LeishMANIAdb
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TNFR-Cys domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TNFR-Cys domain-containing protein
Gene product:
hypothetical protein, conserved in leishmania
Species:
Leishmania braziliensis
UniProt:
A4H3U1_LEIBR
TriTrypDb:
LbrM.04.0250 , LBRM2903_040006800
Length:
522

Annotations

LeishMANIAdb annotations

A strange, fast-evolving receptor-like family of parazitic Kinetoplastids. While absent from many species, this family has expanded enormously on the Angomonas and Strigomonas lineages.. Very likely GPI-anchored protein. Very putatively might be involved in interactions with bacteria, explaining its expansion in symbiontic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 65
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 8
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

A4H3U1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3U1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0008233 peptidase activity 3 3
GO:0016787 hydrolase activity 2 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 78 82 PF00656 0.443
CLV_PCSK_SKI1_1 252 256 PF00082 0.575
CLV_PCSK_SKI1_1 453 457 PF00082 0.660
CLV_PCSK_SKI1_1 72 76 PF00082 0.575
DEG_APCC_DBOX_1 452 460 PF00400 0.384
DEG_SCF_TRCP1_1 475 481 PF00400 0.351
DEG_SPOP_SBC_1 258 262 PF00917 0.365
DOC_CKS1_1 228 233 PF01111 0.321
DOC_CYCLIN_RxL_1 246 257 PF00134 0.373
DOC_PP2B_LxvP_1 310 313 PF13499 0.377
DOC_USP7_MATH_1 110 114 PF00917 0.493
DOC_USP7_MATH_1 137 141 PF00917 0.386
DOC_USP7_MATH_1 154 158 PF00917 0.521
DOC_USP7_MATH_1 199 203 PF00917 0.409
DOC_USP7_MATH_1 224 228 PF00917 0.452
DOC_USP7_MATH_1 384 388 PF00917 0.515
DOC_USP7_MATH_1 404 408 PF00917 0.414
DOC_WW_Pin1_4 227 232 PF00397 0.319
DOC_WW_Pin1_4 431 436 PF00397 0.412
DOC_WW_Pin1_4 485 490 PF00397 0.406
LIG_14-3-3_CanoR_1 116 124 PF00244 0.475
LIG_14-3-3_CanoR_1 395 400 PF00244 0.418
LIG_14-3-3_CanoR_1 438 446 PF00244 0.525
LIG_14-3-3_CanoR_1 88 94 PF00244 0.506
LIG_BIR_II_1 1 5 PF00653 0.568
LIG_BRCT_BRCA1_1 236 240 PF00533 0.473
LIG_BRCT_BRCA1_1 313 317 PF00533 0.350
LIG_Clathr_ClatBox_1 181 185 PF01394 0.342
LIG_FHA_1 141 147 PF00498 0.473
LIG_FHA_1 158 164 PF00498 0.326
LIG_FHA_1 220 226 PF00498 0.433
LIG_FHA_1 228 234 PF00498 0.361
LIG_FHA_1 31 37 PF00498 0.502
LIG_FHA_1 343 349 PF00498 0.372
LIG_FHA_1 355 361 PF00498 0.346
LIG_FHA_1 45 51 PF00498 0.511
LIG_FHA_1 468 474 PF00498 0.399
LIG_FHA_1 502 508 PF00498 0.481
LIG_FHA_1 54 60 PF00498 0.441
LIG_FHA_2 29 35 PF00498 0.440
LIG_FHA_2 316 322 PF00498 0.458
LIG_FHA_2 356 362 PF00498 0.475
LIG_FHA_2 406 412 PF00498 0.396
LIG_LIR_Apic_2 398 404 PF02991 0.426
LIG_LIR_Gen_1 279 288 PF02991 0.409
LIG_LIR_Gen_1 304 313 PF02991 0.463
LIG_LIR_LC3C_4 230 234 PF02991 0.316
LIG_LIR_Nem_3 132 136 PF02991 0.470
LIG_LIR_Nem_3 279 285 PF02991 0.410
LIG_LIR_Nem_3 304 310 PF02991 0.493
LIG_LIR_Nem_3 42 46 PF02991 0.443
LIG_PDZ_Class_2 517 522 PF00595 0.704
LIG_PTB_Apo_2 462 469 PF02174 0.373
LIG_PTB_Phospho_1 462 468 PF10480 0.379
LIG_SH2_CRK 401 405 PF00017 0.463
LIG_SH2_CRK 487 491 PF00017 0.395
LIG_SH2_NCK_1 401 405 PF00017 0.417
LIG_SH2_NCK_1 446 450 PF00017 0.370
LIG_SH2_NCK_1 487 491 PF00017 0.392
LIG_SH2_STAP1 295 299 PF00017 0.342
LIG_SH2_STAP1 46 50 PF00017 0.459
LIG_SH2_STAT3 468 471 PF00017 0.394
LIG_SH2_STAT5 269 272 PF00017 0.464
LIG_SH2_STAT5 446 449 PF00017 0.388
LIG_SH2_STAT5 46 49 PF00017 0.496
LIG_SH2_STAT5 468 471 PF00017 0.446
LIG_SH2_STAT5 487 490 PF00017 0.375
LIG_SH3_3 148 154 PF00018 0.507
LIG_SUMO_SIM_anti_2 162 167 PF11976 0.459
LIG_SUMO_SIM_par_1 142 147 PF11976 0.459
LIG_SUMO_SIM_par_1 162 167 PF11976 0.268
LIG_SUMO_SIM_par_1 209 214 PF11976 0.341
LIG_SUMO_SIM_par_1 224 230 PF11976 0.364
MOD_CDK_SPxxK_3 431 438 PF00069 0.412
MOD_CK1_1 123 129 PF00069 0.381
MOD_CK1_1 140 146 PF00069 0.426
MOD_CK1_1 157 163 PF00069 0.498
MOD_CK1_1 167 173 PF00069 0.429
MOD_CK1_1 227 233 PF00069 0.326
MOD_CK1_1 257 263 PF00069 0.401
MOD_CK1_1 264 270 PF00069 0.397
MOD_CK1_1 272 278 PF00069 0.409
MOD_CK1_1 283 289 PF00069 0.395
MOD_CK1_1 300 306 PF00069 0.367
MOD_CK1_1 326 332 PF00069 0.385
MOD_CK1_1 366 372 PF00069 0.482
MOD_CK1_1 39 45 PF00069 0.512
MOD_CK1_1 405 411 PF00069 0.409
MOD_CK1_1 434 440 PF00069 0.428
MOD_CK1_1 478 484 PF00069 0.517
MOD_CK1_1 67 73 PF00069 0.427
MOD_CK2_1 283 289 PF00069 0.458
MOD_GlcNHglycan 105 108 PF01048 0.677
MOD_GlcNHglycan 125 128 PF01048 0.527
MOD_GlcNHglycan 132 136 PF01048 0.639
MOD_GlcNHglycan 166 169 PF01048 0.670
MOD_GlcNHglycan 256 259 PF01048 0.622
MOD_GlcNHglycan 263 266 PF01048 0.674
MOD_GlcNHglycan 285 288 PF01048 0.628
MOD_GlcNHglycan 299 302 PF01048 0.667
MOD_GlcNHglycan 323 326 PF01048 0.595
MOD_GlcNHglycan 365 368 PF01048 0.730
MOD_GlcNHglycan 38 41 PF01048 0.598
MOD_GlcNHglycan 386 389 PF01048 0.676
MOD_GlcNHglycan 475 478 PF01048 0.715
MOD_GlcNHglycan 69 72 PF01048 0.630
MOD_GlcNHglycan 78 81 PF01048 0.665
MOD_GlcNHglycan 85 88 PF01048 0.576
MOD_GSK3_1 116 123 PF00069 0.384
MOD_GSK3_1 142 149 PF00069 0.464
MOD_GSK3_1 186 193 PF00069 0.345
MOD_GSK3_1 199 206 PF00069 0.449
MOD_GSK3_1 254 261 PF00069 0.427
MOD_GSK3_1 26 33 PF00069 0.612
MOD_GSK3_1 271 278 PF00069 0.489
MOD_GSK3_1 289 296 PF00069 0.395
MOD_GSK3_1 297 304 PF00069 0.441
MOD_GSK3_1 311 318 PF00069 0.412
MOD_GSK3_1 319 326 PF00069 0.499
MOD_GSK3_1 386 393 PF00069 0.526
MOD_GSK3_1 416 423 PF00069 0.423
MOD_GSK3_1 433 440 PF00069 0.521
MOD_GSK3_1 467 474 PF00069 0.488
MOD_GSK3_1 475 482 PF00069 0.454
MOD_GSK3_1 72 79 PF00069 0.510
MOD_GSK3_1 83 90 PF00069 0.457
MOD_N-GLC_1 140 145 PF02516 0.679
MOD_NEK2_1 131 136 PF00069 0.433
MOD_NEK2_1 240 245 PF00069 0.369
MOD_NEK2_1 254 259 PF00069 0.447
MOD_NEK2_1 281 286 PF00069 0.391
MOD_NEK2_1 297 302 PF00069 0.465
MOD_NEK2_1 354 359 PF00069 0.384
MOD_NEK2_1 36 41 PF00069 0.459
MOD_NEK2_1 479 484 PF00069 0.343
MOD_NEK2_1 52 57 PF00069 0.501
MOD_NEK2_1 64 69 PF00069 0.362
MOD_NEK2_1 83 88 PF00069 0.440
MOD_NEK2_1 89 94 PF00069 0.432
MOD_PIKK_1 326 332 PF00454 0.381
MOD_PIKK_1 410 416 PF00454 0.415
MOD_PIKK_1 437 443 PF00454 0.402
MOD_PIKK_1 467 473 PF00454 0.407
MOD_PIKK_1 64 70 PF00454 0.489
MOD_PIKK_1 96 102 PF00454 0.415
MOD_PK_1 26 32 PF00069 0.468
MOD_PKA_2 240 246 PF00069 0.361
MOD_PKA_2 394 400 PF00069 0.413
MOD_PKA_2 437 443 PF00069 0.518
MOD_PKA_2 87 93 PF00069 0.452
MOD_Plk_1 140 146 PF00069 0.500
MOD_Plk_1 272 278 PF00069 0.412
MOD_Plk_1 34 40 PF00069 0.514
MOD_Plk_1 44 50 PF00069 0.322
MOD_Plk_2-3 28 34 PF00069 0.371
MOD_Plk_4 126 132 PF00069 0.479
MOD_Plk_4 159 165 PF00069 0.397
MOD_Plk_4 190 196 PF00069 0.502
MOD_Plk_4 235 241 PF00069 0.390
MOD_Plk_4 264 270 PF00069 0.409
MOD_Plk_4 303 309 PF00069 0.405
MOD_Plk_4 355 361 PF00069 0.502
MOD_Plk_4 405 411 PF00069 0.446
MOD_Plk_4 89 95 PF00069 0.401
MOD_ProDKin_1 227 233 PF00069 0.320
MOD_ProDKin_1 431 437 PF00069 0.415
MOD_ProDKin_1 485 491 PF00069 0.410
TRG_ENDOCYTIC_2 487 490 PF00928 0.427
TRG_NES_CRM1_1 128 139 PF08389 0.467

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P251 Leptomonas seymouri 21% 100%
A0A381M9M8 Leishmania infantum 67% 99%
A0A3S5H581 Leishmania donovani 67% 99%
A0A3S5H583 Leishmania donovani 67% 99%
A0A451EJW1 Leishmania donovani 67% 99%
A0A451EJW4 Leishmania donovani 67% 99%
A0A451EJW6 Leishmania donovani 25% 74%
A4H3T7 Leishmania braziliensis 97% 100%
A4H3T8 Leishmania braziliensis 94% 100%
A4H3T9 Leishmania braziliensis 94% 100%
A4H3U0 Leishmania braziliensis 99% 100%
A4HS14 Leishmania infantum 25% 74%
E9AJZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 66% 85%
E9AK01 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 74%
Q9N852 Leishmania major 67% 100%
Q9N853 Leishmania major 67% 100%
Q9N856 Leishmania major 67% 100%
Q9XZX9 Leishmania major 24% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS