LeishMANIAdb
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Dispersed gene family protein 1 (DGF-1)

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Dispersed gene family protein 1 (DGF-1)
Gene product:
hypothetical protein, conserved in leishmania (fragment)
Species:
Leishmania braziliensis
UniProt:
A4H3T7_LEIBR
TriTrypDb:
LbrM.04.0210 , LBRM2903_040006800
Length:
362

Annotations

LeishMANIAdb annotations

A strange, fast-evolving receptor-like family of parazitic Kinetoplastids. While absent from many species, this family has expanded enormously on the Angomonas and Strigomonas lineages.. Very likely GPI-anchored protein. Very putatively might be involved in interactions with bacteria, explaining its expansion in symbiontic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 40
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 11, no: 1
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

A4H3T7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3T7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0008233 peptidase activity 3 3
GO:0016787 hydrolase activity 2 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 136 140 PF00656 0.625
CLV_PCSK_SKI1_1 130 134 PF00082 0.385
CLV_PCSK_SKI1_1 310 314 PF00082 0.581
DEG_Nend_UBRbox_4 1 3 PF02207 0.455
DEG_SCF_FBW7_1 50 57 PF00400 0.462
DEG_SPOP_SBC_1 316 320 PF00917 0.385
DOC_CKS1_1 286 291 PF01111 0.337
DOC_CYCLIN_RxL_1 304 315 PF00134 0.385
DOC_CYCLIN_yCln2_LP_2 12 18 PF00134 0.458
DOC_PP2B_LxvP_1 12 15 PF13499 0.451
DOC_USP7_MATH_1 168 172 PF00917 0.488
DOC_USP7_MATH_1 195 199 PF00917 0.427
DOC_USP7_MATH_1 212 216 PF00917 0.374
DOC_USP7_MATH_1 23 27 PF00917 0.474
DOC_USP7_MATH_1 257 261 PF00917 0.402
DOC_USP7_MATH_1 282 286 PF00917 0.465
DOC_USP7_MATH_1 333 337 PF00917 0.505
DOC_USP7_MATH_1 52 56 PF00917 0.451
DOC_WW_Pin1_4 19 24 PF00397 0.462
DOC_WW_Pin1_4 285 290 PF00397 0.335
DOC_WW_Pin1_4 48 53 PF00397 0.482
DOC_WW_Pin1_4 5 10 PF00397 0.439
LIG_14-3-3_CanoR_1 146 152 PF00244 0.679
LIG_14-3-3_CanoR_1 174 182 PF00244 0.481
LIG_14-3-3_CanoR_1 32 41 PF00244 0.456
LIG_BRCT_BRCA1_1 294 298 PF00533 0.483
LIG_Clathr_ClatBox_1 239 243 PF01394 0.356
LIG_CtBP_PxDLS_1 15 19 PF00389 0.467
LIG_FHA_1 103 109 PF00498 0.703
LIG_FHA_1 112 118 PF00498 0.657
LIG_FHA_1 199 205 PF00498 0.479
LIG_FHA_1 216 222 PF00498 0.317
LIG_FHA_1 278 284 PF00498 0.363
LIG_FHA_1 286 292 PF00498 0.336
LIG_FHA_1 51 57 PF00498 0.451
LIG_FHA_1 89 95 PF00498 0.708
LIG_FHA_2 33 39 PF00498 0.465
LIG_FHA_2 342 348 PF00498 0.472
LIG_FHA_2 87 93 PF00498 0.620
LIG_LIR_Gen_1 338 346 PF02991 0.440
LIG_LIR_LC3C_4 288 292 PF02991 0.330
LIG_LIR_Nem_3 100 104 PF02991 0.683
LIG_LIR_Nem_3 190 194 PF02991 0.485
LIG_LIR_Nem_3 338 343 PF02991 0.471
LIG_MYND_1 10 14 PF01753 0.439
LIG_MYND_1 48 52 PF01753 0.453
LIG_SH2_STAP1 104 108 PF00017 0.678
LIG_SH2_STAT5 104 107 PF00017 0.680
LIG_SH2_STAT5 327 330 PF00017 0.492
LIG_SH3_3 206 212 PF00018 0.499
LIG_SH3_3 42 48 PF00018 0.448
LIG_SH3_3 58 64 PF00018 0.434
LIG_SH3_3 8 14 PF00018 0.440
LIG_SUMO_SIM_anti_2 220 225 PF11976 0.471
LIG_SUMO_SIM_par_1 105 114 PF11976 0.689
LIG_SUMO_SIM_par_1 13 19 PF11976 0.460
LIG_SUMO_SIM_par_1 200 205 PF11976 0.475
LIG_SUMO_SIM_par_1 220 225 PF11976 0.277
