TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3U6_LEIBR

TriTrypDb:

LbrM.04.0300 , LBRM2903_040007600

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3U6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3U6

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.615
CLV_C14_Caspase3-7	84	88	PF00656	0.669
CLV_NRD_NRD_1	101	103	PF00675	0.603
CLV_NRD_NRD_1	201	203	PF00675	0.373
CLV_NRD_NRD_1	271	273	PF00675	0.516
CLV_PCSK_KEX2_1	101	103	PF00082	0.604
CLV_PCSK_KEX2_1	201	203	PF00082	0.364
CLV_PCSK_KEX2_1	267	269	PF00082	0.442
CLV_PCSK_KEX2_1	271	273	PF00082	0.429
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.490

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Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZG7	Leptomonas seymouri	53%	89%
A0A1X0NLP6	Trypanosomatidae	32%	100%
A0A3R7L3M0	Trypanosoma rangeli	31%	100%
A0A3S5H590	Leishmania donovani	77%	100%
A4HS21	Leishmania infantum	77%	100%
C9ZY14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AK08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q9XZY6	Leishmania major	73%	98%

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