LeishMANIAdb
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Putative beta-fructofuranosidase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative beta-fructofuranosidase
Gene product:
beta-fructofuranosidase, putative
Species:
Leishmania braziliensis
UniProt:
A4H3V1_LEIBR
TriTrypDb:
LbrM.04.0350 , LBRM2903_040008100
Length:
641

Annotations

LeishMANIAdb annotations

An expanded and variable family of glycosidases. Some Leishmaniid members even incorporate an extra N-terminal fructofuronidase domain after the signal peptide.. Seems to be evolving rapidly for unclear reasons

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 4
Pissara et al. yes yes: 28
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 7
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4H3V1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3V1

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 19
GO:0008152 metabolic process 1 19
GO:0044238 primary metabolic process 2 19
GO:0071704 organic substance metabolic process 2 19
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 19
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 4 19
GO:0004564 beta-fructofuranosidase activity 5 10
GO:0016787 hydrolase activity 2 19
GO:0016798 hydrolase activity, acting on glycosyl bonds 3 19

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 206 210 PF00656 0.232
CLV_NRD_NRD_1 317 319 PF00675 0.488
CLV_NRD_NRD_1 8 10 PF00675 0.575
CLV_PCSK_KEX2_1 150 152 PF00082 0.357
CLV_PCSK_KEX2_1 317 319 PF00082 0.416
CLV_PCSK_KEX2_1 7 9 PF00082 0.581
CLV_PCSK_PC1ET2_1 150 152 PF00082 0.339
CLV_PCSK_SKI1_1 285 289 PF00082 0.434
CLV_PCSK_SKI1_1 294 298 PF00082 0.457
CLV_PCSK_SKI1_1 625 629 PF00082 0.661
CLV_PCSK_SKI1_1 9 13 PF00082 0.353
DEG_APCC_DBOX_1 521 529 PF00400 0.473
DEG_APCC_DBOX_1 8 16 PF00400 0.358
DEG_COP1_1 418 428 PF00400 0.374
DOC_CKS1_1 471 476 PF01111 0.224
DOC_CYCLIN_yCln2_LP_2 407 413 PF00134 0.224
DOC_MAPK_gen_1 7 15 PF00069 0.567
DOC_MAPK_HePTP_8 5 17 PF00069 0.361
DOC_MAPK_HePTP_8 595 607 PF00069 0.371
DOC_MAPK_MEF2A_6 598 607 PF00069 0.371
DOC_MAPK_MEF2A_6 7 15 PF00069 0.591
DOC_MAPK_NFAT4_5 8 16 PF00069 0.565
DOC_PP2B_PxIxI_1 465 471 PF00149 0.370
DOC_PP4_FxxP_1 179 182 PF00568 0.311
DOC_PP4_FxxP_1 244 247 PF00568 0.456
DOC_PP4_FxxP_1 310 313 PF00568 0.477
DOC_PP4_FxxP_1 471 474 PF00568 0.384
DOC_USP7_MATH_1 163 167 PF00917 0.227
DOC_USP7_MATH_1 292 296 PF00917 0.441
DOC_USP7_MATH_1 420 424 PF00917 0.448
DOC_USP7_MATH_1 434 438 PF00917 0.344
DOC_USP7_MATH_1 453 457 PF00917 0.522
DOC_USP7_MATH_1 477 481 PF00917 0.469
DOC_WW_Pin1_4 156 161 PF00397 0.245
DOC_WW_Pin1_4 381 386 PF00397 0.563
DOC_WW_Pin1_4 451 456 PF00397 0.228
DOC_WW_Pin1_4 470 475 PF00397 0.183
DOC_WW_Pin1_4 549 554 PF00397 0.475
DOC_WW_Pin1_4 617 622 PF00397 0.662
DOC_WW_Pin1_4 91 96 PF00397 0.467
LIG_14-3-3_CanoR_1 294 299 PF00244 0.373
LIG_14-3-3_CanoR_1 317 321 PF00244 0.249
LIG_14-3-3_CanoR_1 404 408 PF00244 0.404
LIG_14-3-3_CanoR_1 433 439 PF00244 0.266
LIG_Actin_WH2_2 245 263 PF00022 0.329
LIG_APCC_ABBA_1 558 563 PF00400 0.327
LIG_APCC_ABBA_1 567 572 PF00400 0.327
LIG_BRCT_BRCA1_1 294 298 PF00533 0.409
LIG_BRCT_BRCA1_1 306 310 PF00533 0.313
LIG_BRCT_BRCA1_1 490 494 PF00533 0.503
LIG_Clathr_ClatBox_1 173 177 PF01394 0.224
LIG_deltaCOP1_diTrp_1 101 107 PF00928 0.461
LIG_FHA_1 357 363 PF00498 0.393
LIG_FHA_1 384 390 PF00498 0.512
LIG_FHA_1 441 447 PF00498 0.474
LIG_FHA_1 457 463 PF00498 0.455
LIG_FHA_1 537 543 PF00498 0.396
LIG_FHA_1 55 61 PF00498 0.423
LIG_FHA_1 577 583 PF00498 0.351
LIG_FHA_1 588 594 PF00498 0.351
LIG_FHA_1 600 606 PF00498 0.428
LIG_FHA_1 626 632 PF00498 0.638
LIG_FHA_2 125 131 PF00498 0.420
LIG_FHA_2 295 301 PF00498 0.347
LIG_FHA_2 307 313 PF00498 0.374
LIG_FHA_2 322 328 PF00498 0.458
LIG_FHA_2 404 410 PF00498 0.437
LIG_FHA_2 416 422 PF00498 0.441
LIG_FHA_2 491 497 PF00498 0.333
LIG_FHA_2 518 524 PF00498 0.464
LIG_FHA_2 635 641 PF00498 0.573
LIG_FHA_2 80 86 PF00498 0.311
LIG_FHA_2 88 94 PF00498 0.311
LIG_LIR_Apic_2 177 182 PF02991 0.327
LIG_LIR_Apic_2 183 189 PF02991 0.275
LIG_LIR_Apic_2 241 247 PF02991 0.432
LIG_LIR_Apic_2 307 313 PF02991 0.477
LIG_LIR_Apic_2 613 619 PF02991 0.573
LIG_LIR_Gen_1 257 266 PF02991 0.375
LIG_LIR_Gen_1 283 292 PF02991 0.477
LIG_LIR_Gen_1 293 304 PF02991 0.490
LIG_LIR_Gen_1 347 357 PF02991 0.401
LIG_LIR_Gen_1 396 405 PF02991 0.475
LIG_LIR_Gen_1 630 639 PF02991 0.582
LIG_LIR_Nem_3 105 110 PF02991 0.416
LIG_LIR_Nem_3 248 252 PF02991 0.349
LIG_LIR_Nem_3 257 262 PF02991 0.387
LIG_LIR_Nem_3 270 274 PF02991 0.287
LIG_LIR_Nem_3 283 289 PF02991 0.330
LIG_LIR_Nem_3 293 299 PF02991 0.317
LIG_LIR_Nem_3 300 304 PF02991 0.294
LIG_LIR_Nem_3 309 314 PF02991 0.412
LIG_LIR_Nem_3 347 353 PF02991 0.408
LIG_LIR_Nem_3 396 401 PF02991 0.527
LIG_LIR_Nem_3 463 468 PF02991 0.424
LIG_LIR_Nem_3 630 635 PF02991 0.566
LIG_LIR_Nem_3 75 81 PF02991 0.326
LIG_LYPXL_yS_3 465 468 PF13949 0.404
LIG_NRBOX 630 636 PF00104 0.610
LIG_PCNA_yPIPBox_3 342 356 PF02747 0.404
LIG_PDZ_Class_2 636 641 PF00595 0.569
LIG_Pex14_1 195 199 PF04695 0.322
LIG_PTB_Apo_2 113 120 PF02174 0.347
LIG_PTB_Apo_2 626 633 PF02174 0.600
LIG_PTB_Phospho_1 113 119 PF10480 0.347
LIG_PTB_Phospho_1 626 632 PF10480 0.602