LIG_SUMO_SIM_par_1 267 272 PF11976 0.354
LIG_SUMO_SIM_par_1 282 288 PF11976 0.382
LIG_WRC_WIRS_1 339 344 PF05994 0.410
LIG_WW_3 46 50 PF00397 0.452
MOD_CK1_1 125 131 PF00069 0.635
MOD_CK1_1 181 187 PF00069 0.386
MOD_CK1_1 19 25 PF00069 0.470
MOD_CK1_1 198 204 PF00069 0.409
MOD_CK1_1 215 221 PF00069 0.329
MOD_CK1_1 225 231 PF00069 0.442
MOD_CK1_1 285 291 PF00069 0.335
MOD_CK1_1 315 321 PF00069 0.505
MOD_CK1_1 322 328 PF00069 0.421
MOD_CK1_1 338 344 PF00069 0.413
MOD_CK1_1 97 103 PF00069 0.707
MOD_CK2_1 32 38 PF00069 0.467
MOD_CK2_1 329 335 PF00069 0.484
MOD_CK2_1 341 347 PF00069 0.461
MOD_GlcNHglycan 127 130 PF01048 0.435
MOD_GlcNHglycan 136 139 PF01048 0.408
MOD_GlcNHglycan 143 146 PF01048 0.493
MOD_GlcNHglycan 163 166 PF01048 0.250
MOD_GlcNHglycan 183 186 PF01048 0.498
MOD_GlcNHglycan 190 194 PF01048 0.657
MOD_GlcNHglycan 224 227 PF01048 0.704
MOD_GlcNHglycan 25 28 PF01048 0.675
MOD_GlcNHglycan 3 6 PF01048 0.648
MOD_GlcNHglycan 314 317 PF01048 0.731
MOD_GlcNHglycan 321 324 PF01048 0.633
MOD_GlcNHglycan 331 334 PF01048 0.529
MOD_GlcNHglycan 357 360 PF01048 0.802
MOD_GlcNHglycan 56 59 PF01048 0.664
MOD_GlcNHglycan 96 99 PF01048 0.402
MOD_GSK3_1 1 8 PF00069 0.450
MOD_GSK3_1 10 17 PF00069 0.467
MOD_GSK3_1 130 137 PF00069 0.642
MOD_GSK3_1 141 148 PF00069 0.638
MOD_GSK3_1 174 181 PF00069 0.369
MOD_GSK3_1 19 26 PF00069 0.465
MOD_GSK3_1 200 207 PF00069 0.367
MOD_GSK3_1 244 251 PF00069 0.385
MOD_GSK3_1 257 264 PF00069 0.445
MOD_GSK3_1 28 35 PF00069 0.482
MOD_GSK3_1 312 319 PF00069 0.511
MOD_GSK3_1 329 336 PF00069 0.326
MOD_GSK3_1 355 362 PF00069 0.615
MOD_GSK3_1 48 55 PF00069 0.455
MOD_GSK3_1 84 91 PF00069 0.745
MOD_N-GLC_1 198 203 PF02516 0.682
MOD_NEK2_1 1 6 PF00069 0.450
MOD_NEK2_1 110 115 PF00069 0.701
MOD_NEK2_1 122 127 PF00069 0.566
MOD_NEK2_1 141 146 PF00069 0.697
MOD_NEK2_1 147 152 PF00069 0.640
MOD_NEK2_1 16 21 PF00069 0.470
MOD_NEK2_1 189 194 PF00069 0.479
MOD_NEK2_1 298 303 PF00069 0.392
MOD_NEK2_1 312 317 PF00069 0.441
MOD_NEK2_1 355 360 PF00069 0.637
MOD_NEK2_1 94 99 PF00069 0.660
MOD_PIKK_1 122 128 PF00454 0.696
MOD_PIKK_1 154 160 PF00454 0.366
MOD_PK_1 84 90 PF00069 0.613
MOD_PKA_2 145 151 PF00069 0.648
MOD_PKA_2 298 304 PF00069 0.384
MOD_Plk_1 102 108 PF00069 0.510
MOD_Plk_1 198 204 PF00069 0.478
MOD_Plk_1 92 98 PF00069 0.714
MOD_Plk_2-3 86 92 PF00069 0.585
MOD_Plk_4 147 153 PF00069 0.558
MOD_Plk_4 184 190 PF00069 0.475
MOD_Plk_4 217 223 PF00069 0.364
MOD_Plk_4 248 254 PF00069 0.465
MOD_Plk_4 293 299 PF00069 0.485
MOD_Plk_4 322 328 PF00069 0.393
MOD_Plk_4 335 341 PF00069 0.399
MOD_ProDKin_1 19 25 PF00069 0.458
MOD_ProDKin_1 285 291 PF00069 0.335
MOD_ProDKin_1 48 54 PF00069 0.481
MOD_ProDKin_1 5 11 PF00069 0.438
TRG_NES_CRM1_1 186 197 PF08389 0.477

Homologs

Protein Taxonomy Sequence identity Coverage
A0A381M9M8 Leishmania infantum 76% 69%
A0A3S5H581 Leishmania donovani 75% 69%
A0A3S5H583 Leishmania donovani 75% 69%
A0A451EJW1 Leishmania donovani 75% 69%
A0A451EJW4 Leishmania donovani 75% 69%
A4H3T9 Leishmania braziliensis 99% 69%
A4H3U0 Leishmania braziliensis 97% 69%
A4H3U1 Leishmania braziliensis 97% 69%
Q9N852 Leishmania major 77% 68%
Q9N853 Leishmania major 77% 68%
Q9N856 Leishmania major 77% 68%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS