Reverse transcriptase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H3T5_LEIBR

TriTrypDb:

LbrM.04.0190 , LBRM2903_040006700

Length:

468

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H3T5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H3T5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	267	269	PF00675	0.493
CLV_NRD_NRD_1	313	315	PF00675	0.447
CLV_NRD_NRD_1	444	446	PF00675	0.588
CLV_PCSK_KEX2_1	267	269	PF00082	0.493
CLV_PCSK_KEX2_1	313	315	PF00082	0.447
CLV_PCSK_KEX2_1	444	446	PF00082	0.588
CLV_PCSK_SKI1_1	224	228	PF00082	0.633
CLV_PCSK_SKI1_1	267	271	PF00082	0.692
DEG_APCC_DBOX_1	266	274	PF00400	0.549
DEG_APCC_DBOX_1	73	81	PF00400	0.377
DEG_APCC_KENBOX_2	67	71	PF00400	0.521
DEG_SPOP_SBC_1	156	160	PF00917	0.530
DOC_CKS1_1	188	193	PF01111	0.608
DOC_CKS1_1	376	381	PF01111	0.498
DOC_MAPK_gen_1	313	323	PF00069	0.479
DOC_MAPK_gen_1	404	414	PF00069	0.482
DOC_USP7_MATH_1	147	151	PF00917	0.628
DOC_USP7_MATH_1	156	160	PF00917	0.595
DOC_USP7_MATH_1	170	174	PF00917	0.608
DOC_USP7_MATH_1	20	24	PF00917	0.561
DOC_USP7_MATH_1	277	281	PF00917	0.531
DOC_USP7_MATH_1	379	383	PF00917	0.563
DOC_USP7_MATH_1	453	457	PF00917	0.531
DOC_USP7_MATH_1	55	59	PF00917	0.378
DOC_USP7_MATH_1	83	87	PF00917	0.416
DOC_USP7_MATH_1	92	96	PF00917	0.427
DOC_USP7_UBL2_3	35	39	PF12436	0.507
DOC_USP7_UBL2_3	68	72	PF12436	0.521
DOC_WW_Pin1_4	14	19	PF00397	0.614
DOC_WW_Pin1_4	165	170	PF00397	0.658
DOC_WW_Pin1_4	172	177	PF00397	0.633
DOC_WW_Pin1_4	187	192	PF00397	0.707
DOC_WW_Pin1_4	257	262	PF00397	0.527
DOC_WW_Pin1_4	375	380	PF00397	0.514
DOC_WW_Pin1_4	437	442	PF00397	0.543
LIG_14-3-3_CanoR_1	214	221	PF00244	0.587
LIG_14-3-3_CanoR_1	383	393	PF00244	0.427
LIG_14-3-3_CanoR_1	431	438	PF00244	0.516
LIG_14-3-3_CanoR_1	454	459	PF00244	0.529
LIG_14-3-3_CanoR_1	91	99	PF00244	0.547
LIG_Actin_WH2_2	391	409	PF00022	0.473
LIG_eIF4E_1	116	122	PF01652	0.541
LIG_eIF4E_1	365	371	PF01652	0.488
LIG_FHA_1	156	162	PF00498	0.560
LIG_FHA_1	232	238	PF00498	0.591
LIG_FHA_1	354	360	PF00498	0.570
LIG_FHA_1	38	44	PF00498	0.466
LIG_FHA_1	388	394	PF00498	0.431
LIG_FHA_1	398	404	PF00498	0.418
LIG_FHA_2	188	194	PF00498	0.691
LIG_FHA_2	226	232	PF00498	0.738
LIG_Integrin_isoDGR_2	133	135	PF01839	0.550
LIG_LIR_Gen_1	111	122	PF02991	0.666
LIG_LIR_Gen_1	82	92	PF02991	0.398
LIG_LIR_Nem_3	111	117	PF02991	0.507
LIG_LIR_Nem_3	367	372	PF02991	0.632
LIG_LIR_Nem_3	413	417	PF02991	0.346
LIG_LIR_Nem_3	82	87	PF02991	0.385
LIG_PCNA_yPIPBox_3	322	331	PF02747	0.373
LIG_SH2_CRK	328	332	PF00017	0.357
LIG_SH2_CRK	84	88	PF00017	0.528
LIG_SH2_NCK_1	216	220	PF00017	0.514
LIG_SH2_NCK_1	254	258	PF00017	0.496
LIG_SH2_SRC	417	420	PF00017	0.303
LIG_SH2_STAP1	216	220	PF00017	0.514
LIG_SH2_STAT3	427	430	PF00017	0.452
LIG_SH2_STAT5	116	119	PF00017	0.510
LIG_SH2_STAT5	128	131	PF00017	0.654
LIG_SH2_STAT5	372	375	PF00017	0.495
LIG_SH2_STAT5	417	420	PF00017	0.381
LIG_SH3_3	188	194	PF00018	0.699
LIG_SH3_3	329	335	PF00018	0.441
LIG_SH3_3	447	453	PF00018	0.541
LIG_WW_3	168	172	PF00397	0.518
MOD_CDK_SPxK_1	165	171	PF00069	0.525
MOD_CDK_SPxxK_3	437	444	PF00069	0.547
MOD_CK1_1	14	20	PF00069	0.542
MOD_CK1_1	150	156	PF00069	0.632
MOD_CK1_1	160	166	PF00069	0.787
MOD_CK1_1	235	241	PF00069	0.537
MOD_CK1_1	387	393	PF00069	0.439
MOD_CK1_1	437	443	PF00069	0.544
MOD_CK1_1	86	92	PF00069	0.404
MOD_CK1_1	95	101	PF00069	0.462
MOD_CK2_1	187	193	PF00069	0.667
MOD_GlcNHglycan	129	132	PF01048	0.560
MOD_GlcNHglycan	154	157	PF01048	0.726
MOD_GlcNHglycan	217	220	PF01048	0.604
MOD_GlcNHglycan	247	250	PF01048	0.595
MOD_GlcNHglycan	279	282	PF01048	0.376
MOD_GlcNHglycan	349	352	PF01048	0.595
MOD_GlcNHglycan	35	38	PF01048	0.629
MOD_GlcNHglycan	360	363	PF01048	0.550
MOD_GlcNHglycan	81	84	PF01048	0.385
MOD_GSK3_1	12	19	PF00069	0.611
MOD_GSK3_1	136	143	PF00069	0.669
MOD_GSK3_1	147	154	PF00069	0.627
MOD_GSK3_1	156	163	PF00069	0.769
MOD_GSK3_1	231	238	PF00069	0.626
MOD_GSK3_1	33	40	PF00069	0.553
MOD_GSK3_1	371	378	PF00069	0.651
MOD_GSK3_1	430	437	PF00069	0.541
MOD_GSK3_1	453	460	PF00069	0.527
MOD_GSK3_1	79	86	PF00069	0.380
MOD_N-GLC_1	126	131	PF02516	0.519
MOD_N-GLC_1	135	140	PF02516	0.531
MOD_N-GLC_1	202	207	PF02516	0.543
MOD_N-GLC_1	379	384	PF02516	0.538
MOD_NEK2_1	233	238	PF00069	0.652
MOD_NEK2_1	371	376	PF00069	0.573
MOD_NEK2_2	239	244	PF00069	0.523
MOD_NEK2_2	381	386	PF00069	0.507
MOD_PIKK_1	147	153	PF00454	0.541
MOD_PIKK_1	384	390	PF00454	0.478
MOD_PIKK_1	431	437	PF00454	0.512
MOD_PIKK_1	86	92	PF00454	0.546
MOD_PIKK_1	93	99	PF00454	0.576
MOD_PKA_2	147	153	PF00069	0.625
MOD_PKA_2	170	176	PF00069	0.524
MOD_PKA_2	179	185	PF00069	0.537
MOD_PKA_2	275	281	PF00069	0.629
MOD_PKA_2	394	400	PF00069	0.336
MOD_PKA_2	430	436	PF00069	0.617
MOD_PKA_2	453	459	PF00069	0.529
MOD_PKA_2	50	56	PF00069	0.588
MOD_PKA_2	93	99	PF00069	0.584
MOD_PKB_1	60	68	PF00069	0.539
MOD_Plk_1	109	115	PF00069	0.598
MOD_Plk_4	109	115	PF00069	0.441
MOD_Plk_4	285	291	PF00069	0.391
MOD_Plk_4	389	395	PF00069	0.485
MOD_ProDKin_1	14	20	PF00069	0.612
MOD_ProDKin_1	165	171	PF00069	0.660
MOD_ProDKin_1	172	178	PF00069	0.631
MOD_ProDKin_1	187	193	PF00069	0.711
MOD_ProDKin_1	257	263	PF00069	0.519
MOD_ProDKin_1	375	381	PF00069	0.515
MOD_ProDKin_1	437	443	PF00069	0.544
MOD_SUMO_rev_2	30	37	PF00179	0.552
TRG_DiLeu_BaLyEn_6	265	270	PF01217	0.541
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.422
TRG_ENDOCYTIC_2	328	331	PF00928	0.356
TRG_ENDOCYTIC_2	84	87	PF00928	0.526
TRG_ER_diArg_1	144	147	PF00400	0.683
TRG_ER_diArg_1	221	224	PF00400	0.545
TRG_ER_diArg_1	267	269	PF00400	0.484
TRG_ER_diArg_1	313	316	PF00400	0.554
TRG_ER_diArg_1	444	446	PF00400	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVL6	Leptomonas seymouri	35%	100%
A0A3S5H580	Leishmania donovani	61%	100%
A4HS10	Leishmania infantum	60%	100%
E9ACP7	Leishmania major	61%	100%
E9AJZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%