Putative mitochondrial exoribonuclease DSS-1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial exoribonuclease DSS-1, putative

Species:

Leishmania braziliensis

UniProt:

A4H3V2_LEIBR

TriTrypDb:

LbrM.04.0360 , LBRM2903_040008200

Length:

838

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000178	exosome (RNase complex)	4	1
GO:0032991	protein-containing complex	1	1
GO:1902494	catalytic complex	2	1
GO:1905354	exoribonuclease complex	3	1

Expansion

Sequence features

A4H3V2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3V2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004527	exonuclease activity	5	6
GO:0004532	RNA exonuclease activity	5	6
GO:0004540	RNA nuclease activity	4	12
GO:0005488	binding	1	12
GO:0008408	3'-5' exonuclease activity	6	6
GO:0008859	exoribonuclease II activity	7	6
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	6
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	6
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0000175	3'-5'-RNA exonuclease activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.558
CLV_C14_Caspase3-7	396	400	PF00656	0.454
CLV_C14_Caspase3-7	411	415	PF00656	0.501
CLV_C14_Caspase3-7	483	487	PF00656	0.525
CLV_C14_Caspase3-7	541	545	PF00656	0.495
CLV_C14_Caspase3-7	689	693	PF00656	0.572
CLV_C14_Caspase3-7	834	838	PF00656	0.672
CLV_NRD_NRD_1	232	234	PF00675	0.563
CLV_NRD_NRD_1	24	26	PF00675	0.732
CLV_NRD_NRD_1	288	290	PF00675	0.354
CLV_NRD_NRD_1	350	352	PF00675	0.264
CLV_NRD_NRD_1	559	561	PF00675	0.354
CLV_NRD_NRD_1	592	594	PF00675	0.260
CLV_NRD_NRD_1	611	613	PF00675	0.672
CLV_NRD_NRD_1	707	709	PF00675	0.612
CLV_NRD_NRD_1	744	746	PF00675	0.768
CLV_PCSK_FUR_1	230	234	PF00082	0.550
CLV_PCSK_KEX2_1	232	234	PF00082	0.563
CLV_PCSK_KEX2_1	24	26	PF00082	0.732
CLV_PCSK_KEX2_1	288	290	PF00082	0.354
CLV_PCSK_KEX2_1	350	352	PF00082	0.260
CLV_PCSK_KEX2_1	559	561	PF00082	0.354
CLV_PCSK_KEX2_1	592	594	PF00082	0.260
CLV_PCSK_KEX2_1	611	613	PF00082	0.627
CLV_PCSK_KEX2_1	696	698	PF00082	0.563
CLV_PCSK_KEX2_1	707	709	PF00082	0.603
CLV_PCSK_KEX2_1	744	746	PF00082	0.697
CLV_PCSK_PC1ET2_1	696	698	PF00082	0.492
CLV_PCSK_SKI1_1	176	180	PF00082	0.441
CLV_PCSK_SKI1_1	288	292	PF00082	0.260
CLV_PCSK_SKI1_1	350	354	PF00082	0.264
DEG_APCC_DBOX_1	175	183	PF00400	0.492
DEG_Nend_Nbox_1	1	3	PF02207	0.487
DEG_SPOP_SBC_1	387	391	PF00917	0.516
DEG_SPOP_SBC_1	47	51	PF00917	0.548
DEG_SPOP_SBC_1	622	626	PF00917	0.720
DEG_SPOP_SBC_1	736	740	PF00917	0.700
DEG_SPOP_SBC_1	94	98	PF00917	0.564
DOC_ANK_TNKS_1	231	238	PF00023	0.535
DOC_ANK_TNKS_1	438	445	PF00023	0.395
DOC_CKS1_1	11	16	PF01111	0.714
DOC_CKS1_1	759	764	PF01111	0.630
DOC_CYCLIN_RxL_1	173	180	PF00134	0.497
DOC_CYCLIN_yCln2_LP_2	36	42	PF00134	0.512
DOC_MAPK_gen_1	318	327	PF00069	0.471
DOC_MAPK_gen_1	468	477	PF00069	0.416
DOC_MAPK_gen_1	592	599	PF00069	0.463
DOC_MAPK_gen_1	696	702	PF00069	0.501
DOC_MAPK_gen_1	744	751	PF00069	0.589
DOC_MAPK_JIP1_4	745	751	PF00069	0.709
DOC_PP2B_LxvP_1	729	732	PF13499	0.669
DOC_PP2B_PxIxI_1	464	470	PF00149	0.462
DOC_PP4_FxxP_1	302	305	PF00568	0.460
DOC_PP4_FxxP_1	460	463	PF00568	0.554
DOC_SPAK_OSR1_1	661	665	PF12202	0.483
DOC_USP7_MATH_1	239	243	PF00917	0.478
DOC_USP7_MATH_1	277	281	PF00917	0.524
DOC_USP7_MATH_1	40	44	PF00917	0.795
DOC_USP7_MATH_1	520	524	PF00917	0.577
DOC_USP7_MATH_1	553	557	PF00917	0.534
DOC_USP7_MATH_1	637	641	PF00917	0.503
DOC_USP7_MATH_1	719	723	PF00917	0.647
DOC_USP7_MATH_1	732	736	PF00917	0.671
DOC_WW_Pin1_4	10	15	PF00397	0.724
DOC_WW_Pin1_4	35	40	PF00397	0.733
DOC_WW_Pin1_4	388	393	PF00397	0.521
DOC_WW_Pin1_4	586	591	PF00397	0.536
DOC_WW_Pin1_4	690	695	PF00397	0.696
DOC_WW_Pin1_4	758	763	PF00397	0.683
LIG_14-3-3_CanoR_1	112	121	PF00244	0.461
LIG_14-3-3_CanoR_1	288	297	PF00244	0.462
LIG_14-3-3_CanoR_1	318	324	PF00244	0.485
LIG_14-3-3_CanoR_1	350	355	PF00244	0.460
LIG_14-3-3_CanoR_1	4	10	PF00244	0.504
LIG_14-3-3_CanoR_1	519	527	PF00244	0.583
LIG_14-3-3_CanoR_1	529	534	PF00244	0.450
LIG_14-3-3_CanoR_1	559	565	PF00244	0.473
LIG_14-3-3_CanoR_1	621	629	PF00244	0.636
LIG_14-3-3_CanoR_1	651	655	PF00244	0.533
LIG_14-3-3_CanoR_1	717	725	PF00244	0.644
LIG_14-3-3_CanoR_1	744	750	PF00244	0.715
LIG_Actin_WH2_1	77	94	PF00022	0.522
LIG_Actin_WH2_2	78	94	PF00022	0.517
LIG_BIR_III_4	250	254	PF00653	0.460
LIG_BRCT_BRCA1_1	545	549	PF00533	0.554
LIG_BRCT_BRCA1_1	658	662	PF00533	0.494
LIG_deltaCOP1_diTrp_1	72	79	PF00928	0.433
LIG_deltaCOP1_diTrp_1	825	832	PF00928	0.610
LIG_EVH1_2	456	460	PF00568	0.557
LIG_FHA_1	129	135	PF00498	0.388
LIG_FHA_1	243	249	PF00498	0.460
LIG_FHA_1	291	297	PF00498	0.476
LIG_FHA_1	320	326	PF00498	0.460
LIG_FHA_1	331	337	PF00498	0.460
LIG_FHA_1	393	399	PF00498	0.395
LIG_FHA_1	470	476	PF00498	0.431
LIG_FHA_1	516	522	PF00498	0.460
LIG_FHA_1	563	569	PF00498	0.477
LIG_FHA_1	586	592	PF00498	0.460
LIG_FHA_1	6	12	PF00498	0.716
LIG_FHA_1	704	710	PF00498	0.465
LIG_FHA_1	802	808	PF00498	0.444
LIG_FHA_1	97	103	PF00498	0.625
LIG_FHA_2	148	154	PF00498	0.540
LIG_FHA_2	175	181	PF00498	0.470
LIG_FHA_2	242	248	PF00498	0.482
LIG_FHA_2	311	317	PF00498	0.474
LIG_FHA_2	330	336	PF00498	0.478
LIG_FHA_2	407	413	PF00498	0.471
LIG_FHA_2	427	433	PF00498	0.345
LIG_FHA_2	530	536	PF00498	0.557
LIG_FHA_2	539	545	PF00498	0.462
LIG_FHA_2	645	651	PF00498	0.462
LIG_FHA_2	67	73	PF00498	0.557
LIG_GBD_Chelix_1	777	785	PF00786	0.321
LIG_LIR_Apic_2	115	121	PF02991	0.419
LIG_LIR_Apic_2	459	463	PF02991	0.557
LIG_LIR_Gen_1	224	234	PF02991	0.454
LIG_LIR_Gen_1	322	329	PF02991	0.554
LIG_LIR_Gen_1	353	361	PF02991	0.467
LIG_LIR_Gen_1	698	703	PF02991	0.513
LIG_LIR_Gen_1	761	772	PF02991	0.491
LIG_LIR_Gen_1	821	832	PF02991	0.556
LIG_LIR_Nem_3	224	229	PF02991	0.423
LIG_LIR_Nem_3	273	278	PF02991	0.512
LIG_LIR_Nem_3	298	304	PF02991	0.461
LIG_LIR_Nem_3	322	326	PF02991	0.555
LIG_LIR_Nem_3	353	357	PF02991	0.462
LIG_LIR_Nem_3	659	665	PF02991	0.360
LIG_LIR_Nem_3	698	702	PF02991	0.495
LIG_LIR_Nem_3	761	767	PF02991	0.474
LIG_LIR_Nem_3	821	827	PF02991	0.555
LIG_LYPXL_yS_3	594	597	PF13949	0.395
LIG_NRBOX	724	730	PF00104	0.416
LIG_NRBOX	80	86	PF00104	0.380
LIG_PCNA_yPIPBox_3	77	85	PF02747	0.477
LIG_PDZ_Class_2	833	838	PF00595	0.668
LIG_Pex14_1	663	667	PF04695	0.409
LIG_Pex14_1	75	79	PF04695	0.357
LIG_Pex14_1	828	832	PF04695	0.603
LIG_Pex14_2	323	327	PF04695	0.460
LIG_RPA_C_Fungi	20	32	PF08784	0.501
LIG_SH2_CRK	354	358	PF00017	0.396
LIG_SH2_CRK	88	92	PF00017	0.539
LIG_SH2_NCK_1	531	535	PF00017	0.365
LIG_SH2_NCK_1	636	640	PF00017	0.288
LIG_SH2_PTP2	184	187	PF00017	0.444
LIG_SH2_PTP2	699	702	PF00017	0.316
LIG_SH2_SRC	184	187	PF00017	0.444
LIG_SH2_SRC	667	670	PF00017	0.286
LIG_SH2_SRC	93	96	PF00017	0.628
LIG_SH2_STAP1	339	343	PF00017	0.365
LIG_SH2_STAP1	715	719	PF00017	0.575
LIG_SH2_STAP1	824	828	PF00017	0.627
LIG_SH2_STAT3	202	205	PF00017	0.531
LIG_SH2_STAT5	184	187	PF00017	0.420
LIG_SH2_STAT5	264	267	PF00017	0.321
LIG_SH2_STAT5	268	271	PF00017	0.308
LIG_SH2_STAT5	275	278	PF00017	0.303
LIG_SH2_STAT5	295	298	PF00017	0.309
LIG_SH2_STAT5	418	421	PF00017	0.438
LIG_SH2_STAT5	531	534	PF00017	0.359
LIG_SH2_STAT5	584	587	PF00017	0.426
LIG_SH2_STAT5	667	670	PF00017	0.441
LIG_SH2_STAT5	699	702	PF00017	0.512
LIG_SH2_STAT5	715	718	PF00017	0.466
LIG_SH2_STAT5	766	769	PF00017	0.428
LIG_SH2_STAT5	771	774	PF00017	0.416
LIG_SH3_3	118	124	PF00018	0.436
LIG_SH3_3	157	163	PF00018	0.438
LIG_SH3_3	271	277	PF00018	0.306
LIG_SH3_3	449	455	PF00018	0.420
LIG_SH3_3	707	713	PF00018	0.606
LIG_SH3_3	740	746	PF00018	0.760
LIG_SH3_3	767	773	PF00018	0.536
LIG_SH3_3	8	14	PF00018	0.714
LIG_SUMO_SIM_anti_2	148	156	PF11976	0.428
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.477
LIG_SUMO_SIM_par_1	472	479	PF11976	0.312
LIG_SUMO_SIM_par_1	7	13	PF11976	0.484
LIG_TRAF2_1	362	365	PF00917	0.321
LIG_TRAF2_1	628	631	PF00917	0.635
LIG_TRAF2_1	647	650	PF00917	0.446
LIG_TYR_ITIM	352	357	PF00017	0.311
LIG_UBA3_1	113	119	PF00899	0.301
MOD_CDC14_SPxK_1	589	592	PF00782	0.315
MOD_CDC14_SPxK_1	693	696	PF00782	0.425
MOD_CDK_SPxK_1	586	592	PF00069	0.315
MOD_CDK_SPxK_1	690	696	PF00069	0.447
MOD_CDK_SPxxK_3	586	593	PF00069	0.306
MOD_CDK_SPxxK_3	690	697	PF00069	0.675
MOD_CK1_1	242	248	PF00069	0.314
MOD_CK1_1	270	276	PF00069	0.306
MOD_CK1_1	374	380	PF00069	0.416
MOD_CK1_1	43	49	PF00069	0.790
MOD_CK1_1	50	56	PF00069	0.695
MOD_CK1_1	562	568	PF00069	0.343
MOD_CK1_1	735	741	PF00069	0.730
MOD_CK1_1	96	102	PF00069	0.587
MOD_CK2_1	147	153	PF00069	0.542
MOD_CK2_1	174	180	PF00069	0.476
MOD_CK2_1	241	247	PF00069	0.306
MOD_CK2_1	277	283	PF00069	0.346
MOD_CK2_1	310	316	PF00069	0.324
MOD_CK2_1	329	335	PF00069	0.406
MOD_CK2_1	359	365	PF00069	0.280
MOD_CK2_1	426	432	PF00069	0.245
MOD_CK2_1	529	535	PF00069	0.374
MOD_CK2_1	644	650	PF00069	0.359
MOD_CK2_1	718	724	PF00069	0.643
MOD_GlcNHglycan	104	107	PF01048	0.501
MOD_GlcNHglycan	241	244	PF01048	0.314
MOD_GlcNHglycan	32	35	PF01048	0.590
MOD_GlcNHglycan	372	376	PF01048	0.428
MOD_GlcNHglycan	399	402	PF01048	0.421
MOD_GlcNHglycan	616	619	PF01048	0.585
MOD_GlcNHglycan	625	628	PF01048	0.671
MOD_GlcNHglycan	66	69	PF01048	0.470
MOD_GlcNHglycan	674	677	PF01048	0.569
MOD_GlcNHglycan	721	724	PF01048	0.636
MOD_GlcNHglycan	734	737	PF01048	0.511
MOD_GSK3_1	239	246	PF00069	0.311
MOD_GSK3_1	26	33	PF00069	0.747
MOD_GSK3_1	388	395	PF00069	0.373
MOD_GSK3_1	43	50	PF00069	0.671
MOD_GSK3_1	469	476	PF00069	0.358
MOD_GSK3_1	515	522	PF00069	0.307
MOD_GSK3_1	539	546	PF00069	0.357
MOD_GSK3_1	578	585	PF00069	0.315
MOD_GSK3_1	682	689	PF00069	0.476
MOD_GSK3_1	719	726	PF00069	0.683
MOD_GSK3_1	727	734	PF00069	0.648
MOD_GSK3_1	735	742	PF00069	0.531
MOD_GSK3_1	758	765	PF00069	0.647
MOD_N-GLC_1	337	342	PF02516	0.335
MOD_N-GLC_1	43	48	PF02516	0.561
MOD_NEK2_1	107	112	PF00069	0.477
MOD_NEK2_1	113	118	PF00069	0.424
MOD_NEK2_1	147	152	PF00069	0.569
MOD_NEK2_1	290	295	PF00069	0.318
MOD_NEK2_1	515	520	PF00069	0.438
MOD_NEK2_1	543	548	PF00069	0.400
MOD_NEK2_1	554	559	PF00069	0.318
MOD_NEK2_1	579	584	PF00069	0.441
MOD_NEK2_1	644	649	PF00069	0.371
MOD_NEK2_1	655	660	PF00069	0.326
MOD_NEK2_1	66	71	PF00069	0.425
MOD_NEK2_1	718	723	PF00069	0.598
MOD_NEK2_1	777	782	PF00069	0.503
MOD_PIKK_1	107	113	PF00454	0.538
MOD_PIKK_1	481	487	PF00454	0.472
MOD_PIKK_1	723	729	PF00454	0.613
MOD_PIKK_1	801	807	PF00454	0.387
MOD_PIKK_1	831	837	PF00454	0.652
MOD_PK_1	337	343	PF00069	0.321
MOD_PKA_1	288	294	PF00069	0.438
MOD_PKA_1	30	36	PF00069	0.512
MOD_PKA_1	350	356	PF00069	0.306
MOD_PKA_1	559	565	PF00069	0.438
MOD_PKA_2	288	294	PF00069	0.405
MOD_PKA_2	350	356	PF00069	0.306
MOD_PKA_2	515	521	PF00069	0.306
MOD_PKA_2	559	565	PF00069	0.438
