TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3U6_LEIBR

TriTrypDb:

LbrM.04.0300 , LBRM2903_040007600

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3U6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3U6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	242	246	PF00656	0.615
CLV_C14_Caspase3-7	84	88	PF00656	0.669
CLV_NRD_NRD_1	101	103	PF00675	0.603
CLV_NRD_NRD_1	201	203	PF00675	0.373
CLV_NRD_NRD_1	271	273	PF00675	0.516
CLV_PCSK_KEX2_1	101	103	PF00082	0.604
CLV_PCSK_KEX2_1	201	203	PF00082	0.364
CLV_PCSK_KEX2_1	267	269	PF00082	0.442
CLV_PCSK_KEX2_1	271	273	PF00082	0.429
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.490
CLV_PCSK_SKI1_1	163	167	PF00082	0.476
CLV_PCSK_SKI1_1	175	179	PF00082	0.396
CLV_PCSK_SKI1_1	197	201	PF00082	0.406
CLV_PCSK_SKI1_1	271	275	PF00082	0.514
DEG_SPOP_SBC_1	117	121	PF00917	0.592
DOC_CYCLIN_RxL_1	194	204	PF00134	0.398
DOC_MAPK_gen_1	201	209	PF00069	0.488
DOC_MAPK_gen_1	53	59	PF00069	0.420
DOC_USP7_MATH_1	109	113	PF00917	0.666
DOC_USP7_MATH_1	122	126	PF00917	0.653
DOC_USP7_MATH_1	227	231	PF00917	0.453
DOC_USP7_MATH_1	238	242	PF00917	0.568
DOC_USP7_UBL2_3	103	107	PF12436	0.526
DOC_WW_Pin1_4	113	118	PF00397	0.644
DOC_WW_Pin1_4	190	195	PF00397	0.489
DOC_WW_Pin1_4	69	74	PF00397	0.587
LIG_14-3-3_CanoR_1	201	209	PF00244	0.384
LIG_14-3-3_CanoR_1	46	51	PF00244	0.521
LIG_BIR_II_1	1	5	PF00653	0.730
LIG_BIR_III_4	85	89	PF00653	0.578
LIG_BRCT_BRCA1_1	186	190	PF00533	0.627
LIG_FHA_1	164	170	PF00498	0.416
LIG_FHA_1	202	208	PF00498	0.322
LIG_FHA_1	250	256	PF00498	0.523
LIG_LIR_Gen_1	204	214	PF02991	0.289
LIG_LIR_Nem_3	204	209	PF02991	0.279
LIG_LIR_Nem_3	49	55	PF02991	0.504
LIG_PCNA_PIPBox_1	134	143	PF02747	0.548
LIG_PCNA_yPIPBox_3	89	103	PF02747	0.669
LIG_SH2_CRK	52	56	PF00017	0.495
LIG_SH2_GRB2like	78	81	PF00017	0.603
LIG_SH2_PTP2	206	209	PF00017	0.536
LIG_SH2_SRC	158	161	PF00017	0.517
LIG_SH2_SRC	78	81	PF00017	0.724
LIG_SH2_STAP1	141	145	PF00017	0.524
LIG_SH2_STAT3	24	27	PF00017	0.547
LIG_SH2_STAT5	206	209	PF00017	0.495
LIG_SH2_STAT5	24	27	PF00017	0.508
LIG_SH2_STAT5	56	59	PF00017	0.403
LIG_SH2_STAT5	62	65	PF00017	0.407
MOD_CDK_SPxxK_3	190	197	PF00069	0.525
MOD_CK1_1	116	122	PF00069	0.650
MOD_CK1_1	184	190	PF00069	0.693
MOD_CK1_1	7	13	PF00069	0.680
MOD_CK2_1	109	115	PF00069	0.775
MOD_GlcNHglycan	10	13	PF01048	0.762
MOD_GlcNHglycan	111	114	PF01048	0.716
MOD_GlcNHglycan	124	127	PF01048	0.656
MOD_GlcNHglycan	186	189	PF01048	0.638
MOD_GlcNHglycan	229	232	PF01048	0.616
MOD_GlcNHglycan	69	72	PF01048	0.583
MOD_GSK3_1	1	8	PF00069	0.642
MOD_GSK3_1	10	17	PF00069	0.576
MOD_GSK3_1	109	116	PF00069	0.709
MOD_GSK3_1	118	125	PF00069	0.673
MOD_GSK3_1	184	191	PF00069	0.622
MOD_N-GLC_1	113	118	PF02516	0.525
MOD_NEK2_1	1	6	PF00069	0.527
MOD_NEK2_1	140	145	PF00069	0.439
MOD_NEK2_1	249	254	PF00069	0.334
MOD_PIKK_1	135	141	PF00454	0.546
MOD_PKA_1	201	207	PF00069	0.317
MOD_PKA_2	184	190	PF00069	0.621
MOD_PKA_2	201	207	PF00069	0.364
MOD_ProDKin_1	113	119	PF00069	0.638
MOD_ProDKin_1	190	196	PF00069	0.481
MOD_ProDKin_1	69	75	PF00069	0.584
TRG_ENDOCYTIC_2	206	209	PF00928	0.536
TRG_ENDOCYTIC_2	52	55	PF00928	0.497
TRG_ENDOCYTIC_2	56	59	PF00928	0.491
TRG_ER_diArg_1	200	202	PF00400	0.393
TRG_ER_diArg_1	270	272	PF00400	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZG7	Leptomonas seymouri	53%	89%
A0A1X0NLP6	Trypanosomatidae	32%	100%
A0A3R7L3M0	Trypanosoma rangeli	31%	100%
A0A3S5H590	Leishmania donovani	77%	100%
A4HS21	Leishmania infantum	77%	100%
C9ZY14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AK08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q9XZY6	Leishmania major	73%	98%