Anaphase promoting complex, subunit 10-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

anaphase promoting complex, subunit 10-like protein

Species:

Leishmania braziliensis

UniProt:

A4H3W0_LEIBR

TriTrypDb:

LbrM.04.0440 , LBRM2903_040009000

Length:

337

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	10
GO:0000152	nuclear ubiquitin ligase complex	3	10
GO:0005680	anaphase-promoting complex	4	10
GO:0031461	cullin-RING ubiquitin ligase complex	4	10
GO:0032991	protein-containing complex	1	10
GO:0140513	nuclear protein-containing complex	2	10
GO:0140535	intracellular protein-containing complex	2	10
GO:1902494	catalytic complex	2	10
GO:1990234	transferase complex	3	10

Expansion

Sequence features

A4H3W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3W0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	10
GO:0006511	ubiquitin-dependent protein catabolic process	7	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0007049	cell cycle	2	10
GO:0008152	metabolic process	1	10
GO:0009056	catabolic process	2	10
GO:0009057	macromolecule catabolic process	4	10
GO:0009987	cellular process	1	10
GO:0010498	proteasomal protein catabolic process	5	10
GO:0019538	protein metabolic process	3	10
GO:0019941	modification-dependent protein catabolic process	6	10
GO:0030163	protein catabolic process	4	10
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	10
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043632	modification-dependent macromolecule catabolic process	5	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044248	cellular catabolic process	3	10
GO:0044260	obsolete cellular macromolecule metabolic process	3	10
GO:0044265	obsolete cellular macromolecule catabolic process	4	10
GO:0051301	cell division	2	10
GO:0051603	proteolysis involved in protein catabolic process	5	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901565	organonitrogen compound catabolic process	4	10
GO:1901575	organic substance catabolic process	3	10
GO:0000209	protein polyubiquitination	8	1
GO:0016567	protein ubiquitination	7	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043412	macromolecule modification	4	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0070979	protein K11-linked ubiquitination	9	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.607
CLV_PCSK_KEX2_1	201	203	PF00082	0.300
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.300
DEG_APCC_DBOX_1	108	116	PF00400	0.530
DEG_COP1_1	34	46	PF00400	0.444
DEG_Nend_UBRbox_2	1	3	PF02207	0.684
DEG_SPOP_SBC_1	241	245	PF00917	0.411
DEG_SPOP_SBC_1	33	37	PF00917	0.639
DOC_CKS1_1	114	119	PF01111	0.530
DOC_PP2B_LxvP_1	49	52	PF13499	0.203
DOC_USP7_MATH_1	24	28	PF00917	0.702
DOC_USP7_MATH_1	241	245	PF00917	0.530
DOC_USP7_MATH_1	33	37	PF00917	0.753
DOC_WW_Pin1_4	113	118	PF00397	0.476
DOC_WW_Pin1_4	131	136	PF00397	0.476
DOC_WW_Pin1_4	217	222	PF00397	0.465
DOC_WW_Pin1_4	247	252	PF00397	0.542
LIG_deltaCOP1_diTrp_1	266	270	PF00928	0.530
LIG_FHA_1	37	43	PF00498	0.576
LIG_FHA_2	114	120	PF00498	0.530
LIG_FHA_2	175	181	PF00498	0.457
LIG_FHA_2	270	276	PF00498	0.530
LIG_FHA_2	328	334	PF00498	0.604
LIG_Integrin_isoDGR_2	284	286	PF01839	0.247
LIG_LIR_Gen_1	162	173	PF02991	0.549
LIG_LIR_Gen_1	45	54	PF02991	0.484
LIG_LIR_Nem_3	162	168	PF02991	0.579
LIG_LIR_Nem_3	45	49	PF02991	0.573
LIG_LYPXL_SIV_4	227	235	PF13949	0.502
LIG_SH2_CRK	228	232	PF00017	0.468
LIG_SH2_GRB2like	124	127	PF00017	0.530
LIG_SH2_NCK_1	228	232	PF00017	0.502
LIG_SH2_SRC	124	127	PF00017	0.502
LIG_SH2_STAP1	228	232	PF00017	0.502
LIG_SH2_STAT5	124	127	PF00017	0.490
LIG_SxIP_EBH_1	219	230	PF03271	0.389
LIG_TRAF2_1	12	15	PF00917	0.579
LIG_TRAF2_1	159	162	PF00917	0.530
LIG_TYR_ITIM	226	231	PF00017	0.502
LIG_WRC_WIRS_1	43	48	PF05994	0.358
MOD_CDK_SPK_2	131	136	PF00069	0.447
MOD_CK1_1	19	25	PF00069	0.704
MOD_CK1_1	209	215	PF00069	0.548
MOD_CK1_1	245	251	PF00069	0.389
MOD_CK1_1	27	33	PF00069	0.632
MOD_CK1_1	36	42	PF00069	0.476
MOD_CK1_1	69	75	PF00069	0.554
MOD_CK2_1	113	119	PF00069	0.530
MOD_CK2_1	327	333	PF00069	0.641
MOD_CK2_1	8	14	PF00069	0.634
MOD_GlcNHglycan	126	129	PF01048	0.316
MOD_GlcNHglycan	145	148	PF01048	0.240
MOD_GlcNHglycan	195	198	PF01048	0.313
MOD_GlcNHglycan	2	6	PF01048	0.574
MOD_GlcNHglycan	244	247	PF01048	0.385
MOD_GlcNHglycan	27	30	PF01048	0.675
MOD_GlcNHglycan	49	52	PF01048	0.366
MOD_GlcNHglycan	68	71	PF01048	0.275
MOD_GlcNHglycan	77	80	PF01048	0.235
MOD_GSK3_1	143	150	PF00069	0.513
MOD_GSK3_1	217	224	PF00069	0.436
MOD_GSK3_1	241	248	PF00069	0.461
MOD_GSK3_1	32	39	PF00069	0.572
MOD_N-GLC_1	259	264	PF02516	0.314
MOD_NEK2_1	235	240	PF00069	0.381
MOD_NEK2_1	269	274	PF00069	0.530
MOD_PIKK_1	14	20	PF00454	0.650
MOD_PIKK_1	245	251	PF00454	0.389
MOD_PK_1	9	15	PF00069	0.636
MOD_PKA_2	304	310	PF00069	0.554
MOD_PKA_2	8	14	PF00069	0.634
MOD_Plk_1	129	135	PF00069	0.447
MOD_Plk_1	9	15	PF00069	0.636
MOD_Plk_4	269	275	PF00069	0.533
MOD_Plk_4	69	75	PF00069	0.533
MOD_ProDKin_1	113	119	PF00069	0.476
MOD_ProDKin_1	131	137	PF00069	0.476
MOD_ProDKin_1	217	223	PF00069	0.465
MOD_ProDKin_1	247	253	PF00069	0.542
TRG_ENDOCYTIC_2	228	231	PF00928	0.550
TRG_ENDOCYTIC_2	300	303	PF00928	0.530
TRG_NES_CRM1_1	148	161	PF08389	0.389
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.241

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2G0	Leptomonas seymouri	56%	98%
A0A1X0P6H6	Trypanosomatidae	36%	100%
A0A3R7LQ45	Trypanosoma rangeli	36%	100%
A0A3S5H5A1	Leishmania donovani	76%	99%
A4HS34	Leishmania infantum	76%	99%
E9AK21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q9U198	Leishmania major	74%	100%
V5BNI3	Trypanosoma cruzi	39%	100%