Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H3U3_LEIBR

TriTrypDb:

LbrM.04.0270 , LBRM2903_040007200

Length:

358

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26167471
Might belong to a Kinetoplastid-specific lectin domain protein family. Experiments of homologues indicate them to localize to ER (PMID: 26167471). Highly expanded in the Trypanosoma genus, while relatively limited in Leishmaniids.. Localization: ER (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 5
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4H3U3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3U3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.495
CLV_C14_Caspase3-7	221	225	PF00656	0.587
CLV_NRD_NRD_1	312	314	PF00675	0.506
CLV_PCSK_KEX2_1	312	314	PF00082	0.493
DOC_CKS1_1	117	122	PF01111	0.458
DOC_CYCLIN_yCln2_LP_2	178	184	PF00134	0.506
DOC_MAPK_gen_1	46	54	PF00069	0.356
DOC_PP2B_PxIxI_1	112	118	PF00149	0.426
DOC_PP4_FxxP_1	182	185	PF00568	0.506
DOC_PP4_FxxP_1	37	40	PF00568	0.464
DOC_USP7_MATH_1	144	148	PF00917	0.510
DOC_USP7_MATH_1	32	36	PF00917	0.474
DOC_USP7_MATH_1	75	79	PF00917	0.440
DOC_WW_Pin1_4	116	121	PF00397	0.457
LIG_14-3-3_CanoR_1	134	138	PF00244	0.538
LIG_14-3-3_CanoR_1	146	150	PF00244	0.541
LIG_14-3-3_CanoR_1	162	168	PF00244	0.514
LIG_14-3-3_CanoR_1	217	223	PF00244	0.484
LIG_14-3-3_CanoR_1	312	320	PF00244	0.719
LIG_BIR_II_1	1	5	PF00653	0.486
LIG_BRCT_BRCA1_1	77	81	PF00533	0.454
LIG_deltaCOP1_diTrp_1	265	272	PF00928	0.306
LIG_FHA_1	154	160	PF00498	0.530
LIG_FHA_1	205	211	PF00498	0.502
LIG_FHA_1	280	286	PF00498	0.282
LIG_FHA_1	63	69	PF00498	0.468
LIG_FHA_2	122	128	PF00498	0.641
LIG_FHA_2	219	225	PF00498	0.590
LIG_FHA_2	234	240	PF00498	0.460
LIG_FHA_2	304	310	PF00498	0.638
LIG_LIR_Apic_2	34	40	PF02991	0.467
LIG_LIR_Gen_1	82	93	PF02991	0.489
LIG_LIR_LC3C_4	282	286	PF02991	0.269
LIG_LIR_Nem_3	102	108	PF02991	0.492
LIG_LIR_Nem_3	239	243	PF02991	0.430
LIG_LIR_Nem_3	265	270	PF02991	0.338
LIG_LIR_Nem_3	29	33	PF02991	0.389
LIG_LIR_Nem_3	78	84	PF02991	0.476
LIG_MAD2	241	249	PF02301	0.343
LIG_NRP_CendR_1	355	358	PF00754	0.486
LIG_Pex14_1	211	215	PF04695	0.534
LIG_Pex14_1	268	272	PF04695	0.396
LIG_Pex14_2	176	180	PF04695	0.513
LIG_Pex14_2	272	276	PF04695	0.383
LIG_SH2_CRK	28	32	PF00017	0.474
LIG_SH2_CRK	85	89	PF00017	0.533
LIG_SH2_SRC	38	41	PF00017	0.436
LIG_SH2_STAP1	169	173	PF00017	0.502
LIG_SH2_STAT3	161	164	PF00017	0.517
LIG_SH2_STAT3	169	172	PF00017	0.525
LIG_SH2_STAT3	319	322	PF00017	0.728
LIG_SH2_STAT5	319	322	PF00017	0.735
LIG_SH2_STAT5	38	41	PF00017	0.429
LIG_SH2_STAT5	59	62	PF00017	0.480
LIG_SH3_3	178	184	PF00018	0.512
LIG_Sin3_3	64	71	PF02671	0.472
LIG_SUMO_SIM_anti_2	12	18	PF11976	0.619
LIG_SUMO_SIM_anti_2	282	288	PF11976	0.449
LIG_WW_1	184	187	PF00397	0.503
MOD_CK1_1	122	128	PF00069	0.455
MOD_CK1_1	145	151	PF00069	0.454
MOD_CK1_1	257	263	PF00069	0.474
MOD_CK1_1	321	327	PF00069	0.729
MOD_CK1_1	331	337	PF00069	0.748
MOD_CK1_1	342	348	PF00069	0.797
MOD_CK2_1	303	309	PF00069	0.639
MOD_CK2_1	334	340	PF00069	0.712
MOD_CK2_1	342	348	PF00069	0.747
MOD_Cter_Amidation	310	313	PF01082	0.438
MOD_GlcNHglycan	124	127	PF01048	0.730
MOD_GlcNHglycan	20	23	PF01048	0.612
MOD_GlcNHglycan	257	260	PF01048	0.695
MOD_GlcNHglycan	333	336	PF01048	0.586
MOD_GSK3_1	253	260	PF00069	0.510
MOD_GSK3_1	324	331	PF00069	0.772
MOD_GSK3_1	75	82	PF00069	0.513
MOD_N-GLC_1	342	347	PF02516	0.588
MOD_N-GLC_2	129	131	PF02516	0.686
MOD_NEK2_1	18	23	PF00069	0.439
MOD_NEK2_2	32	37	PF00069	0.395
MOD_PIKK_1	119	125	PF00454	0.527
MOD_PIKK_1	318	324	PF00454	0.735
MOD_PKA_2	133	139	PF00069	0.537
MOD_PKA_2	145	151	PF00069	0.538
MOD_PKA_2	311	317	PF00069	0.800
MOD_Plk_1	48	54	PF00069	0.396
MOD_Plk_1	62	68	PF00069	0.538
MOD_Plk_4	32	38	PF00069	0.433
MOD_Plk_4	80	86	PF00069	0.536
MOD_Plk_4	9	15	PF00069	0.525
MOD_ProDKin_1	116	122	PF00069	0.456
TRG_ENDOCYTIC_2	28	31	PF00928	0.494
TRG_ENDOCYTIC_2	84	87	PF00928	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY91	Leptomonas seymouri	46%	100%
A0A0N1PG18	Leptomonas seymouri	33%	80%
A0A3S5H587	Leishmania donovani	81%	100%
A0A3S5H6P8	Leishmania donovani	35%	85%
A4H7B4	Leishmania braziliensis	33%	85%
A4HS17	Leishmania infantum	81%	100%
A4HVQ9	Leishmania infantum	35%	85%
E9AK04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
E9APF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	86%
Q4QG23	Leishmania major	32%	100%
Q9XZY2	Leishmania major	81%	100%