LeishMANIAdb
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Reverse transcriptase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Reverse transcriptase domain-containing protein
Gene product:
hypothetical protein
Species:
Leishmania braziliensis
UniProt:
A4H3V8_LEIBR
TriTrypDb:
LbrM.04.0420 , LBRM2903_220020300
Length:
358

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3V8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3V8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 10 12 PF00675 0.583
CLV_NRD_NRD_1 31 33 PF00675 0.738
CLV_NRD_NRD_1 324 326 PF00675 0.763
CLV_PCSK_KEX2_1 132 134 PF00082 0.511
CLV_PCSK_KEX2_1 288 290 PF00082 0.659
CLV_PCSK_KEX2_1 31 33 PF00082 0.728
CLV_PCSK_KEX2_1 324 326 PF00082 0.763
CLV_PCSK_KEX2_1 96 98 PF00082 0.726
CLV_PCSK_PC1ET2_1 132 134 PF00082 0.611
CLV_PCSK_PC1ET2_1 288 290 PF00082 0.683
CLV_PCSK_PC1ET2_1 96 98 PF00082 0.726
CLV_PCSK_PC7_1 320 326 PF00082 0.760
CLV_PCSK_SKI1_1 147 151 PF00082 0.390
CLV_PCSK_SKI1_1 175 179 PF00082 0.490
CLV_PCSK_SKI1_1 187 191 PF00082 0.358
CLV_PCSK_SKI1_1 324 328 PF00082 0.766
CLV_PCSK_SKI1_1 72 76 PF00082 0.683
DEG_Nend_Nbox_1 1 3 PF02207 0.642
DOC_ANK_TNKS_1 333 340 PF00023 0.644
DOC_CKS1_1 253 258 PF01111 0.658
DOC_CYCLIN_RxL_1 183 192 PF00134 0.622
DOC_MAPK_DCC_7 120 130 PF00069 0.619
DOC_MAPK_DCC_7 187 195 PF00069 0.589
DOC_MAPK_gen_1 217 225 PF00069 0.577
DOC_MAPK_gen_1 284 292 PF00069 0.545
DOC_MAPK_MEF2A_6 187 195 PF00069 0.589
DOC_PP2B_LxvP_1 128 131 PF13499 0.629
DOC_PP4_FxxP_1 253 256 PF00568 0.608
DOC_USP7_MATH_1 26 30 PF00917 0.734
DOC_USP7_UBL2_3 284 288 PF12436 0.698
DOC_WW_Pin1_4 14 19 PF00397 0.642
DOC_WW_Pin1_4 252 257 PF00397 0.593
DOC_WW_Pin1_4 326 331 PF00397 0.663
LIG_14-3-3_CanoR_1 133 138 PF00244 0.605
LIG_14-3-3_CanoR_1 224 230 PF00244 0.556
LIG_14-3-3_CanoR_1 77 84 PF00244 0.511
LIG_APCC_ABBA_1 203 208 PF00400 0.573
LIG_BRCT_BRCA1_1 118 122 PF00533 0.414
LIG_FHA_1 109 115 PF00498 0.366
LIG_FHA_1 275 281 PF00498 0.501
LIG_FHA_1 35 41 PF00498 0.547
LIG_FHA_1 77 83 PF00498 0.490
LIG_FHA_2 258 264 PF00498 0.544
LIG_LIR_Apic_2 240 246 PF02991 0.588
LIG_LIR_Apic_2 250 256 PF02991 0.440
LIG_LIR_Gen_1 119 130 PF02991 0.441
LIG_LIR_Nem_3 119 125 PF02991 0.430
LIG_LIR_Nem_3 263 269 PF02991 0.566
LIG_Pex14_1 145 149 PF04695 0.383
LIG_Pex14_2 266 270 PF04695 0.612
LIG_PTB_Apo_2 320 327 PF02174 0.762
LIG_SH2_STAP1 167 171 PF00017 0.623
LIG_SH2_STAP1 206 210 PF00017 0.404
LIG_SH3_2 19 24 PF14604 0.762
LIG_SH3_3 13 19 PF00018 0.693
LIG_SH3_3 182 188 PF00018 0.515
LIG_SH3_3 262 268 PF00018 0.683
LIG_SH3_4 24 31 PF00018 0.586
LIG_SUMO_SIM_anti_2 111 119 PF11976 0.364
LIG_SUMO_SIM_par_1 111 119 PF11976 0.364
LIG_TRAF2_1 260 263 PF00917 0.696
LIG_UBA3_1 112 120 PF00899 0.442
MOD_CDK_SPxxK_3 14 21 PF00069 0.714
MOD_CK1_1 237 243 PF00069 0.600
MOD_CK1_1 30 36 PF00069 0.648
MOD_CK1_1 38 44 PF00069 0.519
MOD_CK1_1 76 82 PF00069 0.512
MOD_CK2_1 257 263 PF00069 0.619
MOD_Cter_Amidation 282 285 PF01082 0.673
MOD_Cter_Amidation 94 97 PF01082 0.693
MOD_GlcNHglycan 220 223 PF01048 0.563
MOD_GlcNHglycan 239 242 PF01048 0.267
MOD_GSK3_1 133 140 PF00069 0.608
MOD_GSK3_1 26 33 PF00069 0.697
MOD_GSK3_1 34 41 PF00069 0.512
MOD_N-GLC_1 302 307 PF02516 0.753
MOD_NEK2_1 115 120 PF00069 0.563
MOD_NEK2_1 193 198 PF00069 0.405
MOD_NEK2_1 210 215 PF00069 0.345
MOD_NEK2_1 73 78 PF00069 0.520
MOD_PIKK_1 131 137 PF00454 0.613
MOD_PKA_2 218 224 PF00069 0.571
MOD_PKA_2 30 36 PF00069 0.707
MOD_PKA_2 76 82 PF00069 0.505
MOD_Plk_4 108 114 PF00069 0.552
MOD_Plk_4 193 199 PF00069 0.502
MOD_Plk_4 225 231 PF00069 0.481
MOD_Plk_4 276 282 PF00069 0.618
MOD_ProDKin_1 14 20 PF00069 0.652
MOD_ProDKin_1 252 258 PF00069 0.597
MOD_ProDKin_1 326 332 PF00069 0.668
MOD_SUMO_rev_2 258 266 PF00179 0.599
TRG_DiLeu_BaEn_2 321 327 PF01217 0.761
TRG_DiLeu_BaLyEn_6 124 129 PF01217 0.479
TRG_DiLeu_BaLyEn_6 185 190 PF01217 0.460
TRG_ENDOCYTIC_2 200 203 PF00928 0.553
TRG_ER_diArg_1 324 326 PF00400 0.763

Homologs

Protein Taxonomy Sequence identity Coverage
A4H3V7 Leishmania braziliensis 98% 100%
V5AIG5 Trypanosoma cruzi 31% 99%
V5AKL6 Trypanosoma cruzi 33% 83%
V5AQ13 Trypanosoma cruzi 30% 68%
V5AYH0 Trypanosoma cruzi 32% 90%
V5CYJ8 Trypanosoma cruzi 31% 76%
V5CZT1 Trypanosoma cruzi 31% 100%
V5D055 Trypanosoma cruzi 33% 100%
V5D405 Trypanosoma cruzi 31% 91%
V5DI78 Trypanosoma cruzi 30% 71%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS