Variant-specific surface protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved in leishmania

Species:

Leishmania braziliensis

UniProt:

A4H3T6_LEIBR

TriTrypDb:

LbrM.04.0200 , LBRM2903_040006800

Length:

284

Annotations

LeishMANIAdb annotations

A strange, fast-evolving receptor-like family of parazitic Kinetoplastids. While absent from many species, this family has expanded enormously on the Angomonas and Strigomonas lineages.. Very likely GPI-anchored protein. Very putatively might be involved in interactions with bacteria, explaining its expansion in symbiontic species.. Localization: Cell surface (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3T6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3T6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	14	18	PF00082	0.524
CLV_PCSK_SKI1_1	215	219	PF00082	0.538
DEG_Nend_Nbox_1	1	3	PF02207	0.736
DEG_SPOP_SBC_1	20	24	PF00917	0.727
DOC_CYCLIN_RxL_1	8	19	PF00134	0.734
DOC_PP2B_LxvP_1	72	75	PF13499	0.715
DOC_USP7_MATH_1	146	150	PF00917	0.793
DOC_USP7_MATH_1	166	170	PF00917	0.549
DOC_WW_Pin1_4	193	198	PF00397	0.750
DOC_WW_Pin1_4	83	88	PF00397	0.756
LIG_14-3-3_CanoR_1	200	208	PF00244	0.731
LIG_14-3-3_CanoR_1	241	249	PF00244	0.717
LIG_BRCT_BRCA1_1	75	79	PF00533	0.641
LIG_FHA_1	105	111	PF00498	0.708
LIG_FHA_1	117	123	PF00498	0.579
LIG_FHA_1	204	210	PF00498	0.733
LIG_FHA_1	230	236	PF00498	0.722
LIG_FHA_1	266	272	PF00498	0.549
LIG_FHA_2	168	174	PF00498	0.811
LIG_FHA_2	78	84	PF00498	0.777
LIG_LIR_Apic_2	160	166	PF02991	0.803
LIG_LIR_Gen_1	41	50	PF02991	0.738
LIG_LIR_Gen_1	66	75	PF02991	0.708
LIG_LIR_Nem_3	41	47	PF02991	0.714
LIG_LIR_Nem_3	66	72	PF02991	0.702
LIG_PDZ_Class_2	279	284	PF00595	0.549
LIG_SH2_CRK	163	167	PF00017	0.808
LIG_SH2_CRK	249	253	PF00017	0.720
LIG_SH2_NCK_1	163	167	PF00017	0.808
LIG_SH2_NCK_1	249	253	PF00017	0.720
LIG_SH2_STAP1	57	61	PF00017	0.637
LIG_SH2_STAT3	230	233	PF00017	0.722
LIG_SH2_STAT5	208	211	PF00017	0.724
LIG_SH2_STAT5	230	233	PF00017	0.722
LIG_SH2_STAT5	249	252	PF00017	0.477
LIG_SH2_STAT5	31	34	PF00017	0.697
MOD_CDK_SPxxK_3	193	200	PF00069	0.748
MOD_CK1_1	128	134	PF00069	0.779
MOD_CK1_1	167	173	PF00069	0.810
MOD_CK1_1	19	25	PF00069	0.723
MOD_CK1_1	196	202	PF00069	0.741
MOD_CK1_1	240	246	PF00069	0.714
MOD_CK1_1	26	32	PF00069	0.650
MOD_CK1_1	34	40	PF00069	0.515
MOD_CK1_1	45	51	PF00069	0.537
MOD_CK1_1	62	68	PF00069	0.494
MOD_CK1_1	88	94	PF00069	0.734
MOD_CK2_1	45	51	PF00069	0.724
MOD_GlcNHglycan	127	130	PF01048	0.573
MOD_GlcNHglycan	148	151	PF01048	0.594
MOD_GlcNHglycan	18	21	PF01048	0.530
MOD_GlcNHglycan	237	240	PF01048	0.535
MOD_GlcNHglycan	25	28	PF01048	0.455
MOD_GlcNHglycan	47	50	PF01048	0.535
MOD_GlcNHglycan	61	64	PF01048	0.412
MOD_GlcNHglycan	87	90	PF01048	0.560
MOD_GSK3_1	148	155	PF00069	0.785
MOD_GSK3_1	16	23	PF00069	0.724
MOD_GSK3_1	195	202	PF00069	0.744
MOD_GSK3_1	229	236	PF00069	0.725
MOD_GSK3_1	237	244	PF00069	0.621
MOD_GSK3_1	33	40	PF00069	0.488
MOD_GSK3_1	51	58	PF00069	0.556
MOD_GSK3_1	59	66	PF00069	0.654
MOD_GSK3_1	73	80	PF00069	0.556
MOD_GSK3_1	81	88	PF00069	0.668
MOD_NEK2_1	116	121	PF00069	0.721
MOD_NEK2_1	16	21	PF00069	0.548
MOD_NEK2_1	2	7	PF00069	0.722
MOD_NEK2_1	43	48	PF00069	0.669
MOD_NEK2_1	59	64	PF00069	0.590
MOD_PIKK_1	172	178	PF00454	0.807
MOD_PIKK_1	199	205	PF00454	0.728
MOD_PIKK_1	229	235	PF00454	0.720
MOD_PIKK_1	88	94	PF00454	0.734
MOD_PKA_2	199	205	PF00069	0.728
MOD_PKA_2	2	8	PF00069	0.725
MOD_PKA_2	240	246	PF00069	0.714
MOD_Plk_1	34	40	PF00069	0.619
MOD_Plk_4	117	123	PF00069	0.729
MOD_Plk_4	167	173	PF00069	0.810
MOD_Plk_4	26	32	PF00069	0.738
MOD_Plk_4	65	71	PF00069	0.704
MOD_ProDKin_1	193	199	PF00069	0.751
MOD_ProDKin_1	83	89	PF00069	0.760
TRG_ENDOCYTIC_2	249	252	PF00928	0.714