LeishMANIAdb
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TNFR-Cys domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TNFR-Cys domain-containing protein
Gene product:
hypothetical protein, conserved in leishmania
Species:
Leishmania braziliensis
UniProt:
A4H3T9_LEIBR
TriTrypDb:
LbrM.04.0230 , LBRM2903_040006800
Length:
522

Annotations

LeishMANIAdb annotations

A strange, fast-evolving receptor-like family of parazitic Kinetoplastids. While absent from many species, this family has expanded enormously on the Angomonas and Strigomonas lineages.. Very likely GPI-anchored protein. Very putatively might be involved in interactions with bacteria, explaining its expansion in symbiontic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 65
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 8
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

A4H3T9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3T9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0008233 peptidase activity 3 3
GO:0016787 hydrolase activity 2 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 78 82 PF00656 0.434
CLV_PCSK_SKI1_1 252 256 PF00082 0.575
CLV_PCSK_SKI1_1 453 457 PF00082 0.663
CLV_PCSK_SKI1_1 72 76 PF00082 0.576
DEG_SPOP_SBC_1 258 262 PF00917 0.363
DOC_CYCLIN_RxL_1 246 257 PF00134 0.369
DOC_PP2B_LxvP_1 310 313 PF13499 0.377
DOC_USP7_MATH_1 110 114 PF00917 0.485
DOC_USP7_MATH_1 137 141 PF00917 0.384
DOC_USP7_MATH_1 154 158 PF00917 0.519
DOC_USP7_MATH_1 199 203 PF00917 0.411
DOC_USP7_MATH_1 224 228 PF00917 0.448
DOC_USP7_MATH_1 275 279 PF00917 0.460
DOC_USP7_MATH_1 384 388 PF00917 0.474
DOC_USP7_MATH_1 404 408 PF00917 0.428
DOC_WW_Pin1_4 321 326 PF00397 0.377
DOC_WW_Pin1_4 431 436 PF00397 0.417
LIG_14-3-3_CanoR_1 116 124 PF00244 0.477
LIG_14-3-3_CanoR_1 438 446 PF00244 0.523
LIG_14-3-3_CanoR_1 479 487 PF00244 0.444
LIG_14-3-3_CanoR_1 88 94 PF00244 0.502
LIG_BIR_II_1 1 5 PF00653 0.571
LIG_BRCT_BRCA1_1 236 240 PF00533 0.475
LIG_Clathr_ClatBox_1 181 185 PF01394 0.344
LIG_FHA_1 141 147 PF00498 0.468
LIG_FHA_1 158 164 PF00498 0.325
LIG_FHA_1 220 226 PF00498 0.430
LIG_FHA_1 31 37 PF00498 0.496
LIG_FHA_1 343 349 PF00498 0.371
LIG_FHA_1 355 361 PF00498 0.344
LIG_FHA_1 442 448 PF00498 0.414
LIG_FHA_1 45 51 PF00498 0.514
LIG_FHA_1 468 474 PF00498 0.404
LIG_FHA_1 504 510 PF00498 0.502
LIG_FHA_1 54 60 PF00498 0.432
LIG_FHA_2 284 290 PF00498 0.461
LIG_FHA_2 29 35 PF00498 0.434
LIG_FHA_2 316 322 PF00498 0.449