MOD_PKA_2	650	656	PF00069	0.536
MOD_PKA_2	672	678	PF00069	0.566
MOD_PKB_1	424	432	PF00069	0.215
MOD_Plk_1	270	276	PF00069	0.306
MOD_Plk_1	278	284	PF00069	0.306
MOD_Plk_1	337	343	PF00069	0.316
MOD_Plk_1	43	49	PF00069	0.523
MOD_Plk_1	458	464	PF00069	0.417
MOD_Plk_1	543	549	PF00069	0.438
MOD_Plk_1	579	585	PF00069	0.438
MOD_Plk_1	723	729	PF00069	0.613
MOD_Plk_1	762	768	PF00069	0.565
MOD_Plk_2-3	310	316	PF00069	0.341
MOD_Plk_2-3	473	479	PF00069	0.320
MOD_Plk_4	113	119	PF00069	0.422
MOD_Plk_4	270	276	PF00069	0.326
MOD_Plk_4	291	297	PF00069	0.306
MOD_Plk_4	374	380	PF00069	0.468
MOD_Plk_4	403	409	PF00069	0.245
MOD_Plk_4	54	60	PF00069	0.486
MOD_Plk_4	579	585	PF00069	0.438
MOD_Plk_4	602	608	PF00069	0.437
MOD_Plk_4	650	656	PF00069	0.456
MOD_Plk_4	80	86	PF00069	0.398
MOD_ProDKin_1	10	16	PF00069	0.725
MOD_ProDKin_1	35	41	PF00069	0.737
MOD_ProDKin_1	388	394	PF00069	0.392
MOD_ProDKin_1	586	592	PF00069	0.413
MOD_ProDKin_1	690	696	PF00069	0.687
MOD_ProDKin_1	758	764	PF00069	0.672
TRG_DiLeu_BaEn_1	109	114	PF01217	0.521
TRG_DiLeu_BaEn_1	650	655	PF01217	0.467
TRG_DiLeu_BaEn_1	724	729	PF01217	0.641
TRG_DiLeu_BaEn_2	297	303	PF01217	0.306
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.362
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.442
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.330
TRG_DiLeu_LyEn_5	109	114	PF01217	0.521
TRG_ENDOCYTIC_2	264	267	PF00928	0.332
TRG_ENDOCYTIC_2	275	278	PF00928	0.309
TRG_ENDOCYTIC_2	354	357	PF00928	0.315
TRG_ENDOCYTIC_2	569	572	PF00928	0.442
TRG_ENDOCYTIC_2	594	597	PF00928	0.306
TRG_ENDOCYTIC_2	699	702	PF00928	0.461
TRG_ENDOCYTIC_2	715	718	PF00928	0.486
TRG_ENDOCYTIC_2	824	827	PF00928	0.626
TRG_ENDOCYTIC_2	88	91	PF00928	0.440
TRG_ER_diArg_1	288	290	PF00400	0.438
TRG_ER_diArg_1	349	351	PF00400	0.306
TRG_ER_diArg_1	424	427	PF00400	0.312
TRG_ER_diArg_1	428	431	PF00400	0.312
TRG_ER_diArg_1	558	560	PF00400	0.439
TRG_ER_diArg_1	591	593	PF00400	0.306
TRG_ER_diArg_1	707	709	PF00400	0.578
TRG_ER_diArg_1	743	745	PF00400	0.775
TRG_NES_CRM1_1	111	126	PF08389	0.367
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	519	524	PF00026	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA76	Leptomonas seymouri	68%	100%
A0A0S4J212	Bodo saltans	43%	100%
A0A1X0NLV5	Trypanosomatidae	52%	100%
A0A3S5H597	Leishmania donovani	82%	98%
A0A422NN62	Trypanosoma rangeli	51%	100%
A4HS28	Leishmania infantum	82%	98%
C9ZY19	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AK15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
Q86MA2	Trypanosoma brucei brucei	51%	100%
Q9XZX1	Leishmania major	82%	100%
V5B958	Trypanosoma cruzi	51%	100%