CHAD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3V0_LEIBR

TriTrypDb:

LbrM.04.0340 , LBRM2903_040008000

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H3V0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3V0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.653
CLV_NRD_NRD_1	117	119	PF00675	0.548
CLV_NRD_NRD_1	154	156	PF00675	0.481
CLV_NRD_NRD_1	167	169	PF00675	0.432
CLV_NRD_NRD_1	242	244	PF00675	0.528
CLV_PCSK_KEX2_1	117	119	PF00082	0.548
CLV_PCSK_KEX2_1	135	137	PF00082	0.587
CLV_PCSK_KEX2_1	154	156	PF00082	0.481
CLV_PCSK_KEX2_1	169	171	PF00082	0.438
CLV_PCSK_KEX2_1	62	64	PF00082	0.510
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.599
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.438
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.510
CLV_PCSK_SKI1_1	184	188	PF00082	0.390
CLV_PCSK_SKI1_1	4	8	PF00082	0.634
DOC_CKS1_1	226	231	PF01111	0.641
DOC_CYCLIN_yClb3_PxF_3	110	118	PF00134	0.479
DOC_PP1_SILK_1	232	237	PF00149	0.372
DOC_WW_Pin1_4	175	180	PF00397	0.505
DOC_WW_Pin1_4	225	230	PF00397	0.657
LIG_14-3-3_CanoR_1	12	22	PF00244	0.523
LIG_BIR_II_1	1	5	PF00653	0.524
LIG_eIF4E_1	86	92	PF01652	0.554
LIG_FHA_1	219	225	PF00498	0.644
LIG_FHA_1	68	74	PF00498	0.663
LIG_FHA_2	144	150	PF00498	0.455
LIG_FHA_2	226	232	PF00498	0.527
LIG_GBD_Chelix_1	91	99	PF00786	0.543
LIG_LIR_Gen_1	134	144	PF02991	0.506
LIG_LIR_Gen_1	146	156	PF02991	0.485
LIG_LIR_Gen_1	16	26	PF02991	0.690
LIG_LIR_Gen_1	83	93	PF02991	0.561
LIG_LIR_Nem_3	134	140	PF02991	0.491
LIG_LIR_Nem_3	146	151	PF02991	0.463
LIG_LIR_Nem_3	16	22	PF02991	0.530
LIG_LIR_Nem_3	50	56	PF02991	0.557
LIG_LIR_Nem_3	83	89	PF02991	0.495
LIG_LIR_Nem_3	94	99	PF02991	0.419
LIG_SH2_CRK	96	100	PF00017	0.454
LIG_SH2_SRC	207	210	PF00017	0.628
LIG_SH2_STAP1	148	152	PF00017	0.474
LIG_SH2_STAP1	56	60	PF00017	0.545
LIG_SH2_STAT3	11	14	PF00017	0.645
LIG_SH2_STAT5	195	198	PF00017	0.618
LIG_SH2_STAT5	227	230	PF00017	0.529
LIG_SH2_STAT5	241	244	PF00017	0.468
LIG_SH2_STAT5	60	63	PF00017	0.538
LIG_SH3_3	107	113	PF00018	0.469
LIG_SH3_3	25	31	PF00018	0.701
LIG_SUMO_SIM_par_1	69	74	PF11976	0.476
LIG_TYR_ITAM	83	99	PF00017	0.555
LIG_TYR_ITIM	84	89	PF00017	0.492
LIG_UBA3_1	181	187	PF00899	0.388
MOD_CK2_1	225	231	PF00069	0.510
MOD_GSK3_1	67	74	PF00069	0.471
MOD_PKA_1	117	123	PF00069	0.483
MOD_PKA_2	117	123	PF00069	0.331
MOD_PKA_2	218	224	PF00069	0.704
MOD_Plk_4	143	149	PF00069	0.455
MOD_Plk_4	56	62	PF00069	0.561
MOD_ProDKin_1	175	181	PF00069	0.504
MOD_ProDKin_1	225	231	PF00069	0.648
TRG_DiLeu_BaEn_1	87	92	PF01217	0.548
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.556
TRG_ENDOCYTIC_2	137	140	PF00928	0.493
TRG_ENDOCYTIC_2	148	151	PF00928	0.463
TRG_ENDOCYTIC_2	156	159	PF00928	0.403
TRG_ENDOCYTIC_2	86	89	PF00928	0.496
TRG_ENDOCYTIC_2	96	99	PF00928	0.455
TRG_ER_diArg_1	117	119	PF00400	0.548
TRG_ER_diArg_1	153	155	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	189	193	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	204	208	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3B4	Leptomonas seymouri	78%	84%
A0A0S4J2A8	Bodo saltans	46%	76%
A0A1X0NL02	Trypanosomatidae	59%	92%
A0A3S5H594	Leishmania donovani	92%	80%
A4HS25	Leishmania infantum	92%	97%
C9ZY18	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	90%
E9AK12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q9BLQ5	Leishmania major	89%	100%
V5ATQ3	Trypanosoma cruzi	63%	93%