LIG_FHA_2 356 362 PF00498 0.471
LIG_FHA_2 406 412 PF00498 0.403
LIG_IRF3_LxIS_1 32 39 PF10401 0.333
LIG_LIR_Apic_2 398 404 PF02991 0.456
LIG_LIR_Gen_1 280 288 PF02991 0.393
LIG_LIR_Gen_1 304 313 PF02991 0.462
LIG_LIR_Nem_3 132 136 PF02991 0.474
LIG_LIR_Nem_3 280 285 PF02991 0.391
LIG_LIR_Nem_3 304 310 PF02991 0.492
LIG_LIR_Nem_3 42 46 PF02991 0.443
LIG_PDZ_Class_2 517 522 PF00595 0.707
LIG_SH2_CRK 401 405 PF00017 0.489
LIG_SH2_CRK 487 491 PF00017 0.397
LIG_SH2_NCK_1 401 405 PF00017 0.443
LIG_SH2_NCK_1 487 491 PF00017 0.395
LIG_SH2_STAP1 46 50 PF00017 0.459
LIG_SH2_STAT3 468 471 PF00017 0.401
LIG_SH2_STAT5 269 272 PF00017 0.461
LIG_SH2_STAT5 446 449 PF00017 0.389
LIG_SH2_STAT5 46 49 PF00017 0.497
LIG_SH2_STAT5 468 471 PF00017 0.454
LIG_SH2_STAT5 487 490 PF00017 0.378
LIG_SH3_3 148 154 PF00018 0.510
LIG_SUMO_SIM_anti_2 162 167 PF11976 0.460
LIG_SUMO_SIM_par_1 142 147 PF11976 0.455
LIG_SUMO_SIM_par_1 162 167 PF11976 0.269
LIG_SUMO_SIM_par_1 209 214 PF11976 0.342
LIG_SUMO_SIM_par_1 230 235 PF11976 0.452
LIG_SUMO_SIM_par_1 47 56 PF11976 0.476
LIG_WRC_WIRS_1 281 286 PF05994 0.346
MOD_CDK_SPxxK_3 431 438 PF00069 0.417
MOD_CK1_1 123 129 PF00069 0.381
MOD_CK1_1 140 146 PF00069 0.422
MOD_CK1_1 157 163 PF00069 0.497
MOD_CK1_1 167 173 PF00069 0.435
MOD_CK1_1 257 263 PF00069 0.396
MOD_CK1_1 264 270 PF00069 0.397
MOD_CK1_1 280 286 PF00069 0.365
MOD_CK1_1 300 306 PF00069 0.372
MOD_CK1_1 326 332 PF00069 0.391
MOD_CK1_1 366 372 PF00069 0.467
MOD_CK1_1 39 45 PF00069 0.513
MOD_CK1_1 405 411 PF00069 0.421
MOD_CK1_1 434 440 PF00069 0.429
MOD_CK1_1 478 484 PF00069 0.524
MOD_CK1_1 67 73 PF00069 0.428
MOD_CK2_1 271 277 PF00069 0.447
MOD_CK2_1 283 289 PF00069 0.444
MOD_GlcNHglycan 105 108 PF01048 0.681
MOD_GlcNHglycan 125 128 PF01048 0.527
MOD_GlcNHglycan 132 136 PF01048 0.643
MOD_GlcNHglycan 166 169 PF01048 0.675
MOD_GlcNHglycan 256 259 PF01048 0.620
MOD_GlcNHglycan 263 266 PF01048 0.675
MOD_GlcNHglycan 273 276 PF01048 0.582
MOD_GlcNHglycan 299 302 PF01048 0.672
MOD_GlcNHglycan 325 328 PF01048 0.613
MOD_GlcNHglycan 365 368 PF01048 0.726
MOD_GlcNHglycan 38 41 PF01048 0.600
MOD_GlcNHglycan 386 389 PF01048 0.645
MOD_GlcNHglycan 475 478 PF01048 0.711
MOD_GlcNHglycan 69 72 PF01048 0.631
MOD_GlcNHglycan 78 81 PF01048 0.656
MOD_GlcNHglycan 85 88 PF01048 0.568
MOD_GSK3_1 116 123 PF00069 0.386
MOD_GSK3_1 142 149 PF00069 0.465
MOD_GSK3_1 186 193 PF00069 0.344
MOD_GSK3_1 199 206 PF00069 0.451
MOD_GSK3_1 254 261 PF00069 0.423
MOD_GSK3_1 26 33 PF00069 0.608
MOD_GSK3_1 271 278 PF00069 0.484
MOD_GSK3_1 297 304 PF00069 0.446
MOD_GSK3_1 311 318 PF00069 0.409
MOD_GSK3_1 319 326 PF00069 0.498
MOD_GSK3_1 386 393 PF00069 0.505
MOD_GSK3_1 433 440 PF00069 0.525
MOD_GSK3_1 467 474 PF00069 0.493
MOD_GSK3_1 475 482 PF00069 0.455
MOD_GSK3_1 72 79 PF00069 0.509
MOD_GSK3_1 83 90 PF00069 0.448
MOD_N-GLC_1 140 145 PF02516 0.674
MOD_NEK2_1 131 136 PF00069 0.436
MOD_NEK2_1 240 245 PF00069 0.366
MOD_NEK2_1 254 259 PF00069 0.444
MOD_NEK2_1 297 302 PF00069 0.469
MOD_NEK2_1 354 359 PF00069 0.383
MOD_NEK2_1 36 41 PF00069 0.459
MOD_NEK2_1 52 57 PF00069 0.492
MOD_NEK2_1 64 69 PF00069 0.367
MOD_NEK2_1 83 88 PF00069 0.431
MOD_NEK2_1 89 94 PF00069 0.430
MOD_PIKK_1 326 332 PF00454 0.386
MOD_PIKK_1 410 416 PF00454 0.404
MOD_PIKK_1 437 443 PF00454 0.398
MOD_PIKK_1 467 473 PF00454 0.412
MOD_PIKK_1 64 70 PF00454 0.493
MOD_PIKK_1 96 102 PF00454 0.415
MOD_PK_1 26 32 PF00069 0.465
MOD_PKA_2 240 246 PF00069 0.358
MOD_PKA_2 437 443 PF00069 0.514
MOD_PKA_2 478 484 PF00069 0.353
MOD_PKA_2 87 93 PF00069 0.445
MOD_Plk_1 140 146 PF00069 0.495
MOD_Plk_1 34 40 PF00069 0.511
MOD_Plk_1 44 50 PF00069 0.322
MOD_Plk_2-3 28 34 PF00069 0.366
MOD_Plk_4 126 132 PF00069 0.479
MOD_Plk_4 159 165 PF00069 0.396
MOD_Plk_4 190 196 PF00069 0.502
MOD_Plk_4 235 241 PF00069 0.391
MOD_Plk_4 264 270 PF00069 0.409
MOD_Plk_4 277 283 PF00069 0.337
MOD_Plk_4 303 309 PF00069 0.404
MOD_Plk_4 355 361 PF00069 0.499
MOD_Plk_4 405 411 PF00069 0.458
MOD_Plk_4 89 95 PF00069 0.400
MOD_ProDKin_1 321 327 PF00069 0.382
MOD_ProDKin_1 431 437 PF00069 0.418
TRG_ENDOCYTIC_2 487 490 PF00928 0.430
TRG_NES_CRM1_1 128 139 PF08389 0.469

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P251 Leptomonas seymouri 22% 100%
A0A381M9M8 Leishmania infantum 69% 99%
A0A3S5H581 Leishmania donovani 69% 99%
A0A3S5H583 Leishmania donovani 69% 99%
A0A451EJW1 Leishmania donovani 69% 99%
A0A451EJW4 Leishmania donovani 69% 99%
A0A451EJW6 Leishmania donovani 24% 74%
A4H3T7 Leishmania braziliensis 99% 100%
A4H3T8 Leishmania braziliensis 99% 100%
A4H3U0 Leishmania braziliensis 94% 100%
A4H3U1 Leishmania braziliensis 94% 100%
A4HS14 Leishmania infantum 24% 74%
E9AJZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 68% 85%
E9AK01 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 74%
Q9N852 Leishmania major 69% 100%
Q9N853 Leishmania major 69% 100%
Q9N856 Leishmania major 68% 100%
Q9XZX9 Leishmania major 24% 74%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS