LeishMANIAdb
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Surface antigen-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Surface antigen-like protein
Gene product:
surface antigen-like protein (fragment)
Species:
Leishmania braziliensis
UniProt:
A4H3U2_LEIBR
TriTrypDb:
LbrM.04.0260 , LBRM2903_040007000 *
Length:
466

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 25
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 7, no: 0
NetGPI no yes: 0, no: 7
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3U2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3U2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 260 264 PF00656 0.289
CLV_PCSK_KEX2_1 122 124 PF00082 0.519
CLV_PCSK_PC1ET2_1 122 124 PF00082 0.519
CLV_PCSK_SKI1_1 154 158 PF00082 0.496
CLV_PCSK_SKI1_1 4 8 PF00082 0.642
DEG_Nend_UBRbox_1 1 4 PF02207 0.517
DEG_SCF_FBW7_1 285 290 PF00400 0.340
DEG_SPOP_SBC_1 141 145 PF00917 0.320
DEG_SPOP_SBC_1 99 103 PF00917 0.289
DOC_CKS1_1 284 289 PF01111 0.339
DOC_CKS1_1 67 72 PF01111 0.266
DOC_PP1_RVXF_1 152 158 PF00149 0.300
DOC_PP4_FxxP_1 284 287 PF00568 0.275
DOC_USP7_MATH_1 141 145 PF00917 0.320
DOC_USP7_MATH_1 156 160 PF00917 0.304
DOC_USP7_MATH_1 243 247 PF00917 0.372
DOC_USP7_MATH_1 344 348 PF00917 0.290
DOC_USP7_MATH_1 406 410 PF00917 0.310
DOC_USP7_MATH_1 56 60 PF00917 0.452
DOC_USP7_MATH_1 73 77 PF00917 0.305
DOC_USP7_MATH_1 99 103 PF00917 0.320
DOC_USP7_MATH_2 318 324 PF00917 0.264
DOC_WW_Pin1_4 283 288 PF00397 0.338
DOC_WW_Pin1_4 66 71 PF00397 0.273
LIG_14-3-3_CanoR_1 329 337 PF00244 0.318
LIG_14-3-3_CanoR_1 389 398 PF00244 0.375
LIG_14-3-3_CanoR_1 440 447 PF00244 0.294
LIG_BRCT_BRCA1_1 179 183 PF00533 0.410
LIG_eIF4E_1 283 289 PF01652 0.326
LIG_FHA_1 103 109 PF00498 0.293
LIG_FHA_1 214 220 PF00498 0.281
LIG_FHA_1 229 235 PF00498 0.307
LIG_FHA_1 331 337 PF00498 0.295
LIG_FHA_1 344 350 PF00498 0.308
LIG_FHA_1 55 61 PF00498 0.431
LIG_FHA_2 288 294 PF00498 0.281
LIG_FHA_2 389 395 PF00498 0.294
LIG_LIR_Nem_3 322 327 PF02991 0.310
LIG_LIR_Nem_3 436 442 PF02991 0.330
LIG_Pex14_2 41 45 PF04695 0.284
LIG_SH2_CRK 324 328 PF00017 0.306
LIG_SH2_CRK 439 443 PF00017 0.323
LIG_SH2_NCK_1 357 361 PF00017 0.275
LIG_SH2_STAP1 197 201 PF00017 0.290
LIG_SH2_STAP1 248 252 PF00017 0.410
LIG_SH2_STAP1 357 361 PF00017 0.332
LIG_SH2_STAT5 176 179 PF00017 0.276
LIG_SH2_STAT5 197 200 PF00017 0.349
LIG_SH2_STAT5 24 27 PF00017 0.365
LIG_SH2_STAT5 248 251 PF00017 0.426
LIG_SH2_STAT5 254 257 PF00017 0.353
LIG_SH2_STAT5 283 286 PF00017 0.341
LIG_SH2_STAT5 398 401 PF00017 0.391
LIG_SH2_STAT5 411 414 PF00017 0.319
LIG_SH2_STAT5 433 436 PF00017 0.327
LIG_SH2_STAT5 95 98 PF00017 0.330
LIG_SH3_2 306 311 PF14604 0.331
LIG_SH3_3 14 20 PF00018 0.443
LIG_SH3_3 267 273 PF00018 0.291
LIG_SH3_3 303 309 PF00018 0.328
LIG_SH3_3 47 53 PF00018 0.318
LIG_SH3_3 64 70 PF00018 0.328
LIG_SH3_3 93 99 PF00018 0.358
LIG_TRFH_1 283 287 PF08558 0.330
LIG_TRFH_1 95 99 PF08558 0.330
LIG_WRC_WIRS_1 42 47 PF05994 0.273
MOD_CK1_1 102 108 PF00069 0.316
MOD_CK1_1 208 214 PF00069 0.299
MOD_CK1_1 220 226 PF00069 0.386
MOD_CK1_1 246 252 PF00069 0.397
MOD_CK1_1 257 263 PF00069 0.372
MOD_CK1_1 268 274 PF00069 0.399
MOD_CK1_1 384 390 PF00069 0.389
MOD_CK2_1 114 120 PF00069 0.352
MOD_CK2_1 287 293 PF00069 0.286
MOD_CK2_1 41 47 PF00069 0.285
MOD_Cter_Amidation 120 123 PF01082 0.545
MOD_GlcNHglycan 207 210 PF01048 0.586
MOD_GlcNHglycan 219 222 PF01048 0.586
MOD_GlcNHglycan 245 248 PF01048 0.579
MOD_GlcNHglycan 250 253 PF01048 0.561
MOD_GlcNHglycan 383 386 PF01048 0.620
MOD_GlcNHglycan 92 95 PF01048 0.531
MOD_GSK3_1 156 163 PF00069 0.352
MOD_GSK3_1 19 26 PF00069 0.529
MOD_GSK3_1 205 212 PF00069 0.380
MOD_GSK3_1 213 220 PF00069 0.404
MOD_GSK3_1 268 275 PF00069 0.377
MOD_GSK3_1 283 290 PF00069 0.335
MOD_GSK3_1 37 44 PF00069 0.408
MOD_GSK3_1 381 388 PF00069 0.358
MOD_GSK3_1 406 413 PF00069 0.327
MOD_GSK3_1 421 428 PF00069 0.335
MOD_GSK3_1 98 105 PF00069 0.277
MOD_N-GLC_2 186 188 PF02516 0.483
MOD_N-GLC_2 380 382 PF02516 0.538
MOD_NEK2_1 157 162 PF00069 0.320
MOD_NEK2_1 219 224 PF00069 0.371
MOD_NEK2_1 330 335 PF00069 0.286
MOD_NEK2_1 41 46 PF00069 0.270
MOD_NEK2_1 421 426 PF00069 0.334
MOD_NEK2_1 434 439 PF00069 0.291
MOD_NEK2_2 406 411 PF00069 0.311
MOD_OFUCOSY 255 261 PF10250 0.487
MOD_OFUCOSY 269 276 PF10250 0.540
MOD_OFUCOSY 328 334 PF10250 0.469
MOD_OFUCOSY 404 410 PF10250 0.521
MOD_PIKK_1 102 108 PF00454 0.265
MOD_PIKK_1 148 154 PF00454 0.312
MOD_PIKK_1 274 280 PF00454 0.331
MOD_PIKK_1 440 446 PF00454 0.336
MOD_PKA_2 328 334 PF00069 0.315
MOD_PKA_2 388 394 PF00069 0.270
MOD_Plk_1 209 215 PF00069 0.263
MOD_Plk_1 81 87 PF00069 0.354
MOD_Plk_2-3 320 326 PF00069 0.256
MOD_Plk_4 37 43 PF00069 0.339
MOD_Plk_4 452 458 PF00069 0.292
MOD_Plk_4 56 62 PF00069 0.354
MOD_ProDKin_1 283 289 PF00069 0.339
MOD_ProDKin_1 66 72 PF00069 0.268
MOD_SUMO_rev_2 174 183 PF00179 0.279
TRG_ENDOCYTIC_2 324 327 PF00928 0.311
TRG_ENDOCYTIC_2 439 442 PF00928 0.323
TRG_ER_diArg_1 1 4 PF00400 0.517

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H584 Leishmania donovani 68% 92%
A4H3Y2 Leishmania braziliensis 29% 81%
A4H439 Leishmania braziliensis 34% 100%
A4HS13 Leishmania infantum 67% 92%
E9AK00 Leishmania mexicana (strain MHOM/GT/2001/U1103) 67% 94%
Q9XZX8 Leishmania major 65% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS