
MOD_GSK3_1	11	18	PF00069	0.619
MOD_GSK3_1	129	136	PF00069	0.627
MOD_GSK3_1	3	10	PF00069	0.697
MOD_GSK3_1	303	310	PF00069	0.586
MOD_GSK3_1	98	105	PF00069	0.525
MOD_NEK2_1	264	269	PF00069	0.475
MOD_NEK2_1	355	360	PF00069	0.533
MOD_PKA_1	7	13	PF00069	0.623
MOD_PKA_2	222	228	PF00069	0.478
MOD_PKB_1	7	15	PF00069	0.536
MOD_Plk_1	255	261	PF00069	0.405
MOD_Plk_1	61	67	PF00069	0.530
MOD_Plk_2-3	250	256	PF00069	0.301
MOD_Plk_4	250	256	PF00069	0.423
MOD_Plk_4	310	316	PF00069	0.426
MOD_SUMO_for_1	43	46	PF00179	0.395
MOD_SUMO_rev_2	154	160	PF00179	0.503
TRG_DiLeu_BaEn_1	250	255	PF01217	0.413
TRG_DiLeu_BaEn_1	270	275	PF01217	0.387
TRG_ENDOCYTIC_2	144	147	PF00928	0.421
TRG_ENDOCYTIC_2	84	87	PF00928	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0D5	Leptomonas seymouri	77%	98%
A0A0S4JCG4	Bodo saltans	44%	75%
A0A1X0NKZ6	Trypanosomatidae	43%	100%
A0A3R7R703	Trypanosoma rangeli	46%	100%
A0A3S5H5A3	Leishmania donovani	92%	100%
A4HS36	Leishmania infantum	92%	100%
C9ZY33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AK23	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O97220	Leishmania major	91%	100%
V5D9X8	Trypanosoma cruzi	45%	100%