LIG_SH2_CRK 301 305 PF00017 0.384
LIG_SH2_CRK 311 315 PF00017 0.347
LIG_SH2_CRK 441 445 PF00017 0.439
LIG_SH2_NCK_1 32 36 PF00017 0.504
LIG_SH2_NCK_1 350 354 PF00017 0.395
LIG_SH2_NCK_1 441 445 PF00017 0.439
LIG_SH2_PTP2 286 289 PF00017 0.476
LIG_SH2_SRC 311 314 PF00017 0.355
LIG_SH2_SRC 32 35 PF00017 0.508
LIG_SH2_STAP1 234 238 PF00017 0.335
LIG_SH2_STAP1 596 600 PF00017 0.469
LIG_SH2_STAT5 126 129 PF00017 0.300
LIG_SH2_STAT5 234 237 PF00017 0.473
LIG_SH2_STAT5 259 262 PF00017 0.327
LIG_SH2_STAT5 271 274 PF00017 0.309
LIG_SH2_STAT5 286 289 PF00017 0.269
LIG_SH2_STAT5 441 444 PF00017 0.327
LIG_SH2_STAT5 492 495 PF00017 0.425
LIG_SH2_STAT5 527 530 PF00017 0.473
LIG_SH2_STAT5 583 586 PF00017 0.327
LIG_SH2_STAT5 610 613 PF00017 0.524
LIG_SH2_STAT5 86 89 PF00017 0.311
LIG_SH3_2 189 194 PF14604 0.455
LIG_SH3_2 48 53 PF14604 0.323
LIG_SH3_3 154 160 PF00018 0.300
LIG_SH3_3 186 192 PF00018 0.463
LIG_SH3_3 28 34 PF00018 0.450
LIG_SH3_3 286 292 PF00018 0.475
LIG_SH3_3 443 449 PF00018 0.333
LIG_SH3_3 45 51 PF00018 0.261
LIG_SH3_3 518 524 PF00018 0.338
LIG_SH3_3 65 71 PF00018 0.176
LIG_SH3_3 89 95 PF00018 0.467
LIG_SUMO_SIM_par_1 120 127 PF11976 0.441
LIG_SUMO_SIM_par_1 172 177 PF11976 0.224
LIG_SUMO_SIM_par_1 601 606 PF11976 0.505
LIG_TYR_ITIM 299 304 PF00017 0.370
LIG_TYR_ITIM 30 35 PF00017 0.535
LIG_TYR_ITIM 348 353 PF00017 0.384
LIG_TYR_ITSM 307 314 PF00017 0.420
LIG_TYR_ITSM 394 401 PF00017 0.552
MOD_CK1_1 222 228 PF00069 0.482
MOD_CK1_1 232 238 PF00069 0.492
MOD_CK1_1 456 462 PF00069 0.484
MOD_CK2_1 124 130 PF00069 0.420
MOD_CK2_1 321 327 PF00069 0.477
MOD_CK2_1 451 457 PF00069 0.500
MOD_CK2_1 490 496 PF00069 0.383
MOD_CK2_1 517 523 PF00069 0.514
MOD_CK2_1 562 568 PF00069 0.439
MOD_CK2_1 87 93 PF00069 0.458
MOD_Cter_Amidation 148 151 PF01082 0.339
MOD_DYRK1A_RPxSP_1 91 95 PF00069 0.458
MOD_GlcNHglycan 110 113 PF01048 0.323
MOD_GlcNHglycan 224 227 PF01048 0.411
MOD_GlcNHglycan 338 341 PF01048 0.329
MOD_GlcNHglycan 479 482 PF01048 0.438
MOD_GlcNHglycan 512 515 PF01048 0.346
MOD_GlcNHglycan 517 520 PF01048 0.364
MOD_GlcNHglycan 532 535 PF01048 0.278
MOD_GSK3_1 152 159 PF00069 0.293
MOD_GSK3_1 215 222 PF00069 0.403
MOD_GSK3_1 225 232 PF00069 0.404
MOD_GSK3_1 260 267 PF00069 0.329
MOD_GSK3_1 379 386 PF00069 0.548
MOD_GSK3_1 447 454 PF00069 0.382
MOD_GSK3_1 490 497 PF00069 0.248
MOD_GSK3_1 510 517 PF00069 0.313
MOD_GSK3_1 528 535 PF00069 0.363
MOD_GSK3_1 87 94 PF00069 0.454
MOD_N-GLC_1 117 122 PF02516 0.461
MOD_N-GLC_1 393 398 PF02516 0.519
MOD_N-GLC_1 434 439 PF02516 0.385
MOD_N-GLC_1 499 504 PF02516 0.329
MOD_N-GLC_1 625 630 PF02516 0.658
MOD_NEK2_1 229 234 PF00069 0.328
MOD_NEK2_1 260 265 PF00069 0.330
MOD_NEK2_1 304 309 PF00069 0.432
MOD_NEK2_1 328 333 PF00069 0.410
MOD_NEK2_1 344 349 PF00069 0.496
MOD_NEK2_1 488 493 PF00069 0.319
MOD_NEK2_1 528 533 PF00069 0.345
MOD_NEK2_1 627 632 PF00069 0.623
MOD_NEK2_1 634 639 PF00069 0.518
MOD_NEK2_2 306 311 PF00069 0.477
MOD_PIKK_1 328 334 PF00454 0.233
MOD_PIKK_1 356 362 PF00454 0.520
MOD_PIKK_1 379 385 PF00454 0.551
MOD_PIKK_1 456 462 PF00454 0.230
MOD_PIKK_1 528 534 PF00454 0.376
MOD_PKA_2 316 322 PF00069 0.452
MOD_PKA_2 403 409 PF00069 0.404
MOD_PKA_2 494 500 PF00069 0.348
MOD_Plk_1 292 298 PF00069 0.270
MOD_Plk_1 393 399 PF00069 0.537
MOD_Plk_1 415 421 PF00069 0.366
MOD_Plk_1 434 440 PF00069 0.466
MOD_Plk_1 499 505 PF00069 0.232
MOD_Plk_1 562 568 PF00069 0.327
MOD_Plk_2-3 490 496 PF00069 0.404
MOD_Plk_2-3 608 614 PF00069 0.423
MOD_Plk_4 110 116 PF00069 0.469
MOD_Plk_4 152 158 PF00069 0.284
MOD_Plk_4 229 235 PF00069 0.399
MOD_Plk_4 306 312 PF00069 0.467
MOD_Plk_4 393 399 PF00069 0.576
MOD_Plk_4 499 505 PF00069 0.352
MOD_Plk_4 562 568 PF00069 0.338
MOD_Plk_4 611 617 PF00069 0.411
MOD_Plk_4 627 633 PF00069 0.663
MOD_Plk_4 634 640 PF00069 0.540
MOD_ProDKin_1 156 162 PF00069 0.245
MOD_ProDKin_1 381 387 PF00069 0.565
MOD_ProDKin_1 451 457 PF00069 0.228
MOD_ProDKin_1 470 476 PF00069 0.183
MOD_ProDKin_1 549 555 PF00069 0.475
MOD_ProDKin_1 617 623 PF00069 0.667
MOD_ProDKin_1 91 97 PF00069 0.467
MOD_SUMO_for_1 570 573 PF00179 0.395
MOD_SUMO_rev_2 351 357 PF00179 0.447
TRG_DiLeu_BaEn_2 556 562 PF01217 0.395
TRG_DiLeu_BaLyEn_6 521 526 PF01217 0.475
TRG_ENDOCYTIC_2 259 262 PF00928 0.373
TRG_ENDOCYTIC_2 286 289 PF00928 0.458
TRG_ENDOCYTIC_2 301 304 PF00928 0.369
TRG_ENDOCYTIC_2 311 314 PF00928 0.273
TRG_ENDOCYTIC_2 32 35 PF00928 0.508
TRG_ENDOCYTIC_2 350 353 PF00928 0.395
TRG_ENDOCYTIC_2 398 401 PF00928 0.381
TRG_ENDOCYTIC_2 441 444 PF00928 0.327
TRG_ENDOCYTIC_2 465 468 PF00928 0.447
TRG_ENDOCYTIC_2 632 635 PF00928 0.626
TRG_ER_diArg_1 6 9 PF00400 0.577
TRG_NES_CRM1_1 573 585 PF08389 0.395

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBT6 Leptomonas seymouri 75% 100%
A0A0S4J9J2 Bodo saltans 33% 100%
A0A1X0NFY9 Trypanosomatidae 41% 100%
A0A1X0NTL0 Trypanosomatidae 39% 100%
A0A1X0NTM3 Trypanosomatidae 41% 100%
A0A1X0NY19 Trypanosomatidae 41% 100%
A0A1X0NYR4 Trypanosomatidae 38% 100%
A0A1X0P322 Trypanosomatidae 39% 100%
A0A1X0P5Y7 Trypanosomatidae 42% 100%
A0A3Q8IB13 Leishmania donovani 26% 100%
A0A3Q8IFU7 Leishmania donovani 28% 100%
A0A3S5H595 Leishmania donovani 84% 100%
A0A3S5H596 Leishmania donovani 80% 100%
