LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

TNFR-Cys domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TNFR-Cys domain-containing protein
Gene product:
hypothetical protein, conserved in leishmania
Species:
Leishmania braziliensis
UniProt:
A4H3U1_LEIBR
TriTrypDb:
LbrM.04.0250 , LBRM2903_040006800
Length:
522

Annotations

LeishMANIAdb annotations

A strange, fast-evolving receptor-like family of parazitic Kinetoplastids. While absent from many species, this family has expanded enormously on the Angomonas and Strigomonas lineages.. Very likely GPI-anchored protein. Very putatively might be involved in interactions with bacteria, explaining its expansion in symbiontic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 65
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 8
NetGPI no yes: 0, no: 19
Cellular components
TermNameLevelCount
GO:0005737 cytoplasm 2 3
GO:0110165 cellular anatomical entity 1 3
Previous1Next

Expansion

Sequence features

A4H3U1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3U1

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 3
GO:0008233 peptidase activity 3 3
GO:0016787 hydrolase activity 2 3
GO:0140096 catalytic activity, acting on a protein 2 3
Previous1Next

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 78 82 PF00656 0.443
CLV_PCSK_SKI1_1 252 256 PF00082 0.575
CLV_PCSK_SKI1_1 453 457 PF00082 0.660
CLV_PCSK_SKI1_1 72 76 PF00082 0.575
DEG_APCC_DBOX_1 452 460 PF00400 0.384
DEG_SCF_TRCP1_1 475 481 PF00400 0.351
DEG_SPOP_SBC_1 258 262 PF00917 0.365
DOC_CKS1_1 228 233 PF01111 0.321
DOC_CYCLIN_RxL_1 246 257 PF00134 0.373
DOC_PP2B_LxvP_1 310 313 PF13499 0.377
Previous12345…17Next

Homologs

ProteinTaxonomySequence identityCoverage
A0A0N0P251 Leptomonas seymouri 21% 100%
A0A381M9M8 Leishmania infantum 67% 99%
A0A3S5H581 Leishmania donovani 67% 99%
A0A3S5H583 Leishmania donovani 67% 99%
A0A451EJW1 Leishmania donovani 67% 99%
A0A451EJW4 Leishmania donovani 67% 99%
A0A451EJW6 Leishmania donovani 25% 74%
A4H3T7 Leishmania braziliensis 97% 100%
A4H3T8 Leishmania braziliensis 94% 100%
A4H3T9 Leishmania braziliensis 94% 100%
Previous12Next

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS