Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H3V9_LEIBR

TriTrypDb:

LbrM.04.0430 , LBRM2903_040008900

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 1
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4H3V9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3V9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.718
CLV_C14_Caspase3-7	252	256	PF00656	0.594
CLV_NRD_NRD_1	228	230	PF00675	0.587
CLV_NRD_NRD_1	249	251	PF00675	0.402
CLV_NRD_NRD_1	84	86	PF00675	0.630
CLV_PCSK_KEX2_1	228	230	PF00082	0.587
CLV_PCSK_KEX2_1	249	251	PF00082	0.402
CLV_PCSK_SKI1_1	70	74	PF00082	0.607
DEG_APCC_DBOX_1	84	92	PF00400	0.256
DEG_Nend_Nbox_1	1	3	PF02207	0.449
DOC_PP2B_LxvP_1	22	25	PF13499	0.447
DOC_USP7_MATH_1	199	203	PF00917	0.692
DOC_USP7_MATH_1	213	217	PF00917	0.607
DOC_USP7_MATH_1	31	35	PF00917	0.404
DOC_USP7_MATH_1	75	79	PF00917	0.344
DOC_WW_Pin1_4	149	154	PF00397	0.545
DOC_WW_Pin1_4	47	52	PF00397	0.436
LIG_14-3-3_CanoR_1	128	136	PF00244	0.263
LIG_14-3-3_CanoR_1	148	152	PF00244	0.372
LIG_14-3-3_CanoR_1	228	233	PF00244	0.752
LIG_14-3-3_CanoR_1	249	254	PF00244	0.677
LIG_BRCT_BRCA1_1	201	205	PF00533	0.681
LIG_BRCT_BRCA1_1	220	224	PF00533	0.678
LIG_deltaCOP1_diTrp_1	84	89	PF00928	0.404
LIG_DLG_GKlike_1	249	257	PF00625	0.597
LIG_FHA_1	27	33	PF00498	0.330
LIG_FHA_1	58	64	PF00498	0.351
LIG_FHA_2	132	138	PF00498	0.461
LIG_FHA_2	31	37	PF00498	0.371
LIG_LIR_Apic_2	150	154	PF02991	0.537
LIG_LIR_Gen_1	33	41	PF02991	0.314
LIG_LIR_Nem_3	113	119	PF02991	0.408
LIG_LIR_Nem_3	133	139	PF02991	0.380
LIG_LIR_Nem_3	33	38	PF02991	0.466
LIG_LIR_Nem_3	84	90	PF02991	0.432
LIG_LYPXL_yS_3	139	142	PF13949	0.429
LIG_SH2_GRB2like	136	139	PF00017	0.467
LIG_SH2_GRB2like	80	83	PF00017	0.396
LIG_SH2_NCK_1	151	155	PF00017	0.544
LIG_SH2_NCK_1	189	193	PF00017	0.583
LIG_SH2_SRC	189	192	PF00017	0.581
LIG_SH2_SRC	80	83	PF00017	0.434
LIG_SH2_STAP1	145	149	PF00017	0.332
LIG_SH2_STAP1	55	59	PF00017	0.469
LIG_SH2_STAT5	116	119	PF00017	0.347
LIG_SH2_STAT5	124	127	PF00017	0.276
LIG_SH2_STAT5	180	183	PF00017	0.304
LIG_SH2_STAT5	76	79	PF00017	0.317
LIG_SH2_STAT5	80	83	PF00017	0.332
LIG_SH2_STAT5	90	93	PF00017	0.293
LIG_SUMO_SIM_par_1	163	169	PF11976	0.303
LIG_WRC_WIRS_1	32	37	PF05994	0.432
MOD_CDK_SPxxK_3	149	156	PF00069	0.544
MOD_CK1_1	15	21	PF00069	0.550
MOD_CK1_1	204	210	PF00069	0.683
MOD_CK1_1	215	221	PF00069	0.689
MOD_CK1_1	223	229	PF00069	0.687
MOD_CK1_1	230	236	PF00069	0.708
MOD_CK1_1	243	249	PF00069	0.660
MOD_CK1_1	26	32	PF00069	0.339
MOD_CK2_1	149	155	PF00069	0.546
MOD_CK2_1	228	234	PF00069	0.698
MOD_GlcNHglycan	108	111	PF01048	0.598
MOD_GlcNHglycan	17	20	PF01048	0.624
MOD_GlcNHglycan	201	204	PF01048	0.481
MOD_GlcNHglycan	77	80	PF01048	0.586
MOD_GSK3_1	106	113	PF00069	0.411
MOD_GSK3_1	193	200	PF00069	0.716
MOD_GSK3_1	204	211	PF00069	0.672
MOD_GSK3_1	215	222	PF00069	0.713
MOD_GSK3_1	223	230	PF00069	0.688
MOD_GSK3_1	239	246	PF00069	0.732
MOD_GSK3_1	249	256	PF00069	0.615
MOD_GSK3_1	26	33	PF00069	0.390
MOD_GSK3_1	54	61	PF00069	0.363
MOD_GSK3_1	97	104	PF00069	0.455
MOD_N-GLC_1	102	107	PF02516	0.595
MOD_NEK2_1	101	106	PF00069	0.456
MOD_NEK2_1	12	17	PF00069	0.575
MOD_NEK2_1	130	135	PF00069	0.430
MOD_NEK2_1	166	171	PF00069	0.346
MOD_NEK2_1	224	229	PF00069	0.732
MOD_NEK2_1	244	249	PF00069	0.681
MOD_NEK2_1	54	59	PF00069	0.346
MOD_NEK2_1	62	67	PF00069	0.320
MOD_PIKK_1	102	108	PF00454	0.429
MOD_PIKK_1	122	128	PF00454	0.265
MOD_PIKK_1	234	240	PF00454	0.722
MOD_PIKK_1	70	76	PF00454	0.351
MOD_PKA_1	228	234	PF00069	0.782
MOD_PKA_1	249	255	PF00069	0.599
MOD_PKA_1	70	76	PF00069	0.388
MOD_PKA_2	147	153	PF00069	0.363
MOD_PKA_2	207	213	PF00069	0.607
MOD_PKA_2	227	233	PF00069	0.741
MOD_PKA_2	248	254	PF00069	0.611
MOD_PKB_1	206	214	PF00069	0.612
MOD_Plk_1	102	108	PF00069	0.422
MOD_Plk_1	26	32	PF00069	0.310
MOD_Plk_4	58	64	PF00069	0.442
MOD_Plk_4	97	103	PF00069	0.455
MOD_ProDKin_1	149	155	PF00069	0.546
MOD_ProDKin_1	47	53	PF00069	0.433
MOD_SUMO_rev_2	150	159	PF00179	0.400
MOD_SUMO_rev_2	65	73	PF00179	0.411
MOD_SUMO_rev_2	78	88	PF00179	0.272
TRG_ENDOCYTIC_2	139	142	PF00928	0.391
TRG_ER_diArg_1	205	208	PF00400	0.614
TRG_NLS_MonoExtC_3	184	190	PF00514	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRH3	Leptomonas seymouri	27%	94%
A0A0N1HTB7	Leptomonas seymouri	32%	87%
A0A0N1PBW5	Leptomonas seymouri	34%	89%
A0A3S7WNP1	Leishmania donovani	66%	100%
A4HS33	Leishmania infantum	66%	100%
E9AK20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q9XZX6	Leishmania major	68%	100%