Reverse transcriptase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H3V7_LEIBR

TriTrypDb:

LbrM.04.0410 , LBRM2903_220020300

Length:

357

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3V7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3V7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.571
CLV_NRD_NRD_1	30	32	PF00675	0.547
CLV_NRD_NRD_1	323	325	PF00675	0.493
CLV_PCSK_KEX2_1	131	133	PF00082	0.338
CLV_PCSK_KEX2_1	287	289	PF00082	0.654
CLV_PCSK_KEX2_1	30	32	PF00082	0.547
CLV_PCSK_KEX2_1	323	325	PF00082	0.493
CLV_PCSK_KEX2_1	95	97	PF00082	0.454
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.338
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.412
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.454
CLV_PCSK_PC7_1	319	325	PF00082	0.492
CLV_PCSK_SKI1_1	146	150	PF00082	0.278
CLV_PCSK_SKI1_1	174	178	PF00082	0.370
CLV_PCSK_SKI1_1	186	190	PF00082	0.283
CLV_PCSK_SKI1_1	323	327	PF00082	0.492
CLV_PCSK_SKI1_1	71	75	PF00082	0.628
DEG_Nend_Nbox_1	1	3	PF02207	0.418
DOC_CKS1_1	252	257	PF01111	0.388
DOC_CYCLIN_RxL_1	182	191	PF00134	0.364
DOC_MAPK_DCC_7	119	129	PF00069	0.343
DOC_MAPK_DCC_7	186	194	PF00069	0.324
DOC_MAPK_gen_1	216	224	PF00069	0.302
DOC_MAPK_gen_1	283	291	PF00069	0.504
DOC_MAPK_MEF2A_6	186	194	PF00069	0.324
DOC_PP2B_LxvP_1	127	130	PF13499	0.357
DOC_PP4_FxxP_1	252	255	PF00568	0.534
DOC_USP7_MATH_1	25	29	PF00917	0.732
DOC_USP7_UBL2_3	283	287	PF12436	0.428
DOC_WW_Pin1_4	14	19	PF00397	0.601
DOC_WW_Pin1_4	251	256	PF00397	0.495
DOC_WW_Pin1_4	325	330	PF00397	0.519
LIG_14-3-3_CanoR_1	132	137	PF00244	0.336
LIG_14-3-3_CanoR_1	76	83	PF00244	0.595
LIG_APCC_ABBA_1	202	207	PF00400	0.296
LIG_BRCT_BRCA1_1	117	121	PF00533	0.298
LIG_FHA_1	108	114	PF00498	0.255
LIG_FHA_1	274	280	PF00498	0.459
LIG_FHA_1	34	40	PF00498	0.425
LIG_FHA_1	76	82	PF00498	0.475
LIG_FHA_2	257	263	PF00498	0.486
LIG_LIR_Apic_2	239	245	PF02991	0.318
LIG_LIR_Apic_2	249	255	PF02991	0.308
LIG_LIR_Gen_1	118	129	PF02991	0.327
LIG_LIR_Nem_3	118	124	PF02991	0.313
LIG_LIR_Nem_3	262	268	PF02991	0.440
LIG_Pex14_1	144	148	PF04695	0.381
LIG_Pex14_2	265	269	PF04695	0.342
LIG_PTB_Apo_2	319	326	PF02174	0.492
LIG_SH2_STAP1	166	170	PF00017	0.350
LIG_SH2_STAP1	205	209	PF00017	0.289
LIG_SH3_2	19	24	PF14604	0.603
LIG_SH3_3	13	19	PF00018	0.536
LIG_SH3_3	181	187	PF00018	0.405
LIG_SH3_3	261	267	PF00018	0.407
LIG_SUMO_SIM_anti_2	110	118	PF11976	0.252
LIG_SUMO_SIM_par_1	110	118	PF11976	0.252
LIG_TRAF2_1	259	262	PF00917	0.427
LIG_UBA3_1	111	119	PF00899	0.315
MOD_CDK_SPxxK_3	14	21	PF00069	0.441
MOD_CK1_1	236	242	PF00069	0.329
MOD_CK1_1	29	35	PF00069	0.584
MOD_CK1_1	37	43	PF00069	0.307
MOD_CK1_1	75	81	PF00069	0.556
MOD_CK2_1	256	262	PF00069	0.563
MOD_Cter_Amidation	281	284	PF01082	0.601
MOD_Cter_Amidation	93	96	PF01082	0.421
MOD_GlcNHglycan	219	222	PF01048	0.290
MOD_GlcNHglycan	238	241	PF01048	0.253
MOD_GSK3_1	132	139	PF00069	0.566
MOD_GSK3_1	25	32	PF00069	0.685
MOD_GSK3_1	33	40	PF00069	0.326
MOD_N-GLC_1	301	306	PF02516	0.633
MOD_NEK2_1	114	119	PF00069	0.288
MOD_NEK2_1	192	197	PF00069	0.291
MOD_NEK2_1	209	214	PF00069	0.240
MOD_NEK2_1	72	77	PF00069	0.401
MOD_PIKK_1	130	136	PF00454	0.546
MOD_PKA_2	217	223	PF00069	0.297
MOD_PKA_2	29	35	PF00069	0.435
MOD_PKA_2	75	81	PF00069	0.514
MOD_Plk_4	107	113	PF00069	0.280
MOD_Plk_4	192	198	PF00069	0.440
MOD_Plk_4	275	281	PF00069	0.351
MOD_ProDKin_1	14	20	PF00069	0.612
MOD_ProDKin_1	251	257	PF00069	0.501
MOD_ProDKin_1	325	331	PF00069	0.521
MOD_SUMO_rev_2	257	265	PF00179	0.480
TRG_DiLeu_BaEn_2	320	326	PF01217	0.491
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.357
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.362
TRG_ENDOCYTIC_2	199	202	PF00928	0.280
TRG_ER_diArg_1	323	325	PF00400	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H3V8	Leishmania braziliensis	98%	100%
V5AIG5	Trypanosoma cruzi	31%	99%
V5AKL6	Trypanosoma cruzi	33%	83%
V5AQ13	Trypanosoma cruzi	30%	68%
V5AYH0	Trypanosoma cruzi	32%	90%
V5CYJ8	Trypanosoma cruzi	31%	76%
V5CZT1	Trypanosoma cruzi	32%	100%
V5D055	Trypanosoma cruzi	32%	100%
V5D405	Trypanosoma cruzi	31%	91%
V5DI78	Trypanosoma cruzi	30%	71%