A0A3S7WXQ4 Leishmania donovani 28% 100%
A0A3S7WXS2 Leishmania donovani 28% 100%
A2R0E0 Aspergillus niger (strain CBS 513.88 / FGSC A1513) 25% 100%
A2X5P7 Oryza sativa subsp. indica 32% 100%
A2YZ01 Oryza sativa subsp. indica 28% 100%
A4HCV9 Leishmania braziliensis 24% 100%
A4HCW0 Leishmania braziliensis 27% 100%
A4HG14 Leishmania braziliensis 27% 100%
A4HS26 Leishmania infantum 83% 100%
A4HS27 Leishmania infantum 81% 100%
A4I0D9 Leishmania infantum 26% 100%
A4I0E0 Leishmania infantum 28% 100%
A4IAW1 Leishmania infantum 64% 91%
B6DXP5 Leymus chinensis 28% 100%
B6DZC8 Triticum aestivum 29% 100%
B6DZD0 Triticum urartu 29% 100%
B6DZD1 Aegilops speltoides 30% 100%
B6DZD2 Aegilops tauschii 30% 100%
D2IGW7 Bromus pictus 30% 100%
E1ABX2 Aspergillus ficuum 26% 100%
E8NHF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E8NHF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9ACV4 Leishmania major 25% 100%
E9AK13 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
E9AZE3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
H2DF88 Rosa hybrid cultivar 30% 100%
O24509 Phaseolus vulgaris 29% 98%
O33833 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) 26% 100%
P05656 Bacillus subtilis (strain 168) 24% 95%
P26792 Daucus carota 30% 100%
P29000 Solanum lycopersicum 29% 100%
P29001 Vigna radiata var. radiata 31% 99%
P49174 Zea mays 30% 100%
P80065 Daucus carota 30% 97%
P92916 Allium cepa 28% 100%
P93761 Capsicum annuum 29% 100%
Q01IS7 Oryza sativa subsp. indica 29% 100%
Q01IS8 Oryza sativa subsp. indica 30% 100%
Q0E0P0 Oryza sativa subsp. japonica 31% 100%
Q0J360 Oryza sativa subsp. japonica 28% 100%
Q0JDC5 Oryza sativa subsp. japonica 29% 100%
Q0JDC6 Oryza sativa subsp. japonica 30% 100%
Q1PEF8 Arabidopsis thaliana 29% 100%
Q2UXF7 Triticum aestivum 29% 100%
Q39692 Daucus carota 28% 100%
Q39693 Daucus carota 29% 100%
Q43089 Pisum sativum 28% 100%
Q43857 Vicia faba 31% 100%
Q43866 Arabidopsis thaliana 31% 100%
Q4QB75 Leishmania major 27% 100%
Q4QB76 Leishmania major 26% 100%
Q56UD0 Oryza sativa subsp. japonica 30% 100%
Q56UD1 Oryza sativa subsp. japonica 26% 100%
Q5FC15 Asparagus officinalis 30% 100%
Q5JJV0 Oryza sativa subsp. japonica 30% 100%
Q67XZ3 Arabidopsis thaliana 29% 100%
Q70AT7 Hordeum vulgare 29% 100%
Q70XE6 Beta vulgaris 29% 100%
Q76HP6 Aspergillus niger 26% 100%
Q84LA1 Triticum aestivum 29% 100%
Q84PN8 Triticum aestivum 29% 100%
Q8W4S6 Arabidopsis thaliana 28% 100%
Q9LIB9 Arabidopsis thaliana 29% 100%
Q9XTP3 Leishmania major 83% 100%
Q9XZX0 Leishmania major 81% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS