LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

TNFR-Cys domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TNFR-Cys domain-containing protein
Gene product:
hypothetical protein, conserved in leishmania
Species:
Leishmania braziliensis
UniProt:
A4H3T8_LEIBR
TriTrypDb:
LbrM.04.0220 , LBRM2903_040006800
Length:
572

Annotations

LeishMANIAdb annotations

A strange, fast-evolving receptor-like family of parazitic Kinetoplastids. While absent from many species, this family has expanded enormously on the Angomonas and Strigomonas lineages.. Very likely GPI-anchored protein. Very putatively might be involved in interactions with bacteria, explaining its expansion in symbiontic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 50
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 11, no: 3
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

A4H3T8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3T8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0008233 peptidase activity 3 3
GO:0016787 hydrolase activity 2 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 124 128 PF00082 0.585
CLV_PCSK_SKI1_1 304 308 PF00082 0.577
CLV_PCSK_SKI1_1 503 507 PF00082 0.698
DEG_Nend_UBRbox_1 1 4 PF02207 0.648
DEG_SPOP_SBC_1 310 314 PF00917 0.371
DOC_CYCLIN_RxL_1 298 309 PF00134 0.374
DOC_PP2B_LxvP_1 362 365 PF13499 0.387
DOC_USP7_MATH_1 162 166 PF00917 0.500
DOC_USP7_MATH_1 189 193 PF00917 0.432
DOC_USP7_MATH_1 206 210 PF00917 0.414
DOC_USP7_MATH_1 251 255 PF00917 0.401
DOC_USP7_MATH_1 276 280 PF00917 0.460
DOC_USP7_MATH_1 327 331 PF00917 0.463
DOC_USP7_MATH_1 436 440 PF00917 0.530
DOC_USP7_MATH_1 456 460 PF00917 0.298
DOC_WW_Pin1_4 373 378 PF00397 0.385
DOC_WW_Pin1_4 483 488 PF00397 0.434
LIG_14-3-3_CanoR_1 140 146 PF00244 0.513
LIG_14-3-3_CanoR_1 168 176 PF00244 0.491
LIG_14-3-3_CanoR_1 490 498 PF00244 0.550
LIG_14-3-3_CanoR_1 529 537 PF00244 0.452
LIG_BRCT_BRCA1_1 288 292 PF00533 0.472
LIG_Clathr_ClatBox_1 233 237 PF01394 0.346
LIG_FHA_1 106 112 PF00498 0.441
LIG_FHA_1 193 199 PF00498 0.483
LIG_FHA_1 210 216 PF00498 0.339
LIG_FHA_1 272 278 PF00498 0.381
LIG_FHA_1 31 37 PF00498 0.661
LIG_FHA_1 395 401 PF00498 0.379
LIG_FHA_1 407 413 PF00498 0.346
LIG_FHA_1 518 524 PF00498 0.411
LIG_FHA_1 554 560 PF00498 0.524
LIG_FHA_1 83 89 PF00498 0.519
LIG_FHA_1 97 103 PF00498 0.356
LIG_FHA_2 336 342 PF00498 0.472
LIG_FHA_2 368 374 PF00498 0.451
LIG_FHA_2 408 414 PF00498 0.479
LIG_FHA_2 42 48 PF00498 0.663
LIG_FHA_2 458 464 PF00498 0.386
LIG_FHA_2 81 87 PF00498 0.451
LIG_LIR_Apic_2 450 456 PF02991 0.391
LIG_LIR_Gen_1 332 340 PF02991 0.402
LIG_LIR_Gen_1 356 365 PF02991 0.378
LIG_LIR_Nem_3 184 188 PF02991 0.496
LIG_LIR_Nem_3 22 28 PF02991 0.658
LIG_LIR_Nem_3 332 337 PF02991 0.399
LIG_LIR_Nem_3 356 362 PF02991 0.480
LIG_LIR_Nem_3 94 98 PF02991 0.504
LIG_PDZ_Class_2 567 572 PF00595 0.728
LIG_SH2_CRK 453 457 PF00017 0.390
LIG_SH2_CRK 537 541 PF00017 0.407
LIG_SH2_NCK_1 453 457 PF00017 0.383
LIG_SH2_NCK_1 537 541 PF00017 0.404
LIG_SH2_STAP1 98 102 PF00017 0.478
LIG_SH2_STAT3 518 521 PF00017 0.405
LIG_SH2_STAT5 321 324 PF00017 0.464
LIG_SH2_STAT5 49 52 PF00017 0.658
LIG_SH2_STAT5 498 501 PF00017 0.440
LIG_SH2_STAT5 518 521 PF00017 0.461
LIG_SH2_STAT5 537 540 PF00017 0.387
LIG_SH2_STAT5 98 101 PF00017 0.480
LIG_SH3_3 200 206 PF00018 0.521
LIG_SH3_3 52 58 PF00018 0.640
LIG_SUMO_SIM_anti_2 214 219 PF11976 0.478
LIG_SUMO_SIM_par_1 194 199 PF11976 0.479
LIG_SUMO_SIM_par_1 261 266 PF11976 0.350
LIG_SUMO_SIM_par_1 282 287 PF11976 0.464
LIG_SUMO_SIM_par_1 99 108 PF11976 0.495
LIG_WRC_WIRS_1 333 338 PF05994 0.356
MOD_CDK_SPxxK_3 483 490 PF00069 0.436
MOD_CK1_1 119 125 PF00069 0.438
MOD_CK1_1 17 23 PF00069 0.654
MOD_CK1_1 175 181 PF00069 0.393
MOD_CK1_1 192 198 PF00069 0.430
MOD_CK1_1 209 215 PF00069 0.362
MOD_CK1_1 309 315 PF00069 0.488
MOD_CK1_1 316 322 PF00069 0.426
MOD_CK1_1 332 338 PF00069 0.373
MOD_CK1_1 352 358 PF00069 0.379
MOD_CK1_1 378 384 PF00069 0.396
MOD_CK1_1 418 424 PF00069 0.452
MOD_CK1_1 457 463 PF00069 0.381
MOD_CK1_1 486 492 PF00069 0.456
MOD_CK1_1 528 534 PF00069 0.532
MOD_CK1_1 91 97 PF00069 0.546
MOD_CK2_1 323 329 PF00069 0.452
MOD_CK2_1 335 341 PF00069 0.458
MOD_GlcNHglycan 121 124 PF01048 0.643
MOD_GlcNHglycan 130 133 PF01048 0.676
MOD_GlcNHglycan 137 140 PF01048 0.582
MOD_GlcNHglycan 157 160 PF01048 0.691
MOD_GlcNHglycan 177 180 PF01048 0.531
MOD_GlcNHglycan 184 188 PF01048 0.679
MOD_GlcNHglycan 308 311 PF01048 0.706
MOD_GlcNHglycan 315 318 PF01048 0.630
MOD_GlcNHglycan 325 328 PF01048 0.506
MOD_GlcNHglycan 351 354 PF01048 0.675
MOD_GlcNHglycan 377 380 PF01048 0.620
MOD_GlcNHglycan 417 420 PF01048 0.711
MOD_GlcNHglycan 438 441 PF01048 0.615
MOD_GlcNHglycan 50 53 PF01048 0.464
MOD_GlcNHglycan 525 528 PF01048 0.729
MOD_GlcNHglycan 90 93 PF01048 0.635
MOD_GSK3_1 124 131 PF00069 0.478
MOD_GSK3_1 135 142 PF00069 0.500
MOD_GSK3_1 168 175 PF00069 0.381
MOD_GSK3_1 17 24 PF00069 0.654
MOD_GSK3_1 194 201 PF00069 0.383
MOD_GSK3_1 238 245 PF00069 0.396
MOD_GSK3_1 251 258 PF00069 0.462
MOD_GSK3_1 306 313 PF00069 0.494
MOD_GSK3_1 323 330 PF00069 0.493
MOD_GSK3_1 349 356 PF00069 0.488
MOD_GSK3_1 363 370 PF00069 0.394
MOD_GSK3_1 371 378 PF00069 0.511
MOD_GSK3_1 438 445 PF00069 0.513
MOD_GSK3_1 485 492 PF00069 0.556
MOD_GSK3_1 493 500 PF00069 0.474
MOD_GSK3_1 517 524 PF00069 0.497
MOD_GSK3_1 525 532 PF00069 0.460
MOD_GSK3_1 78 85 PF00069 0.522
MOD_N-GLC_1 192 197 PF02516 0.686
MOD_NEK2_1 104 109 PF00069 0.410
MOD_NEK2_1 116 121 PF00069 0.376
MOD_NEK2_1 135 140 PF00069 0.381
MOD_NEK2_1 141 146 PF00069 0.471
MOD_NEK2_1 183 188 PF00069 0.489
MOD_NEK2_1 292 297 PF00069 0.415
MOD_NEK2_1 306 311 PF00069 0.435
MOD_NEK2_1 349 354 PF00069 0.474
MOD_NEK2_1 406 411 PF00069 0.391
MOD_NEK2_1 88 93 PF00069 0.487
MOD_PIKK_1 116 122 PF00454 0.507
MOD_PIKK_1 148 154 PF00454 0.373
MOD_PIKK_1 30 36 PF00454 0.659
MOD_PIKK_1 378 384 PF00454 0.391
MOD_PIKK_1 462 468 PF00454 0.406
MOD_PIKK_1 489 495 PF00454 0.422
MOD_PIKK_1 517 523 PF00454 0.417
MOD_PK_1 78 84 PF00069 0.412
MOD_PKA_2 139 145 PF00069 0.468
MOD_PKA_2 17 23 PF00069 0.654
MOD_PKA_2 292 298 PF00069 0.393
MOD_PKA_2 489 495 PF00069 0.545
MOD_PKA_2 528 534 PF00069 0.357
MOD_Plk_1 192 198 PF00069 0.502
MOD_Plk_1 86 92 PF00069 0.533
MOD_Plk_1 96 102 PF00069 0.409
MOD_Plk_2-3 80 86 PF00069 0.378
MOD_Plk_4 141 147 PF00069 0.407
MOD_Plk_4 178 184 PF00069 0.494
MOD_Plk_4 211 217 PF00069 0.371
MOD_Plk_4 242 248 PF00069 0.483
MOD_Plk_4 287 293 PF00069 0.473
MOD_Plk_4 316 322 PF00069 0.394
MOD_Plk_4 329 335 PF00069 0.337
MOD_Plk_4 355 361 PF00069 0.478
MOD_Plk_4 407 413 PF00069 0.520
MOD_Plk_4 457 463 PF00069 0.501
MOD_ProDKin_1 373 379 PF00069 0.389
MOD_ProDKin_1 483 489 PF00069 0.436
TRG_ENDOCYTIC_2 537 540 PF00928 0.432
TRG_NES_CRM1_1 180 191 PF08389 0.485
TRG_NLS_MonoCore_2 3 8 PF00514 0.650
TRG_NLS_MonoExtN_4 2 9 PF00514 0.650

Homologs

Protein Taxonomy Sequence identity Coverage
A0A381M9M8 Leishmania infantum 69% 100%
A0A3S5H581 Leishmania donovani 68% 100%
A0A3S5H583 Leishmania donovani 69% 100%
A0A451EJW1 Leishmania donovani 68% 100%
A0A451EJW4 Leishmania donovani 68% 100%
A4H3T9 Leishmania braziliensis 99% 100%
A4H3U0 Leishmania braziliensis 94% 100%
A4H3U1 Leishmania braziliensis 94% 100%
E9AJZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 68% 93%
Q9N852 Leishmania major 69% 100%
Q9N853 Leishmania major 68% 100%
Q9N856 Leishmania major 68% 100%
Q9XZX9 Leishmania major 23% 81%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS